Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies

Critical Reviews in Toxicology

Volumn 42, Issue 5, 2012, Pages 323-357

  Saghir, Shakil Ahmed ^a,b   Khan, Sarosh Ahmed ^b   McCoy, Alene Theresa ^a  

^a DOW CHEMICAL COMPANY   (United States)

^b AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

adult; age related changes; children; enzymes; extrahepatic; fetus; hepatic; human; mouse; neonate; Ontogeny; phase i; phase ii; rat; young

Indexed keywords

ACYLTRANSFERASE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ARYLDIALKYLPHOSPHATASE; CHEMICAL AGENT; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C11; CYTOCHROME P450 2C12; CYTOCHROME P450 2D1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; CYTOCHROME P450 4A1; CYTOCHROME P450 4B1; DRUG METABOLIZING ENZYME; EPOXIDE HYDROLASE; ESTERASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; OXIDOREDUCTASE; SULFOTRANSFERASE; THIOPURINE METHYLTRANSFERASE; UNINDEXED DRUG; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT;

AGE; BIOTRANSFORMATION; DEVELOPMENTAL STAGE; EXPOSURE; HUMAN; METABOLIC CAPACITY; METABOLITE; NONHUMAN; ONTOGENY; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; TOXICITY TESTING;

ANIMALS; DATABASES, BIBLIOGRAPHIC; EMBRYO, MAMMALIAN; ENZYMES; GROWTH AND DEVELOPMENT; HUMANS; LIVER; MICE; RATS; TOXICITY TESTS; XENOBIOTICS;

ANIMALIA; MAMMALIA; RATTUS;

EID: 84859898953     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2012.674100     Document Type: Review

References (323)

1. Ahonen M. (1991). Neurofilament immunoreactivity and acetylcholinesterase activity in the developing sympathetic tissuesof the rat. Histochemistry 96:467-478.
2. Alam SN, Roberts RJ, Fischer LJ. (1977). Age-related differences in salicylamide and acetaminophen conjugation in man. J Pediatr90:130-135. (Pubitemid 8015655)
3. Alcorn J, McNamara PJ. (2003). Pharmacokinetics in the newborn. Adv Drug Deliv Rev 55:667-686. (Pubitemid 36428679)
4. Alcorn J, Elbarbry FA, Allouh MZ, McNamara PJ. (2007). Evaluation of the assumptions of an ontogeny model of rat hepatic cytochromeP450 activity. Drug Metab Dispos 35:2225-2231. (Pubitemid 350146209)
5. Alnouti Y, Klaassen CD. (2006). Tissue distribution and ontogeny of sulfotransferase enzymes in mice. Toxicol Sci 93:242-255. (Pubitemid 44400443)
6. Alnouti Y, Klaassen CD. (2008). Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA byprototypical microsomal enzyme inducers in mice. Toxicol Sci 101:51-64. (Pubitemid 350239011)
7. Androutsopoulos VP, Tsatsakis AM, Spandidos DA. (2009). Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.BMC Cancer 9:187.
8. Anttila S, Hukkanen J, Hakkola J, Stjernvall T, Beaune P, Edwards RJ, Boobis AR, Pelkonen O, Raunio H. (1997). Expression andlocalization of CYP3A4 and CYP3A5 in human lung. Am J Respir Cell Mol Biol 16:242-249. (Pubitemid 127497446)
9. Asaoka Y, Sakai H, Sasaki J, Goryo M, Yanai T, Masegi T, Okada K. (2010). Changes in the gene expression and enzyme activity ofhepatic cytochrome P450 in juvenile Sprague-Dawley rats. J Vet Med Sci 72:471-479.
10. Atterberry TT, Burnett WT, Chambers JE. (1997). Age-related differences in parathion and chlorpyrifos toxicity in male rats:target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol Appl Pharmacol 147:411-418. (Pubitemid 28062758)
11. Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN. (1998). Paraoxonase inhibits high-density lipoproteinoxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 101:1581-1590. (Pubitemid 28198486)
12. Baetge G, Pintar JE, Gershon MD. (1990). Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: precursorsof noncatecholaminergic enteric neurons. Dev Biol 141:353-380.
13. Balak KJ, Keith RH, Felder MR. (1982). Genetic and developmental regulation of mouse liver alcohol dehydrogenase. J Biol Chem257:15000-15007. (Pubitemid 13164849)
14. Balistreri WF, Zimmer L, Suchy FJ, Bove KE. (1984). Bile salt sulfotransferase: alterations during maturation and noninducibilityduring substrate ingestion. J Lipid Res 25:228-235. (Pubitemid 14165022)
15. Barker EV, Hume R, Hallas A, Coughtrie WH. (1994).Dehydroepiandrosterone sulfotransferase in the developinghuman fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes.Endocrinology 134:982-989. (Pubitemid 24057248)
16. Bean R, Seckl JR, Lathe R, Martin C. (2001). Ontogeny of the neurosteroid enzyme Cyp7b in the mouse. Mol Cell Endocrinol174:137-144. (Pubitemid 32288877)
17. Beckett GJ, Howie AF, Hume R, Matharoo B, Hiley C, Jones P, Strange RC. (1990). Human glutathione S-transferases: radioimmunoassaystudies on the expression of alpha-, mu-and pi-class isoenzymes in developing lung and kidney. Biochim Biophys Acta 1036:176-182.
18. Bell DR, Plant NJ, Rider CG, Na L, Brown S, Ateitalla I, Acharya SK,Davies MH, Elias E, Jenkins NA. (1993). Species-specific inductionof cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Biochem J 294 (Pt 1):173-180. (Pubitemid 23251927)
19. Belteki G, Kempster SL, Forhead AJ, Giussani DA, Fowden AL,Curley A, Charnock-Jones DS, Smith GC. (2010). Paraoxonase-3,a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and human. J Clin EndocrinolMetab 95:3798-3805.
20. Berdel B, Morys J, Maciejewska B, Narkiewicz O. (1996). Acetylcholinesterase activity as a marker of maturation of thebasolateral complex of the amygdaloid body in the rat. Int J Dev Neurosci 14:543-549. (Pubitemid 26375477)
21. Bièche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, de Waziers I. (2007). Reverse transcriptase-PCRquantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. PharmacogenetGenomics 17:731-742. (Pubitemid 47263068)
22. Blake MJ, Castro L, Leeder JS, Kearns GL. (2005). Ontogeny of drug metabolizing enzymes in the neonate. Semin Fetal Neonatal Med10:123-138. (Pubitemid 40215540)
23. Blake MJ, Gaedigk A, Pearce RE, Bomgaars LR, Christensen ML, Stowe C, James LP, Wilson JT, Kearns GL, Leeder JS. (2007). Ontogeny ofdextromethorphan O-and N-demethylation in the first year of life. Clin Pharmacol Ther 81:510-516. (Pubitemid 46452306)
24. Blum M, Demierre A, Grant DM, Heim M, Meyer UA. (1991). Molecular mechanism of slow acetylation of drugs and carcinogens inhumans. Proc Natl Acad Sci US 88:5237-5241. (Pubitemid 21914719)
25. Boleda MD, Farrés J, Guerri C, Parés X. (1992). Alcohol dehydrogenase isoenzymes in rat development. Effect of maternal ethanolconsumption. Biochem Pharmacol 43:1555-1561.
26. Bolling BW, Court MH, Blumberg JB, Chen CY. (2011). Microsomalquercetin glucuronidation in rat small intestine depends on ageand segment. Drug Metab Dispos 39:1406-1414.
27. Borlakoglu JT, Clarke S, Huang SW, Dils RR, Haegele KD, Gibson GG. (1992). Lactational transfer of 3,3′,4,4′-tetrachloro-and2,2′, 4,4′,5,5′-hexachlorobiphenyl induces cytochrome P450IVA1 in neonates. Evidence for a potential synergistic mechanism.Biochem Pharmacol 43:153-157.
28. Borlakoglu JT, Scott A, Henderson CJ, Wolf CR. (1993). Expression of P450 isoenzymes during rat liver organogenesis. Int J Biochem25:1659-1668. (Pubitemid 23323097)
29. Brzezinski MR, Boutelet-Bochan H, Person RE, Fantel AG, Juchau MR. (1999). Catalytic activity and quantitation of cytochrome P-450 2E1in prenatal human brain. J Pharmacol Exp Ther 289:1648-1653. (Pubitemid 29246702)
30. Büdefeld T, Jezek D, Rozman D, Majdic G. (2009). Initiation of steroidogenesis precedes expression of cholesterologenic enzymesin the fetal mouse testes. Anat Histol Embryol 38:461-466.
31. Buratti FM, De Angelis G, Ricceri L, Venerosi A, Calamandrei G, Testai E. (2011). Foetal and neonatal exposure to chlorpyrifos:biochemical and metabolic alterations in the mouse liver at different developmental stages. Toxicology 280:98-108.
32. Burchell B, Coughtrie M, Jackson M, Harding D, Fournel-Gigleux S, Leakey J, Hume R. (1989). Development of human liver UDPglucuronosyltransferases.Dev Pharmacol Ther 13:70-77.
33. Calafat AM, Weuve J, Ye X, Jia LT, Hu H, Ringer S, Huttner K, Hauser R. (2009). Exposure to bisphenol A and other phenols in neonatalintensive care unit premature infants. Environ Health Perspect117:639-644.
34. Candy JM, Perry EK, Perry RH, Bloxham CA, Thompson J, Johnson M,Oakley AE, Edwardson JA. (1985). Evidence for the early prenataldevelopment of cortical cholinergic afferents from the nucleus ofMeynert in the human foetus. Neurosci Lett 61:91-95. (Pubitemid 16201130)
35. Cappiello M, Giuliani L, Rane A, Pacifici GM. (1991). Dopaminesulphotransferase is better developed than p- nitrophenolsulphotransferase in the human fetus. Dev Pharmacol Ther16:83-88.
36. Card SE, Tompkins SF, Brien JF. (1989). Ontogeny of the activityof alcohol dehydrogenase and aldehyde dehydrogenases inthe liver and placenta of the guinea pig. Biochem Pharmacol38:2535-2541. (Pubitemid 19188418)
37. Chambers JE, Chambers HW. 1990 Time course of inhibition ofacetylcholinesterase and aliesterases following parathion andparaoxon exposures in rats. Toxicol Appl Pharmacol 103 420-429. (Pubitemid 20154721)
38. Chanda SM, Mortensen SR, Moser VC, Padilla S. (1997). Tissue-specificeffects of chlorpyrifos on carboxylesterase and cholinesteraseactivity in adult rats: an in vitro and in vivo comparison. FundamAppl Toxicol 38:148-157.
39. Chen Y, Liu YQ, Su T, Ren X, Shi L, Liu D, Gu J, Zhang QY, Ding X. (2003).Immunoblot analysis and immunohistochemical characterizationof CYP2A expression in human olfactory mucosa. BiochemPharmacol 66:1245-1251. (Pubitemid 37130299)
40. Choonara IA, McKay P, Hain R, Rane A. (1989). Morphine metabolismin children. Br J Clin Pharmacol 28:599-604.
41. Chordikian FJ, Tabakoff B, Alivisatos SG. (1975). Ontogeny ofmultiple forms of monoamine oxidase in mouse brain. Brain Res93:301-308.
42. Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, Stoilov I. (2003).Comparative expression profiling of 40 mouse cytochrome P450genes in embryonic and adult tissues. Arch Biochem Biophys414:91-100. (Pubitemid 36555449)
43. Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL.(1986). Human cholesterol side-chain cleavage enzyme, P450scc:cDNA cloning, assignment of the gene to chromosome 15, andexpression in the placenta. Proc Natl Acad Sci USA 83:8962-8966. (Pubitemid 17223521)
44. Clarke DW, Smith GN, Patrick J, Richardson B, Brien JF. (1989).Activity of alcohol dehydrogenase and aldehyde dehydrogenase inmaternal liver, fetal liver and placenta of the near-term pregnantewe. Dev Pharmacol Ther 12:35-41. (Pubitemid 19055549)
45. Clement JG. (1984). Role of aliesterase in organophosphate poisoning.Fundam Appl Toxicol 4:S96-105. (Pubitemid 14005965)
46. Cohen SN, Baumgartner R, Steinberg MS, Weber WW. (1973).Changes in the physicochemical characteristics of rabbit liverN-acetyltransferase during post-natal development. BiochimBiophys Acta 304:473-481.
47. Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM,Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. (2003).Expression of human paraoxonase (PON1) during development.Pharmacogenetics 13:357-364. (Pubitemid 36724529)
48. Corley RA, Mast TJ, Carney EW, Rogers JM, Daston GP. (2003).Evaluation of physiologically based models of pregnancy andlactation for their application in children's health risk assessments.Crit Rev Toxicol 33:137-211. (Pubitemid 36432873)
49. Cossar D, Bell J, Strange R, Jones M, Sandison A, Hume R. (1990). Thealpha and pi isoenzymes of glutathione S-transferase in humanfetal lung: in utero ontogeny compared with differentiation in lungorgan culture. Biochim Biophys Acta 1037:221-226. (Pubitemid 20043415)
50. Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE.(1999). The role of paraoxonase (PON1) in the detoxication oforganophosphates and its human polymorphism. Chem BiolInteract 119-120:429-438. (Pubitemid 29278580)
51. Coulter CL, Myers DA, Nathanielsz PW, Bird IM. (2000). Ontogeny ofangiotensin II type 1 receptor and cytochrome P450(c11) in thesheep adrenal gland. Biol Reprod 62:714-719. (Pubitemid 30118313)
52. Court MH. (2010). Interindividual variability in hepatic drugglucuronidation: studies into the role of age, sex, enzyme inducers,and genetic polymorphism using the human liver bank as a modelsystem. Drug Metab Rev 42:209-224.
53. Coyle JT, Yamamura HI. (1976). Neurochemical aspects of theontogenesis of cholinergic neurons in the rat brain. Brain Res118:429-440.
54. Cresteil T, Beaune P, Kremers P, Celier C, Guengerich FP, LerouxJP. (1985). Immunoquantification of epoxide hydrolase andcytochrome P-450 isozymes in fetal and adult human livermicrosomes. Eur J Biochem 151:345-350. (Pubitemid 16215760)
55. Croom EL, Stevens JC, Hines RN, Wallace AD, Hodgson E. (2009).Human hepatic CYP2B6 developmental expression: the impact ofage and genotype. Biochem Pharmacol 78:184-190.
56. Cui JY, Choudhuri S, Knight TR, Klaassen CD. (2010). Genetic andepigenetic regulation and expression signatures of glutathioneS-transferases in developing mouse liver. Toxicol Sci 116:32-43.
57. Czekaj P, Bryzek A, Czekaj TM, Koryciak-Komarska H, WiaderkiewiczA, Plewka D, Sieron AL. (2010). Cytochrome P450 mRNAexpressions along with in vitro differentiation of hepatocyteprecursor cells from fetal, young and old rats. Folia HistochemCytobiol 48:46-57.
58. de Waziers I, Cugnenc PH, Yang CS, Leroux JP, Beaune PH. (1990).Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathionetransferases in rat and human hepatic and extrahepatic tissues.J Pharmacol Exp Ther 253:387-394. (Pubitemid 20141526)
59. de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. (1999a).Cytochrome P450 3A: ontogeny and drug disposition. ClinPharmacokinet 37:485-505. (Pubitemid 30032252)
60. de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. (1999b). Glucuronidation in humans. Pharmacogenetic and developmentalaspects. Clin Pharmacokinet 36:439-452.
61. de Wildt SN, Kearns GL, Murry DJ, Koren G, van den Anker JN. (2010).Ontogeny of midazolam glucuronidation in preterm infants. Eur JClin Pharmacol 66:165-170.
62. de Zwart L, Scholten M, Monbaliu JG, Annaert PP, Van Houdt JM,Van den Wyngaert I, De Schaepdrijver LM, Bailey GP, CooganTP, Coussement WC, Mannens GS. (2008). The ontogeny of drugmetabolizing enzymes and transporters in the rat. Reprod Toxicol26:220-230.
63. Denlinger CL, Vesell ES. (1989). Hormonal regulation of thedevelopmental pattern of epoxide hydrolases. Studies in rat liver.Biochem Pharmacol 38:603-610. (Pubitemid 19050099)
64. Deren JS. (1971). Development of structure and function in the fetaland newborn stomach. Am J Clin Nutr 24:144-159.
65. Dolphin CT, Cullingford TE, Shephard EA, Smith RL, Phillips IR.(1996). Differential developmental and tissue-specific regulationof expression of the genes encoding three members of the flavincontainingmonooxygenase family of man, FMO1, FMO3 andFM04. Eur J Biochem 235:683-689. (Pubitemid 26060969)
66. Dorman DC, Allen SL, Byczkowski JZ, Claudio L, Fisher JE Jr, Fisher JW,Harry GJ, Li AA, Makris SL, Padilla S, Sultatos LG, Mileson BE. (2001).Methods to identify and characterize developmental neurotoxicityfor human health risk assessment. III: pharmacokinetic andpharmacodynamic considerations. Environ Health Perspect 109Suppl 1:101-111. (Pubitemid 32318306)
67. Dourson M, Charnley G, Scheuplein R, Barkhurst M. (2004).Chemicals and drugs risk assessment differential sensitivity ofchildren and adults to chemical toxicity. Hum Ecol Risk Assess10, 21-27. (Pubitemid 38554713)
68. Duanmu Z, Weckle A, Koukouritaki SB, Hines RN, Falany JL, Falany CN,Kocarek TA, Runge-Morris M. (2006). Developmental expressionof aryl, estrogen, and hydroxysteroid sulfotransferases in pre-andpostnatal human liver. J Pharmacol Exp Ther 316:1310-1317. (Pubitemid 43345307)
69. Dunn RT 2nd, Gleason BA, Hartley DP, Klaassen CD. (1999). Postnatalontogeny and hormonal regulation of sulfotransferase SULT1B1 inmale and female rats. J Pharmacol Exp Ther 290:319-324. (Pubitemid 29302338)
70. Durrington PN, Mackness B, Mackness MI. (2001). Paraoxonase andatherosclerosis. Arterioscler Thromb Vasc Biol 21:473-480.
71. Ecobichon DJ, Stephens DS. (1973). Perinatal development of humanblood esterases. Clin Pharmacol Ther 14:41-47.
72. Ecobichon DJ. The perinatal guinea pig as a model for toxicologicalstudies. In: Toxicology and the Newborn. S. Kacew and M.J. Reasor,eds. New York: Elsevier Science Publisher B.V., 1984. pp. 34-65.
73. Eidne KA, Bass NM, Sherman M, Millar RP, Kirsch RE. (1984). Ligandinconcentrations in the steroidogenic tissues of the rat duringdevelopment. Biochim Biophys Acta 801:424-428. (Pubitemid 14006512)
74. Ejiri N, Katayama K, Doi K. (2005). Induction of cytochrome P450isozymes by phenobarbital in pregnant rat and fetal livers andplacenta. Exp Mol Pathol 78:150-155. (Pubitemid 40248798)
75. Elbarbry F, Alcorn J. (2009). Ontogeny of glutathione and glutathionerelatedantioxidant enzymes in rat liver. Res Vet Sci 87:242-244.
76. Elbarbry FA, McNamara PJ, Alcorn J. (2007). Ontogeny of hepaticCYP1A2 and CYP2E1 expression in rat. J Biochem Mol Toxicol21:41-50. (Pubitemid 46555358)
77. Elbarbry FA. (2006). Ontogeny of rat CYP2E1 and CYP1A2: acharacterization and a pharmacokinetic model, Ph.D. thesissubmitted to the College of Pharmacy and Nutrition, University ofSaskatchewan, Saskatoon, Canada.
78. Eltom SE, Babish JG, Schwark WS. (1993). The postnatal developmentof drug-metabolizing enzymes in hepatic, pulmonary and renaltissues of the goat. J Vet Pharmacol Ther 16:152-163. (Pubitemid 23168895)
79. Eltom SE, Schwark WS. (1999). CYP1A1 and CYP1B1, two hydrocarboninduciblecytochromes P450, are constitutively expressed inneonate and adult goat liver, lung and kidney. Pharmacol Toxicol85:65-73. (Pubitemid 29404220)
80. Enayetallah AE, French RA, Thibodeau MS, Grant DF. (2004).Distribution of soluble epoxide hydrolase and of cytochromeP450 2C8, 2C9, and 2J2 in human tissues. J Histochem Cytochem52:447-454. (Pubitemid 38420379)
81. Estonius M, Svensson S, Höög JO. (1996). Alcohol dehydrogenase inhuman tissues: localisation of transcripts coding for five classes ofthe enzyme. FEBS Lett 397:338-342. (Pubitemid 26414045)
82. Estrada L, Kanelakis KC, Levy GN, Weber WW. (2000). Tissue-andgender- specific expression of N-acetyltransferase 2 (Nat2*) duringdevelopment of the outbred mouse strain CD-1. Drug MetabDispos 28:139-146. (Pubitemid 30068996)
83. Estrada-Rodgers L, Levy GN, Weber WW. (1998). Substrate selectivityof mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells.Drug Metab Dispos 26:502-505. (Pubitemid 28223892)
84. Fakis G, Boukouvala S, Buckle V, Payton M, Denning C, Sim E.(2000). Chromosome mapping of the genes for murine arylamineN-acetyltransferases (NATs), enzymes involved in the metabolismof carcinogens: identification of a novel upstream noncoding exonfor murine Nat2. Cytogenet Cell Genet 90:134-138.
85. Falany CN, Li G. (2005). Effects of age and pregnancy on cytochromeP450 induction by octamethyltetracyclosiloxane in femaleSprague-Dawley rats. J Biochem Mol Toxicol 19:129-138. (Pubitemid 40571693)
86. Fernandez E, Perez R, Hernandez A, Tejada P, Arteta M, Ramos JT.(2011). Factors and mechanisms for pharmacokinetic differencesbetween pediatric population and adults. Pharmaceutics 3, 53-72.
87. Foxenberg RJ. (2007). Generation of physiologically relevant kineticdata for the refinement of a human CYP-specific physiologicallybased pharmacokinetic/pharmacodynamic model to improve toimprove the risk assessment of two organophosphate pesticides:parathion and chlorpyrifos. Ph.D. dissertation, State University ofNew York, University of Buffalo
88. Department of Pharmacology andToxicology. P 182.FQPA. (1996). Food Quality Protection Act. Public Law No. 104-170.
89. Fryer AA, Hume R, Strange RC. (1986). The development of glutathioneS-transferase and glutathione peroxidase activities in human lung.Biochim Biophys Acta 883:448-453. (Pubitemid 16001543)
90. Ganiere-Monteil C, Medard Y, Lejus C, Bruneau B, Pineau A, FenneteauO, Bourin M, Jacqz-Aigrain E. (2004). Phenotype and genotype forthiopurine methyltransferase activity in the French Caucasianpopulation: impact of age. Eur J Clin Pharmacol 60:89-96. (Pubitemid 38626437)
91. Gasser R, Philpot RM. (1989). Primary structures of cytochrome P-450isozyme 5 from rabbit and rat and regulation of species-dependentexpression and induction in lung and liver: identification ofcytochrome P-450 gene subfamily IVB. Mol Pharmacol 35:617-625. (Pubitemid 19138911)
92. Gebremichael A, Chang AM, Buckpitt AR, Plopper CG, Pinkerton KE.(1995). Postnatal development of cytochrome P4501A1 and 2B1 inrat lung and liver: effect of aged and diluted sidestream cigarettesmoke. Toxicol Appl Pharmacol 135:246-253. (Pubitemid 26031875)
93. Gibbs JP, Liacouras CA, Baldassano RN, Slattery JT. (1999).Up-regulation of glutathione S-transferase activity in enterocytesof young children. Drug Metab Dispos 27:1466-1469.
94. Gilham DE, Cairns W, Paine MJ, Modi S, Poulsom R, Roberts GC, WolfCR. (1997). Metabolism of MPTP by cytochrome P4502D6 and thedemonstration of 2D6 mRNA in human foetal and adult brain by insitu hybridization. Xenobiotica 27:111-125. (Pubitemid 27068376)
95. Gilissen RA, Hume R, Meerman JH, Coughtrie MW. (1994).Sulphation of N-hydroxy-4-aminobiphenyl and N-hydroxy-4-acetylaminobiphenyl by human foetal and neonatalsulphotransferase. Biochem Pharmacol 48:837-840.
96. Ginsberg G, Hattis D, Sonawane B, Russ A, Banati P, KozlakM, Smolenski S, Goble R. (2002). Evaluation of child/adultpharmacokinetic differences from a database derived from thetherapeutic drug literature. Toxicol Sci 66:185-200. (Pubitemid 34285113)
97. Glatt H. (2000). Sulfotransferases in the bioactivation of xenobiotics.Chem Biol Interact 129:141-170. (Pubitemid 32061058)
98. Greger DL, Philipona C, Blum JW. (2006). Ontogeny of mRNAabundance of nuclear receptors and nuclear receptor target genesin young cattle. Domest Anim Endocrinol 31:76-87. (Pubitemid 43776622)
99. Gu J, Su T, Chen Y, Zhang QY, Ding X. (2000). Expression ofbiotransformation enzymes in human fetal olfactory mucosa:potential roles in developmental toxicity. Toxicol Appl Pharmacol165:158-162. (Pubitemid 30395365)
100. Guengerich FP. (2008). Oxidative, reductive and hydrolytic metabolismof drugs, In Drug metabolism in drug design and development(Zhang D, Zhu M, Griffith Humphreys W edts), John Wiley & Sons,Inc., Hoboken, New Jersey, pp. 15-36.
101. Haehner BD, Gorski JC, Vandenbranden M, Wrighton SA, JanardanSK, Watkins PB, Hall SD. (1996). Bimodal distribution of renalcytochrome P450 3A activity in humans. Mol Pharmacol50:52-59. (Pubitemid 26250074)
102. Hahn T, Desoye G, Lang I, Skofitsch G. (1993). Location and activitiesof acetylcholinesterase and butyrylcholinesterase in the rat andhuman placenta. Anat Embryol 188:435-440. (Pubitemid 24000109)
103. Hakkola J, Pasanen M, Pelkonen O, Hukkanen J, Evisalmi S, Anttila S,Rane A, Mäntylä M, Purkunen R, Saarikoski S, Tooming M, RaunioH. (1997). Expression of CYP1B1 in human adult and fetal tissuesand differential inducibility of CYP1B1 and CYP1A1 by Ah receptorligands in human placenta and cultured cells. Carcinogenesis18:391-397. (Pubitemid 28132434)
104. Hakkola J, Pasanen M, Purkunen R, Saarikoski S, Pelkonen O, MäenpääJ, Rane A, Raunio H. (1994). Expression of xenobiotic-metabolizingcytochrome P450 forms in human adult and fetal liver. BiochemPharmacol 48:59-64. (Pubitemid 24236392)
105. Hakkola J, Pelkonen O, Pasanen M, Raunio H. (1998). Xenobioticmetabolizingcytochrome P450 enzymes in the human feto-placentalunit: role in intrauterine toxicity. Crit Rev Toxicol 28:35-72. (Pubitemid 28100181)
106. Hansen LG, Shane BS. (1994). Xenobiotic metabolism. In: CockerhamLG, Shane BS, eds. Basic environmental toxicology. Boca Raton,Florida: CRC Press, Inc., 49-105.
107. Harada N, Yamada K. (1992). Ontogeny of aromatase messengerribonucleic acid in mouse brain: fluorometrical quantitation bypolymerase chain reaction. Endocrinology 131:2306-2312.
108. Harris C, Thomas DE, Carter MW, Bradshaw WS. (1991). Fetotoxicalterations in the normal ontogenies of rat microsomal andlysosomal enzymes. J Biochem Toxicol 6:181-194.
109. Harris C, Wang SW, Lauchu JJ, Hansen JM. (2003). Methanolmetabolism and embryotoxicity in rat and mouse conceptuses:comparisons of alcohol dehydrogenase (ADH1), formaldehydedehydrogenase (ADH3), and catalase. Reprod Toxicol 17:349-357. (Pubitemid 36626958)
110. Hart SN, Cui Y, Klaassen CD, Zhong XB. (2009). Three patterns ofcytochrome P450 gene expression during liver maturation in mice.Drug Metab Dispos 37:116-121.
111. Hassett C, Richter RJ, Humbert R, Chapline C, Crabb JW, OmiecinskiCJ, Furlong CE. (1991). Characterization of cDNA clones encodingrabbit and human serum paraoxonase: the mature protein retainsits signal sequence. Biochemistry 30:10141-10149.
112. Hattis D, Ginsberg G, Sonawane B, Smolenski S, Russ A, KozlakM, Goble R. (2003). Differences in pharmacokinetics betweenchildren and adults-II. Children's variability in drug eliminationhalf-lives and in some parameters needed for physiologicallybasedpharmacokinetic modeling. Risk Anal 23:117-142. (Pubitemid 36255427)
113. Hayes JD, Pulford DJ. (1995). The glutathione S-transferase supergenefamily: regulation of GST and the contribution of the isoenzymesto cancer chemoprotection and drug resistance. Crit Rev BiochemMol Biol 30:445-600.
114. Hein DW, Trinidad A, Yerokun T, Ferguson RJ, Kirlin WG, WeberWW. (1988). Genetic control of acetyl coenzyme A-dependentarylamine N-acetyltransferase, hydrazine N-acetyltransferase, andN-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J,A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.Acongenic inbred mouse. Drug Metab Dispos 16:341-347.
115. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xio GH,Devanaboyina US, Nagju NA, Feng Y. (2002). Molecular genetics andepidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomark Prev 9:29-42.
116. Henderson CJ, Bammler T, Wolf CR. (1994). Deduced aminoacid sequence of a murine cytochrome P-450 Cyp4a protein:developmental and hormonal regulation in liver and kidney. Biochim Biophys Acta 1200:182-190.
117. Her C, Kaur GP, Athwal RS, Weinshilboum RM. (1997). Humansulfotransferase SULT1C1: cDNA cloning, tissue-specificexpression, and chromosomal localization. Genomics 41:467-470. (Pubitemid 27194802)
118. Hiley C, Bell J, Hume R, Strange R. (1989). Differential expression ofalpha and pi isoenzymes of glutathione S-transferase in developinghuman kidney. Biochim Biophys Acta 990:321-324. (Pubitemid 19074652)
119. Hines RN, McCarver DG. (2002). The ontogeny of human drugmetabolizingenzymes: phase I oxidative enzymes. J PharmacolExp Ther 300:355-360. (Pubitemid 34106223)
120. Hines RN. (2008). The ontogeny of drug metabolism enzymesand implications for adverse drug events. Pharmacol Ther118:250-267.
121. Holmes RS. (1979a). Genetics and ontogeny of alcohol dehydrogenaseisozymes in the mouse: evidence for a cis-acting regulator gene(Adt-i) controlling C2 isozyme expression in reproductive tissuesand close linkage of Adh-3 and Adt-i on chromosome 3. BiochemGenet 17:461-472. (Pubitemid 10241825)
122. Holmes RS. (1979b). Genetics, ontogeny, and testosterone inducibilityof aldehyde oxidase isozymes in the mouse: evidence for twogenetic loci (Aox-I and Aox-2) closely linked on chromosome 1. Biochem Genet 17:517-527. (Pubitemid 10241828)
123. Hong JY, Pan JM, Dong ZG, Ning SM, Yang CS. (1987). Regulation ofN-nitrosodimethylamine demethylase in rat liver and kidney. Cancer Res 47:5948-5953. (Pubitemid 18018735)
124. Horbach GJ, Van Asten JG, Rietjens IM, Kremers P, Van Bezooijen CF.(1992). The effect of age on inducibility of various types of rat livercytochrome P-450. Xenobiotica 22:515-522.
125. Hsu MH, Savas U, Griffin KJ, Johnson EF. (2007). Human cytochromep450 family 4 enzymes: function, genetic variation and regulation.Drug Metab Rev 39:515-538. (Pubitemid 47355735)
126. Huang CT, Rodriguez JT, Woodward WE, Nichols BL. (1976).Comparison of patterns of fecal bile acid and neutral sterolbetween children and adults. Am J Clin Nutr 29:1196-1203.
127. Huen K, Harley K, Brooks J, Hubbard A, Bradman A, Eskenazi B,Holland N. (2009). Developmental changes in PON1 enzymeactivity in young children and effects of PON1 polymorphisms. Environ Health Perspect 117:1632-1638.
128. Hume R, Barker EV, Coughtrie MW. (1996a). Differential expressionand immunohistochemical localisation of the phenol andhydroxysteroid sulphotransferase enzyme families in thedeveloping lung. Histochem Cell Biol 105:147-152. (Pubitemid 26069838)
129. Hume R, Burchell A, Allan BB, Wolf CR, Kelly RW, Hallas A, BurchellB. (1996b). The ontogeny of key endoplasmic reticulum proteins inhuman embryonic and fetal red blood cells. Blood 87:762-770. (Pubitemid 26030333)
130. Hume R, Coughtrie MW, Burchell B. (1995). Differential localisation ofUDP-glucuronosyltransferase in kidney during human embryonicand fetal development. Arch Toxicol 69:242-247.
131. Hustert E, Haberl M, Burk O, Wolbold R, He YQ, Klein K, Nuessler AC,Neuhaus P, Klattig J, Eiselt R, Koch I, Zibat A, Brockmöller J, HalpertJR, Zanger UM, Wojnowski L. (2001). The genetic determinants ofthe CYP3A5 polymorphism. Pharmacogenetics 11:773-779. (Pubitemid 33151512)
132. Ichikawa H, Matsuo S, Wakisaka S, Akai M. (1991). Ontogenyof cholinergic ganglionic cells which take up L-3,4-dihydroxyphenylalanine and contain vasoactive intestinalpolypeptide in the mouse tongue. Acta Anat (Basel) 140:135-138.
133. ICRP 2003 Publication 89: Basic anatomical and physiological datafor use in radiological protection: reference values. Oxford, UK: Elsevier Science Ltd.
134. Ilhan A, Gartner W, Nabokikh A, Daneva T, Majdic O, Cohen G,Böhmig GA, Base W, Hörl WH, Wagner L. (2008). Localizationand characterization of the novel protein encoded by C20orf3. Biochem J 414:485-495.
135. Imaoka S, Fujita S, Funae Y. (1991). Age-dependent expressionof cytochrome P-450s in rat liver. Biochim Biophys Acta1097:187-192.
136. Irizar A, Ioannides C. (1995). Expression and inducibility of cytochromeP450 proteins belonging to families 2,3 and 4 in the rabbit aorta. Biochem Biophys Res Commun 213:916-921.
137. James MO. (2011). Ontogeny of hepatic glutathione transferaseenzymes in humans. Presented at the 17th North American RegionalISSX Meeting
138. Atlanta, GA.Johnson EF, Walker DL, Griffin KJ, Clark JE, Okita RT, Muerhoff AS,Masters BS. (1990). Cloning and expression of three rabbit kidneycDNAs encoding lauric acid omega-hydroxylases. Biochemistry29:873-879. (Pubitemid 20053795)
139. Johnson TN, Tanner MS, Taylor CJ, Tucker GT. (2001). EnterocyticCYP3A4 in a paediatric population: developmental changes andthe effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol51:451-460. (Pubitemid 32852983)
140. Johnson TN. (2003). The development of drug metabolising enzymesand their influence on the susceptibility to adverse drug reactionsin children. Toxicology 192:37-48. (Pubitemid 37153342)
141. Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, HinesRN, McCarver DG. (2003). Human hepatic CYP2E1 expressionduring development. J Pharmacol Exp Ther 307:402-407. (Pubitemid 37151933)
142. Jokanovic M. (1989). Role of carboxylesterase in soman, sarin andtabun poisoning in rats. Pharmacol Toxicol 65:181-184. (Pubitemid 19233799)
143. Jones AL, Hume R, Bamforth KJ, Coughtrie MW. (1992). Estrogen andphenol sulfotransferase activities in human fetal lung. Early HumDev 28:65-77.
144. Josephy PD, Guengerich FP, Miners JO. (2005). "Phase I" and "PhaseII" drug metabolism: terminology that we should phase out? DrugMetab Rev 37:575-580. (Pubitemid 43068148)
145. Karanth S, Pope C. (2000). Carboxylesterase and A-esterase activitiesduring maturation and aging: relationship to the toxicity ofchlorpyrifos and parathion in rats. Toxicol Sci 58:282-289. (Pubitemid 32042426)
146. Kawaji A, Isobe M, Tochino Y, Takabatake E, Chikaoka Y, Nomura Y,Tamura M. (1998). Flavin-containing monooxygenase mediatedmetabolism of benzydamine in perfused brain and liver. BiochimBiophys Acta 1425:41-46. (Pubitemid 28479711)
147. Kelso GJ, Stuart WD, Richter RJ, Furlong CE, Jordan-Starck TC, HarmonyJA. (1994). Apolipoprotein J is associated with paraoxonase inhuman plasma. Biochemistry 33:832-839. (Pubitemid 24064123)
148. Kennedy B, Ziegler MG. (2000). Ontogeny of epinephrine metabolicpathways in the rat: role of glucocorticoids. Int J Dev Neurosci18:53-59. (Pubitemid 30116709)
149. Kester MH, Kaptein E, Roest TJ, van Dijk CH, Tibboel D, Meinl W,Glatt H, Coughtrie MW, Visser TJ. (1999). Characterization ofhuman iodothyronine sulfotransferases. J Clin Endocrinol Metab84:1357-1364.
150. Kimoto T, Ishii H, Higo S, Hojo Y, Kawato S. (2010). Semicomprehensiveanalysis of the postnatal age-related changes in the mRNAexpression of sex steroidogenic enzymes and sex steroid receptorsin the male rat hippocampus. Endocrinology 151:5795-5806.
151. Kimura S, Donovan JC, Nebert DW. (1987). Expression of the mouseP(1)450 gene during differentiation without foreign chemicalstimulation. J Exp Pathol 3:61-74. (Pubitemid 17043274)
152. Kishi M, Emi Y, Sakaguchi M, Ikushiro S, Iyanagi T. (2008). Ontogenicisoform switching of UDP-glucuronosyltransferase family 1 in ratliver. Biochem Biophys Res Commun 377:815-819.
153. Kiss J, Patel AJ. (1992). Development of the cholinergic fibresinnervating the cerebral cortex of the rat. Int J Dev Neurosci10:153-170.
154. Kopin IJ. (1985). Catecholamine metabolism: basic aspects andclinical significance. Pharmacol Rev 37:333-364. (Pubitemid 16106624)
155. Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarverDG, Hines RN. (2004). Developmental expression of human hepaticCYP2C9 and CYP2C19. J Pharmacol Exp Ther 308:965-974. (Pubitemid 38263972)
156. Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, Hines RN. (2002).Human hepatic flavin-containing monooxygenases 1 (FMO1) and3 (FMO3) developmental expression. Pediatr Res 51:236-243. (Pubitemid 34101340)
157. Krishna DR, Klotz U. (1994). Extrahepatic metabolism of drugs inhumans. Clin Pharmacokinet 26:144-160.
158. Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB,Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C,Yasuda K, Venkataramanan R, Strom S, Thummel K, BoguskiMS, Schuetz E. (2001). Sequence diversity in CYP3A promotersand characterization of the genetic basis of polymorphic CYP3A5expression. Nat Genet 27:383-391. (Pubitemid 32268418)
159. Kuntzman R, Mark LC, Brand LC, Jacobson BM, Levin W, ConneyAH. (1966). Metabolism of drugs and carcinogens by human liverenzymes. J Pharmacol Exp Ther 152:151-156.
160. Lacroix D, Sonnier M, Moncion A, Cheron G, Cresteil T. (1997).Expression of CYP3A in the human liver-evidence that the shiftbetween CYP3A7 and CYP3A4 occurs immediately after birth. EurJ Biochem 247:625-634. (Pubitemid 27308642)
161. LaKind JS, Amina Wilkins A, Berlin CM Jr. (2004). Environmentalchemicals in human milk: a review of levels, infant exposures andhealth, and guidance for future research. Toxicol Appl Pharmacol198:184-208. (Pubitemid 38960725)
162. Lang T, Klein K, Fischer J, Nüssler AK, Neuhaus P, Hofmann U,Eichelbaum M, Schwab M, Zanger UM. (2001). Extensivegenetic polymorphism in the human CYP2B6 gene with impacton expression and function in human liver. Pharmacogenetics11:399-415. (Pubitemid 32656581)
163. Leakey JE, Hume R, Burchell B. (1987). Development of multipleactivities of UDP-glucuronyltransferase in human liver. BiochemJ 243:859-861. (Pubitemid 17073727)
164. Leeder JS, Kearns GL. (1997). Pharmacogenetics in pediatrics.Implications for practice. Pediatr Clin North Am 44:55-77.
165. Lephart ED, Simpson ER, McPhaul MJ, Kilgore MW, Wilson JD,Ojeda SR. (1992). Brain aromatase cytochrome P-450 messengerRNA levels and enzyme activity during prenatal and perinataldevelopment in the rat. Brain Res Mol Brain Res 16:187-192. (Pubitemid 23035959)
166. Levy E, Trudel K, Bendayan M, Seidman E, Delvin E, Elchebly M,Lavoie JC, Precourt LP, Amre D, Sinnett D. (2007). Biological role,protein expression, subcellular localization, and oxidative stressresponse of paraoxonase 2 in the intestine of humans and rats. AmJ Physiol Gastrointest Liver Physiol 293:G1252-G1261. (Pubitemid 350255038)
167. Li W, Gu Y, James MO, Hines RN, Simpson P, Langaee T, StacpoolePW. (2012). Prenatal and postnatal expression of glutathionetransferase ? 1 in human liver and the roles of haplotype andsubject age in determining activity with dichloroacetate. DrugMetab Dispos 40:232-239.
168. Lin YS, Dowling AL, Quigley SD, Farin FM, Zhang J, Lamba J, SchuetzEG, Thummel KE. (2002). Co-regulation of CYP3A4 and CYP3A5and contribution to hepatic and intestinal midazolam metabolism.Mol Pharmacol 62:162-172. (Pubitemid 34680528)
169. Lindahl R. (1977). Aldehyde dehydrogenase in 2- acetamidofluoreneinducedrat hepatomas. Ontogeny and evidence that the newisoenzymes are not due to normal gene de-repression. BiochemJ 164:119-123. (Pubitemid 8070672)
170. Liu L, Klaassen CD. (1996a). Ontogeny and hormonal basis of femaledominantrat hepatic sulfotransferases. J Pharmacol Exp Ther279:386-391. (Pubitemid 27166935)
171. Liu L, Klaassen CD. (1996b). Ontogeny and hormonal basis ofmale-dominant rat hepatic sulfotransferases. Mol Pharmacol50:565-572. (Pubitemid 26303587)
172. Lund J, Mason JI, Simpson ER, Waterman MR. (1989). Developmentalregulation of P-45017 alpha gene expression in fetal bovine adrenal.Endocr Res 15:17-29.
173. Macé K, Bowman ED, Vautravers P, Shields PG, Harris CC, PfeiferAM. (1998). Characterisation of xenobiotic-metabolising enzymeexpression in human bronchial mucosa and peripheral lungtissues. Eur J Cancer 34:914-920. (Pubitemid 28248506)
174. Mackness B, Beltran-Debon R, Aragones G, Joven J, Camps J, MacknessM. (2010). Human tissue distribution of paraoxonases 1 and 2mRNA. IUBMB Life 62:480-482.
175. Mäenpää J, Rane A, Raunio H, Honkakoski P, Pelkonen O. (1993).Cytochrome P450 isoforms in human fetal tissues related tophenobarbital-inducible forms in the mouse. Biochem Pharmacol45:899-907. (Pubitemid 23071441)
176. Martell KJ, Levy GN, Weber WW. (1992). Cloned mouseN-acetyltransferases: enzymatic properties of expressed Nat-1 andNat-2 gene products. Mol Pharmacol 42:265-272. (Pubitemid 23026158)
177. Marty MS, Saghir SA, Clark AJ, Zablotny CL, Bus JS, Perala AW,Yano BL, Neal BH. (2009). A dietary dose range-finding andtoxicokinetic (TK) study of 2,4-dichlorophenoxyacetic acid(2,4-D) in adult CRL:CD(SD) rats and their offspring: II. Toxicity.108:1262.
178. Maslova MN, Ozirskaia EV. (1979). [External brain acetylcholinesterasein the ontogeny of precocial and altricial rodents]. Zh Evol BiokhimFiziol 15:48-53. (Pubitemid 9116563)
179. Matsubara S, Yamamoto S, Sogawa K, Yokotani N, Fujii-Kuriyama Y,Haniu M, Shively JE, Gotoh O, Kusunose E, Kusunose M. (1987).cDNA cloning and inducible expression during pregnancy of themRNA for rabbit pulmonary prostaglandin omega-hydroxylase(cytochrome P-450p-2). J Biol Chem 262:13366-13371.
180. Matsumoto J, Yokota H, Yuasa A. (2002). Developmental increases inrat hepatic microsomal UDP-glucuronosyltransferase activitiestoward xenoestrogens and decreases during pregnancy. EnvironHealth Perspect 110:193-196. (Pubitemid 34163038)
181. Maxwell DM. (1992). The specificity of carboxylesterase protectionagainst the toxicity of organophosphorus compounds. ToxicolAppl Pharmacol 114:306-312.
182. McCarver DG, Hines RN. (2002). The ontogeny of human drugmetabolizingenzymes: phase II conjugation enzymes andregulatory mechanisms. J Pharmacol Exp Ther 300:361-366. (Pubitemid 34106224)
183. McCarver DG. (2004). Applicability of the principles of developmentalpharmacology to the study of environmental toxicants. Pediatrics113:969-972. (Pubitemid 38437349)
184. McCombie RR, Dolphin CT, Povey S, Phillips IR, Shephard EA. (1996).Localization of human flavin-containing monooxygenase genesFMO2 and FMO5 to chromosome 1q. Genomics 34:426-429. (Pubitemid 26234742)
185. McLeod HL, Krynetski EY, Wilimas JA, Evans WE. (1995). Higheractivity of polymorphic thiopurine S-methyltransferase inerythrocytes from neonates compared to adults. Pharmacogenetics5:281-286.
186. McQueen CA, Chau B. (2003). Neonatal ontogeny of murine arylamineN-acetyltransferases: implications for arylamine genotoxicity.Toxicol Sci 73:279-286. (Pubitemid 36701733)
187. McQueen CA, Mitchell MK, Dang LN, Chau B, Tjalkens RB, PhilbertMA. (2003). Prenatal expression of N-acetyltransferases in C57Bl/6mice. Chem Biol Interact 145:77-87.
188. Meyer RP, Podvinec M, Meyer UA. (2002). Cytochrome P450 CYP1A1accumulates in the cytosol of kidney and brain and is activated byheme. Mol Pharmacol 62:1061-1067. (Pubitemid 35222496)
189. Micic M, Leposavic G, Ugresic N, Bogojevic M, Isakovic K. (1992).Parasympathetic innervation of the rat thymus during firstlife period: histochemical and biochemical study. Thymus19:173-182.
190. Mitra A, Hilbelink DR, Dwornik JJ, Kulkarni A. (1992). A novel modelto assess developmental toxicity of dihaloalkanes in humans:bioactivation of 1,2-dibromoethane by the isozymes of humanfetal liver glutathione S-transferase. Teratog, Carcinog Mutagen12:113-127.
191. Miyagi SJ, Collier AC. (2007). Pediatric development ofglucuronidation: the ontogeny of hepatic UGT1A4. Drug MetabDispos 35:1587-1592. (Pubitemid 47296052)
192. Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, TsuiLC, Prochazka M. (1998). Human PON2 gene at 7q21.3: cloning,multiple mRNA forms, and missense polymorphisms in the codingsequence. Gene 213:149-157. (Pubitemid 28284734)
193. Morselli PL. (1989). Clinical pharmacology of the perinatal period andearly infancy. Clin Pharmacokinet 17 Suppl 1:13-28. (Pubitemid 20013416)
194. Moser R, Oberley TD, Daggett DA, Friedman AL, Johnson JA, SiegelFL. (1995). Effects of lead administration on developing rat kidney.I. Glutathione S-transferase isoenzymes. Toxicol Appl Pharmacol131:85-93.
195. Muerhoff AS, Williams DE, Masters BS. (1990). Purification andproperties of pregnancy-inducible rabbit lung cytochrome P-450prostaglandin omega-hydroxylase. Meth Enzymol 187:253-267. (Pubitemid 20309289)
196. Murray GI, Foster CO, Barnes TS, Weaver RJ, Snyder CP, Ewen SW,Melvin WT, Burke MD. (1992). Cytochrome P450IA expression inadult and fetal human liver. Carcinogenesis 13:165-169.
197. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, EstabrookRW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O.(1993). The P450 superfamily: update on new sequences, genemapping, accession numbers, early trivial names of enzymes, andnomenclature. DNA Cell Biol 12:1-51. (Pubitemid 23064489)
198. Ng CJ, Wadleigh DJ, Gangopadhyay A, Hama S, Grijalva VR, Navab M,Fogelman AM, Reddy ST. (2001). Paraoxonase-2 is a ubiquitouslyexpressed protein with antioxidant properties and is capable ofpreventing cell-mediated oxidative modification of low densitylipoprotein. J Biol Chem 276:44444-44449.
199. Novick RM, Mitzey AM, Brownfield MS, Elfarra AA. (2009). Differentiallocalization of flavin-containing monooxygenase (FMO) isoforms1, 3, and 4 in rat liver and kidney and evidence for expression ofFMO4 in mouse, rat, and human liver and kidney microsomes. JPharmacol Exp Ther 329:1148-1155.
200. NRC (National Research Council). Pesticides in the diets of infantsand children. Washington, DC: National Academy Press, 1993.
201. Odum J, Orton TC. (1983). Hepatic microsomal glucuronidationof clofibric acid in the adult and neonate albino rat. BiochemPharmacol 32:3565-3569. (Pubitemid 14205365)
202. Omiecinski CJ, Aicher L, Swenson L. (1994). Developmental expressionof human microsomal epoxide hydrolase. J Pharmacol Exp Ther269:417-423. (Pubitemid 24143282)
203. Omiecinski CJ, Redlich CA, Costa P. (1990). Induction anddevelopmental expression of cytochrome P450IA1 messengerRNA in rat and human tissues: detection by the polymerase chainreaction. Cancer Res 50:4315-4321. (Pubitemid 20225671)
204. Ozols J. (1999). Isolation and complete covalent structure of livermicrosomal paraoxonase. Biochem J 338 (Pt 2):265-272.
205. Pacifici GM, Bencini C, Rane A. (1986). Acetyltransferase in humans:development and tissue distribution. Pharmacology 32:283-291.
206. Pacifici GM, Temellini A, Giuliani L, Rane A, Thomas H, Oesch F.(1988a). Cytosolic epoxide hydrolase in humans: developmentand tissue distribution. Arch Toxicol 62:254-257. (Pubitemid 18266672)
207. Pacifici GM, Franchi M, Colizzi C, Giuliani L, Rane A. (1988b).Sulfotransferase in humans: development and tissue distribution. Pharmacology 36:411-419.
208. Pacifici GM, Franchi M, Giuliani L, Rane A. (1989). Development of theglucuronyltransferase and sulphotransferase towards 2-naphtholin human fetus. Dev Pharmacol Ther 14:108-114.
209. Pacifici GM, Peng D, Rane A. (1983). Epoxide hydrolase and arylhydrocarbon hydroxylase in human fetal tissues: activities innuclear and microsomal fractions and in isolated hepatocytes.Pediatr Pharmacol (New York) 3:189-197. (Pubitemid 14102402)
210. Pacifici GM, Rane A. (1981). Intestinal and hepatic morphineglucuronidation in immature and pregnant rats. Dev PharmacolTher 3:160-167. (Pubitemid 12180453)
211. Pacifici GM, Rane A. (1983). Epoxide hydrolase in human fetal liver.Pharmacology 26:241-248. (Pubitemid 13119053)
212. Pacifici GM, Romiti P, Giuliani L, Rane A. (1991). Thiopurinemethyltransferase in humans: development and tissue distribution.Dev Pharmacol Ther 17:16-23.
213. Pacifici GM, Säwe J, Kager L, Rane A. (1982). Morphine glucuronidationin human fetal and adult liver. Eur J Clin Pharmacol 22:553-558. (Pubitemid 12059202)
214. Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL,Perkins JD, Thummel KE. (1997). Characterization of interintestinaland intraintestinal variations in human CYP3A-dependentmetabolism. J Pharmacol Exp Ther 283:1552-1562. (Pubitemid 28016533)
215. Pariente-Khayat A, Pons G, Rey E, Richard MO, D'Athis P, Moran C,Badoual J, Olive G. (1991). Caffeine acetylator phenotyping duringmaturation in infants. Pediatr Res 29:492-495.
216. Pariente-Khayat A, Rey E, Gendrel D, Vauzelle-Kervroëdan F,Crémier O, d'Athis P, Badoual J, Olive G, Pons G. (1997). Isoniazidacetylation metabolic ratio during maturation in children. ClinPharmacol Ther 62:377-383. (Pubitemid 27475221)
217. Park-Hah JO, Klemetsdal B, Lysaa R, Choi KH, Aarbakke J. (1996).Thiopurine methyltransferase activity in a Korean populationsample of children. Clin Pharmacol Ther 60:68-74. (Pubitemid 26279223)
218. Parkinson A. (1996). Biotransformation of xenobiotics. In: KlaassenCD, ed. Casarett & Doull's toxicology: the basic science of poisons.New York: McGraw-Hill, 113-186.
219. Partridge CA, Singh SV, Hong TD, Theodore C, Dao DD, Awasthi YC.(1985). Rat lung glutathione S-transferases: subunit structure and theinterrelationship with the liver enzymes. Int J Biochem 17:331-340. (Pubitemid 15086257)
220. Pasanen M, Pelkonen O, Kauppila A, Park SS, Friedman FK, GelboinHV. (1987). Characterization of human fetal hepatic cytochromeP-450-associated 7-ethoxyresorufin O-deethylase and arylhydrocarbon hydroxylase activities by monoclonal antibodies.Dev Pharmacol Ther 10:125-132. (Pubitemid 17084335)
221. Pasanen M, Pelkonen O. (1986). Purification and immunologicalcharacterization of human placental mitochondrial cytochromeP-450. J Steroid Biochem 24:669-675. (Pubitemid 16115674)
222. Pasanen M, Pelkonen O. (1989). Human placental xenobiotic andsteroid biotransformations catalyzed by cytochrome P450,epoxide hydrolase, and glutathione S-transferase activities andtheir relationships to maternal cigarette smoking. Drug Metab Rev21:427-461. (Pubitemid 20206007)
223. Pasanen M. (1999). The expression and regulation of drug metabolismin human placenta. Adv Drug Deliv Rev 38:81-97. (Pubitemid 29216955)
224. Patel HR, Hewer A, Hayes JD, Phillips DH, Campbell FC. (1998). Agedependentchange of metabolic capacity and genotoxic injury inrat intestine. Chem Biol Interact 113:27-37. (Pubitemid 28279789)
225. Payne AK, Morgan SE, Gandolfi AJ, Brendel K. (1995). Biotransformationof sevoflurane by rat neonate liver slices. Drug Metab Dispos23:497-500.
226. Payton M, Smelt V, Upton A, Sim E. (1999). A method for genotypingmurine arylamine N-acetyltransferase type 2 (NAT2): a geneexpressed in preimplantation embryonic stem cells encoding anenzyme acetylating the folate catabolite p-aminobenzoylglutamate. Biochem Pharmacol 58:779-785. (Pubitemid 29329527)
227. Pikkarainen PH, Räihä NC. (1967). Development of alcoholdehydrogenase activity in the human liver. Pediatr Res 1:165-168.
228. Plopper CG, Weir AJ, Morin D, Chang A, Philpot RM, Buckpitt AR.(1993). Postnatal changes in the expression and distribution ofpulmonary cytochrome P450 monooxygenases during Clara celldifferentiation in rabbits. Mol Pharmacol 44:51-61. (Pubitemid 23230459)
229. Podosinovikova NP, Dolgo-Saburov VB. (1979). [The structuralcatalytic characteristics of brain acetylcholinesterase in rabbitpostnatal ontogeny]. Zh Evol Biokhim Fiziol 15:54-58.
230. Polk DH. (1995). Thyroid hormone metabolism during development.Reprod Fertil Dev 7:469-477.
231. Pons G, Rey E, Carrier O, Richard MO, Moran C, Badoual J, Olive G.(1989). Maturation of AFMU excretion in infants. Fundam ClinPharmacol 3:589-595. (Pubitemid 20003757)
232. Pope CN, Karanth S, Liu J, Yan B. (2005). Comparative carboxylesteraseactivities in infant and adult liver and their in vitro sensitivity tochlorpyrifos oxon. Regul Toxicol Pharmacol 42:64-69. (Pubitemid 40724417)
233. Poulsen LL, Ziegler DM. (1995). Multisubstrate flavin- containingmonooxygenases: applications of mechanism to specificity. ChemBiol Interact 96:57-73.
234. Pretheeban M, Hammond G, Bandiera S, Riggs W, Rurak D. (2011).Ontogenesis of UDP-glucuronosyltransferase enzymes insheep. Comp Biochem Physiol, Part A Mol Integr Physiol 159:159-166.
235. Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, MohrenweiserHW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE,Zeldin DC, Grant DF. (2003). Polymorphisms in human solubleepoxide hydrolase. Mol Pharmacol 64:482-490.
236. Radi ZA, Ackermann MR. (2011). Ontogeny of pulmonarycyclooxygenase-1 (COX-1) and-2 (COX-2). Pathophysiology18:215-219.
237. Räihä NC, Koskinen M, Pikkarainen P. (1967). Developmental changesin alcohol-dehydrogenase activity in rat and guinea-pig liver. Biochem J 103:623-626.
238. Raj PP, Nelson EB, Estabrook RW. (1971). Studies on drug metabolismin human liver. Chem Biol Interact 3:303-304.
239. Ratanasavanh D, Beaune P, Morel F, Flinois JP, Guengerich FP,Guillouzo A. (1991). Intralobular distribution and quantitation ofcytochrome P-450 enzymes in human liver as a function of age. Hepatology 13:1142-1151.
240. Ravindranath V, Bhamre S, Bhagwat SV, Anandatheerthavarada HK,Shankar SK, Tirumalai PS. (1995). Xenobiotic metabolism in brain.Toxicol Lett 82-83:633-638. (Pubitemid 26054750)
241. Rawat AK. (1976). Effect of maternal ethanol consumption of fetalhepatic metabolism in the rat. Ann N Y Acad Sci 273:175-187.
242. Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, GangopadhyayA, Shih DM, Lusis AJ, Navab M, Fogelman AM. (2001). Humanparaoxonase-3 is an HDL-associated enzyme with biologicalactivity similar to paraoxonase-1 protein but is not regulated byoxidized lipids. Arterioscler Thromb Vasc Biol 21:542-547. (Pubitemid 32323386)
243. Renaud HJ, Cui JY, Khan M, Klaassen CD. (2011). Tissue distributionand gender-divergent expression of 78 cytochrome P450 mRNAs inmice. Toxicol Sci 124:261-277.
244. Ribeiro V, Lechner MC. (1992). Cloning and characterization of anovel CYP3A1 allelic variant: analysis of CYP3A1 and CYP3A2 sexhormone-dependent expression reveals that the CYP3A2 gene isregulated by testosterone. Arch Biochem Biophys 293:147-152.
245. Rich KJ, Boobis AR. (1997). Expression and inducibility of P450enzymes during liver ontogeny. Microsc Res Tech 39:424-435. (Pubitemid 27523011)
246. Rich KJ, Foster JR, Edwards RJ, Davies DS, Boobis AR. (1993).Ontogenetic development of the distribution of constitutive and3-methylcholanthrene-induced CYP1A1 and CYP1A2 in rabbitliver. J Histochem Cytochem 41:915-925. (Pubitemid 23147732)
247. Richard K, Hume R, Kaptein E, Stanley EL, Visser TJ, CoughtrieMW. (2001). Sulfation of thyroid hormone and dopamine duringhuman development: ontogeny of phenol sulfotransferases andarylsulfatase in liver, lung, and brain. J Clin Endocrinol Metab86:2734-2742. (Pubitemid 32545731)
248. Rodrigo L, Hernández AF, López-Caballero JJ, Gil F, Pla A. (2001).Immunohistochemical evidence for the expression andinduction of paraoxonase in rat liver, kidney, lung and braintissue. Implications for its physiological role. Chem Biol Interact137:123-137. (Pubitemid 32825504)
249. Rodrigues-Lima F, Cooper RN, Goudeau B, Atmane N, ChamagneAM, Butler-Browne G, Sim E, Vicart P, Dupret JM. (2003). Skeletalmuscles express the xenobiotic-metabolizing enzyme arylamineN-acetyltransferase. J Histochem Cytochem 51:789-796. (Pubitemid 36628860)
250. Rollins DE, von Bahr C, Glaumann H, Moldéus P, Rane A. (1979).Acetaminophen: potentially toxic metabolite formed by humanfetal and adult liver microsomes and isolated fetal liver cells. Science 205:1414-1416. (Pubitemid 10226659)
251. Roman LJ, Palmer CN, Clark JE, Muerhoff AS, Griffin KJ, JohnsonEF, Masters BS. (1993). Expression of rabbit cytochromes P4504Awhich catalyze the omega-hydroxylation of arachidonic acid, fattyacids, and prostaglandins. Arch Biochem Biophys 307:57-65. (Pubitemid 23333974)
252. Rosati A, Maniori S, Decorti G, Candussio L, Giraldi T, Bartoli F.(2003). Physiological regulation of P-glycoprotein, MRP1, MRP2and cytochrome P450 3A2 during rat ontogeny. Dev Growth Differ45:377-387. (Pubitemid 37271829)
253. Rouet P, Dansette P, Frayssinet C. (1984). Ontogeny of benzo(a)pyrenehydroxylase, epoxide hydrolase and glutathione-S transferase inthe brain, lung and liver of C57Bl/6 mice. Dev Pharmacol Ther7:245-258. (Pubitemid 14116890)
254. Rout UK, Holmes RS. (1988). Postnatal development of mousealdehyde dehydrogenases. Agarose-isoelectric focusing analysesof the heart, lung, skin and ocular isozymes. In: Kuriyama K,Takada A, Fshii H, eds. Biomedical and social aspects of alcoholand alcoholism. Amsterdam: Elsevier Science Publishers,139-143.
255. Rout UK, Holmes RS. (1991). Postnatal development of mouse alcoholdehydrogenases: agarose isoelectric focusing analyses of the liver,kidney, stomach and ocular isozymes. Biol Neonate 59:93-97.
256. Saghir SA, Marty MS, Clark AJ, Zablotny CL, Bus JS, Perala AW,Yano BL, Neal BH. (2009). A dietary dose range-finding andtoxicokinetic (TK) study of 2,4-dichlorophenoxyacetic acid (2,4-D)in adult CRL:CD(SD) rats and their offspring: I. toxicokinetics. TheToxicologist 108:1161.
257. Salman ED, Kadlubar SA, Falany CN. (2009). Expression andlocalization of cytosolic sulfotransferase (SULT) 1A1 and SULT1A3in normal human brain. Drug Metab Dispos 37:706-709.
258. Sawamura A, Kusunose E, Satouchi K, Kusunose M. (1993). Catalyticproperties of rabbit kidney fatty acid omega-hydroxylasecytochrome P-450ka2 (CYP4A7). Biochim Biophys Acta1168:30-36. (Pubitemid 23149147)
259. Scarborough PE, Ma J, Qu W, Zeldin DC. (1999). P450 subfamilyCYP2J and their role in the bioactivation of arachidonic acid inextrahepatic tissues. Drug Metab Rev 31:205-234. (Pubitemid 29106659)
260. Schenkman JB, Choudhary D, Jansson I, Sarfaraze M, Stoilov I. (2003).Involvement of cytochromes P450 in development. Proc IndianNatl Sci Acad B69:929-941.
261. Schuetz JD, Beach DL, Guzelian PS. (1994). Selective expression ofcytochrome P450 CYP3A mRNAs in embryonic and adult humanliver. Pharmacogenetics 4:11-20.
262. Scheuplein RJ. (2000). Pesticides and infant risk: is there a need for anadditional safety margin? Regul Toxicol Pharmacol 31:267-279. (Pubitemid 30640371)
263. Shamir R, Hartman C, Karry R, Pavlotzky E, Eliakim R, Lachter J,Suissa A, Aviram M. (2005). Paraoxonases (PONs) 1, 2, and 3are expressed in human and mouse gastrointestinal tract and inCaco-2 cell line: selective secretion of PON1 and PON2. Free RadicBiol Med 39:336-344. (Pubitemid 40910190)
264. Shehin-Johnson SE, Williams DE, Larsen-Su S, Stresser DM, HinesRN. (1995). Tissue-specific expression of flavin-containingmonooxygenase (FMO) forms 1 and 2 in the rabbit. J PharmacolExp Ther 272:1293-1299.
265. Shepard EA, Dolphin CT, Fox MF, Povey S, Smith R, Phillips IR. (1993).Localization of genes encoding three distinct flavin- containingmonooxygenases to human chromosome 1q. Genomics 16:85-89. (Pubitemid 23123795)
266. Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP,Sutter TR. (1996b). Activation of chemically diverse procarcinogensby human cytochrome P-450 1B1. Cancer Res 56:2979-2984. (Pubitemid 26199741)
267. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. (1994).Interindividual variations in human liver cytochrome P-450enzymes involved in the oxidation of drugs, carcinogens and toxicchemicals: studies with liver microsomes of 30 Japanese and 30Caucasians. J Pharmacol Exp Ther 270:414-423. (Pubitemid 24229655)
268. Shimada T, Yamazaki H, Mimura M, Wakamiya N, Ueng YF, GuengerichFP, Inui Y. (1996a). Characterization of microsomal cytochromeP450 enzymes involved in the oxidation of xenobiotic chemicals inhuman fetal liver and adult lungs. Drug Metab Dispos 24:515-522. (Pubitemid 26143771)
269. Simpson AE, Brammar WJ, Pratten MK, Elcombe CR. (1995).Translactational induction of CYP4A expression in 10.5-dayneonatal rats by the hypolipidemic drug clofibrate. BiochemPharmacol 50:2021-2032. (Pubitemid 26089928)
270. Simpson AE. (1997). The cytochrome P450 4 (CYP4) family. GenPharmacol 28:351-359. (Pubitemid 27116195)
271. Singh SV, Dao DD, Partridge CA, Theodore C, Srivastava SK, Awasthi YC.(1985). Different forms of human liver glutathione S-transferasesarise from dimeric combinations of at least four immunologicallyand functionally distinct subunits. Biochem J 232:781-790. (Pubitemid 16207316)
272. Singh SV, Leal T, Ansari GA, Awasthi YC. (1987). Purification andcharacterization of glutathione S-transferases of human kidney. Biochem J 246:179-186. (Pubitemid 17122304)
273. Sipes IG, Gandolfi AJ. (1986). Biotransformation of Toxicants.In: Klaassen CD, Amdur MO, Doull J, eds. Casarett & Doull'stoxicology: the basic science of poisons. New York: MacMillanPublishing Co, 64-98.
274. Sjöblom M, Pilström L, Mørland J. (1978). Activity of alcoholdehydrogenase and acetaldehyde dehydrogenases in the liver andplacenta during the development of the rat. Enzyme 23:108-115. (Pubitemid 8314246)
275. Smelt VA, Upton A, Adjaye J, Payton MA, Boukouvala S, JohnsonN, Mardon HJ, Sim E. (2000). Expression of arylamineN-acetyltransferases in pre-term placentas and in human preimplantationembryos. Hum Mol Genet 9:1101-1107. (Pubitemid 30216016)
276. Smith JN, Timchalk C, Bartels MJ, Poet TS. (2011). In vitro agedependentenzymatic metabolism of chlorpyrifos and chlorpyrifosoxonin human hepatic microsomes and chlorpyrifos-oxon inplasma. Drug Metab Dispos 39:1353-1362.
277. Smith M, Hopkinson DA, Harris H. (1971). Developmental changesand polymorphism in human alcohol dehydrogenase. Ann HumGenet 34:251-271.
278. Smolen TN, Smolen A, van de Kamp JL. (1990). Developmental profileof hepatic alcohol and aldehyde dehydrogenase activities in longsleepand short-sleep mice. Alcohol 7:69-74. (Pubitemid 20090081)
279. Sonnier M, Cresteil T. (1998). Delayed ontogenesis of CYP1A2 in thehuman liver. Eur J Biochem 251:893-898. (Pubitemid 28108986)
280. Stanley EL, Hume R, Coughtrie MW. (2005). Expression profiling ofhuman fetal cytosolic sulfotransferases involved in steroid andthyroid hormone metabolism and in detoxification. Mol CellEndocrinol 240:32-42. (Pubitemid 41133369)
281. Stanley LA, Copp AJ, Pope J, Rolls S, Smelt V, Perry VH, Sim E. (1998).Immunochemical detection of arylamine N-acetyltransferaseduring mouse embryonic development and in adult mouse brain.Teratology 58:174-182. (Pubitemid 28542486)
282. Stejskalova L, Vecerova L, Peréz LM, Vrzal R, Dvorak Z, Nachtigal P,Pavek P. (2011). Aryl hydrocarbon receptor and aryl hydrocarbonnuclear translocator expression in human and rat placentas andtranscription activity in human trophoblast cultures. Toxicol Sci123:26-36.
283. Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, Tandler PJ,Zaya MJ. (2003). Developmental expression of the major humanhepatic CYP3A enzymes. J Pharmacol Exp Ther 307:573-582. (Pubitemid 37310671)
284. Stevens JC, Marsh SA, Zaya MJ, Regina KJ, Divakaran K, Le M, HinesRN. (2008). Developmental changes in human liver CYP2D6expression. Drug Metab Dispos 36:1587-1593.
285. Strange RC, Davis BA, Faulder CG, Cotton W, Bain AD, HopkinsonDA, Hume R. (1985). The human glutathione S-transferases:developmental aspects of the GST1, GST2, and GST3 loci. BiochemGenet 23:1011-1028. (Pubitemid 16190019)
286. Strange RC, Howie AF, Hume R, Matharoo B, Bell J, Hiley C, Jones P,Beckett GJ. (1989). The development expression of alpha-, muandpi-class glutathione S-transferases in human liver. BiochimBiophys Acta 993:186-190. (Pubitemid 20004635)
287. Strassburg CP, Strassburg A, Kneip S, Barut A, Tukey RH, Rodeck B,Manns MP. (2002). Developmental aspects of human hepatic drugglucuronidation in young children and adults. Gut 50:259-265. (Pubitemid 34087942)
288. Strolin Benedetti M, Baltes EL. (2003). Drug metabolism anddisposition in children. Fund Clin Pharmacol 17: 281-299.
289. Strum JM, Ito T, Philpot RM, DeSanti AM, McDowell EM. (1990).The immunocytochemical detection of cytochrome P-450monooxygenase in the lungs of fetal, neonatal, and adult hamsters.Am J Respir Cell Mol Biol 2:493-501.
290. Su T, Sheng JJ, Lipinskas TW, Ding X. (1996). Expression of CYP2Agenes in rodent and human nasal mucosa. Drug Metab Dispos24:884-890. (Pubitemid 26274747)
291. Tangalakis K, Coghlan JP, Connell J, Crawford R, Darling P, Hammond VE,Haralambidis J, Penschow J, Wintour EM. (1989). Tissue distributionand levels of gene expression of three steroid hydroxylases in ovinefetal adrenal glands. Acta Endocrinol 120:225-232. (Pubitemid 19049763)
292. Tateishi T, Nakura H, Asoh M, Watanabe M, Tanaka M, KumaiT, Takashima S, Imaoka S, Funae Y, Yabusaki Y, Kamataki T,Kobayashi S. (1997). A comparison of hepatic cytochrome P450protein expression between infancy and postinfancy. Life Sci61:2567-2574. (Pubitemid 28035581)
293. Tayama Y, Miyake K, Sugihara K, Kitamura S, Kobayashi M, MoritaS, Ohta S, Kihira K. (2007). Developmental changes of aldehydeoxidase activity in young Japanese children. Clin Pharmacol Ther81:567-572. (Pubitemid 46452303)
294. Tee LB, Gilmore KS, Meyer DJ, Ketterer B, Vandenberghe Y, Yeoh GC.(1992). Expression of glutathione S-transferase during rat liverdevelopment. Biochem J 282 (Pt 1):209-218.
295. Thompson CM, Sonawane B, Grafström RC. (2009). The ontogeny,distribution, and regulation of alcohol dehydrogenase 3:implications for pulmonary physiology. Drug Metab Dispos37:1565-1571.
296. Timms GP, Holmes RS. (1981). Genetics and ontogeny of aldehydedehydrogenase isozymes in th mouse: evidence for a locuscontrolling the inducibility of the liver microsomal isozyme. Biochem Genet 19:1223-1236. (Pubitemid 12183423)
297. Treluyer JM, Gueret G, Cheron G, Sonnier M, Cresteil T. (1997).Developmental expression of CYP2C and CYP2C-dependentactivities in the human liver: in-vivo/in-vitro correlation andinducibility. Pharmacogenetics 7:441-452. (Pubitemid 27517572)
298. Treluyer JM, Jacqz-Aigrain E, Alvarez F, Cresteil T. (1991). Expressionof CYP2D6 in developing human liver. Eur J Biochem 202:583-588.
299. Tuteja N, Gonzalez FJ, Nebert DW. (1985). Developmental and tissuespecificdifferential regulation of the mouse dioxin-inducibleP1-450 and P3-450 genes. Dev Biol 112:177-184. (Pubitemid 16200632)
300. Upton A, Johnson N, Sandy J, Sim E. (2001). ArylamineN- acetyltransferases-of mice, men and microorganisms. TrendsPharmacol Sci 22:140-146.
301. van den Berg H, van den Anker JN, Beijnen JH. (2012). Cytostatic drugsin infants: a review on pharmacokinetic data in infants. CancerTreat Rev 38:3-26.
302. van Lieshout EM, Knapen MF, Lange WP, Steegers EA, Peters WH.(1998). Localization of glutathione S-transferases alpha and pi inhuman embryonic tissues at 8 weeks gestational age. Hum Reprod13:1380-1386. (Pubitemid 28279199)
303. Vida C, Corpas I, De la Fuente M, González EM. (2011). Age-relatedchanges in xanthine oxidase activity and lipid peroxidation, aswell as in the correlation between both parameters, in plasma andseveral organs from female mice. J Physiol Biochem 67:551-558.
304. Vieira I, Sonnier M, Cresteil T. (1996). Developmental expressionof CYP2E1 in the human liver. Hypermethylation control ofgene expression during the neonatal period. Eur J Biochem238:476-483.
305. Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC. (1996). Molecularcloning
306. Wyde ME, Kirwan SE, Zhang F, Laughter A, Hoffman HB, Bartolucci-Page E, Gaido KW, Yan B, You L. (2005). Di-n-butyl phthalateactivates constitutive androstane receptor and pregnane X receptorand enhances the expression of steroid-metabolizing enzymes inthe liver of rat fetuses. Toxicol Sci 86:281-290. (Pubitemid 41418641)
307. Xie HG, Wood AJ, Kim RB, Stein CM, Wilkinson GR. (2004).Genetic variability in CYP3A5 and its possible consequences.Pharmacogenomics 5:243-272. (Pubitemid 38499965)
308. Xu Y, Agrawal S, Cook TJ, Knipp GT. (2008). Maternal di-(2-ethylhexyl)- phthalate exposure influences essential fatty acid homeostasis inrat placenta. Placenta 29:962-969.
309. Yamamoto S, Kusunose E, Matsubara S, Ichihara K, Kusunose M.(1986). Occurrence of cytochrome P-450 with prostaglandinomega-hydroxylase activity in rabbit placental microsomes. JBiochem 100:175-181. (Pubitemid 16093960)
310. Yang D, Pearce RE, Wang X, Gaedigk R, Wan YJ, Yan B. (2009). Humancarboxylesterases HCE1 and HCE2: ontogenic expression, interindividualvariability and differential hydrolysis of oseltamivir,aspirin, deltamethrin and permethrin. Biochem Pharmacol77:238-247.
311. Yang HY, Lee QP, Rettie AE, Juchau MR. (1994). Functional cytochromeP4503A isoforms in human embryonic tissues: expression duringorganogenesis. Mol Pharmacol 46:922-928. (Pubitemid 24364106)
312. Yang HY, Namkung MJ, Juchau MR. (1995). Expression of functionalcytochrome P4501A1 in human embryonic hepatic tissues duringorganogenesis. Biochem Pharmacol 49:717-726.
313. Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A,Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E,Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, LumPY. (2010). Systematic genetic and genomic analysis of cytochromeP450 enzyme activities in human liver. Genome Res 20:1020-1036.
314. Yanni SB, Annaert PP, Augustijns P, Ibrahim JG, Benjamin DK Jr, ThakkerDR. (2010). In vitro hepatic metabolism explains higher clearance ofvoriconazole in children versus adults: role of CYP2C19 and flavincontainingmonooxygenase 3. Drug Metab Dispos 38:25-31.
315. Yeung CK, Lang DH, Thummel KE, Rettie AE. (2000).Immunoquantitation of FMO1 in human liver, kidney, andintestine. Drug Metab Dispos 28:1107-1111. (Pubitemid 30660367)
316. Yokotani N, Bernhardt R, Sogawa K, Kusunose E, Gotoh O, KusunoseM, Fujii-Kuriyama Y. (1989). Two forms of omega-hydroxylasetoward prostaglandin A and laurate. cDNA cloning and theirexpression. J Biol Chem 264:21665-21669.
317. Yokotani N, Kusunose E, Sogawa K, Kawashima H, Kinosaki M,Kusunose M, Fujii-Kuriyama Y. (1991). cDNA cloning andexpression of the mRNA for cytochrome P-450kd which shows a fattyacid omega-hydroxylating activity. Eur J Biochem 196:531-536.
318. Yoshimura R, Kusunose E, Yokotani N, Yamamoto S, Kubota I,Kusunose M. (1990). Purification and characterization of twoforms of fatty acid omega-hydroxylase cytochrome P-450 fromrabbit kidney cortex microsomes. J Biochem 108:544-548. (Pubitemid 20336663)
319. You L, Chan SK, Bruce JM, Archibeque-Engle S, Casanova M, CortonJC, Heck H. (1999). Modulation of testosterone-metabolizinghepatic cytochrome P-450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p'-DDE. Toxicol ApplPharmacol 158:197-205. (Pubitemid 29343442)
320. Yun KU, Oh SJ, Oh JM, Kang KW, Myung CS, Song GY, Kim BH, Kim SK.(2010). Age-related changes in hepatic expression and activity ofcytochrome P450 in male rats. Arch Toxicol 84:939-946.
321. Zaya MJ, Hines RN, Stevens JC. (2006). Epirubicin glucuronidationand UGT2B7 developmental expression. Drug Metab Dispos34:2097-2101. (Pubitemid 44837771)
322. Zeilinska E, Niewiaroski W, Bodalski J, Stanczyk A, Bolanowski W,Rebowski G. (1997). Arylamine N-acetyltransferase (NAT2) genemutations in children with allergic diseases. Clin Pharmacol Ther62:635-642. (Pubitemid 28068067)
323. Zhao LZ, Huang M, Chen J, Ee PL, Chan E, Duan W, Guan YY, Hong YH,Chen X, Zhou S. (2006). Induction of propranolol metabolism byGinkgo biloba extract EGb 761 in rats. Curr Drug Metab 7:577-587. (Pubitemid 44226586)