Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

Pharmaceutical Research

Volumn 14, Issue 4, 1997, Pages 492-496

  Annaert, Pieter ^a   Kinget, Renaat ^a   Naesens, Lieve ^b   De Clercq, Erik ^b   Augustijns, Patrick ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Bis(POM) PMEA; Caco 2; Intestinal metabolism; Intestinal permeability; Prodrug

Indexed keywords

ADEFOVIR; DRUG METABOLITE; PRODRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; NONHUMAN; PRIORITY JOURNAL;

ADENINE; ANIMALS; ANTIVIRAL AGENTS; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INTESTINAL ABSORPTION; PHOSPHONIC ACIDS; PRODRUGS; SWINE;

EID: 0030974779     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012155717819     Document Type: Article

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