Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2) during development of the outbred mouse strain CD-1

Drug Metabolism and Disposition

Volumn 28, Issue 2, 2000, Pages 139-146

  Estrada, Lourdes ^a,b   Kanelakis, Kimon C ^a   Levy, Gerald N ^a   Weber, Wendell W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE;

ARTICLE; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HORMONAL REGULATION; IMMUNOBLOTTING; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; STRAIN DIFFERENCE; TISSUE SPECIFICITY;

AGING; ALLELES; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CYTOSOL; FEMALE; GENOTYPE; IMMUNOBLOTTING; KIDNEY; LIVER; MALE; MICE; ORGAN SPECIFICITY; PHENOTYPE; PLASMIDS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RIBONUCLEASES; RNA, MESSENGER; SEX CHARACTERISTICS;

MAMMALIA; RODENTIA; VERTEBRATA;

EID: 0033967807     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Ambrosone CB, Freudenheim JL, Graham S, Marshall JR, Vena JE, Brasure JR, Michalek AM, Laughlin R, Nemoto T, Gillenwater KA, Harrington AM and Shields PG (1996) Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. J Am Med Assoc 276:1494-1501.
2. Arnone MI and Davidson EH (1997) The hardwiring of development: Organization and function of genomic regulatory systems. Development 124:1851-1864.
3. Ballestero RP, Wilmot GR, Leski ML, Uhler MD and Agranoff BW (1995) Isolation of cDNA clones encoding RICH: A protein induced goldfish optic nerve regeneration with homology to mammalian 2′,3′-cyclic-nucleotide 3′-phosphodiesterases. Proc Natl Acad Sci USA 92:8621-8625.
4. Bardin CW and Catterall JF (1981) Testosterone: A major determinant of extragenital sexual dimorphism. Science (Wash DC) 211:1285-1294.
5. Beato M, Chavez S and Truss M (1996) Transcriptional regulation by steroid hormones. Steroids 61:240-251.
6. Brusick D, Bakshi K and Jagannath DR (1976) The application of in vitro mutagenesis techniques to investigations of comparative metabolism in mice, in Metabolic Activation in Mutagenesis Testing (de Serres FJ, Fouts JR, Bend JR and Philpot RM eds) pp 125-141, Elsevier/North-Holland, New York.
7. Cohen SN, Baumgartner R, Steinberg MS and Weber WW (1973) Changes in the physicochemical characteristics of rabbit liver N-acetyltransferase during post-natal development. Biochim Biophys Acta 304:473-481.
8. DeLeon JH (1996) Characterization of Congenic Mouse (NAT2*) and Human (NAT1*) N-Acetyltransferases. Doctoral dissertation. The University of Michigan, Ann Arbor.
9. DeLeon JH, Martell KJ, Vatsis KP and Weber WW (1995) Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9). Drug Metab Dispos 23:1354-1361.
10. Estrada-Rodgers L, Levy GN and Weber WW (1998) Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter. Gene Expression 7:13-24.
11. Evans DAP, Manley KA and McKusick VA (1960) Genetic control of isoniazid metabolism in man. Br Med J 13:485-491.
12. Grant DM, Hughes NC, Janezic SA, Goodfellow GH, Chen HJ, Gaedigk A, Yu VL and Grewal R (1997) Human acetyltransferase polymorphisms. Mutat Res 376:61-70.
13. Hasel KW and Sutcliffe JG (1990) Nucleotide sequence of a cDNA coding for mouse cyclophilin. Nucleic Acids Res 18:4019.
14. Hein DW, Omichinski JG, Brewer JA and Weber WW (1982) A unique pharmacogenetic expression of the N-acetylation polymorphism in the inbred hamster. J Pharmacol Exp Ther 220:8-15.
15. Illet K, David B and Kwa R (1987) Acetylation phenotype in colorectal carcinoma. Cancer Res 47:1466-1469.
16. Iselius L and Evans DAP (1983) Formal genetics of isoniazid metabolism in man. Clin Pharmacokinet 8:541-544.
17. Juberg DR, Bond JT and Weber WW (1991) N-Acetylation of aromatic amines: Genetic polymorphism in inbred rat strains. Pharmacogenetics 1:50-57.
18. Kelly SL and Sim E (1994) Arylamine N-acetyltransferase in BALB/c mice: Identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem J 302:347-353.
19. Lang NP, Chu DZ, Hunter CF, Kendall DC, Flammang TJ and Kadlubar FF (1986) Role of aromatic amine acetyltransferase in human colorectal cancer. Arch Surg 121:1259-1261.
20. Levy GN and Weber WW (1992) 2-Aminofluorene-DNA adducts in mouse urinary bladder: Effect of age, sex and acetylator phenotype. Carcinogenesis 13:159-164.
21. Maniatis T, Goodbourn S and Fischer JA (1987) Regulation of inducible and tissue-specific gene expression. Science (Wash DC) 236:1237-1244.
22. Martell KJ, Levy GN and Weber WW (1992) Cloned mouse N-acetyltransferases: Enzymatic properties of expressed Nat-1 and Nat-2 gene products. Mol Pharmacol 42:265-272.
23. Martell KJ, Vatsis KP and Weber WW (1991) Molecular genetic basis of rapid and slow acetylation in mice. Mol Pharmacol 40:218-227.
24. Mattano SS, Erickson RP, Nesbitt MN and Weber WW (1988) Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase. J Hered 79:430-433.
25. Meier CA (1997) Regulation of gene expression by nuclear hormone receptors. J Recept Signal Transduct Res 17:319-335.
26. Menendez-Pelaez A, Marrufo B, Reiter RJ, Santana C and Guerrero JM (1989) Testosterone increases N-acetyltransferase activity in both male and female Syrian hamster harderian glands. Biochem Int 19:115-121.
27. Miller EC, Miller JA and Enomoto M (1964) The comparative carcinogenicities of 2-acetylaminofluorene and its hydroxy metabolite in mice, hamsters, and guinea pigs. Cancer Res 24:2018.
28. Mitchell MK, Futscher BW and McQueen CA (1999) Developmental expression of N-acetyltransferases in C57BL/6 mice. Drug Metab Dispos 27:261-264.
29. Pacifici GM, Bencini C and Rane A (1986) Acetyltransferase in humans: Development and tissue distribution. Pharmacology 32:283-291.
30. Paulsen O and Nilsson LG (1985) Distribution of acetylator phenotype in relation to age and sex in Swedish patients. Eur J Clin Pharmacol 28:311-315.
31. Payne AP, McGadey J, Moore MR and Thompson G (1977) Androgenic control of the harderian gland in the male golden hamster. J Endocrinol 75:73-82.
32. Seasholtz AF, Gamm DM, Ballestero RP, Scarpetta MA and Uhler MD (1995) Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain. Proc Natl Acad Sci USA 92:1734-1738.
33. Smolen TN, Brewer JA and Weber WW (1993) Testosterone modulation of N-acetylation in mouse kidney. J Pharmacol Exp Ther 264:854-858.
34. Sonawane BR (1982) Perinatal development of N-acetyltransferase in hepatic and extrahepatic tissues of guinea pigs. Pediatr Pharmacol (New York) 2:223-229.
35. Vatsis KP, Martell KJ and Weber WW (1991) Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc Natl Acad Sci USA 88:6333-6337.
36. Vest MF (1965) The development of conjugation mechanisms and drug toxicity in the newborn. Biol Neonat 8:258-266.
37. Watters C (1978) A one-step biuret assay for protein in the presence of detergent. Anal Biochem 88:695-698.
38. Weber WW (1987) The Acetylator Genes and Drug Response, Oxford University Press, New York.
39. Weber WW, Miceli JN, Hearse DJ and Drummond GS (1976) N-Acetylation of drugs: Pharmacogenetic studies in rabbits selected for their acetylator characteristics. Drug Metab Dispos 4:94-101.
40. Yamamoto KR (1985) Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet 19:209-252.
41. Zidek Z and Janku I (1981) Increased acetylation and elimination of sulphadimidine in rats with adjuvant induced arthritis. Eur J Drug Metab Pharmacokinet 6:255-259.