메뉴 건너뛰기




Volumn , Issue , 2009, Pages 289-308

Oral Drug Absorption, Evaluation, and Prediction

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84859597344     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-444-53242-8.00012-6     Document Type: Chapter
Times cited : (10)

References (95)
  • 1
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon G.L., Lennernas H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research 1995, 12:413-420.
    • (1995) Pharmaceutical Research , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 4
    • 2942529161 scopus 로고    scopus 로고
    • Biowaiver extension potential to BCS class III high solubility-low permeability drugs: Bridging evidence for metformin immediate-release tablet
    • Cheng C-L., Yu L.X., Lee H-L., Yang C-Y., Lue C-S., Chou C-H. Biowaiver extension potential to BCS class III high solubility-low permeability drugs: Bridging evidence for metformin immediate-release tablet. European Journal of Pharmaceutical Sciences 2004, 22:297-304.
    • (2004) European Journal of Pharmaceutical Sciences , vol.22 , pp. 297-304
    • Cheng, C.-L.1    Yu, L.X.2    Lee, H.-L.3    Yang, C.-Y.4    Lue, C.-S.5    Chou, C.-H.6
  • 5
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu C.Y., Benet L.Z. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research 2005, 22:11-23.
    • (2005) Pharmaceutical Research , vol.22 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 6
    • 0032927254 scopus 로고    scopus 로고
    • Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications
    • Fleisher D., Li C., Zhou Y., Pao L.H., Karim A. Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications. Clinical Pharmacokinetics 1999, 36:233-254.
    • (1999) Clinical Pharmacokinetics , vol.36 , pp. 233-254
    • Fleisher, D.1    Li, C.2    Zhou, Y.3    Pao, L.H.4    Karim, A.5
  • 7
    • 14744272833 scopus 로고    scopus 로고
    • The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension
    • Lennernäs H., Abrahamsson B. The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. The Journal of Pharmacy and Pharmacology 2004, 57:273-285.
    • (2004) The Journal of Pharmacy and Pharmacology , vol.57 , pp. 273-285
    • Lennernäs, H.1    Abrahamsson, B.2
  • 8
    • 84882877869 scopus 로고
    • Guidance for Industry, Immediate Release Solid Oral Dosage Forms: Scale-Up and Post-Approval Changes. November, CDER/FDA.
    • Guidance for Industry. (1995). Immediate Release Solid Oral Dosage Forms: Scale-Up and Post-Approval Changes. November, CDER/FDA.
    • (1995)
  • 9
    • 84882877922 scopus 로고    scopus 로고
    • Guidance for industry, Dissolution Testing of Immediate Release Solid Oral Dosage Forms. August, CDER/FDA.
    • Guidance for industry. (1997). Dissolution Testing of Immediate Release Solid Oral Dosage Forms. August, CDER/FDA.
    • (1997)
  • 10
    • 84882923888 scopus 로고    scopus 로고
    • Guidance for industry, Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System. August, CDER/FDA.
    • Guidance for industry. (2000). Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System. August, CDER/FDA.
    • (2000)
  • 11
    • 84882900898 scopus 로고    scopus 로고
    • Buffer solutions, USP-NF Online. United States Pharmacopeia 29/National Formulary 24. Accessed December 12, 2006.
    • Buffer solutions. (2006). USP-NF Online. United States Pharmacopeia 29/National Formulary 24. Accessed December 12, 2006.
    • (2006)
  • 12
    • 84882892082 scopus 로고    scopus 로고
    • Dissolution, USP-NF Online. United States Pharmacopeia 29/National Formulary 24. Accessed December 12, 2006.
    • Dissolution. (2006). USP-NF Online. United States Pharmacopeia 29/National Formulary 24. Accessed December 12, 2006.
    • (2006)
  • 14
    • 0027473738 scopus 로고
    • Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model
    • Oh D.M., Curl R.L., Amido G.L. Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model. Pharmaceutical Research 1993, 10:264-270.
    • (1993) Pharmaceutical Research , vol.10 , pp. 264-270
    • Oh, D.M.1    Curl, R.L.2    Amido, G.L.3
  • 16
    • 0033427120 scopus 로고    scopus 로고
    • An integrated model for determining causes of poor oral drug absorption
    • Yu L.X. An integrated model for determining causes of poor oral drug absorption. Pharmaceutical Research 1999, 16:1883-1887.
    • (1999) Pharmaceutical Research , vol.16 , pp. 1883-1887
    • Yu, L.X.1
  • 17
    • 0030787532 scopus 로고    scopus 로고
    • A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption of the Caco-2 model
    • Delie F., Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption of the Caco-2 model. Critical Reviews in Therapeutic Drug Carrier Systems 1997, 14:221-286.
    • (1997) Critical Reviews in Therapeutic Drug Carrier Systems , vol.14 , pp. 221-286
    • Delie, F.1    Rubas, W.2
  • 18
    • 0024593744 scopus 로고
    • Characterization of human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo I., Raub T., Borchardt R. Characterization of human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96:739-749.
    • (1989) Gastroenterology , vol.96 , pp. 739-749
    • Hidalgo, I.1    Raub, T.2    Borchardt, R.3
  • 19
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson P., Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochemical and Biophysical Research Communications 1991, 175:880-885.
    • (1991) Biochemical and Biophysical Research Communications , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 20
    • 0027497560 scopus 로고
    • Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption
    • Rubas W., Jezyk N., Grass G.M. Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharmaceutical Research 1993, 10:113-118.
    • (1993) Pharmaceutical Research , vol.10 , pp. 113-118
    • Rubas, W.1    Jezyk, N.2    Grass, G.M.3
  • 21
    • 0028810862 scopus 로고
    • The application of cell culture systems in drug discovery and development
    • Borchardt R. The application of cell culture systems in drug discovery and development. Journal of Drug Targeting 1995, 3:179-182.
    • (1995) Journal of Drug Targeting , vol.3 , pp. 179-182
    • Borchardt, R.1
  • 22
    • 0030588714 scopus 로고    scopus 로고
    • Caco-2 mono-layers in experimental and theoretical predictions of drug transport
    • Autursson P., Palm K., Luthman K. Caco-2 mono-layers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 1996, 22:67-84.
    • (1996) Advanced Drug Delivery Reviews , vol.22 , pp. 67-84
    • Autursson, P.1    Palm, K.2    Luthman, K.3
  • 23
    • 84882899227 scopus 로고    scopus 로고
    • Method suitability of a Caco-2 cell model for drug permeability classification. AAPS PharmSci. 2001 AAPS Annual Meeting Supplement
    • Volpe, D.A., Ciavarella, A.B., Asafu-Adjaye, E.B., Ellison, C.D., Faustino, P.J. & Yu, L.X. (2001). Method suitability of a Caco-2 cell model for drug permeability classification. AAPS PharmSci. 2001 AAPS Annual Meeting Supplement.
    • (2001)
    • Volpe, D.A.1    Ciavarella, A.B.2    Asafu-Adjaye, E.B.3    Ellison, C.D.4    Faustino, P.J.5    Yu, L.X.6
  • 25
    • 0027141263 scopus 로고
    • A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa
    • Kim D.C., Burton P.S., Borchardt R.T. A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa. Pharmaceutical Research 1993, 10:1710-1714.
    • (1993) Pharmaceutical Research , vol.10 , pp. 1710-1714
    • Kim, D.C.1    Burton, P.S.2    Borchardt, R.T.3
  • 26
    • 0027136654 scopus 로고
    • In vitro/in vivo models for peptide oral absorption: Comparison of Caco-2 cell permeability with rat intestinal absorption of rennin inhibitory peptides
    • Conradi R.A., Wilkinson K.F., Rush B.D., Hilgers A.R., Ruwart M.J., Burton P.S. In vitro/in vivo models for peptide oral absorption: Comparison of Caco-2 cell permeability with rat intestinal absorption of rennin inhibitory peptides. Pharmaceutical Research 1993, 10:1790-1792.
    • (1993) Pharmaceutical Research , vol.10 , pp. 1790-1792
    • Conradi, R.A.1    Wilkinson, K.F.2    Rush, B.D.3    Hilgers, A.R.4    Ruwart, M.J.5    Burton, P.S.6
  • 27
    • 0028113469 scopus 로고
    • Differentiated intestinal epithelial cell lines as in vitro models for predicting the intestinal absorption of drugs
    • Wils P., Warnery A., Phung-Ba V., Scherman D. Differentiated intestinal epithelial cell lines as in vitro models for predicting the intestinal absorption of drugs. Cell Biology and Toxicology 1994, 10:393-397.
    • (1994) Cell Biology and Toxicology , vol.10 , pp. 393-397
    • Wils, P.1    Warnery, A.2    Phung-Ba, V.3    Scherman, D.4
  • 28
    • 0029836840 scopus 로고    scopus 로고
    • HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans
    • Walter E., Janich S., Roessler B.J., Hilfinger J.M., Amidon G.L. HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans. Journal of Pharmaceutical Sciences 1996, 85:1070-1076.
    • (1996) Journal of Pharmaceutical Sciences , vol.85 , pp. 1070-1076
    • Walter, E.1    Janich, S.2    Roessler, B.J.3    Hilfinger, J.M.4    Amidon, G.L.5
  • 29
    • 0030990079 scopus 로고    scopus 로고
    • In vitro permeability across Caco-2 cells (colonic) can predict in vivo small intestine absorption in man-fact or myth
    • Yee S. In vitro permeability across Caco-2 cells (colonic) can predict in vivo small intestine absorption in man-fact or myth. Pharmaceutical Research 1997, 14:763-766.
    • (1997) Pharmaceutical Research , vol.14 , pp. 763-766
    • Yee, S.1
  • 31
    • 0030023536 scopus 로고    scopus 로고
    • Correlation between paracellular and transcellular drug permeability in the human jejunum and Caco-2 monolayers
    • Lennernäs H., Palm K., Fagerholm U., Artursson P. Correlation between paracellular and transcellular drug permeability in the human jejunum and Caco-2 monolayers. International Journal of Pharmaceutics 1996, 127:103-107.
    • (1996) International Journal of Pharmaceutics , vol.127 , pp. 103-107
    • Lennernäs, H.1    Palm, K.2    Fagerholm, U.3    Artursson, P.4
  • 33
    • 0024505075 scopus 로고
    • The Madin-Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier
    • Cho M., Thompson D., Cramer C., Vidmar T., Scieszka J. The Madin-Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier. Pharmaceutical Research 1989, 6:71-79.
    • (1989) Pharmaceutical Research , vol.6 , pp. 71-79
    • Cho, M.1    Thompson, D.2    Cramer, C.3    Vidmar, T.4    Scieszka, J.5
  • 34
    • 0036891989 scopus 로고    scopus 로고
    • Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells
    • Putnam W.S., Ramanathan S., Pan L., Takahashi L.H., Benet L.Z. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. Journal of Pharmaceutical Sciences 2002, 91:2622-2635.
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , pp. 2622-2635
    • Putnam, W.S.1    Ramanathan, S.2    Pan, L.3    Takahashi, L.H.4    Benet, L.Z.5
  • 35
    • 0031780682 scopus 로고    scopus 로고
    • Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial cell line: comparison with the parental Caco-2 cell line
    • Gres M., Julian B., Bourrie M., Roques C., Berger M., Boulenc X., Berger Y., Fabre G. Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial cell line: comparison with the parental Caco-2 cell line. Pharmaceutical Research 1998, 15:726-733.
    • (1998) Pharmaceutical Research , vol.15 , pp. 726-733
    • Gres, M.1    Julian, B.2    Bourrie, M.3    Roques, C.4    Berger, M.5    Boulenc, X.6    Berger, Y.7    Fabre, G.8
  • 36
    • 0036804483 scopus 로고    scopus 로고
    • Characterization of the transport of uracil across Caco-2 and LLC-PK1 cell monolayers
    • Li H., Chung S.J., Shim C.K. Characterization of the transport of uracil across Caco-2 and LLC-PK1 cell monolayers. Pharmaceutical Research 2002, 19:1495-1501.
    • (2002) Pharmaceutical Research , vol.19 , pp. 1495-1501
    • Li, H.1    Chung, S.J.2    Shim, C.K.3
  • 37
    • 0042125510 scopus 로고    scopus 로고
    • Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro
    • Adachi Y., Suzuki H., Sugiyama Y. Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro. Pharmaceutical Research 2003, 20:1163-1169.
    • (2003) Pharmaceutical Research , vol.20 , pp. 1163-1169
    • Adachi, Y.1    Suzuki, H.2    Sugiyama, Y.3
  • 38
    • 0037335192 scopus 로고    scopus 로고
    • An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: Characterization of transport routes
    • Tavelin S., Taipalensuu J., Hallbook F., Vellonen K.S., Moore V., Artursson P. An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: Characterization of transport routes. Pharmaceutical Research 2003, 20:373-381.
    • (2003) Pharmaceutical Research , vol.20 , pp. 373-381
    • Tavelin, S.1    Taipalensuu, J.2    Hallbook, F.3    Vellonen, K.S.4    Moore, V.5    Artursson, P.6
  • 39
    • 0037336533 scopus 로고    scopus 로고
    • Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers
    • Tavelin S., Taipalensuu J., Soderberg L., Moore V., Chong S., Artursson P. Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers. Pharmaceutical Research 2003, 20:397-405.
    • (2003) Pharmaceutical Research , vol.20 , pp. 397-405
    • Tavelin, S.1    Taipalensuu, J.2    Soderberg, L.3    Moore, V.4    Chong, S.5    Artursson, P.6
  • 40
    • 0029939330 scopus 로고    scopus 로고
    • In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system
    • Chong S., Dando S., Soucek K., Morrison R. In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system. Pharmaceutical Research 1996, 13:120-123.
    • (1996) Pharmaceutical Research , vol.13 , pp. 120-123
    • Chong, S.1    Dando, S.2    Soucek, K.3    Morrison, R.4
  • 41
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • Artursson P., Borchardt R.T. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharmaceutical Research 1997, 14:1655-1658.
    • (1997) Pharmaceutical Research , vol.14 , pp. 1655-1658
    • Artursson, P.1    Borchardt, R.T.2
  • 42
    • 6544259277 scopus 로고
    • The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface
    • Wilson T.H., Wiseman G. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. The Journal of Physiology 1954, 123:116-125.
    • (1954) The Journal of Physiology , vol.123 , pp. 116-125
    • Wilson, T.H.1    Wiseman, G.2
  • 43
    • 0019412116 scopus 로고
    • The uptake of distearyphosphatidylcholine/cholesterol liposomes by rat intestinal sac in vitro
    • Rowland R.N., Woodley J.F. The uptake of distearyphosphatidylcholine/cholesterol liposomes by rat intestinal sac in vitro. Biochimica et Biophysica Acta 1981, 673:217-223.
    • (1981) Biochimica et Biophysica Acta , vol.673 , pp. 217-223
    • Rowland, R.N.1    Woodley, J.F.2
  • 44
    • 0019433074 scopus 로고
    • The uptake of free and liposome entrapped horse radish peroxidase by rat intestinal sacs in vitro
    • Rowland R.N., Woodley J.F. The uptake of free and liposome entrapped horse radish peroxidase by rat intestinal sacs in vitro. FEBS letters 1981, 123:41-44.
    • (1981) FEBS letters , vol.123 , pp. 41-44
    • Rowland, R.N.1    Woodley, J.F.2
  • 46
    • 0028274256 scopus 로고
    • Uptake and transport of poly(N-vinylpyrrolidone-co-maleic acid) by the adult rat small intestine cultured in vitro: effect of chemical structure
    • Pato J., Mora M., Naisbett B., Woodley J.F., Duncan R. Uptake and transport of poly(N-vinylpyrrolidone-co-maleic acid) by the adult rat small intestine cultured in vitro: effect of chemical structure. International Journal of Pharmaceutics 1994, 110:227-237.
    • (1994) International Journal of Pharmaceutics , vol.110 , pp. 227-237
    • Pato, J.1    Mora, M.2    Naisbett, B.3    Woodley, J.F.4    Duncan, R.5
  • 47
    • 0031659639 scopus 로고    scopus 로고
    • An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine
    • Barthe L., Bessouet M., Woodley J.F., Houin G. An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine. European Journal of Drug Metabolism and Pharmacokinetics 1998, 23:313-323.
    • (1998) European Journal of Drug Metabolism and Pharmacokinetics , vol.23 , pp. 313-323
    • Barthe, L.1    Bessouet, M.2    Woodley, J.F.3    Houin, G.4
  • 48
    • 53349115703 scopus 로고
    • Active transport of sodium as the source of electric current in the short-circuited isolated frog skin
    • Ussing H.H., Zerahn K. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiologica Scandinavica 1951, 23:110-127.
    • (1951) Acta Physiologica Scandinavica , vol.23 , pp. 110-127
    • Ussing, H.H.1    Zerahn, K.2
  • 49
    • 0024031266 scopus 로고
    • In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell
    • Grass G.M., Sweetana S.A. In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell. Pharmaceutical Research 1988, 5:372-376.
    • (1988) Pharmaceutical Research , vol.5 , pp. 372-376
    • Grass, G.M.1    Sweetana, S.A.2
  • 50
    • 0023756430 scopus 로고
    • Intestinal 5-fluorouracil absorption: Use of Ussing chambers to assess transport and metabolism
    • Smith P., Mirabelli C., Fondacaro J., Ryan F., Dent J. Intestinal 5-fluorouracil absorption: Use of Ussing chambers to assess transport and metabolism. Pharmaceutical Research 1988, 5:598-603.
    • (1988) Pharmaceutical Research , vol.5 , pp. 598-603
    • Smith, P.1    Mirabelli, C.2    Fondacaro, J.3    Ryan, F.4    Dent, J.5
  • 53
    • 0034126112 scopus 로고    scopus 로고
    • Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo: Importance of drug ionization in the in vitro prediction of in vivo absorption
    • Biosset M., Botham R.P., Haegele K.D., Lenfant B., Pachot P.I. Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo: Importance of drug ionization in the in vitro prediction of in vivo absorption. Eur.J.Pharm. 2000, 10:215-224.
    • (2000) Eur.J.Pharm. , vol.10 , pp. 215-224
    • Biosset, M.1    Botham, R.P.2    Haegele, K.D.3    Lenfant, B.4    Pachot, P.I.5
  • 55
    • 0033958156 scopus 로고    scopus 로고
    • Involvement of an organic anion transporter (Canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
    • Gotoh Y., Suzuki H., Kinoshita S., Hirohashi T., Kato Y., Sugiyama Y. Involvement of an organic anion transporter (Canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats. The Journal of Pharmacology and Experimental Therapeutics 2000, 292:433-439.
    • (2000) The Journal of Pharmacology and Experimental Therapeutics , vol.292 , pp. 433-439
    • Gotoh, Y.1    Suzuki, H.2    Kinoshita, S.3    Hirohashi, T.4    Kato, Y.5    Sugiyama, Y.6
  • 56
    • 0031849072 scopus 로고    scopus 로고
    • Determination of absorption characteristics of AG337, a novel thymiddylate synthase inhibitor, using a perfused rat intestinal model
    • Hu M., Roland K., Ge L., Chen J., Li Y., Tyle P., Roy S. Determination of absorption characteristics of AG337, a novel thymiddylate synthase inhibitor, using a perfused rat intestinal model. Journal of Pharmaceutical Sciences 1998, 87:886-890.
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , pp. 886-890
    • Hu, M.1    Roland, K.2    Ge, L.3    Chen, J.4    Li, Y.5    Tyle, P.6    Roy, S.7
  • 57
    • 0030974779 scopus 로고    scopus 로고
    • Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)
    • Annaert P., Kinget R., Naesens L., de Clercq E., Augustijins P. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2). Pharmaceutical Research 1997, 14:492-496.
    • (1997) Pharmaceutical Research , vol.14 , pp. 492-496
    • Annaert, P.1    Kinget, R.2    Naesens, L.3    de Clercq, E.4    Augustijins, P.5
  • 58
    • 0033943453 scopus 로고    scopus 로고
    • A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: Active efflux transport as a cause of poor bioavailability of the active drug
    • Okudaira N., Tatebayashi T., Speirs G.C., Komiya I., Sugiyama Y. A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: Active efflux transport as a cause of poor bioavailability of the active drug. The Journal of Pharmacology and Experimental Therapeutics 2000, 294:580-587.
    • (2000) The Journal of Pharmacology and Experimental Therapeutics , vol.294 , pp. 580-587
    • Okudaira, N.1    Tatebayashi, T.2    Speirs, G.C.3    Komiya, I.4    Sugiyama, Y.5
  • 60
    • 0029855969 scopus 로고    scopus 로고
    • Comparison between permeability coefficients in rat and human jejunum
    • Fagerholm U., Johansson M., Lennernäs H. Comparison between permeability coefficients in rat and human jejunum. Pharmaceutical Research 1996, 13:1336-1342.
    • (1996) Pharmaceutical Research , vol.13 , pp. 1336-1342
    • Fagerholm, U.1    Johansson, M.2    Lennernäs, H.3
  • 62
    • 0029078054 scopus 로고
    • The effect of surgical bowl manipulation and anesthesia on intestinal glucose absorption in rats
    • Uhing M.R., Kimura R.E. The effect of surgical bowl manipulation and anesthesia on intestinal glucose absorption in rats. The Journal of Clinical Investigation 1995, 95:2790-2798.
    • (1995) The Journal of Clinical Investigation , vol.95 , pp. 2790-2798
    • Uhing, M.R.1    Kimura, R.E.2
  • 63
    • 0027231109 scopus 로고
    • Influence of anesthetic regimens on intestinal absorption in rats
    • Yuasa H., Matsuda K., Watanabe J. Influence of anesthetic regimens on intestinal absorption in rats. Pharmaceutical Research 1993, 10:884-888.
    • (1993) Pharmaceutical Research , vol.10 , pp. 884-888
    • Yuasa, H.1    Matsuda, K.2    Watanabe, J.3
  • 66
    • 0028925908 scopus 로고
    • Regional rectal perfusion, a new in vivo approach to study rectal drug absorption in man
    • Lennernäs H., Fagerholm U., Raab Y., Gerdin B., Hällgren R. Regional rectal perfusion, a new in vivo approach to study rectal drug absorption in man. Pharmaceutical Research 1995, 12:426-432.
    • (1995) Pharmaceutical Research , vol.12 , pp. 426-432
    • Lennernäs, H.1    Fagerholm, U.2    Raab, Y.3    Gerdin, B.4    Hällgren, R.5
  • 67
    • 0030790029 scopus 로고    scopus 로고
    • A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: In-vivo permeability estimation
    • Lennernäs H., Lee I.D., Fagerholm U., Amidon G.L. A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: In-vivo permeability estimation. The Journal of Pharmacy and Pharmacology 1997, 49:682-686.
    • (1997) The Journal of Pharmacy and Pharmacology , vol.49 , pp. 682-686
    • Lennernäs, H.1    Lee, I.D.2    Fagerholm, U.3    Amidon, G.L.4
  • 69
    • 0029999340 scopus 로고    scopus 로고
    • Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-block tailinolol in humans
    • Gramatté T., Oertel R., Terhaag B., Kirch W. Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-block tailinolol in humans. Clinical Pharmacology and Therapeutics 1996, 59:541-549.
    • (1996) Clinical Pharmacology and Therapeutics , vol.59 , pp. 541-549
    • Gramatté, T.1    Oertel, R.2    Terhaag, B.3    Kirch, W.4
  • 71
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski T., Lombardo F., Dominy B., Feeney P. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews 1997, 23:3-25.
    • (1997) Advanced Drug Delivery Reviews , vol.23 , pp. 3-25
    • Lipinski, T.1    Lombardo, F.2    Dominy, B.3    Feeney, P.4
  • 72
    • 0032888376 scopus 로고    scopus 로고
    • A compartmental absorption and transit model for estimating oral drug absorption
    • Yu L.X., Amidon G.L. A compartmental absorption and transit model for estimating oral drug absorption. International Journal of Pharmaceutics 1999, 186:119-125.
    • (1999) International Journal of Pharmaceutics , vol.186 , pp. 119-125
    • Yu, L.X.1    Amidon, G.L.2
  • 74
    • 0033840471 scopus 로고    scopus 로고
    • Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship
    • Andrews W.C., Bennett L., Yu L.X. Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship. Pharmaceutical Research 2000, 17:639-644.
    • (2000) Pharmaceutical Research , vol.17 , pp. 639-644
    • Andrews, W.C.1    Bennett, L.2    Yu, L.X.3
  • 75
    • 0031877469 scopus 로고    scopus 로고
    • A general approach for the prediction of the intestinal absorption of drugs: regression analysis using the physicochemical properties and drug-membrane electrostatic interaction
    • Sugawara M., Takekuma Y., Yamada H., Kobayashi M., Iseki K., Miyazaki K. A general approach for the prediction of the intestinal absorption of drugs: regression analysis using the physicochemical properties and drug-membrane electrostatic interaction. Journal of Pharmaceutical Sciences 1998, 87:960-966.
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , pp. 960-966
    • Sugawara, M.1    Takekuma, Y.2    Yamada, H.3    Kobayashi, M.4    Iseki, K.5    Miyazaki, K.6
  • 76
    • 0032480901 scopus 로고    scopus 로고
    • A general approach for the prediction of the intestinal absorption of drugs: Regression analysis using the physicochemical properties and drug-membrane electrostatic interaction
    • Winiwarter S., Bonham N.M., Ax F., Hallberg A., Lennernäs H., Karlen A. A general approach for the prediction of the intestinal absorption of drugs: Regression analysis using the physicochemical properties and drug-membrane electrostatic interaction. Journal of Medicinal Chemistry 1998, 41:4939-4949.
    • (1998) Journal of Medicinal Chemistry , vol.41 , pp. 4939-4949
    • Winiwarter, S.1    Bonham, N.M.2    Ax, F.3    Hallberg, A.4    Lennernäs, H.5    Karlen, A.6
  • 78
    • 0029848457 scopus 로고    scopus 로고
    • Compartmental transit and dispersion model analysis of small intestinal transit flow in humans
    • Yu L.X., Crison J.R., Amidon G.L. Compartmental transit and dispersion model analysis of small intestinal transit flow in humans. International Journal of Pharmaceutics 1996, 140:111-118.
    • (1996) International Journal of Pharmaceutics , vol.140 , pp. 111-118
    • Yu, L.X.1    Crison, J.R.2    Amidon, G.L.3
  • 79
    • 0032531309 scopus 로고    scopus 로고
    • Characterization of small intestinal transit time distribution in humans
    • Yu L.X., Amidon G.L. Characterization of small intestinal transit time distribution in humans. International Journal of Pharmaceutics 1998, 171:157-163.
    • (1998) International Journal of Pharmaceutics , vol.171 , pp. 157-163
    • Yu, L.X.1    Amidon, G.L.2
  • 80
    • 0028211059 scopus 로고
    • Non-congeneric structure-pharmacokinetic property correlation studies using fuzzy adaptive least-squares: Oral bioavailability
    • Hirono S., Nakagome I., Hirano H., Matsushita Y., Yoshii F., Moriguchi I. Non-congeneric structure-pharmacokinetic property correlation studies using fuzzy adaptive least-squares: Oral bioavailability. Biological & Pharmaceutical Bulletin 1994, 17:306-309.
    • (1994) Biological& Pharmaceutical Bulletin , vol.17 , pp. 306-309
    • Hirono, S.1    Nakagome, I.2    Hirano, H.3    Matsushita, Y.4    Yoshii, F.5    Moriguchi, I.6
  • 82
    • 0036234783 scopus 로고    scopus 로고
    • High-throughput and in silico techniques in drug metabolism and pharmacokinetics
    • van de Waterbeemd H. High-throughput and in silico techniques in drug metabolism and pharmacokinetics. Current Opinion in Drug Discovery & Development 2002, 5:33-43.
    • (2002) Current Opinion in Drug Discovery& Development , vol.5 , pp. 33-43
    • van de Waterbeemd, H.1
  • 83
    • 0030914681 scopus 로고    scopus 로고
    • Polar molecular surface properties predict the intestinal absorption of drugs in humans
    • Palm K., Stenberg P., Luthman K., Artursson P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharmaceutical Research 1997, 14:568-571.
    • (1997) Pharmaceutical Research , vol.14 , pp. 568-571
    • Palm, K.1    Stenberg, P.2    Luthman, K.3    Artursson, P.4
  • 84
    • 0031872134 scopus 로고    scopus 로고
    • Predicting drug absorption from molecular surface properties based on molecular dynamics simulations
    • Krarup L.H., Christensen I.T., Hovgaard L., Frokjaer S. Predicting drug absorption from molecular surface properties based on molecular dynamics simulations. Pharmaceutical Research 1998, 15:972-978.
    • (1998) Pharmaceutical Research , vol.15 , pp. 972-978
    • Krarup, L.H.1    Christensen, I.T.2    Hovgaard, L.3    Frokjaer, S.4
  • 85
    • 0033014577 scopus 로고    scopus 로고
    • Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties
    • Stenberg P., Luthman K., Artursson P. Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties. Pharmaceutical Research 1999, 16:205-212.
    • (1999) Pharmaceutical Research , vol.16 , pp. 205-212
    • Stenberg, P.1    Luthman, K.2    Artursson, P.3
  • 86
    • 0033002003 scopus 로고    scopus 로고
    • Strategies toward predicting peptide cellular permeability from computed molecular descriptors
    • Goodwin J.T., Mao B., Vidmar T.J., Conradi R.A., Burton P.S. Strategies toward predicting peptide cellular permeability from computed molecular descriptors. Journal of Peptide Research 1999, 53:355-369.
    • (1999) Journal of Peptide Research , vol.53 , pp. 355-369
    • Goodwin, J.T.1    Mao, B.2    Vidmar, T.J.3    Conradi, R.A.4    Burton, P.S.5
  • 88
    • 33845748281 scopus 로고    scopus 로고
    • Genetic algorithm-optimized QSRP models for bioavailability, protein binding, and urinary excretion
    • Wang J., Krudy G., Xie X.Q., Wu C., Holland G. Genetic algorithm-optimized QSRP models for bioavailability, protein binding, and urinary excretion. Journal of Chemical Information and Modeling 2006, 46:2674-2683.
    • (2006) Journal of Chemical Information and Modeling , vol.46 , pp. 2674-2683
    • Wang, J.1    Krudy, G.2    Xie, X.Q.3    Wu, C.4    Holland, G.5
  • 89
    • 33746461831 scopus 로고    scopus 로고
    • Computational approaches for modeling human intestinal absorption and permeability
    • Kitchen D.B., Subramanian G. Computational approaches for modeling human intestinal absorption and permeability. Journal of Molecular Modeling 2006, 12:577-589.
    • (2006) Journal of Molecular Modeling , vol.12 , pp. 577-589
    • Kitchen, D.B.1    Subramanian, G.2
  • 93
    • 0346216088 scopus 로고    scopus 로고
    • Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis
    • Alsenz J., Haenel E. Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis. Pharmaceutical Research 2003, 20:1961-1969.
    • (2003) Pharmaceutical Research , vol.20 , pp. 1961-1969
    • Alsenz, J.1    Haenel, E.2
  • 95
    • 0042836926 scopus 로고    scopus 로고
    • Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system
    • Fung E.N., Chu I., Li C., Liu T., Soares A., Morrison R., Nomeir A.A. Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system. Rapid Communications in Mass Spectrometry 2003, 17:2147-2152.
    • (2003) Rapid Communications in Mass Spectrometry , vol.17 , pp. 2147-2152
    • Fung, E.N.1    Chu, I.2    Li, C.3    Liu, T.4    Soares, A.5    Morrison, R.6    Nomeir, A.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.