The cytochrome P450 4 (CYP4) family

General Pharmacology

Volumn 28, Issue 3, 1997, Pages 351-359

  Simpson, Annemarie Elizabeth Claire Merryman ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

arachidonic acid; clofibrate; CYP4 peroxisome proliferators; peroxisomal oxidation; PPAR

Indexed keywords

ANTILIPEMIC AGENT; CLOFIBRATE; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; IBUPROFEN; MESSENGER RNA; NAFENOPIN; PEROXISOME PROLIFERATOR;

ARACHIDONIC ACID METABOLISM; BLOOD FLOW; BRAIN; CORNEA; ENZYME INDUCTION; FATTY ACID METABOLISM; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; INSECT; KIDNEY; LACTATION; LIVER; MAMMAL; MICROSOME; NONHUMAN; PEROXISOME; PLACENTA; PREGNANCY; PRIORITY JOURNAL; RAT; REVIEW;

ANIMALS; ARACHIDONIC ACID; CLOFIBRATE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; HUMANS; ISOENZYMES; KIDNEY; LIPID METABOLISM; LIVER; MICROBODIES;

EID: 0031049745     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00246-7     Document Type: Review

References (106)

1. 2α. J. Lipid Res. 31, 1477-1482.
2. Bacher M. A. and Gibson G. G. (1988) Chlorophenoxyacid herbicides induce microsomal P-450 IVA1 (P452) in rat liver. Chem. Biol. Interact. 65, 145-156.
3. Bains S. K., Gardiner S. M., Mannweiler K., Gillet D. and Gibson G. G. (1985) Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 to the metabolism of lauric acid and arachidonic acid. Biochem. Pharmac. 34, 3221-3229.
4. Bardot O., Aldridge T. C., Latruffe N. and Green S. (1993) PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem. Biophys. Res. Commun. 192, 37-45.
5. Barnett C., Gibson G. G., Wolf C. R., Flatt P. R. and Ioannides C. (1990) Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes. Biochem. J. 268, 765-769.
6. Baron J., Redick J. A. and Guengerich F. P. (1981) An immunohistochemical study on the localizations and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats. J. Biol. Chem. 256, 5931-5937.
7. Bass N. M., Sadovsky Y., Appell R. and Kushner P. J. (1993) Dicarboxylic fatty acids activate the peroxisome-proliferator-activated receptor (PPAR) in rat HTC hepatoma cells. Hepatology 18, 125.
8. Bell D. R., Bars R. G., Gibson G. G. and Elcombe C. R. (1991) Localisation and differential induction of cytochrome P450IVA and acyl-CoA oxidase in rat liver. Biochem. J. 275, 247-252.
9. Bell D. R., Bars R. G. and Elcombe C. R. (1992) Differential tissue-specific expression and induction of cytochrome-P450IVA1 and acyl-CoA oxidase. Eur. J. Biochem. 206, 979-986.
10. Bell D. R. and Elcombe C. R. (1991) Induction of acyl-CoA oxidase and cytochrome P450IVA1 RNA in rat primary hepatocyte culture by peroxisome proliferators. Biochem. J. 280, 249-253.
11. Bell D. R., Plant N. J., Rider C. G., Na L., Brown S., Ateitalla I., Acharya S. K., Davies M. H., Elias E., Jenkins N. A. et al. (1993) Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Biochem. J. 294, 173-180.
12. Bentley P., Calder I., Elcombe C., Grasso P., Stringer D. and Wiegand H. J. (1993) Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem. Toxicol. 31, 857-907.
13. Borlakoglu J. T., Clarke S., Huang S. W., Dils R. R., Haegele K. D. and Gibson G. G. (1992) Lactational transfer of 3,3′,4,4′-tetrachloro- and 2,2′,4,4′5′-hexachlorobiphenyl induces cytochrome P450IVA1 in neonates. Evidence for a potential synergistic mechanism. Biochem. Pharmac. 43, 153-157.
14. Borlakoglu J. T., Henderson C. J. and Wolf C. R. (1993a) Lactational transfer of 2,4,5,2′,4′,5′-hexachlorobiphenyl but not 3,4,3′,4′-tetrachlorobiphenyl, induces neonatal CYP4A1. Biochem. Pharmac. 45, 769-771.
15. Borlakoglu J. T., Scott A., Henderson C. J., Jenke H. J. and Wolf C. R. (1993b) Transplacental transfer of polychlorinated biphenyls induces simultaneously the expression of P450 isoenzymes and the proto-oncogenes c-ha-ras and c-raf. Biochem. Pharmac. 45, 1373-1386.
16. Borlakoglu J. T., Scott A., Henderson C. J. and Wolf C. R. (1993c) Alterations in rat hepatic drug metabolism during pregnancy and lactation. Biochem. Pharmac. 46, 29-36.
17. Bradfield J. Y., Lee Y.-H. and Keeley L. L. (1991) Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation of hypertrehalosemic hormone. Proc. Nat. Acad. Sci. USA 88, 4558-1562.
18. Brown L. P., Foster J. R., Orton T. C., Flint O. P. and Gibson G. G. (1989) Inducibility and functionality of rat embryonic/foetal cytochrome P-450: a study of differentiating limb-bud and mid-brain cells in vitro. Toxicol. In Vitro 3, 253-260.
19. Buhler R., Lindros K. O., Nordling A., Johansson J. and Ingelman-Sundberg M. (1992) Zonation of cytochrome P450 isozyme expression and induction in rat liver. Eur. J. Biochem. 204, 407-412.
20. Chen C. and Hardwick J. P. (1993) Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. Arch. Biochem. Biophys. 300, 18-23.
21. Cresteil T., Beaune P., Celier C., Leroux J. P. and Guengerich F. P. (1986) Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene. J. Pharmac. Exp. Ther. 236, 269-276.
22. Dils R., Clark S. and Knudsen J. (1977) Comparative aspects of milk fat synthesis. In Comparative Aspects of Lactation. Proceedings of the Zoological Society of the London Symposia 41 (Edited by M. Peaker), p. 43. Academic Press, London.
23. Earnshaw D., Dale J. W., Goldfarb P. S. and Gibson G. G. (1988) Differential splicing in the 3′ non-coding region of rat cytochrome P-452 (P450IVA1) mRNA. FEBS Lett. 236, 357-361.
24. Escalante B., Sessa W.C., Falck J. R., Yadagiri P. and Schwartzman M. L. (1990) Cytochrome P450-dependent arachidonic acid metabolites, 19- and 20-hydroxyeicosatetraenoic acids, enhance sodium-potassium ATPase activity in vascular smooth muscle. J. Cardiovasc. Pharmac. 16, 438-443.
25. Frenkel R. A., Slaughter C. A., Orth K., Moomaw C. R., Hicks S. H., Snyder J. M., Bennet M., Prough R. A., Putman R. S. and Milewich L. (1990) Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. J. Steroid Biochem. 35, 333-342.
26. Frolov M. V. and Alatortsev V. E. (1994) Cluster of cytochrome P450 genes on the X chromosome of Drosophila melanogaster. DNA Cell Biol. 13, 663-668.
27. Gandhi R., Varak E. and Goldberg M. L. (1992) Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X-chromosome. DNA Cell Biol. 11, 397-404.
28. Gasser R. and Philpot R. M. (1989) Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB. Molec. Pharmac. 35, 617-625.
29. Gearing K. L., Göttlicher M., Teboul M., Widmark E. and Gustafsson J. A. (1993) Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc. Natl. Acad. Sci. USA 90, 1440-1444.
30. Gibson G. G., Orton T. C. and Tamburini P. P. (1982) Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). Biochem. J. 203, 161-168.
31. Gibson G. G. (1989) Comparative aspects of the mammalian cytochrome P450 IV gene family. Xenobiotica 19, 1123-1148.
32. Green S. (1995) PPAR: a mediator of peroxisome proliferator action. Mutat. Res. 333, 101-109.
33. Hakkola J., Pasanen M., Purkunen R., Saarikoski S., Pelkonen O., Mäenpää J., Rane A. and Raunio H. (1994) Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver. Biochem. Pharmac. 49, 59-64.
34. Hardwick J. P. (1991) CYP4A subfamily: functional analysis by immunohistochemistry and in situ hybridization. Meth. Enzymol. 206, 273-283.
35. LAω). J. Biol. Chem. 262, 801-810.
36. Henderson C. J., Bammler T. and Wolf C. R. (1994) Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: development and hormonal regulation in liver and kidney. Biochim. Biophys. Acta 1200, 182-190.
37. 2-terminal sequence of cytochrome-P450 from kidney microsomes of untreated male rats. Biochem. Biophys. Res. Commun. 141, 711-717.
38. Imaoka S., Nagashima K. and Funae Y. (1990a) Characterisation of three cytochrome P450s purified from renal microsomes of untreated males rats and comparison with human renal cytochrome P450. Arch. Biochem. Biophys. 276, 473-480.
39. Imaoka S., Yamaguchi Y. and Funae Y. (1990b) Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation. Biochim. Biophys. Acta 1036, 18-23.
40. Irizar A. and Ioannides C. (1995) Expression and inducibility of cytochrome P450 proteins belonging to families 2, 3 and 4 in the rabbit aorta. Biochem. Biophys. Res. Commun. 213, 916-921.
41. Issemann I. and Green S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650.
42. Issemann I., Prince R. A., Tugwood J. D. and Green S. (1993) The retinoid x receptor enhances the function of the peroxisome proliferator activated receptor. Biochimie 75, 251-256.
43. Iwai N. and Inagami T. (1991) Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension 17, 161-169.
44. Jarnot B., George M. and Gibson G. G. (1993) Chlorotrifluoroethylene trimer and tetramer are inducers of the CYP4A subfamily. Biochem. Pharmac. 46, 1076-1080.
45. Johnson E. F., Walker D. L., Griffin K. J., Clark J. E., Okita R. T., Muerhoff A. S. and Masters B. S. (1990) Cloning and expression of three rabbit kidney cDNAs encoding lauric acid ω-hydroxylases. Biochemistry 29, 873-879.
46. Kaikaus R. M., Chan W. K., Lysenko N., Ray R., Ortiz M. and Bass N. M. (1993) Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway. J. Biol. Chem. 268, 9593-9603.
47. Kawashima H., Kusunose E., Kikura Y., Kinoshita H., Tanaka S., Yamamoto S., Kishimoto T. and Kusunose M. (1994) Purification and cDNA cloning of human liver CYP4A fatty acid ω-hydroxylase. J. Biochem. 116, 74-80.
48. 2-terminal amino acid sequences of human and rat kidney fatty acid ω-hydroxylases. Biochim. Biophys. Acta 1123, 156-162.
49. Kawashima H. and Strobel H. W. (1995) cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Biochem. Biophys. Res. Commun. 217, 1137-1144.
50. Kikuta Y., Kusunose E., Endo K., Yamamoto S., Sogawa K., Fujii-Kuriyama Y. and Kusunose, M. (1993) A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase. J. Biol. Chem. 268, 9376-9380.
51. Kikuta Y., Kusunose E., Okumoto T., Kibota I. and Kusunose M. (1990) Purification and characterisation of two forms of cytochrome P-450 with w-hydroxylase activities toward prostaglandin A and fatty acids from rabbit liver microsomes. J. Biochem. (Tokyo) 107, 280-286.
52. Kimura S., Hanioka N., Matsunaga E. and Gonzalez F. J. (1989a) The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. DNA 8, 503-516.
53. Kimura S., Hardwick J. P., Kozak C. A. and Gonzalez F. J. (1989b) The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and co-ordinate and tissue-specific regulation of the CYP4A genes. DNA 8, 517-525.
54. Kusunose E., Sawamura A., Kawashima H., Kubota I. A. and Kusunose M. (1989) Isolation of a new form of cytochrome P-450 with prostaglandin A and fatty acid ω-hydroxylase activities from rabbit kidney cortex microsomes. J. Biochem. (Tokyo) 106, 194-196.
55. Lapuerta L., Chacos N., Falck J. R., Jacobson H. and Capdevila J. H. (1988) Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. Am. J. Med. Sci. 295, 275-279.
56. Levi P. E., Rose R. L., Adams N. H. and Hodgson E. (1992) Induction of cytochrome P450 4A1 in mouse liver by the herbicide synergist tridiphane. Pest. Biochem. Physiol. 44, 9-14.
57. Makowska J. M., Anders C., Goldfarb P. S., Bonner F. and Gibson G. G. (1990) Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strains. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation. Biochem Pharmac. 40, 1083-1093.
58. p-2). J. Biol. Chem. 262, 13366-13371.
59. Milton M. N., Elcombe C. R. and Gibson G. G. (1990) On the mechanism of induction of microsomal cytochrome P450IVA1 and peroxisome proliferation in rat liver by clofibrate. Biochem. Pharmac. 40, 2727-2732.
60. Muerhoff A. S., Griffin K. J. and Johnson E. F. (1992a) Characterization of a rabbit gene encoding a clofibrate-inducible fatty acid ω-hydroxylase: CYP4A6. Arch. Biochem. Biophys. 296, 66-72.
61. Muerhoff A. S., Griffin K. J. and Johnson E. F. (1992b) The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome-P450 fatty-acid ω-hydroxylase, by clofibric acid. J. Biol. Chem. 267, 19051-19053.
62. Muerhoff A. S., Williams D. E. and Masters B. S. S. (1990) Purification and properties of pregnancy-inducible rabbit lung cytochrome P-450 prostaglandin ω-hydroxylase. Meth. Enzymol. 187, 253-267.
63. Murray G. I., Taylor A., Barnes T. S., Weaver R., Ewen S. W. B., Melvin W. T. and Burke M. D. (1990) The distribution of different forms of cytochrome P-450 in human liver. Biochem. Soc. Trans. 18, 1202.
64. Neat C. E., Thomassen M. S. and Osmundsen H. (1981) Effect of high fat diets on hepatic fatty acid oxidation in the rat-isolation of rat liver peroxisomes by vertical rotor centrifugation by using a self generated, isoosmotic, percoll gradient. Biochem. J. 196, 149-159.
65. Nebert D. W., Adesnik M., Coon M. J., Estabrook R. W., Gonzalez F. J., Guengerich F. P., Gunsalus I. C., Johnson E. F. Kemper B., Levin W., Phillips I. R., Sato R. and Waterman M. R. (1987) The P450 gene superfamily: recommended nomenclature. DNA 6, 1-11.
66. Nebert D. W. and Gonzalez F. J. (1985) Cytochrome P450 gene expression and regulation. Trends Phys. Sci. 6, 160-164.
67. Nebert D. W. and Nelson D. R. (1991) P450 gene nomenclature based on evolution. Meth. Enzymol. 206, 3-11.
68. Neims A. H., Warner M., Loughnan P. M. and Aranfa J. V. (1976) Developmental aspects of the hepatic cytochrome P450 mono-oxygenase system. Annu. Rev. Pharmac. Toxicol. 16, 427-445.
69. Nelson D. R., Kamataki T., Waxman D. J., Guengerich F. P., Estabrook R. W., Feyereisen R., Gonzalez F. J., Coon M. J., Gunsalus I. C., Gotoh O., Okuda K. and Nebert D. W. (1993) The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12, 1-51.
70. Nhamburo P. T., Gonzalez F. J., McBride O. W., Gelboin H. V. and Kimura S. (1989) Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression and chromosome mapping. Biochemistry 28, 8060-8066.
71. Oinonen T., Nikkola E. and Lindros K. O. (1993) Growth hormone mediates zone specific gene expression in liver. FEBS Lett. 327, 237-240.
72. Omata K., Abe K., Sheu H. L., Yoshida K., Tsutsumi E., Yoshinaga K., Abraham N. G. and Laniado-Schwartzman M. (1992) Roles of renal cytochrome P450-dependent arachidonic acid metabolites in hypertension. Tohoku J. Exp. Med. 166, 93-106.
73. Omiecinski C. J., Hassett C. and Costa P. (1990) Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. Mol. Pharmac. 38, 462-470.
74. Pershon E., Thomas H. and Waechter F. (1993) Immunoelectron microscopic localization of cytochrome P-450 isoenzyme CYP4A1 in liver, ileum and kidney of nafenopin treated male rats. Cell Biol. Int. 17, 99-103.
75. Reddy J. K., Azarnoff D. L. and Hignite C. E. (1980) Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature 283, 397-398.
76. Reddy J. K. and Lalwani N. D. (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 12, 1-58.
77. Rekka E., Ayalogu E. O., Lewis D. F. V., Gibson G. G. and Ioannides C. (1994) Induction of hepatic microsomal CYP4A activity and of peroxisomal beta-oxidation by two non-steroidal anti-inflammatory drugs. Arch. Toxicol. 68, 73-78.
78. Roman L. J., Palmer C. N. A., Clark J. E., Muerhoff A. S., Griffin K. J., Johnson E. F. and Masters B. S. S. (1993) Expression of rabbit cytochromes P4504 which catalyse the co-hydroxylation of arachidonic acid, fatty acids, and prostaglandins. Arch. Biochem. Biophys. 307, 57-65.
79. Sato T., Murayama N., Yamazoe Y. and Kato R. (1995) Suppression of clofibrate-induction of peroxisomal and microsomal fatty acid-oxidizing enzymes by growth hormone and thyroid hormone in primary cultures of rat hepatocytes. Biochim. Biophys. Acta 1256, 327-333.
80. Sawamura A., Kusunose E., Satouchi K. and Kusunose M. (1993) Catalytic properties of rabbit kidney fatty acid omega-hydroxylase cytochrome P-450ka2 (CYP4A7). Biochim. Biophys. Acta 1168, 30-36.
81. +)-ATPase. Nature 314, 620-622.
82. Schwartzman M. L., Martasek P., Rios A. R., Levere R. D., Solangi K., Goodman A. I. and Abraham N. G. (1990) Cytochrome P450-dependent arachidonic acid metabolism in human kidney. Kid. int. 37, 94-99.
83. Scott J. A., Collins F. H. and Feyereisen R. (1994) Diversity of cytochrome P450 genes in the mosquito, Anopheles albimanus. Biochem. Biophys. Res. Commun. 205, 1452-1459.
84. Sharma R. K., Doig M. V., Lewis D. F. V. and Gibson G. G. (1989) Role of hepatic and renal cytochrome P-450 EVA1 in the metabolism of lipid substrates. Biochem. Pharmac. 38, 3621-3629.
85. Sharma R., Lake B. G., Foster J. and Gibson G. G. (1988a) Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolidaemic agents in rat liver. A mechanistic interrelationship. Biochem. Pharmac. 37, 1193-1201.
86. Sharma R., Lake B. G. and Gibson G. G. (1988b) Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid ω-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies. Biochem. Pharmac. 37, 1203-1206.
87. Simpson A. E. C. M. (1994) The ontogeny of cytochrome P450 (CYP4A) gene expression in the rat. Ph.D thesis, University of Leicester, Leicester, UK.
88. Simpson A. E. C. M., Brammar W. J., Pratten M. K., Cockcroft N. and Elcombe C. R. (1996) Placental transfer of the hypolipidemic drug, clofibrate, induces CYP4A expression in 18.5-day fetal rats. Drug Metab. Dispos. 24, 547-554.
89. Simpson A. E. C. M., Brammar W. J., Pratten M. K. and Elcombe C. R. (1995) Translactational induction of CYP4A expression in 10.5-day neonatal rats by the hypolipidemic drug clofibrate. Biochem. Pharmac. 50, 2021-2032.
90. Snyder M., Hirsh J. and Davidson N. (1981) The cuticle genes of Drosophila: a developmentally regulated gene cluster. Cell 25, 165-177.
91. Snyder M. J., Stevens J. L., Andersen J. F. and Feyereisen R. (1995) Expression of cytochrome P450 genes of the CYP4 family in midgut and fat body of the tobacco hornworm, Manduca sexta. Arch. Biochem. Biophys. 321, 13-20.
92. Strömstedt M., Hayashi S.-I., Zaphiropoulos P. G. and Gustafsson J.-Å. (1990) Cloning and characterization of a novel member of the cytochrome P450 subfamily IVA in rat prostate. DNA Cell Biol. 9, 569-577.
93. Strum J. M., Ito T., Philpot R. M., DeSanti A. M. and McDowell E. M. (1990) The immunocytochemical detection of cytochrome P-450 monooxygenase in the lungs of fetal, neonatal, and adult hamsters. Am. J. Respir. Cell Mol. Biol. 2, 493-501.
94. Sundseth S. S. and Waxman D. J. (1992) Sex-dependent expression and clofibrate inducibility of cytochrome-P450 4A fatty-acid ω-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth-hormone and testosterone. J. Biol. Chem. 267, 3915-3921.
95. Tamburini P. P., Masson H. A., Bains S. K. Makowski R. J., Morris B. and Gibson G. G. (1984) Multiple forms of hepatic cytochrome P-450. Purification, characterization and comparison of a novel clofibrate-induced isozyme with other major forms of cytochrome P-450. Eur. J. Biochem. 139, 247-252.
96. Tugwood J. D., Issemann I., Anderson R. G., Bundell K. R., McPheat W. L. and Green S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 11, 433-439.
97. 3 receptors. Cell 65, 1255-1266.
98. Wolf C. R. (1986) Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation. Trends Genet. 2, 209-214.
99. Yamamoto S., Kusonose E., Ogita K., Kaku M., Ichihara K. and Kusunose M. (1984) Role of cytochrome P450 in co-hydroxylation of prostaglandins. J. Biochem. (Tokyo) 96, 593-603.
100. Yokotani N., Bernhardt R., Sogawa K., Kusunose E., Gotoh O., Kusunose M. and Fujii-Kuriyama Y. (1989) Two forms of ω-hydroxylase toward prostaglandin A and laurate. cDNA cloning and their expression. J. Biol. Chem. 264, 21665-21669.
101. KD which shows a fatty acid ω-hydroxylating activity. Eur. J. Biochem. 196, 531-536.
102. P-2 from the cDNA library of human placenta. Gene structure and expression. Eur. J. Biochem. 187, 23-29.
103. Yoshimoto M., Kusunose E., Yamamoto S., Maekawa M. and Kusunose M. (1986) Purification and characterization of two forms of cytochrome P-450 from rat kidney cortex microsomes. Biochem. Int. 13, 749-755.
104. Yoshimura R., Kusunose E., Yokotani N., Yamamoto S., Kubota I. and Kusunose M. (1990) Purification and characterization of two forms of fatty acid ω-hydroxylase cytochrome P-450 from rabbit kidney cortex microsomes. J. Biochem. 108, 544-548.
105. Yu V. C., Delsert C., Anderson B., Holloway J. M., Devary O. V., Näär A. M., Kim S. Y., Boutin J.-M., Glass C. K. and Rosenfeld M. G. (1992) RXR: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67, 1251-1266.
106. Zhang B. W., Marcus S. L., Sajjadi F. G., Alvares K., Reddy J. K., Subramani S., Rachubinski R. A. and Capone J. P. (1992) Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase 3-hydroxyacyl-CoA dehydrogenase. Proc. Natl. Acad. Sci. USA 89, 7541-7545.