The ontogeny of drug metabolizing enzymes and transporters in the rat

Reproductive Toxicology

Volumn 26, Issue 3-4, 2008, Pages 220-230

  de Zwart, Loeckie ^a   Scholten, Martijn ^b   Monbaliu, Johan G ^a   Annaert, Pieter P ^c   Van Houdt, Jos M ^a   Van den Wyngaert, Ilse ^a   De Schaepdrijver, Luc M ^a   Bailey, Graham P ^a   Coogan, Timothy P ^d   Coussement, Werner C ^a   Mannens, Geert S ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d CENTOCOR INC   (United States)

Author keywords

Juvenile animals; Metabolizing enzymes; Ontogeny; Transporters

Indexed keywords

ALBUMIN; BREAST CANCER RESISTANCE PROTEIN; CARBOXYLESTERASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 4A1; CYTOCHROME P450 ISOENZYME; DRUG METABOLIZING ENZYME; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 6; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; PROTEIN; THYROXINE;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GLUCURONIDATION; KIDNEY; LIVER; LIVER METABOLISM; LIVER MICROSOME; METABOLISM; NONHUMAN; ONTOGENY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; URINARY EXCRETION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD PROTEINS; CATECHOLAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; MALE; MICROSOMES, LIVER; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 55949104608     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2008.09.010     Document Type: Article

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