메뉴 건너뛰기




Volumn 21, Issue 3, 2012, Pages 251-257

Mammalian target of rapamycin signaling in the podocyte

Author keywords

autophagy; diabetic nephropathy; glomerulopathy; mTOR; podocyte; proteinuria; rapamycin

Indexed keywords

AUTOPHAGY PROTEIN 5; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NEPHRIN;

EID: 84859632390     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3283520f38     Document Type: Review
Times cited : (35)

References (67)
  • 2
    • 34250006557 scopus 로고    scopus 로고
    • The spectrum of podocytopathies: A unifying view of glomerular diseases
    • DOI 10.1038/sj.ki.5002222, PII 5002222
    • Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007; 71:1205-1214. (Pubitemid 46884251)
    • (2007) Kidney International , vol.71 , Issue.12 , pp. 1205-1214
    • Wiggins, R.C.1
  • 3
    • 79957894759 scopus 로고    scopus 로고
    • The targeted podocyte
    • Fogo AB. The targeted podocyte. J Clin Invest 2011; 121:2142-2145.
    • (2011) J Clin Invest , vol.121 , pp. 2142-2145
    • Fogo, A.B.1
  • 4
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immuno-suppressant rapamycin in yeast. Science 1991; 253:905-909. (Pubitemid 21917235)
    • (1991) Science , vol.253 , Issue.5022 , pp. 905-909
    • Hietman, J.1    Movva, N.R.2    Hall, M.N.3
  • 5
    • 0029842109 scopus 로고    scopus 로고
    • Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    • Choi J, Chen J, Schreiber SL, Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 1996; 273:239-242. (Pubitemid 26285890)
    • (1996) Science , vol.273 , Issue.5272 , pp. 239-242
    • Choi, J.1    Chen, J.2    Schreiber, S.L.3    Clardy, J.4
  • 6
    • 0028825698 scopus 로고
    • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
    • Lorenz MC, Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem 1995; 270: 27531-27537.
    • (1995) J Biol Chem , vol.270 , pp. 27531-27537
    • Lorenz, M.C.1    Heitman, J.2
  • 7
    • 0028360374 scopus 로고
    • A mammalian protein targeted by G1-arresting rapamycin-receptor complex
    • Brown EJ, Albers MW, Shin TB, et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994; 369:756-758.
    • (1994) Nature , vol.369 , pp. 756-758
    • Brown, E.J.1    Albers, M.W.2    Shin, T.B.3
  • 8
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • DOI 10.1016/0092-8674(94)90570-3
    • Sabatini DM, Erdjument-Bromage H, Lui M, et al. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994; 78:35-43. (Pubitemid 24228298)
    • (1994) Cell , vol.78 , Issue.1 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 9
    • 0028598672 scopus 로고
    • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
    • Chiu MI, Katz H, Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci U S A 1994; 91:12574-12578.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12574-12578
    • Chiu, M.I.1    Katz, H.2    Berlin, V.3
  • 12
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
    • Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14:1296-1302. (Pubitemid 38991819)
    • (2004) Current Biology , vol.14 , Issue.14 , pp. 1296-1302
    • Dos, D.S.1    Ali, S.M.2    Kim, D.-H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 15
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-484. (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 16
    • 79961165137 scopus 로고    scopus 로고
    • mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
    • Peterson TR, Sengupta SS, Harris TE, et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011; 146:408-420.
    • (2011) Cell , vol.146 , pp. 408-420
    • Peterson, T.R.1    Sengupta, S.S.2    Harris, T.E.3
  • 17
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-1101. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 18
    • 58649092475 scopus 로고    scopus 로고
    • mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoidinduced protein kinase 1 (SGK1)
    • Garcia-Martinez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoidinduced protein kinase 1 (SGK1). Biochem J 2008; 416:375-385.
    • (2008) Biochem J , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 19
    • 47949125486 scopus 로고    scopus 로고
    • The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
    • Facchinetti V, Ouyang W, Wei H, et al. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008; 27:1932-1943.
    • (2008) EMBO J , vol.27 , pp. 1932-1943
    • Facchinetti, V.1    Ouyang, W.2    Wei, H.3
  • 20
    • 47949104258 scopus 로고    scopus 로고
    • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
    • Ikenoue T, Inoki K, Yang Q, et al. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 2008; 27:1919-1931.
    • (2008) EMBO J , vol.27 , pp. 1919-1931
    • Ikenoue, T.1    Inoki, K.2    Yang, Q.3
  • 21
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010; 40:310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 23
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki K, Li Y,XuT,Guan KL.RhebGTPase is a direct target ofTSC2GAPactivity and regulates mTOR signaling. Genes Develop 2003; 17:1829-1834. (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 26
    • 0041758428 scopus 로고    scopus 로고
    • Tuberous sclerosis: From tubers to mTOR
    • DOI 10.1046/j.1469-1809.2003.00012.x
    • Kwiatkowski DJ. Tuberous sclerosis: from tubers to mTOR. Ann Hum Genet 2003; 67:87-96. (Pubitemid 38312854)
    • (2003) Annals of Human Genetics , vol.67 , Issue.1 , pp. 87-96
    • Kwiatkowski, D.J.1
  • 28
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • DOI 10.1038/ncb839
    • Inoki K, Li Y, Zhu T, et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biol 2002; 4:648-657. (Pubitemid 34993700)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 29
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
    • DOI 10.1016/j.cell.2005.02.031
    • Ma L, Chen Z, Erdjument-Bromage H, et al. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005; 121:179-193. (Pubitemid 40546387)
    • (2005) Cell , vol.121 , Issue.2 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 30
    • 72049105867 scopus 로고    scopus 로고
    • The role of the mammalian target of rapamycin (mTOR) in renal disease
    • Lieberthal W, Levine JS. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 2009; 20:2493-2502.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2493-2502
    • Lieberthal, W.1    Levine, J.S.2
  • 31
    • 79951674629 scopus 로고    scopus 로고
    • mTOR and rapamycin in the kidney: Signaling and therapeutic implications beyond immunosuppression
    • Huber TB, Walz G, Kuehn EW. mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression. Kidney Int 2011; 79:502-511.
    • (2011) Kidney Int , vol.79 , pp. 502-511
    • Huber, T.B.1    Walz, G.2    Kuehn, E.W.3
  • 32
    • 34547851720 scopus 로고    scopus 로고
    • Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis
    • DOI 10.1093/ndt/gfm191
    • Rangan GK, Coombes JD. Renoprotective effects of sirolimus in nonimmune initiated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2007; 22:2175-2182. (Pubitemid 47244694)
    • (2007) Nephrology Dialysis Transplantation , vol.22 , Issue.8 , pp. 2175-2182
    • Rangan, G.K.1    Coombes, J.D.2
  • 35
    • 80155151897 scopus 로고    scopus 로고
    • mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome
    • Ito N, Nishibori Y, Ito Y, et al. mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab Invest 2011; 91:1584-1595.
    • (2011) Lab Invest , vol.91 , pp. 1584-1595
    • Ito, N.1    Nishibori, Y.2    Ito, Y.3
  • 36
    • 79959755211 scopus 로고    scopus 로고
    • Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis
    • Identification of LAT2 as potential upstream regulator of mTOR activation in podocytes
    • Kurayama R, Ito N, Nishibori Y, et al. Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Lab Invest 2011; 91:992-1006. Identification of LAT2 as potential upstream regulator of mTOR activation in podocytes.
    • (2011) Lab Invest , vol.91 , pp. 992-1006
    • Kurayama, R.1    Ito, N.2    Nishibori, Y.3
  • 38
    • 72049120164 scopus 로고    scopus 로고
    • Significance and management of proteinuria in kidney transplant recipients
    • Amer H, Cosio FG. Significance and management of proteinuria in kidney transplant recipients. J Am Soc Nephrol 2009; 20:2490-2492.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2490-2492
    • Amer, H.1    Cosio, F.G.2
  • 39
    • 71049162614 scopus 로고    scopus 로고
    • Rapamycin has dual opposing effects on proteinuric experimental nephropathies: Is it a matter of podocyte damage?
    • Torras J, Herrero-Fresneda I, Gulias O, et al. Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage? Nephrol Dial Transplant 2009; 24:3632-3640.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3632-3640
    • Torras, J.1    Herrero-Fresneda, I.2    Gulias, O.3
  • 40
    • 34548851984 scopus 로고    scopus 로고
    • High sirolimus levels may induce focal segmental glomerulosclerosis de novo
    • Letavernier E, Bruneval P, Mandet C, et al. High sirolimus levels may induce focal segmental glomerulosclerosis de novo. Clin J Am Soc Nephrol 2007; 2:326-333.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 326-333
    • Letavernier, E.1    Bruneval, P.2    Mandet, C.3
  • 41
    • 75149177783 scopus 로고    scopus 로고
    • Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGF
    • Munivenkatappa R, Haririan A, Papadimitriou JC, et al. Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGF. Histol Histopathol 2010; 25:189-196.
    • (2010) Histol Histopathol , vol.25 , pp. 189-196
    • Munivenkatappa, R.1    Haririan, A.2    Papadimitriou, J.C.3
  • 42
    • 79955538137 scopus 로고    scopus 로고
    • Sirolimus and proteinuria in renal transplant patients: Evidence for a dose-dependent effect on slit diaphragmassociated proteins
    • Stallone G, Infante B, Pontrelli P, et al. Sirolimus and proteinuria in renal transplant patients: evidence for a dose-dependent effect on slit diaphragmassociated proteins. Transplantation 2011; 91:997-1004.
    • (2011) Transplantation , vol.91 , pp. 997-1004
    • Stallone, G.1    Infante, B.2    Pontrelli, P.3
  • 43
    • 77957195889 scopus 로고    scopus 로고
    • Loss of nephrin expression in glomeruli of kidney-transplanted patients under m-TOR inhibitor therapy
    • Biancone L, Bussolati B, Mazzucco G, et al. Loss of nephrin expression in glomeruli of kidney-transplanted patients under m-TOR inhibitor therapy. Am J Transplant 2010; 10:2270-2278.
    • (2010) Am J Transplant , vol.10 , pp. 2270-2278
    • Biancone, L.1    Bussolati, B.2    Mazzucco, G.3
  • 44
    • 60549117111 scopus 로고    scopus 로고
    • mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes
    • Vollenbroker B, George B, Wolfgart M, et al. mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. Am J Physiol Renal Physiol 2009; 296:F418-F426.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Vollenbroker, B.1    George, B.2    Wolfgart, M.3
  • 45
    • 37349107870 scopus 로고    scopus 로고
    • The mTOR inhibitor everolimus induces proteinuria and renal deterioration in the remnant kidney model in the rat
    • DOI 10.1097/01.tp.0000282866.92367.99, PII 0000789020071215000016
    • Vogelbacher R, Wittmann S, Braun A, et al. The mTOR inhibitor everolimus induces proteinuria and renal deterioration in the remnant kidney model in the rat. Transplantation 2007; 84:1492-1499. (Pubitemid 350294725)
    • (2007) Transplantation , vol.84 , Issue.11 , pp. 1492-1499
    • Vogelbacher, R.1    Wittmann, S.2    Braun, A.3    Daniel, C.4    Hugo, C.5
  • 46
    • 79957927211 scopus 로고    scopus 로고
    • mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
    • Genetic dissection of the role of mTORC1 in diabetic nephropathy
    • Inoki K, Mori H, Wang J, et al. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest 2011; 121:2181-2196. Genetic dissection of the role of mTORC1 in diabetic nephropathy.
    • (2011) J Clin Invest , vol.121 , pp. 2181-2196
    • Inoki, K.1    Mori, H.2    Wang, J.3
  • 47
    • 79957881425 scopus 로고    scopus 로고
    • Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
    • Genetic dissection of the role of mTOR complexes for podocyte maintenance and disease
    • Godel M, Hartleben B, Herbach N, et al. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 2011; 121:2197-2209. Genetic dissection of the role of mTOR complexes for podocyte maintenance and disease.
    • (2011) J Clin Invest , vol.121 , pp. 2197-2209
    • Godel, M.1    Hartleben, B.2    Herbach, N.3
  • 48
    • 80055108638 scopus 로고    scopus 로고
    • mTOR in podocyte function: Is rapamycin good for diabetic nephropathy?
    • Lu MK, Gong XG, Guan KL. mTOR in podocyte function: is rapamycin good for diabetic nephropathy? Cell Cycle 10:3415-3416.
    • Cell Cycle , vol.10 , pp. 3415-3416
    • Lu, M.K.1    Gong, X.G.2    Guan, K.L.3
  • 50
    • 0345505674 scopus 로고    scopus 로고
    • Nephrin expression is reduced in human diabetic nephropathy: Evidence for a distinct role for glycated albumin and angiotensin II
    • DOI 10.2337/diabetes.52.4.1023
    • Doublier S, Salvidio G, Lupia E, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 2003; 52:1023-1030. (Pubitemid 36384273)
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 1023-1030
    • Doublier, S.1    Salvidio, G.2    Lupia, E.3    Ruotsalainen, V.4    Verzola, D.5    Deferrari, G.6    Camussi, G.7
  • 51
    • 77953719527 scopus 로고    scopus 로고
    • Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: Regulation of endoplasmic reticulum stress-oxidative activation
    • Luo ZF, Feng B, Mu J, et al. Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation. Toxicol Appl Pharmacol 2010; 246:49-57.
    • (2010) Toxicol Appl Pharmacol , vol.246 , pp. 49-57
    • Luo, Z.F.1    Feng, B.2    Mu, J.3
  • 52
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22:132-139.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 53
    • 77951169411 scopus 로고    scopus 로고
    • Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
    • Genetic dissection of the role of autophagy in podocyte maintenance and disease
    • Hartleben B, Godel M, Meyer-Schwesinger C, et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010; 120:1084-1096. Genetic dissection of the role of autophagy in podocyte maintenance and disease.
    • (2010) J Clin Invest , vol.120 , pp. 1084-1096
    • Hartleben, B.1    Godel, M.2    Meyer-Schwesinger, C.3
  • 54
    • 79953834002 scopus 로고    scopus 로고
    • Implications of autophagy for glomerular aging and disease
    • Weide T, Huber TB. Implications of autophagy for glomerular aging and disease. Cell Tissue Res 2011; 343:467-473.
    • (2011) Cell Tissue Res , vol.343 , pp. 467-473
    • Weide, T.1    Huber, T.B.2
  • 55
    • 79956325949 scopus 로고    scopus 로고
    • Spatial coupling of mTOR and autophagy augments secretory phenotypes
    • Identification of the spatial coupling of autophagy and mTOR signaling, which might have important implications for podocyte homeostasis
    • Narita M, Young AR, Arakawa S, et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 2011; 332:966-970. Identification of the spatial coupling of autophagy and mTOR signaling, which might have important implications for podocyte homeostasis.
    • (2011) Science , vol.332 , pp. 966-970
    • Narita, M.1    Young, A.R.2    Arakawa, S.3
  • 56
    • 77957861954 scopus 로고    scopus 로고
    • Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling
    • Sison K, Eremina V, Baelde H, et al. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol 2010; 21:1691-1701.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1691-1701
    • Sison, K.1    Eremina, V.2    Baelde, H.3
  • 58
    • 84863230126 scopus 로고    scopus 로고
    • Inhibition of MTOR disrupts autophagic flux in podocytes
    • [Epub ahead of print] Role of mTOR for autophagic flux in podocytes
    • Cina DP, Onay T, Paltoo A, et al. Inhibition of MTOR disrupts autophagic flux in podocytes. J Am Soc Nephrol 2011. [Epub ahead of print] Role of mTOR for autophagic flux in podocytes.
    • (2011) J Am Soc Nephrol
    • Cina, D.P.1    Onay, T.2    Paltoo, A.3
  • 60
    • 69849089270 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria
    • Dai C, Stolz DB, Kiss LP, et al. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 2009; 20:1997-2008.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1997-2008
    • Dai, C.1    Stolz, D.B.2    Kiss, L.P.3
  • 61
    • 79960425136 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival
    • Kato H, Gruenwald A, Suh JH, et al. Wnt/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 2011; 286:26003-26015.
    • (2011) J Biol Chem , vol.286 , pp. 26003-26015
    • Kato, H.1    Gruenwald, A.2    Suh, J.H.3
  • 62
    • 84855537673 scopus 로고    scopus 로고
    • Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling
    • Identification of Wnt signaling as regulator of podocyte cell cycle control
    • Shkreli M, Sarin KY, Pech MF, et al. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med 2011; 18:111-119. Identification of Wnt signaling as regulator of podocyte cell cycle control.
    • (2011) Nat Med , vol.18 , pp. 111-119
    • Shkreli, M.1    Sarin, K.Y.2    Pech, M.F.3
  • 63
    • 81155132148 scopus 로고    scopus 로고
    • Old friends form alliance against podocytes
    • Simons M, Huber TB. Old friends form alliance against podocytes. Kidney Int 2011; 80:1117-1119.
    • (2011) Kidney Int , vol.80 , pp. 1117-1119
    • Simons, M.1    Huber, T.B.2
  • 64
    • 81155150123 scopus 로고    scopus 로고
    • Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria
    • Wang D, Dai C, Li Y, Liu Y. Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria. Kidney Int 2011; 80:1159-1169.
    • (2011) Kidney Int , vol.80 , pp. 1159-1169
    • Wang, D.1    Dai, C.2    Li, Y.3    Liu, Y.4
  • 66
    • 74949090816 scopus 로고    scopus 로고
    • The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development
    • Karbowniczek M, Zitserman D, Khabibullin D, et al. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest 2010; 120:93-102.
    • (2010) J Clin Invest , vol.120 , pp. 93-102
    • Karbowniczek, M.1    Zitserman, D.2    Khabibullin, D.3
  • 67
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    • Ma J,Meng Y, Kwiatkowski DJ, et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 2010; 120:103-114.
    • (2010) J Clin Invest , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.