Ontogeny of midazolam glucuronidation in preterm infants

European Journal of Clinical Pharmacology

Volumn 66, Issue 2, 2010, Pages 165-170

  De Wildt, Saskia N ^a   Kearns, Greg L ^b,c   Murry, Darryl J ^d   Koren, Gideon ^e,f   Van Den Anker, John N ^a,g  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b CHILDREN S MERCY HOSPITAL   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

^g CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

CYP3A; Glucuronidation; Midazolam; Ontogeny; Urinary metabolic ratio

Indexed keywords

1 HYDROXYMIDAZOLAM; 1 HYDROXYMIDAZOLAM GLUCURONIDE; CYTOCHROME P450 3A; DRUG METABOLITE; MIDAZOLAM; MIDAZOLAM MALEATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; HUMAN; HUMAN EXPERIMENT; MALE; NEWBORN; ONTOGENY; PREMATURITY; PRIORITY JOURNAL; SINGLE DRUG DOSE; URINARY EXCRETION;

ADMINISTRATION, ORAL; AGING; BIOTRANSFORMATION; FEMALE; GLUCURONIDES; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; MIDAZOLAM;

EID: 76949088683     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0741-5     Document Type: Article

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