메뉴 건너뛰기




Volumn 347, Issue 1, 2012, Pages 203-223

Transforming growth factor beta signaling in adult cardiovascular diseases and repair

Author keywords

Aging; Cardiovascular; Disease; Heart; TGFbeta

Indexed keywords

ANGIOTENSIN II; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84859443911     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-011-1241-3     Document Type: Review
Times cited : (83)

References (227)
  • 1
    • 33846429618 scopus 로고    scopus 로고
    • Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    • DOI 10.1161/CIRCULATIONAHA.106.654913, PII 0000301720070123000016
    • Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R (2007) Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115:377-386 (Pubitemid 46148512)
    • (2007) Circulation , vol.115 , Issue.3 , pp. 377-386
    • Aikawa, E.1    Nahrendorf, M.2    Sosnovik, D.3    Lok, V.M.4    Jaffer, F.A.5    Aikawa, M.6    Weissleder, R.7
  • 2
    • 64749086542 scopus 로고    scopus 로고
    • Aortic valve calcification: Basic science to clinical practice
    • Akat K, Borggrefe M, Kaden JJ (2009) Aortic valve calcification: basic science to clinical practice. Heart 95:616-623
    • (2009) Heart , vol.95 , pp. 616-623
    • Akat, K.1    Borggrefe, M.2    Kaden, J.J.3
  • 3
    • 0025270339 scopus 로고
    • TGF beta in murine morphogenetic processes: The early embryo and cardiogenesis
    • Akhurst RJ, Lehnert SA, Faissner A, Duffie E (1990) TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development 108:645-656
    • (1990) Development , vol.108 , pp. 645-656
    • Akhurst, R.J.1    Lehnert, S.A.2    Faissner, A.3    Duffie, E.4
  • 4
    • 0032918581 scopus 로고    scopus 로고
    • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth
    • Akishita M, Ito M, Lehtonen JY, Daviet L, Dzau VJ, Horiuchi M (1999) Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. J Clin Investig 103:63-71 (Pubitemid 29031164)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.1 , pp. 63-71
    • Akishita, M.1    Ito, M.2    Lehtonen, J.Y.A.3    Daviet, L.4    Dzau, V.J.5    Horiuchi, M.6
  • 5
    • 0030920362 scopus 로고    scopus 로고
    • Spatial and temporal expression of the 72-kDa type IV collagenase (MMP- 2) correlates with development and differentiation of valves in the embryonic avian heart
    • DOI 10.1002/(SICI)1097-0177(199707)209:3<261::AID-AJA2>3.0.CO;2-G
    • Alexander SM, Jackson KJ, Bushnell KM, McGuire PG (1997) Spatial and temporal expression of the 72-kDa type IV collagenase (MMP-2) correlates with development and differentiation of valves in the embryonic avian heart. Dev Dyn 209:261-268 (Pubitemid 27282196)
    • (1997) Developmental Dynamics , vol.209 , Issue.3 , pp. 261-268
    • Alexander, S.M.1    Jackson, K.J.2    Bushnell, K.M.3    McGuire, P.G.4
  • 7
    • 79955009402 scopus 로고    scopus 로고
    • SMAD4 mutation segregating in a family with juvenile polyposis, aortopathy, and mitral valve dysfunction
    • Andrabi S, Bekheirnia MR, Robbins-Furman P, Lewis RA, Prior TW, Potocki L (2011) SMAD4 mutation segregating in a family with juvenile polyposis, aortopathy, and mitral valve dysfunction. Am J Med Genet A 155A:1165-1169
    • (2011) Am J Med Genet A , vol.155 A , pp. 1165-1169
    • Andrabi, S.1    Bekheirnia, M.R.2    Robbins-Furman, P.3    Lewis, R.A.4    Prior, T.W.5    Potocki, L.6
  • 9
    • 79958104536 scopus 로고    scopus 로고
    • TGFbeta signaling and congenital heart disease: Insights from mouse studies
    • in press
    • Arthur HM, Bamforth SD (2011) TGFbeta signaling and congenital heart disease: insights from mouse studies. Birth Defects Res A Clin Mol Teratol 10 (in press)
    • (2011) Birth Defects Res A Clin Mol Teratol , vol.10
    • Arthur, H.M.1    Bamforth, S.D.2
  • 12
    • 59649115469 scopus 로고    scopus 로고
    • Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development
    • PMC2805850
    • Azhar M, Runyan RB, Gard C, Sanford LP, Miller ML, Andringa A, Pawlowski S, Rajan S, Doetschman T (2009a) Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev Dyn 238:431-442, PMC2805850
    • (2009) Dev Dyn , vol.238 , pp. 431-442
    • Azhar, M.1    Runyan, R.B.2    Gard, C.3    Sanford, L.P.4    Miller, M.L.5    Andringa, A.6    Pawlowski, S.7    Rajan, S.8    Doetschman, T.9
  • 14
    • 78650047563 scopus 로고    scopus 로고
    • Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract
    • Azhar M, Wang PY, Frugier T, Koishi K, Deng C, Noakes PG, McLennan IS (2010) Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int J Biol Sci 6:546-555
    • (2010) Int J Biol Sci , vol.6 , pp. 546-555
    • Azhar, M.1    Wang, P.Y.2    Frugier, T.3    Koishi, K.4    Deng, C.5    Noakes, P.G.6    McLennan, I.S.7
  • 16
    • 0033534572 scopus 로고    scopus 로고
    • Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily
    • Barbara NP, Wrana JL, Letarte M (1999) Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem 274:584-594
    • (1999) J Biol Chem , vol.274 , pp. 584-594
    • Barbara, N.P.1    Wrana, J.L.2    Letarte, M.3
  • 21
    • 40949083607 scopus 로고    scopus 로고
    • Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-smads and invasive phenotype
    • DOI 10.1158/0008-5472.CAN-07-5089
    • Bharathy S, Xie W, Yingling JM, Reiss M (2008) Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype. Cancer Res 68:1656-1666 (Pubitemid 351416549)
    • (2008) Cancer Research , vol.68 , Issue.6 , pp. 1656-1666
    • Bharathy, S.1    Xie, W.2    Yingling, J.M.3    Reiss, M.4
  • 22
    • 84859440577 scopus 로고    scopus 로고
    • Transforming growth factor-beta: From its effect in T cell activation to a role in dominant tolerance
    • Graca L (ed) Birkhauser, Basel
    • Bommireddy R, Doetschman T (2007) Transforming growth factor-beta: from its effect in T cell activation to a role in dominant tolerance. In: Graca L (ed) The immune synapse as a novel target for therapy. Birkhauser, Basel, pp 155-168
    • (2007) The Immune Synapse As a Novel Target for Therapy , pp. 155-168
    • Bommireddy, R.1    Doetschman, T.2
  • 25
    • 0033605704 scopus 로고    scopus 로고
    • Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
    • Brown CB, Boyer AS, Runyan RB, Barnett JV (1999) Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283:2080-2082
    • (1999) Science , vol.283 , pp. 2080-2082
    • Brown, C.B.1    Boyer, A.S.2    Runyan, R.B.3    Barnett, J.V.4
  • 26
    • 0035138671 scopus 로고    scopus 로고
    • Effects of gestation on ovine fetal and maternal angiotensin receptor subtypes in the heart and major blood vessels
    • DOI 10.1113/eph8602075
    • Burrell JH, Hegarty BD, McMullen JR, Lumbers ER (2001) Effects of gestation on ovine fetal and maternal angiotensin receptor subtypes in the heart and major blood vessels. Exp Physiol 86:71-82 (Pubitemid 32162302)
    • (2001) Experimental Physiology , vol.86 , Issue.1 , pp. 71-82
    • Burrell, J.H.1    Hegarty, B.D.2    McMullen, J.R.3    Lumbers, E.R.4
  • 30
    • 0036344533 scopus 로고    scopus 로고
    • Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
    • Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA (2002b) Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat Med 8:850-855
    • (2002) Nat Med , vol.8 , pp. 850-855
    • Camenisch, T.D.1    Schroeder, J.A.2    Bradley, J.3    Klewer, S.E.4    McDonald, J.A.5
  • 31
    • 84859445671 scopus 로고    scopus 로고
    • Molecular regulation of cushion morphogenesis
    • Harvey R, Rosenthal N (eds) Academic, London
    • Camenisch TD, Runyan RB, Markwald RR (2010) Molecular regulation of cushion morphogenesis. In: Harvey R, Rosenthal N (eds) Heart development and regeneration. Academic, London, pp 363-388
    • (2010) Heart Development and Regeneration , pp. 363-388
    • Camenisch, T.D.1    Runyan, R.B.2    Markwald, R.R.3
  • 32
    • 77954757244 scopus 로고    scopus 로고
    • Transcriptional regulation of heart valve progenitor cells
    • Chakraborty S, Combs MD, Yutzey KE (2010a) Transcriptional regulation of heart valve progenitor cells. Pediatr Cardiol 31:414-421
    • (2010) Pediatr Cardiol , vol.31 , pp. 414-421
    • Chakraborty, S.1    Combs, M.D.2    Yutzey, K.E.3
  • 33
    • 77957298092 scopus 로고    scopus 로고
    • Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves
    • in press
    • Chakraborty S, Wirrig EE, Hinton RB, Merrill WH, Spicer DB, Yutzey KE (2010b) Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol (in press)
    • (2010) Dev Biol
    • Chakraborty, S.1    Wirrig, E.E.2    Hinton, R.B.3    Merrill, W.H.4    Spicer, D.B.5    Yutzey, K.E.6
  • 34
    • 65449146692 scopus 로고    scopus 로고
    • Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm
    • Choudhary B, Zhou J, Li P, Thomas S, Kaartinen V, Sucov HM (2009) Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis 47:115-121
    • (2009) Genesis , vol.47 , pp. 115-121
    • Choudhary, B.1    Zhou, J.2    Li, P.3    Thomas, S.4    Kaartinen, V.5    Sucov, H.M.6
  • 37
    • 35448946457 scopus 로고    scopus 로고
    • Coronary vessel development is dependent on the type III transforming growth factor beta receptor
    • DOI 10.1161/CIRCRESAHA.107.152082
    • Compton LA, Potash DA, Brown CB, Barnett JV (2007) Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res 101:784-791 (Pubitemid 350287193)
    • (2007) Circulation Research , vol.101 , Issue.8 , pp. 784-791
    • Compton, L.A.1    Potash, D.A.2    Brown, C.B.3    Barnett, J.V.4
  • 38
    • 65949102766 scopus 로고    scopus 로고
    • Periostin as a heterofunctional regulator of cardiac development and disease
    • Conway SJ, Molkentin JD (2008) Periostin as a heterofunctional regulator of cardiac development and disease. Curr Genomics 9:548-555
    • (2008) Curr Genomics , vol.9 , pp. 548-555
    • Conway, S.J.1    Molkentin, J.D.2
  • 42
    • 0033926275 scopus 로고    scopus 로고
    • Delayed wound healing in immunodeficient TGF-beta1 knockout mice
    • DOI 10.1046/j.1523-1747.2000.00010.x
    • Crowe MJ, Doetschman T, Greenhalgh DG (2000) Delayed wound healing in immunodeficient TGF-beta1 knockout mice. J Invest Dermatol 115:3-11 (Pubitemid 30470184)
    • (2000) Journal of Investigative Dermatology , vol.115 , Issue.1 , pp. 3-11
    • Crowe, M.J.1    Doetschman, T.2    Greenhalgh, D.G.3
  • 43
    • 55849145475 scopus 로고    scopus 로고
    • Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth
    • Daly AC, Randall RA, Hill CS (2008) Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol Cell Biol 28:6889-6902
    • (2008) Mol Cell Biol , vol.28 , pp. 6889-6902
    • Daly, A.C.1    Randall, R.A.2    Hill, C.S.3
  • 44
    • 33645123434 scopus 로고    scopus 로고
    • Left ventricular diastolic dysfunction in children and young adults with Marfan syndrome
    • Das BB, Taylor AL, Yetman AT (2006) Left ventricular diastolic dysfunction in children and young adults with Marfan syndrome. Pediatr Cardiol 27:256-258
    • (2006) Pediatr Cardiol , vol.27 , pp. 256-258
    • Das, B.B.1    Taylor, A.L.2    Yetman, A.T.3
  • 45
    • 77954054069 scopus 로고    scopus 로고
    • Angiotensin II infusion promotes ascending aortic aneurysms: Attenuation by CCR2 deficiency in apoE -/- Mice
    • (Lond) (in press)
    • Daugherty A, Rateri DL, Charo IF, Owens Iii AP, Howatt DA, Cassis LA (2010) Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE -/- mice. Clin Sci (Lond) (in press)
    • (2010) Clin Sci
    • Daugherty, A.1    Rateri, D.L.2    Charo, I.F.3    Owens Iii, A.P.4    Howatt, D.A.5    Cassis, L.A.6
  • 46
    • 77950154944 scopus 로고    scopus 로고
    • Cardiovascular characteristics in Marfan syndrome and their relation to the genotype
    • De Backer J (2009a) Cardiovascular characteristics in Marfan syndrome and their relation to the genotype. Verh K Acad Geneeskd Belg 71:335-371
    • (2009) Verh K Acad Geneeskd Belg , vol.71 , pp. 335-371
    • De Backer, J.1
  • 47
    • 62449258451 scopus 로고    scopus 로고
    • The expanding cardiovascular phenotype of Marfan syndrome
    • De Backer J (2009b) The expanding cardiovascular phenotype of Marfan syndrome. Eur J Echocardiogr 10:213-215
    • (2009) Eur J Echocardiogr , vol.10 , pp. 213-215
    • De Backer, J.1
  • 49
    • 34548329486 scopus 로고    scopus 로고
    • Differentiation plasticity regulated by TGF-beta family proteins in development and disease
    • DOI 10.1038/ncb434, PII NCB434
    • Derynck R, Akhurst RJ (2007) Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol 9:1000-1004 (Pubitemid 47338137)
    • (2007) Nature Cell Biology , vol.9 , Issue.9 , pp. 1000-1004
    • Derynck, R.1    Akhurst, R.J.2
  • 50
    • 0027413059 scopus 로고
    • RNA and protein localisations of TGFbeta2 in the early mouse embryo suggest an involvement in cardiac development
    • Dickson MC, Slager HG, Duffie E, Mummery CL, Akhurst RJ (1993) RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development. Development 117:625-639 (Pubitemid 23103171)
    • (1993) Development , vol.117 , Issue.2 , pp. 625-639
    • Dickson, M.C.1    Slager, H.G.2    Duffie, E.3    Mummery, C.L.4    Akhurst, R.J.5
  • 52
    • 76649100088 scopus 로고    scopus 로고
    • TGF-beta in the pathogenesis and prevention of disease: A matter of aneurysmic proportions
    • Dietz HC (2010) TGF-beta in the pathogenesis and prevention of disease: a matter of aneurysmic proportions. J Clin Investig 120:403-407
    • (2010) J Clin Investig , vol.120 , pp. 403-407
    • Dietz, H.C.1
  • 54
    • 0032939061 scopus 로고    scopus 로고
    • Interpretation of phenotype in genetically engineered mice
    • Doetschman T (1999) Interpretation of phenotype in genetically engineered mice. Lab Anim Sci 49:137-143
    • (1999) Lab Anim Sci , vol.49 , pp. 137-143
    • Doetschman, T.1
  • 55
    • 0034530165 scopus 로고    scopus 로고
    • Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis
    • DOI 10.1046/j.1432-1327.2000.01825.x
    • Dunker N, Krieglstein K (2000) Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur J Biochem 267:6982-6988 (Pubitemid 32009439)
    • (2000) European Journal of Biochemistry , vol.267 , Issue.24 , pp. 6982-6988
    • Dunker, N.1    Krieglstein, K.2
  • 56
    • 0036459994 scopus 로고    scopus 로고
    • -/- double knockout mice display severe midline fusion defects and early embryonic lethality
    • DOI 10.1007/s00429-002-0273-6
    • Dunker N, Krieglstein K (2002) Tgfbeta2 -/- Tgfbeta3 -/- double knockout mice display severe midline fusion defects and early embryonic lethality. Anat Embryol (Berl) 206:73-83 (Pubitemid 35478051)
    • (2002) Anatomy and Embryology , vol.206 , Issue.1-2 , pp. 73-83
    • Dunker, N.1    Krieglstein, K.2
  • 59
    • 0037241624 scopus 로고    scopus 로고
    • Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation
    • Franceschi RT, Xiao G, Jiang D, Gopalakrishnan R, Yang S, Reith E (2003) Multiple signaling pathways converge on the Cbfa1/ Runx2 transcription factor to regulate osteoblast differentiation. Connect Tissue Res 44(Suppl 1):109-116 (Pubitemid 36395431)
    • (2003) Connective Tissue Research , vol.44 , Issue.SUPPL. 1 , pp. 109-116
    • Franceschi, R.T.1    Xiao, G.2    Jiang, D.3    Gopalakrishnan, R.4    Yang, S.5    Reith, E.6
  • 60
    • 0032910168 scopus 로고    scopus 로고
    • Organization and regulation of mitogen-activated protein kinase signaling pathways
    • DOI 10.1016/S0955-0674(99)80028-3
    • Garrington TP, Johnson GL (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11:211-218 (Pubitemid 29164036)
    • (1999) Current Opinion in Cell Biology , vol.11 , Issue.2 , pp. 211-218
    • Garrington, T.P.1    Johnson, G.L.2
  • 63
    • 40849133772 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta superfamily signaling pathways in human disease
    • Gordon KJ, Blobe GC (2008) Role of transforming growth factor-beta superfamily signaling pathways in human disease. Biochim Biophys Acta 1782:197-228
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 197-228
    • Gordon, K.J.1    Blobe, G.C.2
  • 64
    • 34547122921 scopus 로고    scopus 로고
    • Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors
    • DOI 10.1074/jbc.M702100200
    • Goto K, Kamiya Y, Imamura T, Miyazono K, Miyazawa K (2007) Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors. J Biol Chem 282:20603-20611 (Pubitemid 47100044)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.28 , pp. 20603-20611
    • Goto, K.1    Kamiya, Y.2    Imamura, T.3    Miyazono, K.4    Miyazawa, K.5
  • 65
    • 84859441311 scopus 로고    scopus 로고
    • TGF-beta signaling in vascular biology and dysfunction
    • Goumans MJ, Liu Z, ten Dijke P (2008) TGF-beta signaling in vascular biology and dysfunction. Cell Res 77:791-799
    • (2008) Cell Res , vol.77 , pp. 791-799
    • Goumans, M.J.1    Liu, Z.2    Ten Dijke, P.3
  • 69
    • 57849106306 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the onset of degenerative aortic valve disease
    • Hakuno D, Kimura N, Yoshioka M, Fukuda K (2009) Molecular mechanisms underlying the onset of degenerative aortic valve disease. J Mol Med 87:17-24
    • (2009) J Mol Med , vol.87 , pp. 17-24
    • Hakuno, D.1    Kimura, N.2    Yoshioka, M.3    Fukuda, K.4
  • 70
    • 54949146436 scopus 로고    scopus 로고
    • Functional role of periostin in development and wound repair: Implications for connective tissue disease
    • Hamilton DW (2008) Functional role of periostin in development and wound repair: implications for connective tissue disease. J Cell Commun Signal 2:9-17
    • (2008) J Cell Commun Signal , vol.2 , pp. 9-17
    • Hamilton, D.W.1
  • 71
    • 79951785577 scopus 로고    scopus 로고
    • Heart valve structure and function in development and disease
    • Hinton RB, Yutzey KE (2011) Heart valve structure and function in development and disease. Annu Rev Physiol 73:29-46
    • (2011) Annu Rev Physiol , vol.73 , pp. 29-46
    • Hinton, R.B.1    Yutzey, K.E.2
  • 75
    • 78649726867 scopus 로고    scopus 로고
    • Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity
    • Horbelt D, Guo G, Robinson PN, Knaus P (2010) Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity. J Cell Sci 123:4340-4350
    • (2010) J Cell Sci , vol.123 , pp. 4340-4350
    • Horbelt, D.1    Guo, G.2    Robinson, P.N.3    Knaus, P.4
  • 76
    • 0032973197 scopus 로고    scopus 로고
    • Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta
    • DOI 10.1359/jbmr.1999.14.7.1239
    • Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H, Toyama Y, Bonewald LF, Kudo A (1999) Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res 14:1239-1249 (Pubitemid 29314070)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.7 , pp. 1239-1249
    • Horiuchi, K.1    Amizuka, N.2    Takeshita, S.3    Takamatsu, H.4    Katsuura, M.5    Ozawa, H.6    Toyama, Y.7    Bonewald, L.F.8    Kudo, A.9
  • 77
    • 4143104513 scopus 로고    scopus 로고
    • 2 receptors in the ovine fetal brain
    • DOI 10.1016/j.devbrainres.2004.02.007, PII S0165380604000744
    • Hu F, Morrissey P, Yao J, Xu Z (2004) Development of AT(1) and AT (2) receptors in the ovine fetal brain. Brain Res Dev Brain Res 19 (150):51-61 (Pubitemid 39090083)
    • (2004) Developmental Brain Research , vol.150 , Issue.1 , pp. 51-61
    • Hu, F.1    Morrissey, P.2    Yao, J.3    Xu, Z.4
  • 78
    • 77649186285 scopus 로고    scopus 로고
    • The association between transforming growth factor beta3 polymorphisms and left ventricular structure in hypertensive subjects
    • Hu BC, Li L, Sun RH, Gao PJ, Zhu DL, Wang JG, Chu SL (2010) The association between transforming growth factor beta3 polymorphisms and left ventricular structure in hypertensive subjects. Clin Chim Acta 411:558-562
    • (2010) Clin Chim Acta , vol.411 , pp. 558-562
    • Hu, B.C.1    Li, L.2    Sun, R.H.3    Gao, P.J.4    Zhu, D.L.5    Wang, J.G.6    Chu, S.L.7
  • 79
    • 80053051051 scopus 로고    scopus 로고
    • Cardiovascular disease in the elderly
    • Jackson CF, Wenger NK (2011) Cardiovascular disease in the elderly. Rev Esp Cardiol 64:697-712
    • (2011) Rev Esp Cardiol , vol.64 , pp. 697-712
    • Jackson, C.F.1    Wenger, N.K.2
  • 81
    • 0036898211 scopus 로고    scopus 로고
    • Serotonin mechanisms in heart valve disease I: Serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells
    • Jian B, Xu J, Connolly J, Savani RC, Narula N, Liang B, Levy RJ (2002) Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells. Am J Pathol 161:2111-2121 (Pubitemid 35434857)
    • (2002) American Journal of Pathology , vol.161 , Issue.6 , pp. 2111-2121
    • Jian, B.1    Xu, J.2    Connolly, J.3    Savani, R.C.4    Narula, N.5    Liang, B.6    Levy, R.J.7
  • 82
    • 0037314647 scopus 로고    scopus 로고
    • Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    • DOI 10.1016/S0003-4975(02)04312-6, PII S0003497502043126
    • Jian B, Narula N, Li QY, Mohler ER III, Levy RJ (2003) Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 75:457-465 (Pubitemid 36184488)
    • (2003) Annals of Thoracic Surgery , vol.75 , Issue.2 , pp. 457-465
    • Jian, B.1    Narula, N.2    Li, Q.-Y.3    Mohler III, E.R.4    Levy, R.J.5
  • 83
    • 33845878509 scopus 로고    scopus 로고
    • Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development
    • DOI 10.1242/dev.02597
    • Jiao K, Langworthy M, Batts L, Brown CB, Moses HL, Baldwin HS (2006) Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development. Development 133:4585-4593 (Pubitemid 46017832)
    • (2006) Development , vol.133 , Issue.22 , pp. 4585-4593
    • Jiao, K.1    Langworthy, M.2    Batts, L.3    Brown, C.B.4    Moses, H.L.5    Baldwin, H.S.6
  • 84
    • 31044448265 scopus 로고    scopus 로고
    • Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression
    • DOI 10.1124/mol.105.017483
    • Jinnin M, Ihn H, Tamaki K (2006) Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol 69:597-607 (Pubitemid 43121957)
    • (2006) Molecular Pharmacology , vol.69 , Issue.2 , pp. 597-607
    • Jinnin, M.1    Ihn, H.2    Tamaki, K.3
  • 85
    • 2442568463 scopus 로고    scopus 로고
    • Cardiovascular and renal function of angiotensin II type-2 receptors
    • DOI 10.1016/j.cardiores.2004.01.011, PII S0008636304000185
    • Johren O, Dendorfer A, Dominiak P (2004) Cardiovascular and renal function of angiotensin II type-2 receptors. Cardiovasc Res 62:460-467 (Pubitemid 38648960)
    • (2004) Cardiovascular Research , vol.62 , Issue.3 , pp. 460-467
    • Johren, O.1    Dendorfer, A.2    Dominiak, P.3
  • 86
    • 7444272132 scopus 로고    scopus 로고
    • 1 receptor blockade
    • DOI 10.1016/j.yjmcc.2004.08.004, PII S0022282804002706
    • Jones ES, Black MJ, Widdop RE (2004) Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade. J Mol Cell Cardiol 37:1023-1030 (Pubitemid 39446827)
    • (2004) Journal of Molecular and Cellular Cardiology , vol.37 , Issue.5 , pp. 1023-1030
    • Jones, E.S.1    Black, M.J.2    Widdop, R.E.3
  • 87
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J (1995) Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 11:415-421
    • (1995) Nat Genet , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 88
    • 0032588796 scopus 로고    scopus 로고
    • Strain dependency of TGFbeta1 function during embryogenesis
    • DOI 10.1002/(SICI)1098-2795(199904)52:4<341::AID-MRD2>3.0.CO;2-N
    • Kallapur S, Ormsby I, Doetschman T (1999) Strain dependency of TGFbeta1 function during embryogenesis. Mol Reprod Dev 52:341-349 (Pubitemid 29122259)
    • (1999) Molecular Reproduction and Development , vol.52 , Issue.4 , pp. 341-349
    • Kallapur, S.1    Ormsby, I.2    Doetschman, T.3
  • 89
    • 68549123472 scopus 로고    scopus 로고
    • New regulatory mechanisms of TGF-beta receptor function
    • Kang JS, Liu C, Derynck R (2009) New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol 19:385-394
    • (2009) Trends Cell Biol , vol.19 , pp. 385-394
    • Kang, J.S.1    Liu, C.2    Derynck, R.3
  • 90
    • 77649162900 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy
    • Kehat I, Molkentin JD (2010) Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy. Ann N Y Acad Sci 1188:96-102
    • (2010) Ann N Y Acad Sci , vol.1188 , pp. 96-102
    • Kehat, I.1    Molkentin, J.D.2
  • 92
    • 0042662937 scopus 로고    scopus 로고
    • Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
    • DOI 10.1101/gad.1119303
    • Kim S, Koga T, Isobe M, Kern BE, Yokochi T, Chin YE, Karsenty G, Taniguchi T, Takayanagi H (2003) Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev 17:1979-1991 (Pubitemid 36999325)
    • (2003) Genes and Development , vol.17 , Issue.16 , pp. 1979-1991
    • Kim, S.1    Koga, T.2    Isobe, M.3    Kern, B.E.4    Yokochi, T.5    Chin, Y.E.6    Karsenty, G.7    Taniguchi, T.8    Takayanagi, H.9
  • 94
    • 40549085331 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease
    • Kim L, Kim DK, Yang WI, Shin DH, Jung IM, Park HK, Chang BC (2008) Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease. J Korean Med Sci 23:41-48
    • (2008) J Korean Med Sci , vol.23 , pp. 41-48
    • Kim, L.1    Kim, D.K.2    Yang, W.I.3    Shin, D.H.4    Jung, I.M.5    Park, H.K.6    Chang, B.C.7
  • 96
    • 43149095145 scopus 로고    scopus 로고
    • Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor
    • Kirkbride KC, Townsend TA, Bruinsma MW, Barnett JV, Blobe GC (2008) Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. J Biol Chem 283:7628-7637
    • (2008) J Biol Chem , vol.283 , pp. 7628-7637
    • Kirkbride, K.C.1    Townsend, T.A.2    Bruinsma, M.W.3    Barnett, J.V.4    Blobe, G.C.5
  • 97
    • 1642312177 scopus 로고    scopus 로고
    • Twist genes regulate Runx2 and bone formation
    • Kronenberg HM (2004) Twist genes regulate Runx2 and bone formation. Dev Cell 6:317-318
    • (2004) Dev Cell , vol.6 , pp. 317-318
    • Kronenberg, H.M.1
  • 98
    • 0035006766 scopus 로고    scopus 로고
    • Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation
    • DOI 10.1016/S0925-4773(01)00356-2, PII S0925477301003562
    • Kruzynska-Frejtag A, Machnicki M, Rogers R, Markwald RR, Conway SJ (2001) Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation. Mech Dev 103:183-188 (Pubitemid 32457925)
    • (2001) Mechanisms of Development , vol.103 , Issue.1-2 , pp. 183-188
    • Kruzynska-Frejtag, A.1    Machnicki, M.2    Rogers, R.3    Markwald, R.R.4    Conway, S.J.5
  • 100
    • 39149119226 scopus 로고    scopus 로고
    • The intracellular renin-angiotensin system: Implications in cardiovascular remodeling
    • DOI 10.1097/MNH.0b013e3282f521a8, PII 0004155220080300000009
    • Kumar R, Singh VP, Baker KM (2008) The intracellular renin-angiotensin system: implications in cardiovascular remodeling. Curr Opin Nephrol Hypertens 17:168-173 (Pubitemid 351253042)
    • (2008) Current Opinion in Nephrology and Hypertension , vol.17 , Issue.2 , pp. 168-173
    • Kumar, R.1    Singh, V.P.2    Baker, K.M.3
  • 105
    • 78149464338 scopus 로고    scopus 로고
    • Conditional inactivation of TGF-beta type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects
    • Langlois D, Hneino M, Bouazza L, Parlakian A, Sasaki T, Bricca G, Li JY (2010) Conditional inactivation of TGF-beta type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects. Transgenic Res 19:1069-1082
    • (2010) Transgenic Res , vol.19 , pp. 1069-1082
    • Langlois, D.1    Hneino, M.2    Bouazza, L.3    Parlakian, A.4    Sasaki, T.5    Bricca, G.6    Li, J.Y.7
  • 107
    • 34548386720 scopus 로고    scopus 로고
    • TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
    • DOI 10.1038/sj.emboj.7601818, PII 7601818
    • Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R (2007) TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J 26:3957-3967 (Pubitemid 47367487)
    • (2007) EMBO Journal , vol.26 , Issue.17 , pp. 3957-3967
    • Lee, M.K.1    Pardoux, C.2    Hall, M.C.3    Lee, P.S.4    Warburton, D.5    Qing, J.6    Smith, S.M.7    Derynck, R.8
  • 108
    • 0034704753 scopus 로고    scopus 로고
    • Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
    • DOI 10.1038/35006129
    • Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404:411-414 (Pubitemid 30164345)
    • (2000) Nature , vol.404 , Issue.6776 , pp. 411-414
    • Lewis, K.A.1    Gray, P.C.2    Blount, A.L.3    MacConell, L.A.4    Wiater, E.5    Bitezikjian, L.M.6    Vate, W.7
  • 109
    • 33751103183 scopus 로고    scopus 로고
    • Advances in Runx2 regulation and its isoforms
    • Li YL, Xiao ZS (2007) Advances in Runx2 regulation and its isoforms. Med Hypotheses 68:169-175
    • (2007) Med Hypotheses , vol.68 , pp. 169-175
    • Li, Y.L.1    Xiao, Z.S.2
  • 110
    • 0030877545 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor-beta1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy
    • Li RK, Li G, Mickle DA, Weisel RD, Merante F, Luss H, Rao V, Christakis GT, Williams WG (1997) Overexpression of transforming growth factor-beta1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. Circulation 96:874-881 (Pubitemid 27329622)
    • (1997) Circulation , vol.96 , Issue.3 , pp. 874-881
    • Li, R.-K.1    Li, G.2    Mickle, D.A.G.3    Weisel, R.D.4    Merante, F.5    Luss, H.6    Rao, V.7    Christakis, G.T.8    Williams, W.G.9
  • 111
    • 67649856788 scopus 로고    scopus 로고
    • AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla
    • Li XC, Shao Y, Zhuo JL (2009) AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla. Kidney Int 76:169-177
    • (2009) Kidney Int , vol.76 , pp. 169-177
    • Li, X.C.1    Shao, Y.2    Zhuo, J.L.3
  • 112
    • 77957573525 scopus 로고    scopus 로고
    • Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy
    • Li J, Qu X, Yao J, Caruana G, Ricardo SD, Yamamoto Y, Yamamoto H, Bertram JF (2010) Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes 59:2612-2624
    • (2010) Diabetes , vol.59 , pp. 2612-2624
    • Li, J.1    Qu, X.2    Yao, J.3    Caruana, G.4    Ricardo, S.D.5    Yamamoto, Y.6    Yamamoto, H.7    Bertram, J.F.8
  • 113
    • 79958795388 scopus 로고    scopus 로고
    • Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts
    • Li L, Fan D, Wang C, Wang JY, Cui XB, Wu D, Zhou Y, Wu LL (2011) Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts. Cardiovasc Res 91:80-89
    • (2011) Cardiovasc Res , vol.91 , pp. 80-89
    • Li, L.1    Fan, D.2    Wang, C.3    Wang, J.Y.4    Cui, X.B.5    Wu, D.6    Zhou, Y.7    Wu, L.L.8
  • 114
    • 33751302009 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in the progression of heart failure
    • DOI 10.1007/s00018-006-6085-8
    • Lim H, Zhu YZ (2006) Role of transforming growth factor-beta in the progression of heart failure. Cell Mol Life Sci 63:2584-2596 (Pubitemid 44800713)
    • (2006) Cellular and Molecular Life Sciences , vol.63 , Issue.22 , pp. 2584-2596
    • Lim, H.1    Zhu, Y.Z.2
  • 115
    • 33745102721 scopus 로고    scopus 로고
    • Hearts and bones: Shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development
    • DOI 10.1016/j.ydbio.2006.03.027, PII S0012160606002259
    • Lincoln J, Lange AW, Yutzey KE (2006) Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Dev Biol 294:292-302 (Pubitemid 43884820)
    • (2006) Developmental Biology , vol.294 , Issue.2 , pp. 292-302
    • Lincoln, J.1    Lange, A.W.2    Yutzey, K.E.3
  • 116
    • 79956330132 scopus 로고    scopus 로고
    • Lessons on the pathogenesis of aneurysm from heritable conditions
    • Lindsay ME, Dietz HC (2011) Lessons on the pathogenesis of aneurysm from heritable conditions. Nature 19(473):308-316
    • (2011) Nature , vol.19 , Issue.473 , pp. 308-316
    • Lindsay, M.E.1    Dietz, H.C.2
  • 121
    • 0027276765 scopus 로고
    • Betaglycan presents ligand to the TGFbeta signaling receptor
    • DOI 10.1016/0092-8674(93)90368-Z
    • Lopez-Casillas F, Wrana JL, Massague J (1993) Betaglycan presents ligand to the TGF beta signaling receptor. Cell 73:1435-1444 (Pubitemid 23201155)
    • (1993) Cell , vol.73 , Issue.7 , pp. 1435-1444
    • Lopez-Casillas, F.1    Wrana, J.L.2    Massague, J.3
  • 123
    • 0035117104 scopus 로고    scopus 로고
    • Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling
    • DOI 10.1016/S0925-4773(00)00556-6, PII S0925477300005566
    • Luukko K, Ylikorkala A, Makela TP (2001) Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling. Mech Dev 101:209-212 (Pubitemid 32186328)
    • (2001) Mechanisms of Development , vol.101 , Issue.1-2 , pp. 209-212
    • Luukko, K.1    Ylikorkala, A.2    Makela, T.P.3
  • 124
    • 41249084399 scopus 로고    scopus 로고
    • Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells
    • Makita N, Suzuki M, Asami S, Takahata R, Kohzaki D, Kobayashi S, Hakamazuka T, Hozumi N (2008) Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene 413:8-17
    • (2008) Gene , vol.413 , pp. 8-17
    • Makita, N.1    Suzuki, M.2    Asami, S.3    Takahata, R.4    Kohzaki, D.5    Kobayashi, S.6    Hakamazuka, T.7    Hozumi, N.8
  • 125
  • 126
    • 77649129153 scopus 로고    scopus 로고
    • Developmental basis of adult cardiovascular diseases: Valvular heart diseases
    • Markwald RR, Norris RA, Moreno-Rodriguez R, Levine RA (2010) Developmental basis of adult cardiovascular diseases: valvular heart diseases. Ann NY Acad Sci 1188:177-183
    • (2010) Ann NY Acad Sci , vol.1188 , pp. 177-183
    • Markwald, R.R.1    Norris, R.A.2    Moreno-Rodriguez, R.3    Levine, R.A.4
  • 130
    • 77954051530 scopus 로고    scopus 로고
    • The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells
    • Mendoza-Villanueva D, Deng W, Lopez-Camacho C, Shore P (2010) The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells. Mol Cancer 9:171
    • (2010) Mol Cancer , vol.9 , pp. 171
    • Mendoza-Villanueva, D.1    Deng, W.2    Lopez-Camacho, C.3    Shore, P.4
  • 131
    • 34250695906 scopus 로고    scopus 로고
    • Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart
    • DOI 10.1159/000101315
    • Mercado-Pimentel ME, Runyan RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs 185:146-156 (Pubitemid 46956855)
    • (2007) Cells Tissues Organs , vol.185 , Issue.1-3 , pp. 146-156
    • Mercado-Pimentel, M.E.1    Runyan, R.B.2
  • 132
    • 33947095941 scopus 로고    scopus 로고
    • Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation
    • DOI 10.1016/j.ydbio.2006.12.038, PII S0012160606014941
    • Mercado-Pimentel ME, Hubbard AD, Runyan RB (2007) Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol 304:420-432 (Pubitemid 46399690)
    • (2007) Developmental Biology , vol.304 , Issue.1 , pp. 420-432
    • Mercado-Pimentel, M.E.1    Hubbard, A.D.2    Runyan, R.B.3
  • 133
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and signal transduction
    • Miyazono K, Kamiya Y, Morikawa M (2010) Bone morphogenetic protein receptors and signal transduction. J Biochem 147:35-51
    • (2010) J Biochem , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 136
    • 0038678511 scopus 로고    scopus 로고
    • Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton
    • DOI 10.1002/dvdy.10314
    • Molin DG, Bartram U, Van der HK, Van Iperen L, Speer CP, Hierck BP, Poelmann RE, Gittenberger-de-Groot AC (2003) Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton. Dev Dyn 227:431-444 (Pubitemid 36828765)
    • (2003) Developmental Dynamics , vol.227 , Issue.3 , pp. 431-444
    • Molin, D.G.M.1    Bartram, U.2    Van Der, H.K.3    Van Iperen, L.4    Speer, C.P.5    Hierck, B.P.6    Poelmann, R.E.7    Gittenberger-de-Groot, A.C.8
  • 138
    • 70450187617 scopus 로고    scopus 로고
    • The regulation of TGFbeta signal transduction
    • Moustakas A, Heldin CH (2009) The regulation of TGFbeta signal transduction. Development 136:3699-3714
    • (2009) Development , vol.136 , pp. 3699-3714
    • Moustakas, A.1    Heldin, C.H.2
  • 139
    • 33947636028 scopus 로고    scopus 로고
    • Mitral annulus calcification is associated with valvular and cardiac structural abnormalities
    • Movahed MR, Saito Y, Ahmadi-Kashani M, Ebrahimi R (2007) Mitral annulus calcification is associated with valvular and cardiac structural abnormalities. Cardiovasc Ultrasound 5:14
    • (2007) Cardiovasc Ultrasound , vol.5 , pp. 14
    • Movahed, M.R.1    Saito, Y.2    Ahmadi-Kashani, M.3    Ebrahimi, R.4
  • 140
    • 46249102414 scopus 로고    scopus 로고
    • Uncoupling of chondrocyte differentiation and perichondrial
    • DOI 10.1093/hmg/ddn125
    • Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani RA, Lee B (2008) Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet 17:2244-2254 (Pubitemid 351911990)
    • (2008) Human Molecular Genetics , vol.17 , Issue.14 , pp. 2244-2254
    • Napierala, D.1    Sam, K.2    Morello, R.3    Zheng, Q.4    Munivez, E.5    Shivdasani, R.A.6    Lee, B.7
  • 141
    • 33747166466 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor-beta is associated with increased hyaluronan content and impairment of repair in Marfan syndrome aortic aneurysm
    • DOI 10.1161/CIRCULATIONAHA.105.000927, PII 0000301720060704100060
    • Nataatmadja M, West J, West M (2006) Overexpression of transforming growth factor-beta is associated with increased hyaluronan content and impairment of repair in Marfan syndrome aortic aneurysm. Circulation 114:I371-I377 (Pubitemid 44297178)
    • (2006) Circulation , vol.114 , Issue.SUPPL. 1
    • Nataatmadja, M.1    West, J.2    West, M.3
  • 144
    • 41149143019 scopus 로고    scopus 로고
    • Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects
    • Nie X, Deng CX, Wang Q, Jiao K (2008) Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol 316:417-430
    • (2008) Dev Biol , vol.316 , pp. 417-430
    • Nie, X.1    Deng, C.X.2    Wang, Q.3    Jiao, K.4
  • 150
    • 0036186852 scopus 로고    scopus 로고
    • Mutations in the RUNX2 gene in patients with cleidocranial dysplasia
    • DOI 10.1002/humu.10043
    • Otto F, Kanegane H, Mundlos S (2002) Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Hum Mutat 19:209-216 (Pubitemid 34195181)
    • (2002) Human Mutation , vol.19 , Issue.3 , pp. 209-216
    • Otto, F.1    Kanegane, H.2    Mundlos, S.3
  • 151
    • 0032415762 scopus 로고    scopus 로고
    • Developmental expression of the TGFbetas in the mouse cochlea
    • DOI 10.1016/S0925-4773(98)00184-1, PII S0925477398001841
    • Paradies NE, Sanford LP, Doetschman T, Friedman RA (1998) Developmental expression of the TGF betas in the mouse cochlea. Mechs Dev 79:165-168 (Pubitemid 29038032)
    • (1998) Mechanisms of Development , vol.79 , Issue.1-2 , pp. 165-168
    • Paradies, N.E.1    Sanford, L.P.2    Doetschman, T.3    Friedman, R.A.4
  • 154
    • 34250305402 scopus 로고    scopus 로고
    • Genetic basis for congenital heart defects: Current knowledge - A scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young
    • DOI 10.1161/CIRCULATIONAHA.106.183056, PII 0000301720070612000017
    • Pierpont ME, Basson CT, Benson DW Jr, Gelb BD, Giglia TM, Goldmuntz E, McGee G, Sable CA, Srivastava D, Webb CL (2007) Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 115:3015-3038 (Pubitemid 46912107)
    • (2007) Circulation , vol.115 , Issue.23 , pp. 3015-3038
    • Pierpont, M.E.1    Basson, C.T.2    Benson Jr., D.W.3    Gelb, B.D.4    Giglia, T.M.5    Goldmuntz, E.6    McGee, G.7    Sable, C.A.8    Srivastava, D.9    Webb, C.L.10
  • 156
    • 25444473106 scopus 로고    scopus 로고
    • The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion
    • DOI 10.1128/MCB.25.19.8581-8591.2005
    • Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB (2005) The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol 25:8581-8591 (Pubitemid 41369178)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.19 , pp. 8581-8591
    • Pratap, J.1    Javed, A.2    Languino, L.R.3    Van Wijnen, A.J.4    Stein, J.L.5    Stein, G.S.6    Lian, J.B.7
  • 157
    • 33846034921 scopus 로고    scopus 로고
    • Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone
    • DOI 10.1007/s10555-006-9032-0, Special issue on Bone Metastasis and Cancer
    • Pratap J, Lian JB, Javed A, Barnes GL, van Wijnen AJ, Stein JL, Stein GS (2006) Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev 25:589-600 (Pubitemid 46071865)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.4 , pp. 589-600
    • Pratap, J.1    Lian, J.B.2    Javed, A.3    Barnes, G.L.4    Van Wijnen, A.J.5    Stein, J.L.6    Stein, G.S.7
  • 159
    • 59449092756 scopus 로고    scopus 로고
    • Calcific aortic stenosis: Lessons learned from experimental and clinical studies
    • Rajamannan NM (2009) Calcific aortic stenosis: lessons learned from experimental and clinical studies. Arterioscler Thromb Vasc Biol 29:162-168
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 162-168
    • Rajamannan, N.M.1
  • 165
    • 30944466813 scopus 로고    scopus 로고
    • Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
    • DOI 10.1016/j.cytogfr.2005.09.008, PII S1359610105001127
    • Roberts AB, Tian F, Byfield SD, Stuelten C, Ooshima A, Saika S, Flanders KC (2006) Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev 17:19-27 (Pubitemid 43117513)
    • (2006) Cytokine and Growth Factor Reviews , vol.17 , Issue.1-2 , pp. 19-27
    • Roberts, A.B.1    Tian, F.2    Byfield, S.D.3    Stuelten, C.4    Ooshima, A.5    Saika, S.6    Flanders, K.C.7
  • 166
    • 77956276917 scopus 로고    scopus 로고
    • The TGFbeta type II receptor plays a critical role in the endothelial cells during cardiac development
    • Robson A, Allinson KR, Anderson RH, Henderson DJ, Arthur HM (2010) The TGFbeta type II receptor plays a critical role in the endothelial cells during cardiac development. Dev Dyn 239:2435-2442
    • (2010) Dev Dyn , vol.239 , pp. 2435-2442
    • Robson, A.1    Allinson, K.R.2    Anderson, R.H.3    Henderson, D.J.4    Arthur, H.M.5
  • 167
    • 18844387660 scopus 로고    scopus 로고
    • Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism
    • DOI 10.1161/01.CIR.0000165133.84978.E2
    • Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, Ruiz-Ortega M (2005) Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 111:2509-2517 (Pubitemid 40696140)
    • (2005) Circulation , vol.111 , Issue.19 , pp. 2509-2517
    • Rodriguez-Vita, J.1    Sanchez-Lopez, E.2    Esteban, V.3    Ruperez, M.4    Egido, J.5    Ruiz-Ortega, M.6
  • 169
    • 3242806007 scopus 로고    scopus 로고
    • TGF-beta1 and angiotensin networking in cardiac remodeling
    • Rosenkranz S (2004) TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res 63:423-432
    • (2004) Cardiovasc Res , vol.63 , pp. 423-432
    • Rosenkranz, S.1
  • 171
    • 84859439166 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transformation in the embryonic heart
    • Savagner P (ed) Kluwer/Plenum, Netherlands
    • Runyan RB, Heimark RL, Camenisch TD, Klewer SE (2005) Epithelial-mesenchymal transformation in the embryonic heart. In: Savagner P (ed) Rise and fall of the epithelium. Kluwer/Plenum, Netherlands, pp. 40-55 (http://www.eurekah.com)
    • (2005) Rise and Fall of the Epithelium , pp. 40-55
    • Runyan, R.B.1    Heimark, R.L.2    Camenisch, T.D.3    Klewer, S.E.4
  • 176
    • 0035947593 scopus 로고    scopus 로고
    • Filamin associates with Smads and regulates transforming growth factorbeta signaling
    • Sasaki A, Masuda Y, Ohta Y, Ikeda K, Watanabe K (2001) Filamin associates with Smads and regulates transforming growth factorbeta signaling. J Biol Chem 276:17871-17877
    • (2001) J Biol Chem , vol.276 , pp. 17871-17877
    • Sasaki, A.1    Masuda, Y.2    Ohta, Y.3    Ikeda, K.4    Watanabe, K.5
  • 178
    • 43049141480 scopus 로고    scopus 로고
    • Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development
    • Shelton EL, Yutzey KE (2008) Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development. Dev Biol 317:282-295
    • (2008) Dev Biol , vol.317 , pp. 282-295
    • Shelton, E.L.1    Yutzey, K.E.2
  • 183
    • 0034129650 scopus 로고    scopus 로고
    • Worldwide perspective of valve disease
    • Soler-Soler J, Galve E (2000) Worldwide perspective of valve disease. Heart 83:721-725 (Pubitemid 30345988)
    • (2000) Heart , vol.83 , Issue.6 , pp. 721-725
    • Soler-Soler, J.1    Galve, E.2
  • 184
    • 34548359388 scopus 로고    scopus 로고
    • Myocardial Smad4 is essential for cardiogenesis in mouse embryos
    • DOI 10.1161/CIRCRESAHA.107.155630
    • Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K (2007) Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res 101:277-285 (Pubitemid 47344077)
    • (2007) Circulation Research , vol.101 , Issue.3 , pp. 277-285
    • Song, L.1    Yan, W.2    Chen, X.3    Deng, C.-X.4    Wang, Q.5    Jiao, K.6
  • 185
    • 78650364001 scopus 로고    scopus 로고
    • Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos
    • Song L, Zhao M, Wu B, Zhou B, Wang Q, Jiao K (2011) Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Dev Dyn 240:211-220
    • (2011) Dev Dyn , vol.240 , pp. 211-220
    • Song, L.1    Zhao, M.2    Wu, B.3    Zhou, B.4    Wang, Q.5    Jiao, K.6
  • 186
    • 30944451715 scopus 로고    scopus 로고
    • The early history of TGF-beta, and a brief glimpse of its future
    • Sporn MB (2006) The early history of TGF-beta, and a brief glimpse of its future. Cytokine Growth Factor Rev 17:3-7
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 3-7
    • Sporn, M.B.1
  • 187
    • 0024994768 scopus 로고
    • The transforming growth factor-betas: Past, present, and future
    • DOI 10.1111/j.1749-6632.1990.tb16095.x
    • Sporn MB, Roberts AB (1990) The transforming growth factor-betas: past, present, and future. [Review]. Ann N Y Acad Sci 593:1-6 (Pubitemid 20285219)
    • (1990) Annals of the New York Academy of Sciences , vol.593 , pp. 1-6
    • Sporn, M.B.1    Roberts, A.B.2
  • 192
    • 58149394173 scopus 로고    scopus 로고
    • MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis
    • Stevens MV, Broka DM, Parker P, Rogowitz E, Vaillancourt RR, Camenisch TD (2008) MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis. Circ Res 103:1430-1440
    • (2008) Circ Res , vol.103 , pp. 1430-1440
    • Stevens, M.V.1    Broka, D.M.2    Parker, P.3    Rogowitz, E.4    Vaillancourt, R.R.5    Camenisch, T.D.6
  • 193
    • 0021222607 scopus 로고
    • Surgical pathology of pure aortic stenosis: A study of 374 cases
    • Subramanian R, Olson LJ, Edwards WD (1984) Surgical pathology of pure aortic stenosis: a study of 374 cases. Mayo Clin Proc 59:683-690 (Pubitemid 14014354)
    • (1984) Mayo Clinic Proceedings , vol.59 , Issue.10 , pp. 683-690
    • Subramanian, R.1    Olson, L.J.2    Edwards, W.D.3
  • 194
    • 34247139786 scopus 로고    scopus 로고
    • The Epidemiology of Valvular Heart Disease: A Growing Public Health Problem
    • DOI 10.1016/j.hfc.2006.09.010, PII S155171360600078X, Valvular Disease
    • Supino PG, Borer JS, Preibisz J, Bornstein A (2006) The epidemiology of valvular heart disease: a growing public health problem. Heart Fail Clin 2:379-393 (Pubitemid 46590077)
    • (2006) Heart Failure Clinics , vol.2 , Issue.4 , pp. 379-393
    • Supino, P.G.1    Borer, J.S.2    Preibisz, J.3    Bornstein, A.4
  • 195
    • 0029025486 scopus 로고
    • Abnormalities in elastic fibers and other connective-tissue components of floppy mitral valve
    • Tamura K, Fukuda Y, Ishizaki M, Masuda Y, Yamanaka N, Ferrans VJ (1995) Abnormalities in elastic fibers and other connective-tissue components of floppy mitral valve. Am Heart J 129:1149-1158
    • (1995) Am Heart J , vol.129 , pp. 1149-1158
    • Tamura, K.1    Fukuda, Y.2    Ishizaki, M.3    Masuda, Y.4    Yamanaka, N.5    Ferrans, V.J.6
  • 196
    • 77955054236 scopus 로고    scopus 로고
    • Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects
    • Tang S, Snider P, Firulli AB, Conway SJ (2010) Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects. Dev Biol 344:233-247
    • (2010) Dev Biol , vol.344 , pp. 233-247
    • Tang, S.1    Snider, P.2    Firulli, A.B.3    Conway, S.J.4
  • 198
    • 35448991324 scopus 로고    scopus 로고
    • Extracellular control of TGFbeta signalling in vascular development and disease
    • ten Dijke P, Arthur HM (2007) Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol 8:857-869
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 857-869
    • Ten Dijke, P.1    Arthur, H.M.2
  • 200
    • 78650365007 scopus 로고    scopus 로고
    • Long form of latent TGF-beta binding protein 1 (Ltbp1L) regulates cardiac valve development
    • Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB (2011) Long form of latent TGF-beta binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn 240:176-187
    • (2011) Dev Dyn , vol.240 , pp. 176-187
    • Todorovic, V.1    Finnegan, E.2    Freyer, L.3    Zilberberg, L.4    Ota, M.5    Rifkin, D.B.6
  • 208
    • 4043127381 scopus 로고    scopus 로고
    • Valvular myofibroblast activation by transforming growth factor-beta: Implications for pathological extracellular matrix remodeling in heart valve disease
    • DOI 10.1161/01.RES.0000136520.07995.aa
    • Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA (2004) Valvular myofibroblast activation by transforming growth factorbeta: implications for pathological extracellular matrix remodeling in heart valve disease. Circ Res 95:253-260 (Pubitemid 39056285)
    • (2004) Circulation Research , vol.95 , Issue.3 , pp. 253-260
    • Walker, G.A.1    Masters, K.S.2    Shah, D.N.3    Anseth, K.S.4    Leinwand, L.A.5
  • 209
    • 26844468478 scopus 로고    scopus 로고
    • Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure
    • DOI 10.1161/01.RES.0000185833.42544.06
    • Wang J, Xu N, Feng X, Hou N, Zhang J, Cheng X, Chen Y, Zhang Y, Yang X (2005) Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ Res 97:821-828 (Pubitemid 41447133)
    • (2005) Circulation Research , vol.97 , Issue.8 , pp. 821-828
    • Wang, J.1    Xu, N.2    Feng, X.3    Hou, N.4    Zhang, J.5    Cheng, X.6    Chen, Y.7    Zhang, Y.8    Yang, X.9
  • 210
    • 33750825092 scopus 로고    scopus 로고
    • Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
    • Wang J, Nagy A, Larsson J, Dudas M, Sucov HM, Kaartinen V (2006) Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol 6:51
    • (2006) BMC Dev Biol , vol.6 , pp. 51
    • Wang, J.1    Nagy, A.2    Larsson, J.3    Dudas, M.4    Sucov, H.M.5    Kaartinen, V.6
  • 212
    • 79958105990 scopus 로고    scopus 로고
    • BMP signaling in congenital heart disease: New developments and future directions
    • Wang J, Greene SB, Martin JF (2011) BMP signaling in congenital heart disease: new developments and future directions. Birth Defects Res A Clin Mol Teratol 91:441-448
    • (2011) Birth Defects Res A Clin Mol Teratol , vol.91 , pp. 441-448
    • Wang, J.1    Greene, S.B.2    Martin, J.F.3
  • 213
  • 214
    • 79955712703 scopus 로고    scopus 로고
    • Transcriptional regulation of heart valve development and disease
    • Wirrig EE, Yutzey KE (2011) Transcriptional regulation of heart valve development and disease. Cardiovasc Pathol 20:162-167
    • (2011) Cardiovasc Pathol , vol.20 , pp. 162-167
    • Wirrig, E.E.1    Yutzey, K.E.2
  • 215
    • 61749097816 scopus 로고    scopus 로고
    • Tgf-beta superfamily signaling in embryonic development and homeostasis
    • Wu MY, Hill CS (2009) Tgf-beta superfamily signaling in embryonic development and homeostasis. Dev Cell 16:329-343
    • (2009) Dev Cell , vol.16 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 216
    • 2442500486 scopus 로고    scopus 로고
    • Selective Deficiency of the "Bone-related" Runx2-II Unexpectedly Preserves Osteoblast-mediated Skeletogenesis
    • DOI 10.1074/jbc.M401109200
    • Xiao ZS, Hjelmeland AB, Quarles LD (2004) Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis. J Biol Chem 279:20307-20313 (Pubitemid 38623476)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 20307-20313
    • Xiao, Z.-S.1    Hjelmeland, A.B.2    Quarles, L.D.3
  • 218
    • 77956310581 scopus 로고    scopus 로고
    • Common pathogenic features of atherosclerosis and calcific aortic stenosis: Role of transforming growth factor-beta
    • Xu S, Liu AC, Gotlieb AI (2010) Common pathogenic features of atherosclerosis and calcific aortic stenosis: role of transforming growth factor-beta. Cardiovasc Pathol 19:236-247
    • (2010) Cardiovasc Pathol , vol.19 , pp. 236-247
    • Xu, S.1    Liu, A.C.2    Gotlieb, A.I.3
  • 219
    • 0028057726 scopus 로고
    • Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta
    • Yamashita H, Ichijo H, Grimsby S, Moren A, ten Dijke P, Miyazono K (1994) Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. J Biol Chem 269:1995-2001 (Pubitemid 24035405)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.3 , pp. 1995-2001
    • Yamashita, H.1    Ichijo, H.2    Grimsby, S.3    Moren, A.4    Ten, D.P.5    Miyazono, K.6
  • 220
    • 52049111663 scopus 로고    scopus 로고
    • TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
    • Yamashita M, Fatyol K, Jin C, Wang X, Liu Z, Zhang YE (2008) TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell 31:918-924
    • (2008) Mol Cell , vol.31 , pp. 918-924
    • Yamashita, M.1    Fatyol, K.2    Jin, C.3    Wang, X.4    Liu, Z.5    Zhang, Y.E.6
  • 221
    • 77449126624 scopus 로고    scopus 로고
    • Smad4-mediated TGF-beta signaling in tumorigenesis
    • Yang G, Yang X (2010) Smad4-mediated TGF-beta signaling in tumorigenesis. Int J Biol Sci 6:1-8
    • (2010) Int J Biol Sci , vol.6 , pp. 1-8
    • Yang, G.1    Yang, X.2
  • 222
  • 223
    • 77953695161 scopus 로고    scopus 로고
    • Cellular and molecular basis for the regulation of inflammation by TGF-beta
    • Yoshimura A, Wakabayashi Y, Mori T (2010) Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem 147:781-792
    • (2010) J Biochem , vol.147 , pp. 781-792
    • Yoshimura, A.1    Wakabayashi, Y.2    Mori, T.3
  • 227
    • 77954689542 scopus 로고    scopus 로고
    • Spatiotemporal expression of periostin during skin development and incisional wound healing: Lessons for human fibrotic scar formation
    • Zhou HM, Wang J, Elliott C, Wen W, Hamilton DW, Conway SJ (2010) Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation. J Cell Commun Signal 4:99-107
    • (2010) J Cell Commun Signal , vol.4 , pp. 99-107
    • Zhou, H.M.1    Wang, J.2    Elliott, C.3    Wen, W.4    Hamilton, D.W.5    Conway, S.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.