Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage

Cell Cycle

Volumn 7, Issue 18, 2008, Pages 2877-2885

  Nimbalkar, Dipali ^a   Quelle, Frederick W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Checkpoint; Cytokine; DNA damage; Endoreduplication; Erythropoietin; Irradiation; Phosphoinositide 3 kinase

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYTOKINE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL DEATH; CELL POPULATION; CELL VIABILITY; DNA DAMAGE; ENDOREDUPLICATION; GAMMA IRRADIATION; HEMATOPOIETIC CELL; NONHUMAN;

EID: 51849135030     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.18.6675     Document Type: Article

References (24)

1. Seidenfeld J, Piper M, Flamm C, Hasselblad V, Armitage JO, Bennett CL, Gordon MS, Lichtin AE, Wade JL, Woolf S, Aronson N. Epoetin treatment of anemia associated with cancer therapy: A systematic review and meta-analysis of controlled clinical trials. Journal Of The National Cancer Institute 2001; 93:1204-14.
2. Iliakis G, Wang Y, Guan J, Wang HC. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 2003; 22:5834-47.
3. Quelle FW, Wang J, Feng J, Wang D, Cleveland JL, Ihle JN, Zambetti GP. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes & Dev 1998; 12:1099-107.
4. Canman CE, Gilmer TM, Coutts SB, Kastan MB. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes & Dev 1995; 9:600-11.
5. Collins MK, Marvel J, Malde P, Lopez-Rivas A. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J Exp Med 1992; 176:1043-51.
6. Strasser A, Harris AW, Jacks T, Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 1994; 79:329-39.
7. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of P53 Protein in the Cellular-Response to Dna Damage. Cancer Res 1991; 51:6304-11.
8. Epperly MW, Bray JA, Carlos TM, Prochownik E, Greenberger JS. Biology of marrow stromal cell lines derived from long-term bone marrow cultures of Trp53-deficient mice. Radiation Research 1999; 152:29-40.
9. Henry MK, Lynch JT, Eapen AK, Quelle FW. DNA damage-induced cell cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood 2001; 98:834-41.
10. Eapen AK, Henry MK, Quelle DE, Quelle FW. DNA damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2. Mol Cell Biol 2001; 21:6113-21.
11. Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A, Hay N. Activation of Akt/protein kinase B overcomes a G(2)/M cell cycle checkpoint induced by DNA damage. Mol Cell Biol 2002; 22:7831-41.
12. 2/M phase of the cell cycle. Current Biology 2002; 12:919-24.
13. Henry MK, Nimbalkar D, Hohl RJ, Quelle FW. Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells. Experimental Cell Research 2004; 299:257-66.
14. 2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. Oncogene 2005; 24:1973-81.
15. Shtivelman E. Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR. Mol Cancer Res 2003; 1:959-69.
16. 2 arrest after DNA damage. Science 1998; 282:1497-501.
17. Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996; 381:713-6.
18. Tamulevicius P, Wang ML, Iliakis G. Homology-directed repair is required for the development of radioresistance during S phase: Interplay between double-strand break repair and checkpoint response. Radiation Research 2007; 167:1-11.
19. Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB. p21(Waf1/Cip1/Sdi1)-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 2000; 19:2165-70.
20. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21(Cip1/WAF1) by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology 2001; 3:438.
21. Mayo LD, Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci 2001; 98:11598-603.
22. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3 sigma is required to prevent mitotic catastrophe after DNA damage. Nature 1999; 401:616-20.
23. Nimbalkar D, Henry MK, Quelle FW. Cytokine Activation of Phosphoinositide 3-Kinase Sensitizes Hematopoietic Cells to Cisplatin-induced Death. Cancer Res 2003; 63:1034-9.
24. Hu LM, Hofmann J, Lu YL, Mills GB, Jaffe RB. Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer Res 2002; 62:1087-92.