A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: Active efflux transport as a cause of poor bioavailability of the active drug

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 2, 2000, Pages 580-587

  Okudaira, Noriko ^a   Tatebayashi, Tomoko ^a   Speirs, Graham C ^b   Komiya, Izumi ^a   Sugiyama, Yuichi ^c  

^a MEIJI SEIKA KAISHA LTD   (Japan)

^b Inveresk Research   (United Kingdom)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN RECEPTOR ANTAGONIST; ME 3229; OCTANOL; PRODRUG; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE; INTESTINE ABSORPTION; LIPOPHILICITY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HUMANS; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LIVER; MALE; MESENTERIC VEINS; PIPERIDINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRODRUGS; RATS; THIOPHENES;

EID: 0033943453     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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