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Volumn 17, Issue 16, 2003, Pages 1979-1991

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

Author keywords

Bone remodeling; Osteoblast; Runx2; Stat1

Indexed keywords

BETA INTERFERON; STAT1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; TYROSINE; UNCLASSIFIED DRUG;

EID: 0042662937     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1119303     Document Type: Article
Times cited : (237)

References (46)
  • 1
    • 0030857451 scopus 로고    scopus 로고
    • Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation
    • Bellido, T., Borba, V.Z., Roberson, P., and Manolagas, S.C. 1997. Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation. Endocrinology 138: 3666-3676.
    • (1997) Endocrinology , vol.138 , pp. 3666-3676
    • Bellido, T.1    Borba, V.Z.2    Roberson, P.3    Manolagas, S.C.4
  • 2
    • 0034254726 scopus 로고    scopus 로고
    • How Stat1 mediates constitutive gene expression: A complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene
    • Chatterjee-Kishore, M., Wright, K.L., Ting, J.P., and Stark, G.R. 2000. How Stat1 mediates constitutive gene expression: A complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J. 19: 4111-4122.
    • (2000) EMBO J. , vol.19 , pp. 4111-4122
    • Chatterjee-Kishore, M.1    Wright, K.L.2    Ting, J.P.3    Stark, G.R.4
  • 4
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A., and Leder, P. 1996. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 5
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., and Karsenty, G. 1997. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89: 747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 6
    • 0034285013 scopus 로고    scopus 로고
    • The osteoblast: A sophisticated fibroblast under central surveillance
    • Ducy, P., Schinke, T., and Karsenty, G. 2000. The osteoblast: A sophisticated fibroblast under central surveillance. Science 289: 1501-1504.
    • (2000) Science , vol.289 , pp. 1501-1504
    • Ducy, P.1    Schinke, T.2    Karsenty, G.3
  • 7
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.H., Miyazono, K., and ten Dijke, P. 1997. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 8
    • 0037310863 scopus 로고    scopus 로고
    • RUNX transcription factors as key targets of TGF-β superfamily signaling
    • Ito, Y. and Miyazono, K. 2003. RUNX transcription factors as key targets of TGF-β superfamily signaling. Curr. Opin. Genet. Dev. 13: 43-47.
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , pp. 43-47
    • Ito, Y.1    Miyazono, K.2
  • 9
    • 0032722595 scopus 로고    scopus 로고
    • Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization
    • Javed, A., Gutierrez, S., Montecino, M., van Wijnen, A.J., Stein, J.L., Stein, G.S., and Lian, J.B. 1999. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Mol. Cell. Biol. 19: 7491-7500.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 7491-7500
    • Javed, A.1    Gutierrez, S.2    Montecino, M.3    Van Wijnen, A.J.4    Stein, J.L.5    Stein, G.S.6    Lian, J.B.7
  • 10
    • 0033835880 scopus 로고    scopus 로고
    • Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
    • Jochum, W., David, J.P., Elliott, C., Wutz, A., Plenk Jr., H., Matsuo, K., and Wagner, E.F. 2000. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6: 980-984.
    • (2000) Nat. Med. , vol.6 , pp. 980-984
    • Jochum, W.1    David, J.P.2    Elliott, C.3    Wutz, A.4    Plenk H., Jr.5    Matsuo, K.6    Wagner, E.F.7
  • 11
    • 12644307234 scopus 로고    scopus 로고
    • Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity
    • Kagoshima, H., Akamatsu, Y., Ito, Y., and Shigesada, K. 1996. Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity. J. Biol. Chem. 271: 33074-33082.
    • (1996) J. Biol. Chem. , vol.271 , pp. 33074-33082
    • Kagoshima, H.1    Akamatsu, Y.2    Ito, Y.3    Shigesada, K.4
  • 12
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty, G. and Wagner, E.F. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2: 389-406.
    • (2002) Dev. Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 13
    • 0029678749 scopus 로고    scopus 로고
    • Essential and non-redundant roles of p48 (ISGF3 γ) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies
    • Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R.S., Takasugi, T., Matsuyama, T., et al. 1996. Essential and non-redundant roles of p48 (ISGF3 γ) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Genes Cells 1: 115-124.
    • (1996) Genes Cells , vol.1 , pp. 115-124
    • Kimura, T.1    Kadokawa, Y.2    Harada, H.3    Matsumoto, M.4    Sato, M.5    Kashiwazaki, Y.6    Tarutani, M.7    Tan, R.S.8    Takasugi, T.9    Matsuyama, T.10
  • 14
    • 0036352427 scopus 로고    scopus 로고
    • Runx2, a multifunctional transcription factor in skeletal development
    • Komori, T. 2002. Runx2, a multifunctional transcription factor in skeletal development. J. Cell Biochem. 87: 1-8.
    • (2002) J. Cell Biochem. , vol.87 , pp. 1-8
    • Komori, T.1
  • 15
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R.T., Gao, Y.H., Inada, M., et al. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6    Shimizu, Y.7    Bronson, R.T.8    Gao, Y.H.9    Inada, M.10
  • 16
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong, Y.Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. 1999. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402: 304-309.
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.Y.1    Feige, U.2    Sarosi, I.3    Bolon, B.4    Tafuri, A.5    Morony, S.6    Capparelli, C.7    Li, J.8    Elliott, R.9    McCabe, S.10
  • 17
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee, K.S., Kim, H.J., Li, Q.L., Chi, X.Z., Ueta, C., Komori, T., Wozney, J.M., Kim, E.G., Choi, J.Y., Ryoo, H.M., et al. 2000. Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol. Cell. Biol. 20: 8783-8792.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.G.8    Choi, J.Y.9    Ryoo, H.M.10
  • 19
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas, S.C. 2000. Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21: 115-137.
    • (2000) Endocr. Rev. , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 20
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-β signals
    • Massague, J. 2000. How cells read TGF-β signals. Nat. Rev. Mol. Cell. Biol. 1: 169-178.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 169-178
    • Massague, J.1
  • 24
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea, J.J., Gadina, M., and Schreiber, R.D. 2002. Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. Cell 109 Suppl: S121-S131.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 26
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan, G.A. and Martin, T.J. 2000. Therapeutic approaches to bone diseases. Science 289: 1508-1514.
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 29
    • 0033151612 scopus 로고    scopus 로고
    • FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
    • Sahni, M., Ambrosetti, D.C., Mansukhani, A., Gertner, R., Levy, D., and Basilico, C. 1999. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes & Dev. 13: 1361-1366.
    • (1999) Genes & Dev. , vol.13 , pp. 1361-1366
    • Sahni, M.1    Ambrosetti, D.C.2    Mansukhani, A.3    Gertner, R.4    Levy, D.5    Basilico, C.6
  • 30
    • 0034960254 scopus 로고    scopus 로고
    • STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    • Sahni, M., Raz, R., Coffin, J.D., Levy, D., and Basilico, C. 2001. STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128: 2119-2129.
    • (2001) Development , vol.128 , pp. 2119-2129
    • Sahni, M.1    Raz, R.2    Coffin, J.D.3    Levy, D.4    Basilico, C.5
  • 32
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su, W.C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W.A., and Fu, X.Y. 1997. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 386: 288-292.
    • (1997) Nature , vol.386 , pp. 288-292
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6    Deng, C.7    Horton, W.A.8    Fu, X.Y.9
  • 33
    • 0034121039 scopus 로고    scopus 로고
    • Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
    • Takayanagi, H., Iizuka, H., Juji, T., Nakagawa, T., Yamamoto, A., Miyazaki, T., Koshihara, Y., Oda, H., Nakamura, K., and Tanaka, S. 2000a. Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum. 43: 259-269.
    • (2000) Arthritis Rheum. , vol.43 , pp. 259-269
    • Takayanagi, H.1    Iizuka, H.2    Juji, T.3    Nakagawa, T.4    Yamamoto, A.5    Miyazaki, T.6    Koshihara, Y.7    Oda, H.8    Nakamura, K.9    Tanaka, S.10
  • 35
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., et al. 2002a. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3: 889-901.
    • (2002) Dev. Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1    Kim, S.2    Koga, T.3    Nishina, H.4    Isshiki, M.5    Yoshida, H.6    Saiura, A.7    Isobe, M.8    Yokochi, T.9    Inoue, J.10
  • 37
    • 34247581650 scopus 로고    scopus 로고
    • Signaling crosstalk between RANKL and interferons in osteoclast differentiation
    • Takayanagi, H., Kim, S., and Taniguchi, T. 2002c. Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res. 4 Suppl 3: S227-S232.
    • (2002) Arthritis Res. , vol.4 , Issue.SUPPL. 3
    • Takayanagi, H.1    Kim, S.2    Taniguchi, T.3
  • 38
    • 0035061538 scopus 로고    scopus 로고
    • IRF family of transcription factors as regulators of host defense
    • Taniguchi, T., Ogasawara, K., Takaoka, A., and Tanaka, N. 2001. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19: 623-655.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 623-655
    • Taniguchi, T.1    Ogasawara, K.2    Takaoka, A.3    Tanaka, N.4
  • 39
    • 0033990272 scopus 로고    scopus 로고
    • Reduction in bone formation and elevated bone resorption in ovariectomized rats with special reference to acute inflammation
    • Tanizawa, T., Yamaguchi, A., Uchiyama, Y., Miyaura, C., Ikeda, T., Ejiri, S., Nagal, Y., Yamato, H., Murayama, H., Sato, M., et al. 2000. Reduction in bone formation and elevated bone resorption in ovariectomized rats with special reference to acute inflammation. Bone 26: 43-53.
    • (2000) Bone , vol.26 , pp. 43-53
    • Tanizawa, T.1    Yamaguchi, A.2    Uchiyama, Y.3    Miyaura, C.4    Ikeda, T.5    Ejiri, S.6    Nagal, Y.7    Yamato, H.8    Murayama, H.9    Sato, M.10
  • 40
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science 289: 1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 41
    • 0031836965 scopus 로고    scopus 로고
    • Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfβ
    • Thirunavukkarasu, K., Mahajan, M., McLarren, K.W., Stifani, S., and Karsenty, G. 1998. Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfβ. Mol. Cell. Biol. 18: 4197-4208.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 4197-4208
    • Thirunavukkarasu, K.1    Mahajan, M.2    McLarren, K.W.3    Stifani, S.4    Karsenty, G.5
  • 44
    • 0025857671 scopus 로고
    • Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
    • Yamaguchi, A., Katagiri, T., Ikeda, T., Wozney, J.M., Rosen, V., Wang, E.A., Kahn, A.J., Suda, T., and Yoshiki, S. 1991. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J. Cell Biol. 113: 681-687.
    • (1991) J. Cell Biol. , vol.113 , pp. 681-687
    • Yamaguchi, A.1    Katagiri, T.2    Ikeda, T.3    Wozney, J.M.4    Rosen, V.5    Wang, E.A.6    Kahn, A.J.7    Suda, T.8    Yoshiki, S.9


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