-
1
-
-
27744595555
-
The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation
-
Abbasi S, Su B, Kellems RE, Yang J, Xia Y. 2005. The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation. J Biol Chem 280:36737-36746.
-
(2005)
J Biol Chem
, vol.280
, pp. 36737-36746
-
-
Abbasi, S.1
Su, B.2
Kellems, R.E.3
Yang, J.4
Xia, Y.5
-
2
-
-
26444496532
-
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo
-
Abell AN, Rivera-Perez JA, Cuevas BD, Uhlik MT, Sather S, Johnson NL, Minton SK, Lauder JM, Winter-Vann AM, Nakamura K, Magnuson T, Vaillancourt RR, Heasley LE, Johnson GL. 2005. Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol 25:8948-8959.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8948-8959
-
-
Abell, A.N.1
Rivera-Perez, J.A.2
Cuevas, B.D.3
Uhlik, M.T.4
Sather, S.5
Johnson, N.L.6
Minton, S.K.7
Lauder, J.M.8
Winter-Vann, A.M.9
Nakamura, K.10
Magnuson, T.11
Vaillancourt, R.R.12
Heasley, L.E.13
Johnson, G.L.14
-
3
-
-
35649013184
-
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta
-
Abell AN, Granger DA, Johnson GL. 2007. MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. J Biol Chem 282:30476-30484.
-
(2007)
J Biol Chem
, vol.282
, pp. 30476-30484
-
-
Abell, A.N.1
Granger, D.A.2
Johnson, G.L.3
-
4
-
-
0033622470
-
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
-
Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR. 2000. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6:109-116.
-
(2000)
Mol Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
Panelli, S.6
Valladares, A.7
Perez, L.8
Klein, R.9
Nebreda, A.R.10
-
6
-
-
0034177057
-
Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro
-
Aoki H, Richmond M, Izumo S, Sadoshima J. 2000. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J 347(pt 1):275-284.
-
(2000)
Biochem J
, vol.347
, Issue.PART 1
, pp. 275-284
-
-
Aoki, H.1
Richmond, M.2
Izumo, S.3
Sadoshima, J.4
-
7
-
-
4043056497
-
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
-
Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. 2004. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med 10:849-857.
-
(2004)
Nat Med
, vol.10
, pp. 849-857
-
-
Araki, T.1
Mohi, M.G.2
Ismat, F.A.3
Bronson, R.T.4
Williams, I.R.5
Kutok, J.L.6
Yang, W.7
Pao, L.I.8
Gilliland, D.G.9
Epstein, J.A.10
Neel, B.G.11
-
8
-
-
0033621804
-
Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
-
Arthur HM, Ure J, Smith AJ, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG. 2000. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol 217:42-53.
-
(2000)
Dev Biol
, vol.217
, pp. 42-53
-
-
Arthur, H.M.1
Ure, J.2
Smith, A.J.3
Renforth, G.4
Wilson, D.I.5
Torsney, E.6
Charlton, R.7
Parums, D.V.8
Jowett, T.9
Marchuk, D.A.10
Burn, J.11
Diamond, A.G.12
-
9
-
-
42149083899
-
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
-
Barault L, Veyries N, Jooste V, Lecorre D, Chapusot C, Ferraz JM, Lievre A, Cortet M, Bouvier AM, Rat P, Roignot P, Faivre J, Laurent-Puig P, Piard F. 2008. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer 122:2255-2259.
-
(2008)
Int J Cancer
, vol.122
, pp. 2255-2259
-
-
Barault, L.1
Veyries, N.2
Jooste, V.3
Lecorre, D.4
Chapusot, C.5
Ferraz, J.M.6
Lievre, A.7
Cortet, M.8
Bouvier, A.M.9
Rat, P.10
Roignot, P.11
Faivre, J.12
Laurent-Puig, P.13
Piard, F.14
-
10
-
-
16344395995
-
Mutation analysis of B-RAF gene in human gliomas
-
Basto D, Trovisco V, Lopes JM, Martins A, Pardal F, Soares P, Reis RM. 2005. Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathol 109:207-210.
-
(2005)
Acta Neuropathol
, vol.109
, pp. 207-210
-
-
Basto, D.1
Trovisco, V.2
Lopes, J.M.3
Martins, A.4
Pardal, F.5
Soares, P.6
Reis, R.M.7
-
11
-
-
34247480492
-
The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems
-
Bettinger BT, Amberg DC. 2007. The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems. J Cell Biochem 101:34-43.
-
(2007)
J Cell Biochem
, vol.101
, pp. 34-43
-
-
Bettinger, B.T.1
Amberg, D.C.2
-
12
-
-
42449148304
-
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype
-
Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP, Moss T. 2008. Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Cell Cycle 7:909-916.
-
(2008)
Cell Cycle
, vol.7
, pp. 909-916
-
-
Bisson, N.1
Tremblay, M.2
Robinson, F.3
Kaplan, D.R.4
Trusko, S.P.5
Moss, T.6
-
13
-
-
33749389685
-
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis
-
Bissonauth V, Roy S, Gravel M, Guillemtte S, Charron J. 2006. Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development 113:3429-3440.
-
(2006)
Development
, vol.113
, pp. 3429-3440
-
-
Bissonauth, V.1
Roy, S.2
Gravel, M.3
Guillemtte, S.4
Charron, J.5
-
14
-
-
0034855864
-
Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase
-
Bloem LJ, Pickard TR, Acton S, Donoghue M, Beavis RC, Knierman MD, Wang X. 2001. Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. J Mol Cell Cardiol 33:1739-1750.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 1739-1750
-
-
Bloem, L.J.1
Pickard, T.R.2
Acton, S.3
Donoghue, M.4
Beavis, R.C.5
Knierman, M.D.6
Wang, X.7
-
15
-
-
17644373073
-
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
-
Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ. 2005. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol 25:3670-3681.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3670-3681
-
-
Brancho, D.1
Ventura, J.J.2
Jaeschke, A.3
Doran, B.4
Flavell, R.A.5
Davis, R.J.6
-
16
-
-
0033847008
-
Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme
-
Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A Jr, Kubalak S, Klewer SE, McDonald JA. 2000. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest 106:349-360.
-
(2000)
J Clin Invest
, vol.106
, pp. 349-360
-
-
Camenisch, T.D.1
Spicer, A.P.2
Brehm-Gibson, T.3
Biesterfeldt, J.4
Augustine, M.L.5
Calabro Jr, A.6
Kubalak, S.7
Klewer, S.E.8
McDonald, J.A.9
-
17
-
-
0036344533
-
Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
-
Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA. 2002. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat Med 8:850-855.
-
(2002)
Nat Med
, vol.8
, pp. 850-855
-
-
Camenisch, T.D.1
Schroeder, J.A.2
Bradley, J.3
Klewer, S.E.4
McDonald, J.A.5
-
18
-
-
4143098266
-
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
-
Chadee DN, Kyriakis JM. 2004. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nat Cell Biol 6:770-776.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 770-776
-
-
Chadee, D.N.1
Kyriakis, J.M.2
-
19
-
-
0033579552
-
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
-
Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD. 1999. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J Biol Chem 274:36035-36038.
-
(1999)
J Biol Chem
, vol.274
, pp. 36035-36038
-
-
Chao, T.H.1
Hayashi, M.2
Tapping, R.I.3
Kato, Y.4
Lee, J.D.5
-
20
-
-
0035836668
-
Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells
-
Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, Ganiatsas S, Zon LI, Sun W, Johnson GL, Gelfand EW. 2001. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Proc Natl Acad Sci U S A 98:4599-4604.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4599-4604
-
-
Chayama, K.1
Papst, P.J.2
Garrington, T.P.3
Pratt, J.C.4
Ishizuka, T.5
Webb, S.6
Ganiatsas, S.7
Zon, L.I.8
Sun, W.9
Johnson, G.L.10
Gelfand, E.W.11
-
21
-
-
0035844153
-
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2
-
Chen Z, Cobb MH. 2001. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem 276:16070-16075.
-
(2001)
J Biol Chem
, vol.276
, pp. 16070-16075
-
-
Chen, Z.1
Cobb, M.H.2
-
22
-
-
0038605379
-
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors
-
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH. 2003. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J Biol Chem 278:22278-22283.
-
(2003)
J Biol Chem
, vol.278
, pp. 22278-22283
-
-
Chen, Z.1
Raman, M.2
Chen, L.3
Lee, S.F.4
Gilman, A.G.5
Cobb, M.H.6
-
23
-
-
0242473165
-
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
-
Cheung PC, Campbell DG, Nebreda AR, Cohen P. 2003. Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J 22:5793-5805.
-
(2003)
EMBO J
, vol.22
, pp. 5793-5805
-
-
Cheung, P.C.1
Campbell, D.G.2
Nebreda, A.R.3
Cohen, P.4
-
24
-
-
14844354487
-
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development
-
Chi H, Sarkisian MR, Rakic P, Flavell RA. 2005. Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A 102:3846-3851.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3846-3851
-
-
Chi, H.1
Sarkisian, M.R.2
Rakic, P.3
Flavell, R.A.4
-
25
-
-
4444232333
-
Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation
-
Christe M, Jin N, Wang X, Gould KE, Iversen PW, Yu X, Lorenz JN, Kadambi V, Zuckerman SH, Bloem LJ. 2004. Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation. J Mol Cell Cardiol 37:705-715.
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 705-715
-
-
Christe, M.1
Jin, N.2
Wang, X.3
Gould, K.E.4
Iversen, P.W.5
Yu, X.6
Lorenz, J.N.7
Kadambi, V.8
Zuckerman, S.H.9
Bloem, L.J.10
-
26
-
-
13644250274
-
Expression of the Tpl2/Cot oncogene in human T-cell neoplasias
-
Christoforidou AV, Papadaki HA, Margioris AN, Eliopoulos GD, Tsatsanis C. 2004. Expression of the Tpl2/Cot oncogene in human T-cell neoplasias. Mol Cancer 3:34.
-
(2004)
Mol Cancer
, vol.3
, pp. 34
-
-
Christoforidou, A.V.1
Papadaki, H.A.2
Margioris, A.N.3
Eliopoulos, G.D.4
Tsatsanis, C.5
-
27
-
-
33745497728
-
Highwire restrains synaptic growth by attenuating a MAP kinase signal
-
Collins CA, Wairkar YP, Johnson SL, Di-Antonio A. 2006. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron 51:57-69.
-
(2006)
Neuron
, vol.51
, pp. 57-69
-
-
Collins, C.A.1
Wairkar, Y.P.2
Johnson, S.L.3
Di-Antonio, A.4
-
28
-
-
33644975212
-
Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells
-
Compton LA, Potash DA, Mundell NA, Barnett JV. 2006. Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells. Dev Dyn 235:82-93.
-
(2006)
Dev Dyn
, vol.235
, pp. 82-93
-
-
Compton, L.A.1
Potash, D.A.2
Mundell, N.A.3
Barnett, J.V.4
-
29
-
-
0038721214
-
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
-
Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S. 2003. Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Mol Cell Biol 23:4542-4558.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4542-4558
-
-
Coulombe, P.1
Rodier, G.2
Pelletier, S.3
Pellerin, J.4
Meloche, S.5
-
30
-
-
33747360733
-
MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer
-
Cuevas BD, Winter-Vann AM, Johnson NL, Johnson GL. 2006. MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer. Oncogene 25:4998-5010.
-
(2006)
Oncogene
, vol.25
, pp. 4998-5010
-
-
Cuevas, B.D.1
Winter-Vann, A.M.2
Johnson, N.L.3
Johnson, G.L.4
-
31
-
-
21244463215
-
Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulusspecific manner
-
Das S, Cho J, Lambertz I, Kelliher MA, Eliopoulos AG, Du K, Tsichlis PN. 2005. Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulusspecific manner. J Biol Chem 280:23748-23757.
-
(2005)
J Biol Chem
, vol.280
, pp. 23748-23757
-
-
Das, S.1
Cho, J.2
Lambertz, I.3
Kelliher, M.A.4
Eliopoulos5
AG, D.K.6
Tsichlis, P.N.7
-
32
-
-
0030952084
-
Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
-
Deacon K, Blank JL. 1997. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272:14489-14496.
-
(1997)
J Biol Chem
, vol.272
, pp. 14489-14496
-
-
Deacon, K.1
Blank, J.L.2
-
33
-
-
0034672593
-
Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1
-
Dempsey CE, Sakurai H, Sugita T, Guesdon F. 2000. Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1. Biochim Biophys Acta 1517:46-52.
-
(2000)
Biochim Biophys Acta
, vol.1517
, pp. 46-52
-
-
Dempsey, C.E.1
Sakurai, H.2
Sugita, T.3
Guesdon, F.4
-
34
-
-
33746652899
-
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing
-
Deng M, Chen WL, Takatori A, Peng Z, Zhang L, Mongan M, Parthasarathy R, Sartor M, Miller M, Yang J, Su B, Kao WW, Xia Y. 2006. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Mol Biol Cell 17:3446-3455.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 3446-3455
-
-
Deng, M.1
Chen, W.L.2
Takatori, A.3
Peng, Z.4
Zhang, L.5
Mongan, M.6
Parthasarathy, R.7
Sartor, M.8
Miller, M.9
Yang, J.10
Su, B.11
Kao, W.W.12
Xia, Y.13
-
35
-
-
35048839667
-
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
-
Deng Y, Yang J, McCarty M, Su B. 2007. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. Am J Physiol Cell Physiol 293:C1404-C1411.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Deng, Y.1
Yang, J.2
McCarty, M.3
Su, B.4
-
36
-
-
17244378994
-
Angiotensin II stimulated transcription of cyclooxygenase II is regulated by a novel kinase cascade involving Pyk2, MEKK4 and annexin II
-
Derbyshire ZE, Halfter UM, Heimark RL, Sy TH, Vaillancourt RR. 2005. Angiotensin II stimulated transcription of cyclooxygenase II is regulated by a novel kinase cascade involving Pyk2, MEKK4 and annexin II. Mol Cell Biochem 271:77-90.
-
(2005)
Mol Cell Biochem
, vol.271
, pp. 77-90
-
-
Derbyshire, Z.E.1
Halfter, U.M.2
Heimark, R.L.3
Sy, T.H.4
Vaillancourt, R.R.5
-
37
-
-
17744371331
-
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
-
Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN. 2000. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103:1071-1083.
-
(2000)
Cell
, vol.103
, pp. 1071-1083
-
-
Dumitru, C.D.1
Ceci, J.D.2
Tsatsanis, C.3
Kontoyiannis, D.4
Stamatakis, K.5
Lin, J.H.6
Patriotis, C.7
Jenkins, N.A.8
Copeland, N.G.9
Kollias, G.10
Tsichlis, P.N.11
-
38
-
-
0028122465
-
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
-
Dumont DJ, Gradwohl G, Fong GH, Puri MC, Gertsenstein M, Auerbach A, Breitman ML. 1994. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev 8:1897-1909.
-
(1994)
Genes Dev
, vol.8
, pp. 1897-1909
-
-
Dumont, D.J.1
Gradwohl, G.2
Fong, G.H.3
Puri, M.C.4
Gertsenstein, M.5
Auerbach, A.6
Breitman, M.L.7
-
39
-
-
0033620648
-
Functions of c-Jun in liver and heart development
-
Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K. 1999. Functions of c-Jun in liver and heart development. J Cell Biol 145:1049-1061.
-
(1999)
J Cell Biol
, vol.145
, pp. 1049-1061
-
-
Eferl, R.1
Sibilia, M.2
Hilberg, F.3
Fuchsbichler, A.4
Kufferath, I.5
Guertl, B.6
Zenz, R.7
Wagner, E.F.8
Zatloukal, K.9
-
40
-
-
18844383961
-
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
-
Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, Keating MT. 2005. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 19:1175-1187.
-
(2005)
Genes Dev
, vol.19
, pp. 1175-1187
-
-
Engel, F.B.1
Schebesta, M.2
Duong, M.T.3
Lu, G.4
Ren, S.5
Madwed, J.B.6
Jiang, H.7
Wang, Y.8
Keating, M.T.9
-
41
-
-
34547658027
-
Expression of ASK1 during chick and early mouse development
-
Ferrer-Vaquer A, Maurey P, Firnberg N, Leibbrandt A, Neubuser A. 2007. Expression of ASK1 during chick and early mouse development. Gene Expr Patterns 7:808-816.
-
(2007)
Gene Expr Patterns
, vol.7
, pp. 808-816
-
-
Ferrer-Vaquer, A.1
Maurey, P.2
Firnberg, N.3
Leibbrandt, A.4
Neubuser, A.5
-
42
-
-
33646570007
-
Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation
-
Fritz A, Brayer KJ, McCormick N, Adams DG, Wadzinski BE, Vaillancourt RR. 2006. Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation. J Biol Chem 281:6236-6245.
-
(2006)
J Biol Chem
, vol.281
, pp. 6236-6245
-
-
Fritz, A.1
Brayer, K.J.2
McCormick, N.3
Adams, D.G.4
Wadzinski, B.E.5
Vaillancourt, R.R.6
-
43
-
-
33847002355
-
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
-
Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. 2007. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol 8:57-63.
-
(2007)
Nat Immunol
, vol.8
, pp. 57-63
-
-
Gallagher, E.1
Enzler, T.2
Matsuzawa, A.3
Anzelon-Mills, A.4
Otero, D.5
Holzer, R.6
Janssen, E.7
Gao, M.8
Karin, M.9
-
44
-
-
0036731701
-
Mixed-lineage kinase control of JNK and p38 MAPK pathways
-
Gallo KA, Johnson GL. 2002. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 3:663-672.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 663-672
-
-
Gallo, K.A.1
Johnson, G.L.2
-
45
-
-
0034675925
-
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
-
Garrington TP, Ishizuka T, Papst PJ, Chayama K, Webb S, Yujiri T, Sun W, Sather S, Russell DM, Gibson SB, Keller G, Gelfand EW, Johnson GL. 2000. MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells. EMBO J 19:5387-5395.
-
(2000)
EMBO J
, vol.19
, pp. 5387-5395
-
-
Garrington, T.P.1
Ishizuka, T.2
Papst, P.J.3
Chayama, K.4
Webb, S.5
Yujiri, T.6
Sun, W.7
Sather, S.8
Russell, D.M.9
Gibson, S.B.10
Keller, G.11
Gelfand, E.W.12
Johnson, G.L.13
-
46
-
-
0030934694
-
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
-
Gerwins P, Blank JL, Johnson GL. 1997. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem 272:8288-8295.
-
(1997)
J Biol Chem
, vol.272
, pp. 8288-8295
-
-
Gerwins, P.1
Blank, J.L.2
Johnson, G.L.3
-
49
-
-
42449085424
-
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via MEK, p38, nuclear factor kappaB in human endometriotic epithelial cells
-
Grund EM, Kagan D, Tran CA, Zeitvogel A, Starzinski-Powitz A, Nataraja S, Palmer SS. 2008. Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via MEK, p38, nuclear factor kappaB in human endometriotic epithelial cells. Mol Pharmacol 73:1394-1404.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 1394-1404
-
-
Grund, E.M.1
Kagan, D.2
Tran, C.A.3
Zeitvogel, A.4
Starzinski-Powitz, A.5
Nataraja, S.6
Palmer, S.S.7
-
50
-
-
0036315121
-
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction
-
Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, Su B. 2002. Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol Cell Biol 22:5761-5768.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5761-5768
-
-
Guo, Z.1
Clydesdale, G.2
Cheng, J.3
Kim, K.4
Gan, L.5
McConkey, D.J.6
Ullrich, S.E.7
Zhuang, Y.8
Su, B.9
-
51
-
-
19544390842
-
Interferon-gamma- dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes
-
Halfter UM, Derbyshire ZE, Vaillancourt RR. 2005. Interferon-gamma- dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. Biochem J 388:17-28.
-
(2005)
Biochem J
, vol.388
, pp. 17-28
-
-
Halfter, U.M.1
Derbyshire, Z.E.2
Vaillancourt, R.R.3
-
52
-
-
0036931633
-
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
-
Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. 2002. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129:5827-5838.
-
(2002)
Development
, vol.129
, pp. 5827-5838
-
-
Hamblet, N.S.1
Lijam, N.2
Ruiz-Lozano, P.3
Wang, J.4
Yang, Y.5
Luo, Z.6
Mei, L.7
Chien, K.R.8
Sussman, D.J.9
Wynshaw-Boris, A.10
-
53
-
-
1642444091
-
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis
-
Hammaker DR, Boyle DL, Chabaud-Riou M, Firestein GS. 2004. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol 172:1612-1618.
-
(2004)
J Immunol
, vol.172
, pp. 1612-1618
-
-
Hammaker, D.R.1
Boyle, D.L.2
Chabaud-Riou, M.3
Firestein, G.S.4
-
54
-
-
4043076222
-
Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload
-
Harris IS, Zhang S, Treskov I, Kovacs A, Weinheimer C, Muslin AJ. 2004. Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload. Circulation 110:718-723.
-
(2004)
Circulation
, vol.110
, pp. 718-723
-
-
Harris, I.S.1
Zhang, S.2
Treskov, I.3
Kovacs, A.4
Weinheimer, C.5
Muslin, A.J.6
-
55
-
-
33751082080
-
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex
-
Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S. 2006. The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci 26:11992-12002.
-
(2006)
J Neurosci
, vol.26
, pp. 11992-12002
-
-
Hirai, S.1
Cui de, F.2
Miyata, T.3
Ogawa, M.4
Kiyonari, H.5
Suda, Y.6
Aizawa, S.7
Banba, Y.8
Ohno, S.9
-
56
-
-
39049193311
-
Regulation of ERK3/MAPK6 expression by BRAF
-
Hoeflich KP, Eby MT, Forrest WF, Gray DC, Tien JY, Stern HM, Murray LJ, Davis DP, Modrusan Z, Seshagiri S. 2006. Regulation of ERK3/MAPK6 expression by BRAF. Int J Oncol 29:839-849.
-
(2006)
Int J Oncol
, vol.29
, pp. 839-849
-
-
Hoeflich, K.P.1
Eby, M.T.2
Forrest, W.F.3
Gray, D.C.4
Tien, J.Y.5
Stern, H.M.6
Murray, L.J.7
Davis, D.P.8
Modrusan, Z.9
Seshagiri, S.10
-
57
-
-
33749407705
-
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways
-
Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J. 2006. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem 281:28802-28810.
-
(2006)
J Biol Chem
, vol.281
, pp. 28802-28810
-
-
Huangfu, W.C.1
Omori, E.2
Akira, S.3
Matsumoto, K.4
Ninomiya-Tsuji, J.5
-
58
-
-
0032582644
-
Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades
-
Hutchison M, Berman KS, Cobb MH. 1998. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J Biol Chem 273:28625-28632.
-
(1998)
J Biol Chem
, vol.273
, pp. 28625-28632
-
-
Hutchison, M.1
Berman, K.S.2
Cobb, M.H.3
-
59
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90-94.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
60
-
-
0034697963
-
The challenges of translating knockout phenotypes into gene function
-
Ihle JN. 2000. The challenges of translating knockout phenotypes into gene function. Cell 102:131-134.
-
(2000)
Cell
, vol.102
, pp. 131-134
-
-
Ihle, J.N.1
-
61
-
-
0035663673
-
Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway
-
Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T. 2001. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. J Biochem 130:773-781.
-
(2001)
J Biochem
, vol.130
, pp. 773-781
-
-
Ikeda, A.1
Hasegawa, K.2
Masaki, M.3
Moriguchi, T.4
Nishida, E.5
Kozutsumi, Y.6
Oka, S.7
Kawasaki, T.8
-
62
-
-
33646713486
-
The TGF beta activated kinase TAK1 regulates vascular development in vivo
-
Jadrich JL, O'Connor MB, Coucouvanis E. 2006. The TGF beta activated kinase TAK1 regulates vascular development in vivo. Development 133:1529-1541.
-
(2006)
Development
, vol.133
, pp. 1529-1541
-
-
Jadrich, J.L.1
O'Connor, M.B.2
Coucouvanis, E.3
-
63
-
-
34547219895
-
Metabolic stress signaling mediated by mixed-lineage kinases
-
Jaeschke A, Davis RJ. 2007. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 27:498-508.
-
(2007)
Mol Cell
, vol.27
, pp. 498-508
-
-
Jaeschke, A.1
Davis, R.J.2
-
64
-
-
0029824710
-
Nerve growth factor-mediated activation of the mitogen-activated protein (MAP) kinase cascade involves a signaling complex containing B-Raf and HSP90
-
Jaiswal RK, Weissinger E, Kolch W, Landreth GE. 1996. Nerve growth factor-mediated activation of the mitogen-activated protein (MAP) kinase cascade involves a signaling complex containing B-Raf and HSP90. J Biol Chem 271:23626-23629.
-
(1996)
J Biol Chem
, vol.271
, pp. 23626-23629
-
-
Jaiswal, R.K.1
Weissinger, E.2
Kolch, W.3
Landreth, G.E.4
-
65
-
-
0034010326
-
Fate of the mammalian cardiac neural crest
-
Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. 2000. Fate of the mammalian cardiac neural crest. Development 127:1607-1616.
-
(2000)
Development
, vol.127
, pp. 1607-1616
-
-
Jiang, X.1
Rowitch, D.H.2
Soriano, P.3
McMahon, A.P.4
Sucov, H.M.5
-
66
-
-
0033986791
-
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons
-
Kanamoto T, Mota M, Takeda K, Rubin LL, Miyazono K, Ichijo H, Bazenet CE. 2000. Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Mol Cell Biol 20:196-204.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 196-204
-
-
Kanamoto, T.1
Mota, M.2
Takeda, K.3
Rubin, L.L.4
Miyazono, K.5
Ichijo, H.6
Bazenet, C.E.7
-
67
-
-
0034704153
-
MEKK1 binds raf-1 and the ERK2 cascade components
-
Karandikar M, Xu S, Cobb MH. 2000. MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem 275:40120-40127.
-
(2000)
J Biol Chem
, vol.275
, pp. 40120-40127
-
-
Karandikar, M.1
Xu, S.2
Cobb, M.H.3
-
68
-
-
34547581695
-
Grb10 and active Raf-1 kinase promote Bad-dependent cell survival
-
Kebache S, Ash J, Annis MG, Hagan J, Huber M, Hassard J, Stewart CL, Whiteway M, Nantel A. 2007. Grb10 and active Raf-1 kinase promote Bad-dependent cell survival. J Biol Chem 282:21873-21883.
-
(2007)
J Biol Chem
, vol.282
, pp. 21873-21883
-
-
Kebache, S.1
Ash, J.2
Annis, M.G.3
Hagan, J.4
Huber, M.5
Hassard, J.6
Stewart, C.L.7
Whiteway, M.8
Nantel, A.9
-
69
-
-
1042268043
-
MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts
-
Kesavan K, Lobel-Rice K, Sun W, Lapadat R, Webb S, Johnson GL, Garrington TP. 2004. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts. J Cell Physiol 199:140-148.
-
(2004)
J Cell Physiol
, vol.199
, pp. 140-148
-
-
Kesavan, K.1
Lobel-Rice, K.2
Sun, W.3
Lapadat, R.4
Webb, S.5
Johnson, G.L.6
Garrington, T.P.7
-
70
-
-
0008414331
-
Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart
-
Kim SO, Irwin P, Katz S, Pelech SL. 1998. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. J Cell Biochem 71:286-301.
-
(1998)
J Cell Biochem
, vol.71
, pp. 286-301
-
-
Kim, S.O.1
Irwin, P.2
Katz, S.3
Pelech, S.L.4
-
71
-
-
0020640517
-
Neural crest cells contribute to aorticopulmonary septation
-
Kirby ML, Gale TF, Stewart DE. 1983. Neural crest cells contribute to aorticopulmonary septation. Science 220:1059-1061.
-
(1983)
Science
, vol.220
, pp. 1059-1061
-
-
Kirby, M.L.1
Gale, T.F.2
Stewart, D.E.3
-
72
-
-
33646096207
-
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects
-
Kontaridis MI, Swanson KD, David FS, Barford D, Neel BG. 2006. PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem 281:6785-6792.
-
(2006)
J Biol Chem
, vol.281
, pp. 6785-6792
-
-
Kontaridis, M.I.1
Swanson, K.D.2
David, F.S.3
Barford, D.4
Neel, B.G.5
-
73
-
-
33847071291
-
Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release
-
Kumar P, Coltas IK, Kumar B, Chepeha DB, Bradford CR, Polverini PJ. 2007. Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release. Cancer Res 67:1193-1202.
-
(2007)
Cancer Res
, vol.67
, pp. 1193-1202
-
-
Kumar, P.1
Coltas, I.K.2
Kumar, B.3
Chepeha, D.B.4
Bradford, C.R.5
Polverini, P.J.6
-
74
-
-
34247324325
-
C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A
-
Lamberti A, Longo O, Marra M, Tagliaferri P, Bismuto E, Fiengo A, Viscomi C, Budillon A, Rapp UR, Wang E, Venuta S, Abbruzzese A, Arcari P, Caraglia M. 2007. C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. Cell Death Differ 14:952-962.
-
(2007)
Cell Death Differ
, vol.14
, pp. 952-962
-
-
Lamberti, A.1
Longo, O.2
Marra, M.3
Tagliaferri, P.4
Bismuto, E.5
Fiengo, A.6
Viscomi, C.7
Budillon, A.8
Rapp, U.R.9
Wang, E.10
Venuta, S.11
Abbruzzese, A.12
Arcari, P.13
Caraglia, M.14
-
75
-
-
36448991500
-
-
Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG. 2007. ClustalWand Clustal X version 2.0. Bioinformatics 23:2947-2948
-
Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG. 2007. ClustalWand Clustal X version 2.0. Bioinformatics 23:2947-2948.
-
-
-
-
76
-
-
0036340975
-
PTPN11 mutations in LEOPARD syndrome
-
Legius E, Schrander-Stumpel C, Schollen E, Pulles-Heintzberger C, Gewillig M, Fryns JP. 2002. PTPN11 mutations in LEOPARD syndrome. J Med Genet 39:571-574.
-
(2002)
J Med Genet
, vol.39
, pp. 571-574
-
-
Legius, E.1
Schrander-Stumpel, C.2
Schollen, E.3
Pulles-Heintzberger, C.4
Gewillig, M.5
Fryns, J.P.6
-
77
-
-
10744231710
-
Inhibition of tumor necrosis factor-α-induced SHP-2 phosphatase activity by shear stress: A mechanism to reduce endothelial inflammation
-
Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J. 2003. Inhibition of tumor necrosis factor-α-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation. Arterioscler Thromb Vasc Biol 23:1775-1781.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 1775-1781
-
-
Lerner-Marmarosh, N.1
Yoshizumi, M.2
Che, W.3
Surapisitchat, J.4
Kawakatsu, H.5
Akaike, M.6
Ding, B.7
Huang, Q.8
Yan, C.9
Berk, B.C.10
Abe, J.11
-
78
-
-
0035834071
-
The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy
-
Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. 2001. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A 98:12283-12288.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12283-12288
-
-
Liao, P.1
Georgakopoulos, D.2
Kovacs, A.3
Zheng, M.4
Lerner, D.5
Pu, H.6
Saffitz, J.7
Chien, K.8
Xiao, R.P.9
Kass, D.A.10
Wang, Y.11
-
79
-
-
0032583947
-
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
-
Ling L, Cao Z, Goeddel DV. 1998. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A 95:3792-3797.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 3792-3797
-
-
Ling, L.1
Cao, Z.2
Goeddel, D.V.3
-
81
-
-
0343238874
-
Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse
-
Luckett JC, Huser MB, Giagtzoglou N, Brown JE, Pritchard CA. 2000. Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse. Cell Growth Differ 11:163-171.
-
(2000)
Cell Growth Differ
, vol.11
, pp. 163-171
-
-
Luckett, J.C.1
Huser, M.B.2
Giagtzoglou, N.3
Brown, J.E.4
Pritchard, C.A.5
-
82
-
-
0141621205
-
Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation
-
Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC. 2003. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J Biol Chem 278:37451-37458.
-
(2003)
J Biol Chem
, vol.278
, pp. 37451-37458
-
-
Luo, W.1
Ng, W.W.2
Jin, L.H.3
Ye, Z.4
Han, J.5
Lin, S.C.6
-
83
-
-
14644421097
-
A-Raf associates with and regulates platelet-derived growth factor receptor signalling
-
Mahon ES, Hawrysh AD, Chagpar RB, Johnson LM, Anderson DH. 2005. A-Raf associates with and regulates platelet-derived growth factor receptor signalling. Cell Signal 17:857-868.
-
(2005)
Cell Signal
, vol.17
, pp. 857-868
-
-
Mahon, E.S.1
Hawrysh, A.D.2
Chagpar, R.B.3
Johnson, L.M.4
Anderson, D.H.5
-
84
-
-
0031041171
-
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
-
Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ. 1997. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem 272:4378-4383.
-
(1997)
J Biol Chem
, vol.272
, pp. 4378-4383
-
-
Marais, R.1
Light, Y.2
Paterson, H.F.3
Mason, C.S.4
Marshall, C.J.5
-
85
-
-
0028827104
-
Multiple essential functions of neuregulin in development
-
Meyer D, Birchmeier C. 1995. Multiple essential functions of neuregulin in development. Nature 378:386-390.
-
(1995)
Nature
, vol.378
, pp. 386-390
-
-
Meyer, D.1
Birchmeier, C.2
-
86
-
-
17744384002
-
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
-
Mikula M, Schreiber M, Husak Z, Kucerova L, Ruth J, Wieser R, Zatloukal K, Beug H, Wagner EF, Baccarini M. 2001. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J 20:1952-1962.
-
(2001)
EMBO J
, vol.20
, pp. 1952-1962
-
-
Mikula, M.1
Schreiber, M.2
Husak, Z.3
Kucerova, L.4
Ruth, J.5
Wieser, R.6
Zatloukal, K.7
Beug, H.8
Wagner, E.F.9
Baccarini, M.10
-
87
-
-
0033592944
-
MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes
-
Minamino T, Yujiri T, Papst PJ, Chan ED, Johnson GL, Terada N. 1999. MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc Natl Acad Sci U S A 96:15127-15132.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 15127-15132
-
-
Minamino, T.1
Yujiri, T.2
Papst, P.J.3
Chan, E.D.4
Johnson, G.L.5
Terada, N.6
-
88
-
-
0037133571
-
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq
-
Minamino T, Yujiri T, Terada N, Taffet GE, Michael LH, Johnson GL, Schneider MD. 2002. MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci U S A 99:3866-3871.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 3866-3871
-
-
Minamino, T.1
Yujiri, T.2
Terada, N.3
Taffet, G.E.4
Michael, L.H.5
Johnson, G.L.6
Schneider, M.D.7
-
89
-
-
0036275374
-
Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding
-
Mita H, Tsutsui J, Takekawa M, Witten EA, Saito H. 2002. Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 22:4544-4555.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4544-4555
-
-
Mita, H.1
Tsutsui, J.2
Takekawa, M.3
Witten, E.A.4
Saito, H.5
-
90
-
-
15844431960
-
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
-
Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M. 1996. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem 271:13675-13679.
-
(1996)
J Biol Chem
, vol.271
, pp. 13675-13679
-
-
Moriguchi, T.1
Kuroyanagi, N.2
Yamaguchi, K.3
Gotoh, Y.4
Irie, K.5
Kano, T.6
Shirakabe, K.7
Muro, Y.8
Shibuya, H.9
Matsumoto, K.10
Nishida, E.11
Hagiwara, M.12
-
91
-
-
0034641614
-
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
-
Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM. 2000. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A 97:10454-10459.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
Ding, J.2
Guh-Siesel, L.3
Chartrain, N.A.4
Yang, L.5
Gopal, S.6
Shen, M.M.7
-
92
-
-
0141484661
-
PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway
-
Nakamura K, Johnson GL. 2003. PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. J Biol Chem 278:36989-36992.
-
(2003)
J Biol Chem
, vol.278
, pp. 36989-36992
-
-
Nakamura, K.1
Johnson, G.L.2
-
93
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
Neel BG, Gu H, Pao L. 2003. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 28:284-293.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
94
-
-
0035355360
-
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
-
Nicol RL, Frey N, Pearson G, Cobb M, Richardson J, Olson EN. 2001. Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J 20:2757-2767.
-
(2001)
EMBO J
, vol.20
, pp. 2757-2767
-
-
Nicol, R.L.1
Frey, N.2
Pearson, G.3
Cobb, M.4
Richardson, J.5
Olson, E.N.6
-
95
-
-
34548205302
-
Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling
-
Ortner E, Moelling K. 2007. Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling. Biochem Biophys Res Commun 362:454-459.
-
(2007)
Biochem Biophys Res Commun
, vol.362
, pp. 454-459
-
-
Ortner, E.1
Moelling, K.2
-
96
-
-
34547530823
-
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
-
Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Landstrom A, Bos JM, Ommen SR, Esposito G, Lepri F, Faul C, Mundel P, Lopez Siguero JP, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Torrente I, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD. 2007. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet 39:1007-1012.
-
(2007)
Nat Genet
, vol.39
, pp. 1007-1012
-
-
Pandit, B.1
Sarkozy, A.2
Pennacchio, L.A.3
Carta, C.4
Oishi, K.5
Martinelli, S.6
Pogna, E.A.7
Schackwitz, W.8
Ustaszewska, A.9
Landstrom, A.10
Bos, J.M.11
Ommen, S.R.12
Esposito, G.13
Lepri, F.14
Faul, C.15
Mundel, P.16
Lopez Siguero, J.P.17
Tenconi, R.18
Selicorni, A.19
Rossi, C.20
Mazzanti, L.21
Torrente, I.22
Marino, B.23
Digilio, M.C.24
Zampino, G.25
Ackerman, M.J.26
Dallapiccola, B.27
Tartaglia, M.28
Gelb, B.D.29
more..
-
97
-
-
0037023780
-
Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: Correlation with resistance to etoposide-induced apoptosis
-
Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. 2002. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. J Biol Chem 277:12040-12046.
-
(2002)
J Biol Chem
, vol.277
, pp. 12040-12046
-
-
Pardo, O.E.1
Arcaro, A.2
Salerno, G.3
Raguz, S.4
Downward, J.5
Seckl, M.J.6
-
98
-
-
38149094014
-
Temporal-spatial ablation of neural crest in the mouse results in cardiovascular defects
-
Porras D, Brown CB. 2008. Temporal-spatial ablation of neural crest in the mouse results in cardiovascular defects. Dev Dyn 237:153-162.
-
(2008)
Dev Dyn
, vol.237
, pp. 153-162
-
-
Porras, D.1
Brown, C.B.2
-
99
-
-
33746263912
-
BRAF and NRAS mutations in melanoma and melanocytic nevi
-
Poynter JN, Elder JT, Fullen DR, Nair RP, Soengas MS, Johnson TM, Redman B, Thomas NE, Gruber SB. 2006. BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res 16:267-273.
-
(2006)
Melanoma Res
, vol.16
, pp. 267-273
-
-
Poynter, J.N.1
Elder, J.T.2
Fullen, D.R.3
Nair, R.P.4
Soengas, M.S.5
Johnson, T.M.6
Redman, B.7
Thomas, N.E.8
Gruber, S.B.9
-
100
-
-
0030133927
-
Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene
-
Pritchard CA, Bolin L, Slattery R, Murray R, McMahon M. 1996. Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr Biol 6:614-617.
-
(1996)
Curr Biol
, vol.6
, pp. 614-617
-
-
Pritchard, C.A.1
Bolin, L.2
Slattery, R.3
Murray, R.4
McMahon, M.5
-
101
-
-
34247269029
-
TAO kinases mediate activation of p38 in response to DNA damage
-
Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH. 2007. TAO kinases mediate activation of p38 in response to DNA damage. EMBO J 26:2005-2014.
-
(2007)
EMBO J
, vol.26
, pp. 2005-2014
-
-
Raman, M.1
Earnest, S.2
Zhang, K.3
Zhao, Y.4
Cobb, M.H.5
-
102
-
-
0037047109
-
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
-
Regan CP, Li W, Boucher DM, Spatz S, Su MS, Kuida K. 2002. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A 99:9248-9253.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 9248-9253
-
-
Regan, C.P.1
Li, W.2
Boucher, D.M.3
Spatz, S.4
Su, M.S.5
Kuida, K.6
-
103
-
-
33750367434
-
Development of heart valves requires Gata4 expression in endothelial-derived cells
-
Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT. 2006. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133:3607-3618.
-
(2006)
Development
, vol.133
, pp. 3607-3618
-
-
Rivera-Feliciano, J.1
Lee, K.H.2
Kong, S.W.3
Rajagopal, S.4
Ma, Q.5
Springer, Z.6
Izumo, S.7
Tabin, C.J.8
Pu, W.T.9
-
104
-
-
0032724021
-
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
-
Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. 1999. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 89:115-124.
-
(1999)
Mech Dev
, vol.89
, pp. 115-124
-
-
Sabapathy, K.1
Jochum, W.2
Hochedlinger, K.3
Chang, L.4
Karin, M.5
Wagner, E.F.6
-
105
-
-
0027182438
-
Molecular characterization of angiotensin II - induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype
-
Sadoshima J, Izumo S. 1993. Molecular characterization of angiotensin II - induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73:413-423.
-
(1993)
Circ Res
, vol.73
, pp. 413-423
-
-
Sadoshima, J.1
Izumo, S.2
-
106
-
-
0036074371
-
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
-
Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, Vatner DE, Vatner SF. 2002. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest 110:271-279.
-
(2002)
J Clin Invest
, vol.110
, pp. 271-279
-
-
Sadoshima, J.1
Montagne, O.2
Wang, Q.3
Yang, G.4
Warden, J.5
Liu, J.6
Takagi, G.7
Karoor, V.8
Hong, C.9
Johnson, G.L.10
Vatner, D.E.11
Vatner, S.F.12
-
107
-
-
0030689727
-
Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain
-
Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T. 1997. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. J Biol Chem 272:28622-28629.
-
(1997)
J Biol Chem
, vol.272
, pp. 28622-28629
-
-
Sakuma, H.1
Ikeda, A.2
Oka, S.3
Kozutsumi, Y.4
Zanetta, J.P.5
Kawasaki, T.6
-
108
-
-
0032512552
-
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism
-
Sakurai H, Shigemori N, Hasegawa K, Sugita T. 1998. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism. Biochem Biophys Res Commun 243:545-549.
-
(1998)
Biochem Biophys Res Commun
, vol.243
, pp. 545-549
-
-
Sakurai, H.1
Shigemori, N.2
Hasegawa, K.3
Sugita, T.4
-
109
-
-
33748776858
-
JNK mediates TGFbeta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
-
Santibanez JF. 2006. JNK mediates TGFbeta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett 580:5385-5391.
-
(2006)
FEBS Lett
, vol.580
, pp. 5385-5391
-
-
Santibanez, J.F.1
-
110
-
-
33845810120
-
MEKK4 signaling regulates filamin expression and neuronal migration
-
Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P. 2006. MEKK4 signaling regulates filamin expression and neuronal migration. Neuron 52:789-801.
-
(2006)
Neuron
, vol.52
, pp. 789-801
-
-
Sarkisian, M.R.1
Bartley, C.M.2
Chi, H.3
Nakamura, F.4
Hashimoto-Torii, K.5
Torii, M.6
Flavell, R.A.7
Rakic, P.8
-
112
-
-
0030968634
-
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
-
Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E. 1997. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem 272:8141-8144.
-
(1997)
J Biol Chem
, vol.272
, pp. 8141-8144
-
-
Shirakabe, K.1
Yamaguchi, K.2
Shibuya, H.3
Irie, K.4
Matsuda, S.5
Moriguchi, T.6
Gotoh, Y.7
Matsumoto, K.8
Nishida, E.9
-
113
-
-
0025221348
-
Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy
-
Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. 1990. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem 265:20555-20562.
-
(1990)
J Biol Chem
, vol.265
, pp. 20555-20562
-
-
Shubeita, H.E.1
McDonough, P.M.2
Harris, A.N.3
Knowlton, K.U.4
Glembotski, C.C.5
Brown, J.H.6
Chien, K.R.7
-
114
-
-
0020516786
-
Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response
-
Simpson P. 1983. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. J Clin Invest 72:732-738.
-
(1983)
J Clin Invest
, vol.72
, pp. 732-738
-
-
Simpson, P.1
-
115
-
-
0037457478
-
C-Raf controlled pathways in the protection of tumor cells from apoptosis
-
Slater EP, Stubig T, Lau QC, Achenbach TV, Rapp UR, Muller R. 2003. C-Raf controlled pathways in the protection of tumor cells from apoptosis. Int J Cancer 104:425-432.
-
(2003)
Int J Cancer
, vol.104
, pp. 425-432
-
-
Slater, E.P.1
Stubig, T.2
Lau, Q.C.3
Achenbach, T.V.4
Rapp, U.R.5
Muller, R.6
-
116
-
-
18044387648
-
Raf kinase as a target for anticancer therapeutics
-
Sridhar SS, Hedley D, Siu LL. 2005. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 4:677-685.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 677-685
-
-
Sridhar, S.S.1
Hedley, D.2
Siu, L.L.3
-
118
-
-
34147186130
-
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
-
Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H. 2007. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J Biol Chem 282:7522-7531.
-
(2007)
J Biol Chem
, vol.282
, pp. 7522-7531
-
-
Takeda, K.1
Shimozono, R.2
Noguchi, T.3
Umeda, T.4
Morimoto, Y.5
Naguro, I.6
Tobiume, K.7
Saitoh, M.8
Matsuzawa, A.9
Ichijo, H.10
-
119
-
-
0032514967
-
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
-
Takekawa M, Saito H. 1998. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521-530.
-
(1998)
Cell
, vol.95
, pp. 521-530
-
-
Takekawa, M.1
Saito, H.2
-
120
-
-
0036687249
-
Differential involvement of p38 mitogen-activated kinase kinases MKK3 and MKK6 in T-cell apoptosis
-
Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, Flavell RA. 2002. Differential involvement of p38 mitogen-activated kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep 3:785-791.
-
(2002)
EMBO Rep
, vol.3
, pp. 785-791
-
-
Tanaka, N.1
Kamanaka, M.2
Enslen, H.3
Dong, C.4
Wysk, M.5
Davis, R.J.6
Flavell, R.A.7
-
121
-
-
46949097612
-
TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice
-
Tang M, Wei X, Guo Y, Breslin P, Zhang S, Zhang S, Wei W, Xia Z, Diaz M, Akira S, Zhang J. 2008. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med 205:1611-1619.
-
(2008)
J Exp Med
, vol.205
, pp. 1611-1619
-
-
Tang, M.1
Wei, X.2
Guo, Y.3
Breslin, P.4
Zhang, S.5
Zhang, S.6
Wei, W.7
Xia, Z.8
Diaz, M.9
Akira, S.10
Zhang, J.11
-
122
-
-
18344385476
-
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
-
Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD. 2001. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet 29:465-468.
-
(2001)
Nat Genet
, vol.29
, pp. 465-468
-
-
Tartaglia, M.1
Mehler, E.L.2
Goldberg, R.3
Zampino, G.4
Brunner, H.G.5
Kremer, H.6
van der Burgt, I.7
Crosby, A.H.8
Ion, A.9
Jeffery, S.10
Kalidas, K.11
Patton, M.A.12
Kucherlapati, R.S.13
Gelb, B.D.14
-
123
-
-
4143100212
-
Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome
-
Tartaglia M, Cordeddu V, Chang H, Shaw A, Kalidas K, Crosby A, Patton MA, Sorcini M, van der Burgt I, Jeffery S, Gelb BD. 2004. Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome. Am J Hum Genet 75:492-497.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 492-497
-
-
Tartaglia, M.1
Cordeddu, V.2
Chang, H.3
Shaw, A.4
Kalidas, K.5
Crosby, A.6
Patton, M.A.7
Sorcini, M.8
van der Burgt, I.9
Jeffery, S.10
Gelb, B.D.11
-
124
-
-
0031590424
-
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1
-
Tobiume K, Inage T, Takeda K, Enomoto S, Miyazono K, Ichijo H. 1997. Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Biochem Biophys Res Commun 239:905-910.
-
(1997)
Biochem Biophys Res Commun
, vol.239
, pp. 905-910
-
-
Tobiume, K.1
Inage, T.2
Takeda, K.3
Enomoto, S.4
Miyazono, K.5
Ichijo, H.6
-
125
-
-
0034652303
-
Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa
-
Turgeon B, Saba-El-Leil MK, Meloche S. 2000. Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa. Biochem J 346(pt 1):169-175.
-
(2000)
Biochem J
, vol.346
, Issue.PART 1
, pp. 169-175
-
-
Turgeon, B.1
Saba-El-Leil, M.K.2
Meloche, S.3
-
126
-
-
0033840752
-
Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy
-
Ueyama T, Kawashima S, Sakoda T, Rikitake Y, Ishida T, Kawai M, Yamashita T, Ishido S, Hotta H, Yokoyama M. 2000. Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy. J Mol Cell Cardiol 32:947-960.
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 947-960
-
-
Ueyama, T.1
Kawashima, S.2
Sakoda, T.3
Rikitake, Y.4
Ishida, T.5
Kawai, M.6
Yamashita, T.7
Ishido, S.8
Hotta, H.9
Yokoyama, M.10
-
127
-
-
0344668554
-
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
-
Uhlik MT, Abell AN, Johnson NL, Sun W, Cuevas BD, Lobel-Rice KE, Horne EA, Dell'Acqua ML, Johnson GL. 2003. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol 5:1104-1110.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 1104-1110
-
-
Uhlik, M.T.1
Abell, A.N.2
Johnson, N.L.3
Sun, W.4
Cuevas, B.D.5
Lobel-Rice, K.E.6
Horne, E.A.7
Dell'Acqua, M.L.8
Johnson, G.L.9
-
128
-
-
0033757655
-
Arteriovenous malformations in mice lacking activin receptor-like kinase-1
-
Urness LD, Sorensen LK, Li DY. 2000. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet 26:328-331.
-
(2000)
Nat Genet
, vol.26
, pp. 328-331
-
-
Urness, L.D.1
Sorensen, L.K.2
Li, D.Y.3
-
129
-
-
34347395136
-
Signal transduction in early heart development (I): Cardiogenic induction and heart tube formation
-
Wagner M, Siddiqui MA. 2007. Signal transduction in early heart development (I): cardiogenic induction and heart tube formation. Exp Biol Med (Maywood) 232:852-865.
-
(2007)
Exp Biol Med (Maywood)
, vol.232
, pp. 852-865
-
-
Wagner, M.1
Siddiqui, M.A.2
-
130
-
-
21444439969
-
Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA
-
Wang X, Mader MM, Toth JE, Yu X, Jin N, Campbell RM, Smallwood JK, Christe ME, Chatterjee A, Goodson T Jr, Vlahos CJ, Matter WF, Bloem LJ. 2005a. Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA. J Biol Chem 280:19298-19305.
-
(2005)
J Biol Chem
, vol.280
, pp. 19298-19305
-
-
Wang, X.1
Mader, M.M.2
Toth, J.E.3
Yu, X.4
Jin, N.5
Campbell, R.M.6
Smallwood, J.K.7
Christe, M.E.8
Chatterjee, A.9
Goodson Jr, T.10
Vlahos, C.J.11
Matter, W.F.12
Bloem, L.J.13
-
131
-
-
19944383095
-
Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway
-
Wang X, Merritt AJ, Seyfried J, Guo C, Papadakis ES, Finegan KG, Kayahara M, Dixon J, Boot-Handford RP, Cartwright EJ, Mayer U, Tournier C. 2005b. Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol 25:336-345.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 336-345
-
-
Wang, X.1
Merritt, A.J.2
Seyfried, J.3
Guo, C.4
Papadakis, E.S.5
Finegan, K.G.6
Kayahara, M.7
Dixon, J.8
Boot-Handford, R.P.9
Cartwright, E.J.10
Mayer, U.11
Tournier, C.12
-
132
-
-
0030977312
-
Endothelial apoptosis in Braf-deficient mice
-
Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR, Zimmer A. 1997. Endothelial apoptosis in Braf-deficient mice. Nat Genet 16:293-297.
-
(1997)
Nat Genet
, vol.16
, pp. 293-297
-
-
Wojnowski, L.1
Zimmer, A.M.2
Beck, T.W.3
Hahn, H.4
Bernal, R.5
Rapp, U.R.6
Zimmer, A.7
-
133
-
-
0033997943
-
Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis
-
Wojnowski L, Stancato LF, Larner AC, Rapp UR, Zimmer A. 2000. Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech Dev 91:97-104.
-
(2000)
Mech Dev
, vol.91
, pp. 97-104
-
-
Wojnowski, L.1
Stancato, L.F.2
Larner, A.C.3
Rapp, U.R.4
Zimmer, A.5
-
134
-
-
0030062094
-
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
-
Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. 1996. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. J Biol Chem 271:3265-3271.
-
(1996)
J Biol Chem
, vol.271
, pp. 3265-3271
-
-
Wu, X.1
Noh, S.J.2
Zhou, G.3
Dixon, J.E.4
Guan, K.L.5
-
135
-
-
0034625170
-
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
-
Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. 2000. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A 97:5243-5248.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5243-5248
-
-
Xia, Y.1
Makris, C.2
Su, B.3
Li, E.4
Yang, J.5
Nemerow, G.R.6
Karin, M.7
-
136
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. 1995. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270:2008-2011.
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
-
137
-
-
9144231898
-
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
-
Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, Hikoso S, Takeda T, Watanabe T, Asahi M, Taniike M, Matsumura Y, Tsujimoto I, Hongo K, Kusakari Y, Kurihara S, Nishida K, Ichijo H, Hori M, Otsu K. 2003. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci U S A 100:15883-15888.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15883-15888
-
-
Yamaguchi, O.1
Higuchi, Y.2
Hirotani, S.3
Kashiwase, K.4
Nakayama, H.5
Hikoso, S.6
Takeda, T.7
Watanabe, T.8
Asahi, M.9
Taniike, M.10
Matsumura, Y.11
Tsujimoto, I.12
Hongo, K.13
Kusakari, Y.14
Kurihara, S.15
Nishida, K.16
Ichijo, H.17
Hori, M.18
Otsu, K.19
-
138
-
-
9644295769
-
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
-
Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. 2004. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 114:937-943.
-
(2004)
J Clin Invest
, vol.114
, pp. 937-943
-
-
Yamaguchi, O.1
Watanabe, T.2
Nishida, K.3
Kashiwase, K.4
Higuchi, Y.5
Takeda, T.6
Hikoso, S.7
Hirotani, S.8
Asahi, M.9
Taniike, M.10
Nakai, A.11
Tsujimoto, I.12
Matsumura, Y.13
Miyazaki, J.14
Chien, K.R.15
Matsuzawa, A.16
Sadamitsu, C.17
Ichijo, H.18
Baccarini, M.19
Hori, M.20
Otsu, K.21
more..
-
139
-
-
0036166289
-
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates
-
Yamanaka H, Moriguchi T, Masuyama N, Kusakabe M, Hanafusa H, Takada R, Takada S, Nishida E. 2002. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep 3:69-75.
-
(2002)
EMBO Rep
, vol.3
, pp. 69-75
-
-
Yamanaka, H.1
Moriguchi, T.2
Masuyama, N.3
Kusakabe, M.4
Hanafusa, H.5
Takada, R.6
Takada, S.7
Nishida, E.8
-
140
-
-
2942717178
-
Knockout of ERK5 causes multiple defects in placental and embryonic development
-
Yan L, Carr J, Ashby PR, Murry-Tait V, Thompson C, Arthur JS. 2003. Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol 3:11.
-
(2003)
BMC Dev Biol
, vol.3
, pp. 11
-
-
Yan, L.1
Carr, J.2
Ashby, P.R.3
Murry-Tait, V.4
Thompson, C.5
Arthur, J.S.6
-
141
-
-
0034050739
-
Mekk3 is essential for early embryonic cardiovascular development
-
Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, Su B. 2000. Mekk3 is essential for early embryonic cardiovascular development. Nat Genet 24:309-313.
-
(2000)
Nat Genet
, vol.24
, pp. 309-313
-
-
Yang, J.1
Boerm, M.2
McCarty, M.3
Bucana, C.4
Fidler, I.J.5
Zhuang, Y.6
Su, B.7
-
142
-
-
0034922161
-
The essential role of MEKK3 in TNF-induced NF-kappaB activation
-
Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B. 2001. The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol 2:620-624.
-
(2001)
Nat Immunol
, vol.2
, pp. 620-624
-
-
Yang, J.1
Lin, Y.2
Guo, Z.3
Cheng, J.4
Huang, J.5
Deng, L.6
Liao, W.7
Chen, Z.8
Liu, Z.9
Su, B.10
-
143
-
-
0042850313
-
Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells
-
Yoon MJ, Cho CH, Lee CS, Jang IH, Ryu SH, Koh GY. 2003. Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells. Biochem Biophys Res Commun 308:101-105.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 101-105
-
-
Yoon, M.J.1
Cho, C.H.2
Lee, C.S.3
Jang, I.H.4
Ryu, S.H.5
Koh, G.Y.6
-
144
-
-
0032483967
-
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
-
Yujiri T, Sather S, Fanger GR, Johnson GL. 1998. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282:1911-1914.
-
(1998)
Science
, vol.282
, pp. 1911-1914
-
-
Yujiri, T.1
Sather, S.2
Fanger, G.R.3
Johnson, G.L.4
-
145
-
-
0034691062
-
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation
-
Yujiri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler K, Oka Y, Fanger GR, Henson P, Johnson GL. 2000. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A 97:7272-7277.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7272-7277
-
-
Yujiri, T.1
Ware, M.2
Widmann, C.3
Oyer, R.4
Russell, D.5
Chan, E.6
Zaitsu, Y.7
Clarke, P.8
Tyler, K.9
Oka, Y.10
Fanger, G.R.11
Henson, P.12
Johnson, G.L.13
-
146
-
-
0042237016
-
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
-
Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y. 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 22:4443-4454.
-
(2003)
EMBO J
, vol.22
, pp. 4443-4454
-
-
Zhang, L.1
Wang, W.2
Hayashi, Y.3
Jester, J.V.4
Birk, D.E.5
Gao, M.6
Liu, C.Y.7
Kao, W.W.8
Karin, M.9
Xia, Y.10
-
147
-
-
0033605575
-
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta
-
Zhao Q, Lee FS. 1999. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. J Biol Chem 274:8355-8358.
-
(1999)
J Biol Chem
, vol.274
, pp. 8355-8358
-
-
Zhao, Q.1
Lee, F.S.2
|