Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model

Circulation Research

Volumn 107, Issue 4, 2010, Pages 549-557

  Hinton, Robert B ^a   Adelman Brown, Jennifer ^a   Witt, Sandra ^a   Krishnamurthy, Varun K ^b   Osinska, Hanna ^a   Sakthivel, Bhuvaneswari ^a   James, Jeanne F ^a   Li, Dean Y ^c   Narmoneva, Daria A ^b   Mecham, Robert P ^d   Benson, D Woodrow ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b Department of Biomedical Engineering ^*  (United States)

^c UNIVERSITY OF UTAH   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

extracellular matrix; valve disease; valvular interstitial cells

Indexed keywords

ELASTIN; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA;

AGE DISTRIBUTION; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA VALVE DISEASE; ARTICLE; BIOMECHANICS; BIRTH; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; ECHOCARDIOGRAPHY; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE EXPRESSION PROFILING; HAPLOTYPE; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; JUVENILE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TENSILE STRENGTH;

ANIMALS; AORTIC VALVE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELASTIN; HAPLOIDY; HEART VALVE DISEASES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS;

EID: 77956226707     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.221358     Document Type: Article

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