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Volumn 17, Issue 3, 2012, Pages 1120-1139

RUNX1 and RUNX1-ETO: Roles in hematopoiesis and leukemogenesis

Author keywords

AML; AML1; AML1 ETO; CBFA2; Hematopoiesis; Hematopoietic stem cells; Leukemia; Leukemogenesis; Mouse models; Review; RUNX1; RUNX1 ETO; RUNX1 RUNX1T1

Indexed keywords

ANIMALIA;

EID: 84859243940     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3977     Document Type: Article
Times cited : (137)

References (181)
  • 2
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • DOI 10.1038/287795a0
    • Nussleinvolhard, C & E. Wieschaus: Mutations Affecting Segment Number and Polarity in Drosophila. Nature 287, 795-801 (1980). (Pubitemid 11214475)
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 3
    • 0025047508 scopus 로고
    • The drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous-system
    • Kania, M A, A. S. Bonner, J. B. Duffy, & J. P. Gergen: The Drosophila Segmentation Gene Runt Encodes A Novel Nuclear Regulatory Protein That Is Also Expressed in the Developing Nervous-System. Genes & Development 4, 1701-1713 (1990).
    • (1990) Genes & Development , vol.4 , pp. 1701-1713
    • Kania, M.A.1    Bonner, A.S.2    Duffy, J.B.3    Gergen, J.P.4
  • 4
  • 5
    • 0023139734 scopus 로고
    • Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer
    • Speck, N A & D. Baltimore: 6 Distinct Nuclear Factors Interact with the 75-Base-Pair Repeat of the Moloney Murine Leukemia-Virus Enhancer. Molecular and Cellular Biology 7, 1101-1110 (1987). (Pubitemid 17017431)
    • (1987) Molecular and Cellular Biology , vol.7 , Issue.3 , pp. 1101-1110
    • Speck, N.A.1    Baltimore, D.2
  • 6
    • 0023951439 scopus 로고
    • Modulation of polyomavirus enhancer binding-proteins by ha-ras oncogene
    • Satake, M, T. Ibaraki, & Y. Ito: Modulation of Polyomavirus Enhancer Binding-Proteins by Ha-Ras Oncogene. Oncogene 3, 69-78 (1988).
    • (1988) Oncogene , vol.3 , pp. 69-78
    • Satake, M.1    Ibaraki, T.2    Ito, Y.3
  • 7
    • 0025039291 scopus 로고
    • Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer
    • Kamachi, Y, E. Ogawa, M. Asano, S. Ishida, Y. Murakami, M. Satake, Y. Ito, & K. Shigesada: Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol 64, 4808-4819 (1990). (Pubitemid 20329800)
    • (1990) Journal of Virology , vol.64 , Issue.10 , pp. 4808-4819
    • Kamachi, Y.1    Ogawa, E.2    Asano, M.3    Ishida, S.4    Murakami, Y.5    Satake, M.6    Ito, Y.7    Shigesada, K.8
  • 9
    • 0015694741 scopus 로고
    • Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia
    • Rowley, J D: Identification of A Translocation with Quinacrine Fluorescence in A Patient with Acute Leukemia. Annales de Genetique 16, 109-112 (1973).
    • (1973) Annales de Genetique , vol.16 , pp. 109-112
    • Rowley, J.D.1
  • 10
    • 0019176609 scopus 로고
    • The clinical usefulness of chromosome studies in patients with leukemia
    • Rowley, J D: The clinical usefulness of chromosome studies in patients with leukemia. Compr Ther 6, 57-64 (1980). (Pubitemid 11235525)
    • (1980) Comprehensive Therapy , vol.6 , Issue.7 , pp. 57-64
    • Rowley, J.D.1
  • 11
    • 2942516037 scopus 로고    scopus 로고
    • The 8, 21 translocation in leukemogenesis
    • Peterson, L F & D. E. Zhang: The 8, 21 translocation in leukemogenesis. Oncogene 23, 4255-4262 (2004).
    • (2004) Oncogene , vol.23 , pp. 4255-4262
    • Peterson, L.F.1    Zhang, D.E.2
  • 16
    • 0028837972 scopus 로고
    • An acute myeloid-leukemia gene, aml1, regulates hematopoietic myeloid cell-differentiation and transcriptional activation antagonistically by 2 alternative spliced forms
    • Tanaka, T, K. Tanaka, S. Ogawa, M. Kurokawa, K. Mitani, J. Nishida, Y. Shibata, Y. Yazaki, & H. Hirai: An Acute Myeloid-Leukemia Gene, Aml1, Regulates Hematopoietic Myeloid Cell-Differentiation and Transcriptional Activation Antagonistically by 2 Alternative Spliced Forms. Embo Journal 14, 341-350 (1995).
    • (1995) Embo Journal , vol.14 , pp. 341-350
    • Tanaka, T.1    Tanaka, K.2    Ogawa, S.3    Kurokawa, M.4    Mitani, K.5    Nishida, J.6    Shibata, Y.7    Yazaki, Y.8    Hirai, H.9
  • 17
    • 34249694973 scopus 로고    scopus 로고
    • Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
    • Tsuzuki, S, D. L. Hong, R. Gupta, K. Matsuo, M. Seto, & T. Enver: Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Medicine 4, 880-896 (2007).
    • (2007) PLoS Medicine , vol.4 , pp. 880-896
    • Tsuzuki, S.1    Hong, D.L.2    Gupta, R.3    Matsuo, K.4    Seto, M.5    Enver, T.6
  • 18
    • 64849104891 scopus 로고    scopus 로고
    • Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis
    • Liu, X, Q. Zhang, D. E. Zhang, C. Zhou, H. Xing, Z. Tian, Q. Rao, M. Wang, & J. Wang: Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis. Leukemia 23, 739-745 (2009).
    • (2009) Leukemia , vol.23 , pp. 739-745
    • Liu, X.1    Zhang, Q.2    Zhang, D.E.3    Zhou, C.4    Xing, H.5    Tian, Z.6    Rao, Q.7    Wang, M.8    Wang, J.9
  • 19
    • 0035862878 scopus 로고    scopus 로고
    • Expression and function of a stem cell promoter for the murine CBFα2 gene: Distinct roles and regulation in natural killer and T cell development
    • DOI 10.1006/dbio.2000.9991
    • Telfer, J C & E. V. Rothenberg: Expression and function of a stem cell promoter for the murine CBF alpha 2 gene: Distinct roles and regulation in natural killer and T cell development. Developmental Biology 229, 363-382 (2001). (Pubitemid 32108698)
    • (2001) Developmental Biology , vol.229 , Issue.2 , pp. 363-382
    • Telfer, J.C.1    Rothenberg, E.V.2
  • 21
    • 73949149029 scopus 로고    scopus 로고
    • The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis
    • Sroczynska, P, C. Lancrin, V. Kouskoff, & G. Lacaud: The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis. Blood 114, 5279-5289 (2009).
    • (2009) Blood , vol.114 , pp. 5279-5289
    • Sroczynska, P.1    Lancrin, C.2    Kouskoff, V.3    Lacaud, G.4
  • 23
    • 77951078473 scopus 로고    scopus 로고
    • Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis
    • Bee, T, G. Swiers, S. Muroi, A. Pozner, W. Nottingham, A. C. Santos, P. S. Li, I. Taniuchi, & M. F. T. R. de Bruijn: Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis. Blood 115, 3042-3050 (2010).
    • (2010) Blood , vol.115 , pp. 3042-3050
    • Bee, T.1    Swiers, G.2    Muroi, S.3    Pozner, A.4    Nottingham, W.5    Santos, A.C.6    Li, P.S.7    Taniuchi, I.8    Bruijn, M.F.T.R.D.9
  • 25
    • 78149290282 scopus 로고    scopus 로고
    • A runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells
    • Ng, C E L, T. Yokomizo, N. Yamashita, B. Cirovic, H. Jin, Z. L. Wen, Y. Ito, & M. Osato: A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells. Stem Cells 28, 1869-1881 (2010).
    • (2010) Stem Cells , vol.28 , pp. 1869-1881
    • Ng, C.E.L.1    Yokomizo, T.2    Yamashita, N.3    Cirovic, B.4    Jin, H.5    Wen, Z.L.6    Ito, Y.7    Osato, M.8
  • 28
    • 0027256023 scopus 로고
    • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    • Wang, S, Q. Wang, B. E. Crute, I. N. Melnikova, S. R. Keller, & N. A. Speck: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13, 3324-3339 (1993). (Pubitemid 23157270)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.6 , pp. 3324-3339
    • Wang, S.1    Wang, Q.2    Crute, B.E.3    Melnikova, I.N.4    Keller, S.R.5    Speck, N.A.6
  • 29
    • 0033569711 scopus 로고    scopus 로고
    • The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains
    • DOI 10.1016/S0969-2126(00)80058-1
    • Berardi, M J, C. H. Sun, M. Zehr, F. Abildgaard, J. Peng, N. A. Speck, & J. H. Bushweller: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. Structure 7, 1247-1256 (1999). (Pubitemid 29482986)
    • (1999) Structure , vol.7 , Issue.10 , pp. 1247-1256
    • Berardi, M.J.1    Sun, C.2    Zehr, M.3    Abildgaard, F.4    Peng, J.5    Speck, N.A.6    Bushweller, J.H.7
  • 31
    • 0034660045 scopus 로고    scopus 로고
    • Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFβ
    • Warren, A J, J. Bravo, R. L. Williams, & T. H. Rabbitts: Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. EMBO J 19, 3004-3015 (2000). (Pubitemid 30386771)
    • (2000) EMBO Journal , vol.19 , Issue.12 , pp. 3004-3015
    • Warren, A.J.1    Bravo, J.2    Williams, R.L.3    Rabbitts, T.H.4
  • 33
    • 0036774088 scopus 로고    scopus 로고
    • DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending
    • DOI 10.1016/S0969-2126(02)00853-5, PII S0969212602008535
    • Bartfeld, D, L. Shimon, G. C. Couture, D. Rabinovich, F. Frolow, D. Levanon, Y. Groner, & Z. Shakked: DNA recognition by the RUNX1 transcription factor is mediatedby an allosteric transition in the Runt domain and by DNA bending. Structure 10, 1395-1407 (2002). (Pubitemid 35232385)
    • (2002) Structure , vol.10 , Issue.10 , pp. 1395-1407
    • Bartfeld, D.1    Shimon, L.2    Couture, G.C.3    Rabinovich, D.4    Frolow, F.5    Levanon, D.6    Groner, Y.7    Shakked, Z.8
  • 34
    • 0031940065 scopus 로고    scopus 로고
    • Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor at subunit revealed in the presence of the β subunit
    • Kanno, T, Y. Kanno, L. F. Chen, E. Ogawa, W. Y. Kim, & Y. Ito: Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. Mol Cell Biol 18, 2444-2454 (1998). (Pubitemid 28183414)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 2444-2454
    • Kanno, T.1    Kanno, Y.2    Chen, L.-F.3    Ogawa, E.4    Kim, W.-Y.5    Ito, Y.6
  • 35
    • 0033988402 scopus 로고    scopus 로고
    • Auto-inhibition and partner proteins, core-binding factor β (CBFβ) and Ets-1, modulate DNA binding by CBFα2 (AML1)
    • Gu, T L, T. L. Goetz, B. J. Graves, & N. A. Speck: Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Mol Cell Biol 20, 91-103 (2000). (Pubitemid 30002551)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.1 , pp. 91-103
    • Gu, T.-L.1    Goetz, T.L.2    Graves, B.J.3    Speck, N.A.4
  • 39
    • 1642357581 scopus 로고    scopus 로고
    • Localization of the Domains in Runx Transcription Factors Required for the Repression of CD4 in Thymocytes
    • Telfer, J C, E. E. Hedblom, M. K. Anderson, M. N. Laurent, & E. V. Rothenberg: Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J Immunol 172, 4359-4370 (2004). (Pubitemid 38375251)
    • (2004) Journal of Immunology , vol.172 , Issue.7 , pp. 4359-4370
    • Telfer, J.C.1    Hedblom, E.E.2    Anderson, M.K.3    Laurent, M.N.4    Rothenberg, E.V.5
  • 40
    • 0028073941 scopus 로고
    • Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer
    • Gunther, C V & B. J. Graves: Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer. Mol Cell Biol 14, 7569-7580 (1994). (Pubitemid 24326423)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.11 , pp. 7569-7580
    • Gunther, C.V.1    Graves, B.J.2
  • 41
    • 0033559972 scopus 로고    scopus 로고
    • Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains
    • Kim, W Y, M. Sieweke, E. Ogawa, H. J. Wee, U. Englmeier, T. Graf, & Y. Ito: Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. EMBO J 18, 1609-1620 (1999). (Pubitemid 29127073)
    • (1999) EMBO Journal , vol.18 , Issue.6 , pp. 1609-1620
    • Kim, W.-Y.1    Sieweke, M.2    Ogawa, E.3    Wee, H.-J.4    Englmeier, U.5    Graf, T.6    Yoshiaki, I.7
  • 44
    • 0032101379 scopus 로고    scopus 로고
    • Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
    • DOI 10.1093/emboj/17.11.2994
    • Kitabayashi, I, A. Yokoyama, K. Shimizu, & M. Ohki: Interaction and functional cooperation of the leukemiaassociated factors AML1 and p300 in myeloid cell differentiation. EMBO J 17, 2994-3004 (1998). (Pubitemid 28254372)
    • (1998) EMBO Journal , vol.17 , Issue.11 , pp. 2994-3004
    • Kitabayashi, I.1    Yokoyama, A.2    Shimizu, K.3    Ohki, M.4
  • 46
    • 33744458176 scopus 로고    scopus 로고
    • Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome
    • DOI 10.1038/sj.leu.2404223, PII 2404223
    • Xu, G, R. Kanezaki, T. Toki, S. Watanabe, Y. Takahashi, K. Terui, I. Kitabayashi, & E. Ito: Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. Leukemia 20, 1002-1008 (2006). (Pubitemid 43797291)
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 1002-1008
    • Xu, G.1    Kanezaki, R.2    Toki, T.3    Watanabe, S.4    Takahashi, Y.5    Terui, K.6    Kitabayashi, I.7    Ito, E.8
  • 49
    • 0029844799 scopus 로고    scopus 로고
    • + hematopoietic progenitors: Implications for t(8;21) leukemogenesis and monitoring residual disease
    • Erickson, P F, G. Dessev, R. S. Lasher, G. Philips, M. Robinson, & H. A. Drabkin: ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8, 21) leukemogenesis and monitoring residual disease. Blood 88, 1813-1823 (1996). (Pubitemid 26307079)
    • (1996) Blood , vol.88 , Issue.5 , pp. 1813-1823
    • Erickson, P.F.1    Dessev, G.2    Lasher, R.S.3    Philips, G.4    Robinson, M.5    Drabkin, H.A.6
  • 50
    • 11144244665 scopus 로고    scopus 로고
    • Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation
    • DOI 10.1074/jbc.M405502200
    • Zhang, Y, J. R. Biggs, & A. S. Kraft: Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation. J Biol Chem 279, 53116-53125 (2004). (Pubitemid 40051813)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.51 , pp. 53116-53125
    • Zhang, Y.1    Biggs, J.R.2    Kraft, A.S.3
  • 51
    • 33749643800 scopus 로고    scopus 로고
    • AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex
    • DOI 10.1128/MCB.00597-06
    • Biggs, J R, L. F. Peterson, Y. Zhang, A. S. Kraft, & D. E. Zhang: AML1/RUNX1 phosphorylation by cyclindependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol 26, 7420-7429 (2006). (Pubitemid 44547694)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.20 , pp. 7420-7429
    • Biggs, J.R.1    Peterson, L.F.2    Zhang, Y.3    Kraft, A.S.4    Zhang, D.-E.5
  • 52
    • 38949161909 scopus 로고    scopus 로고
    • Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation
    • DOI 10.1182/blood-2007-08-109702
    • Zhang, L, F. B. Fried, H. Guo, & A. D. Friedman: Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood 111, 1193-1200 (2008). (Pubitemid 351213400)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1193-1200
    • Zhang, L.1    Fried, F.B.2    Guo, H.3    Friedman, A.D.4
  • 53
    • 33748372107 scopus 로고    scopus 로고
    • Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
    • DOI 10.1038/sj.emboj.7601273, PII 7601273
    • Aikawa, Y, L. A. Nguyen, K. Isono, N. Takakura, Y. Tagata, M. L. Schmitz, H. Koseki, & I. Kitabayashi: Roles of HIPK1 and HIPK2 in in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J 25, 3955-3965 (2006). (Pubitemid 44338738)
    • (2006) EMBO Journal , vol.25 , Issue.17 , pp. 3955-3965
    • Aikawa, Y.1    Nguyen, L.A.2    Isono, K.3    Takakura, N.4    Tagata, Y.5    Schmitz, M.L.6    Koseki, H.7    Kitabayashi, I.8
  • 54
    • 55749091957 scopus 로고    scopus 로고
    • PEBP2- beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: Implications for leukemogenesis
    • Wee, H J, D. C. C. Voon, S. C. Bae, & Y. Ito: PEBP2- beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood 112, 3777-3787 (2008).
    • (2008) Blood , vol.112 , pp. 3777-3787
    • Wee, H.J.1    Voon, D.C.C.2    Bae, S.C.3    Ito, Y.4
  • 55
    • 78650941326 scopus 로고    scopus 로고
    • Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3
    • &
    • Guo, H & A. D. Friedman: Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3. J Biol Chem 286, 208-215 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 208-215
    • Guo, H.1    Friedman, A.D.2
  • 56
    • 0037335034 scopus 로고    scopus 로고
    • How the ubiquitin-proteasome system controls transcription
    • DOI 10.1038/nrm1049
    • Muratani, M & W. P. Tansey: How the ubiquitinproteasome system controls transcription. Nat Rev Mol Cell Biol 4, 192-201 (2003). (Pubitemid 36288041)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.3 , pp. 192-201
    • Muratani, M.1    Tansey, W.P.2
  • 57
    • 0035865459 scopus 로고    scopus 로고
    • Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
    • DOI 10.1093/emboj/20.4.723
    • Huang, G, K. Shigesada, K. Ito, H. J. Wee, T. Yokomizo, & Y. Ito: Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin- proteasomemediated degradation. EMBO J 20, 723-733 (2001). (Pubitemid 32167637)
    • (2001) EMBO Journal , vol.20 , Issue.4 , pp. 723-733
    • Huang, G.1    Shigesada, K.2    Ito, K.3    Wee, H.-J.4    Yokomizo, T.5    Ito, Y.6
  • 60
    • 0033405452 scopus 로고    scopus 로고
    • Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    • Palis, J, S. Robertson, M. Kennedy, C. Wall, & G. Keller: Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126, 5073-5084 (1999). (Pubitemid 30000420)
    • (1999) Development , vol.126 , Issue.22 , pp. 5073-5084
    • Palis, J.1    Robertson, S.2    Kennedy, M.3    Wall, C.4    Keller, G.5
  • 61
    • 0027178567 scopus 로고
    • An early pre-liver intraembryonic source of CFU-S in the developing mouse
    • DOI 10.1038/364064a0
    • Medvinsky, A L, N. L. Samoylina, A. M. Muller, & E. A. Dzierzak: An Early Pre-Liver Intra-Embryonic Source of Cfu-S in the Developing Mouse. Nature 364, 64-67 (1993). (Pubitemid 23233456)
    • (1993) Nature , vol.364 , Issue.6432 , pp. 64-67
    • Medvinsky, A.L.1    Samoylina, N.L.2    Muller, A.M.3    Dzierzak, E.A.4
  • 62
    • 0030595341 scopus 로고    scopus 로고
    • Definitive hematopoiesis is autonomously initiated by the AGM region
    • DOI 10.1016/S0092-8674(00)80165-8
    • Medvinsky, A & E. Dzierzak: Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 86, 897- 906 (1996). (Pubitemid 26336794)
    • (1996) Cell , vol.86 , Issue.6 , pp. 897-906
    • Medvinsky, A.1    Dzierzak, E.2
  • 64
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • DOI 10.1016/S0092-8674(00)80986-1
    • Okuda, T, van Deursen J., S. W. Hiebert, G. Grosveld, & J. R. Downing: AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321- 330 (1996). (Pubitemid 26042836)
    • (1996) Cell , vol.84 , Issue.2 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 67
    • 60149110371 scopus 로고    scopus 로고
    • The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage
    • Lancrin, C, P. Sroczynska, C. Stephenson, T. Allen, V. Kouskoff, & G. Lacaud: The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature 457, 892-895 (2009).
    • (2009) Nature , vol.457 , pp. 892-895
    • Lancrin, C.1    Sroczynska, P.2    Stephenson, C.3    Allen, T.4    Kouskoff, V.5    Lacaud, G.6
  • 68
    • 60149100010 scopus 로고    scopus 로고
    • Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
    • Chen, M J, T. Yokomizo, B. M. Zeigler, E. Dzierzak, & N. A. Speck: Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 457, 887-891 (2009).
    • (2009) Nature , vol.457 , pp. 887-891
    • Chen, M.J.1    Yokomizo, T.2    Zeigler, B.M.3    Dzierzak, E.4    Speck, N.A.5
  • 69
    • 9444264705 scopus 로고    scopus 로고
    • Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors
    • DOI 10.1182/blood-2003-12-4349
    • Sun, W & J. R. Downing: Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors. Blood 104, 3565-3572 (2004). (Pubitemid 39564428)
    • (2004) Blood , vol.104 , Issue.12 , pp. 3565-3572
    • Sun, W.1    Downing, J.R.2
  • 70
    • 2342451948 scopus 로고    scopus 로고
    • AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    • DOI 10.1038/nm997
    • Ichikawa, M, T. Asai, T. Saito, S. Seo, I. Yamazaki, T. Yamagata, K. Mitani, S. Chiba, S. Ogawa, M. Kurokawa, & H. Hirai: AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med 10, 299-304 (2004). (Pubitemid 38667622)
    • (2004) Nature Medicine , vol.10 , Issue.3 , pp. 299-304
    • Ichikawa, M.1    Asai, T.2    Saito, T.3    Yamamoto, G.4    Seo, S.5    Yamazaki, I.6    Yamagata, T.7    Mitani, K.8    Chiba, S.9    Hirai, H.10    Ogawa, S.11    Kurokawa, M.12
  • 72
    • 32544445732 scopus 로고    scopus 로고
    • AML1 deletion in adult mice causes splenomegaly and lymphomas
    • DOI 10.1038/sj.onc.1209136, PII 1209136
    • Putz, G, A. Rosner, I. Nuesslein, N. Schmitz, & F. Buchholz: AML1 deletion in adult mice causes splenomegaly and lymphomas. Oncogene 25, 929-939 (2006). (Pubitemid 43237711)
    • (2006) Oncogene , vol.25 , Issue.6 , pp. 929-939
    • Putz, G.1    Rosner, A.2    Nuesslein, I.3    Schmitz, N.4    Buchholz, F.5
  • 73
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R, F. Schwenk, M. Aguet, & K. Rajewsky: Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 75
    • 77949888952 scopus 로고    scopus 로고
    • Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
    • Jacob, B, M. Osato, N. Yamashita, C. Q. Wang, I. Taniuchi, D. R. Littman, N. Asou, & Y. Ito: Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood 115, 1610-1620 (2010).
    • (2010) Blood , vol.115 , pp. 1610-1620
    • Jacob, B.1    Osato, M.2    Yamashita, N.3    Wang, C.Q.4    Taniuchi, I.5    Littman, D.R.6    Asou, N.7    Ito, Y.8
  • 77
    • 0027383818 scopus 로고
    • Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions
    • Meyers, S, J. R. Downing, & S. W. Hiebert: Identification of AML-1 and the (8, 21) translocation protein (AML- 1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNAbinding and protein-protein interactions. Mol Cell Biol 13, 6336-6345 (1993). (Pubitemid 23292627)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.10 , pp. 6336-6345
    • Meyers, S.1    Downing, J.R.2    Hiebert, S.W.3
  • 78
    • 0028209966 scopus 로고
    • Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting
    • Cameron, S, D. S. Taylor, E. C. TePas, N. A. Speck, & B. Mathey-Prevot: Identification of a critical regulatory site in the human interleukin- 3 promoter by in vivo footprinting. Blood 83, 2851-2859 (1994). (Pubitemid 24142716)
    • (1994) Blood , vol.83 , Issue.10 , pp. 2851-2859
    • Cameron, S.1    Taylor, D.S.2    TePas, E.C.3    Speck, N.A.4    Mathey-Prevot, B.5
  • 79
    • 0028998584 scopus 로고
    • Positive and negative regulation of granulocytemacrophage colony- stimulating factor promoter activity by AML1-Related transcription factor, PEBP2
    • Takahashi, A, M. Satake, Y. Yamaguchi-Iwai, S. C. Bae, J. Lu, M. Maruyama, Y. W. Zhang, H. Oka, N. Arai, & K. Arai: Positive and negative regulation of granulocytemacrophage colony- stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood 86, 607- 616 (1995).
    • (1995) Blood , vol.86 , pp. 607-616
    • Takahashi, A.1    Satake, M.2    Yamaguchi-Iwai, Y.3    Bae, S.C.4    Lu, J.5    Maruyama, M.6    Zhang, Y.W.7    Oka, H.8    Arai, N.9    Arai, K.10
  • 80
    • 0027984233 scopus 로고
    • Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
    • Zhang, D E, K. Fujioka, C. J. Hetherington, L. H. Shapiro, H. M. Chen, A. T. Look, & D. G. Tenen: Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol 14, 8085-8095 (1994). (Pubitemid 24373557)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.12 , pp. 8085-8095
    • Zhang, D.-E.1    Fujioka, K.-I.2    Hetherington, C.J.3    Shapiro, L.H.4    Chen, H.-M.5    Look, A.T.6    Tenen, D.G.7
  • 82
    • 0028066779 scopus 로고
    • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
    • Nuchprayoon, I, S. Meyers, L. M. Scott, J. Suzow, S. Hiebert, & A. D. Friedman: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14, 5558-5568 (1994). (Pubitemid 24235984)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.8 , pp. 5558-5568
    • Nuchprayoon, I.1    Meyers, S.2    Scott, L.M.3    Suzow, J.4    Hiebert, S.5    Friedman, A.D.6
  • 83
    • 0033549843 scopus 로고    scopus 로고
    • Synergy of PEBP2/CBF with mi transcription factor (MITF) for transactivation of mouse mast cell protease 6 gene
    • DOI 10.1038/sj.onc.1202844
    • Ogihara, H, T. Kanno, E. Morii, D. K. Kim, Y. M. Lee, M. Sato, W. Y. Kim, S. Nomura, Y. Ito, & Y. Kitamura: Synergy of PEBP2/CBF with mi transcription factor (MITF) for transactivation of mouse mast cell protease 6 gene. Oncogene 18, 4632-4639 (1999). (Pubitemid 29405895)
    • (1999) Oncogene , vol.18 , Issue.32 , pp. 4632-4639
    • Ogihara, H.1    Kanno, T.2    Morii, E.3    Kim, D.-K.4    Lee, Y.-M.5    Sato, M.6    Kim, W.-Y.7    Nomura, S.8    Ito, Y.9    Kitamura, Y.10
  • 84
    • 0027158441 scopus 로고
    • The role of viral enhancer 'core' motif-related sequences in regulating T cell receptor-γ and -δ gene expression
    • Hsiang, Y H, D. Spencer, S. Wang, N. A. Speck, & D. H. Raulet: The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression. J Immunol 150, 3905-3916 (1993). (Pubitemid 23129772)
    • (1993) Journal of Immunology , vol.150 , Issue.9 , pp. 3905-3916
    • Hsiang, Y.-H.H.1    Spencer, D.2    Wang, S.3    Speck, N.A.4    Raulet, D.H.5
  • 85
    • 0029036085 scopus 로고
    • Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins
    • Sun, W, B. J. Graves, & N. A. Speck: Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins. J Virol 69, 4941-4949 (1995).
    • (1995) J Virol , vol.69 , pp. 4941-4949
    • Sun, W.1    Graves, B.J.2    Speck, N.A.3
  • 86
    • 0034666292 scopus 로고    scopus 로고
    • Polyomavirus enhancer-binding protein 2/core binding factor/acute myeloid leukemia factors contribute to the cell type-specific activity of the CD11a integrin gene promoter
    • Puig-Kroger, A, C. Lopez-Rodriguez, M. Relloso, T. Sanchez-Elsner, A. Nueda, E. Munoz, C. Bernabeu, & A. L. Corbi: Polyomavirus enhancer-binding protein 2/core binding factor/acute myeloid leukemia factors contribute to the cell type-specific activity of the CD11a integrin gene promoter. J Biol Chem 275, 28507-28512 (2000).
    • (2000) J Biol Chem , vol.275 , pp. 28507-28512
    • Puig-Kroger, A.1    Lopez-Rodriguez, C.2    Relloso, M.3    Sanchez-Elsner, T.4    Nueda, A.5    Munoz, E.6    Bernabeu, C.7    Corbi, A.L.8
  • 87
    • 0033609568 scopus 로고    scopus 로고
    • AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cellspecific BLK gene promoter
    • Libermann, T A, Z. Pan, Y. Akbarali, C. J. Hetherington, J. Boltax, D. A. Yergeau, & D. E. Zhang: AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cellspecific BLK gene promoter. J Biol Chem 274, 24671- 24676 (1999).
    • (1999) J Biol Chem , vol.274 , pp. 24671-24676
    • Libermann, T.A.1    Pan, Z.2    Akbarali, Y.3    Hetherington, C.J.4    Boltax, J.5    Yergeau, D.A.6    Zhang, D.E.7
  • 88
    • 0034595970 scopus 로고    scopus 로고
    • Transcriptional regulation of the transforming growth factor-β- inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members
    • DOI 10.1074/jbc.M001526200
    • Zhang, Y & R. Derynck: Transcriptional regulation of the transforming growth factor-beta - inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members. J Biol Chem 275, 16979-16985 (2000). (Pubitemid 30398938)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16979-16985
    • Zhang, Y.1    Derynck, R.2
  • 89
    • 0031951663 scopus 로고    scopus 로고
    • ETS-core binding factor: A common composite motif in antigen receptor gene enhancers
    • Erman, B, M. Cortes, B. S. Nikolajczyk, N. A. Speck, & R. Sen: ETS-core binding factor: a common composite motif in antigen receptor gene enhancers. Mol Cell Biol 18, 1322-1330 (1998). (Pubitemid 28100896)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.3 , pp. 1322-1330
    • Erman, B.1    Cortes, M.2    Nikolajczyk, B.S.3    Speck, N.A.4    Sen, R.5
  • 91
    • 70350451993 scopus 로고    scopus 로고
    • Runx-CBF beta complexes control expression of the transcription factor Foxp3 in regulatory T cells
    • Rudra, D, T. Egawa, M. M. W. Chong, P. Treuting, D. R. Littman, & A. Y. Rudensky: Runx-CBF beta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nature Immunology 10, 1170-1U53 (2009).
    • (2009) Nature Immunology , vol.10
    • Rudra, D.1    Egawa, T.2    Chong, M.M.W.3    Treuting, P.4    Littman, D.R.5    Rudensky, A.Y.6
  • 94
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
    • Osato M., Asou N., Abdalla E., Hoshino K., Yamasaki H., Okubo T., Suzushima H., Takatsuki K., Kanno T., Shigesada K., & Ito Y.: Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2aB gene associated with myeloblastic leukemias. Blood 93, 1817- 1824 (1999). (Pubitemid 29128481)
    • (1999) Blood , vol.93 , Issue.6 , pp. 1817-1824
    • Osato, M.1    Asou, N.2    Abdalla, E.3    Hoshino, K.4    Yamasaki, H.5    Okubo, T.6    Suzushima, H.7    Takatsuki, K.8    Kanno, T.9    Shigesada, K.10    Ito, Y.11
  • 99
    • 20444399868 scopus 로고    scopus 로고
    • Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation
    • DOI 10.1182/blood-2005-01-0050
    • Heller, P G, A. C. Glembotsky, M. J. Gandhi, C. L. Cummings, C. J. Pirola, R. F. Marta, L. I. Kornblihtt, J. G. Drachman, & F. C. Molinas: Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation. Blood 105, 4664-4670 (2005). (Pubitemid 40807286)
    • (2005) Blood , vol.105 , Issue.12 , pp. 4664-4670
    • Heller, P.G.1    Glembotsky, A.C.2    Gandhi, M.J.3    Cummings, C.L.4    Pirola, C.J.5    Marta, R.F.6    Kornblihtt, L.I.7    Drachman, J.G.8    Molinas, F.C.9
  • 100
    • 77957739491 scopus 로고    scopus 로고
    • Identification and molecular characterization of a novel 3 mutation in RUNX1 in a family with familial platelet disorder
    • Churpek, J E, J. S. Garcia, J. Madzo, S. A. Jackson, K. Onel, & L. A. Godley: Identification and molecular characterization of a novel 3 ' mutation in RUNX1 in a family with familial platelet disorder. Leukemia & Lymphoma 51, 1931-1935 (2010).
    • (2010) Leukemia & Lymphoma , vol.51 , pp. 1931-1935
    • Churpek, J.E.1    Garcia, J.S.2    Madzo, J.3    Jackson, S.A.4    Onel, K.5    Godley, L.A.6
  • 101
    • 73949129831 scopus 로고    scopus 로고
    • AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
    • Ding, Y, Y. Harada, J. Imagawa, A. Kimura, & H. Harada: AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. Blood 114, 5201-5205 (2009).
    • (2009) Blood , vol.114 , pp. 5201-5205
    • Ding, Y.1    Harada, Y.2    Imagawa, J.3    Kimura, A.4    Harada, H.5
  • 102
    • 77955507360 scopus 로고    scopus 로고
    • AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617Findependent overexpression of NF-E2
    • Wang, W, S. Schwemmers, E. O. Hexner, & H. L. Pahl: AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617Findependent overexpression of NF-E2. Blood 116, 254-266 (2010).
    • (2010) Blood , vol.116 , pp. 254-266
    • Wang, W.1    Schwemmers, S.2    Hexner, E.O.3    Pahl, H.L.4
  • 104
    • 68749109365 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation
    • Kuo, M C, D. C. Liang, C. F. Huang, Y. S. Shih, J. H. Wu, T. L. Lin, & L. Y. Shih: RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. Leukemia 23, 1426-1431 (2009).
    • (2009) Leukemia , vol.23 , pp. 1426-1431
    • Kuo, M.C.1    Liang, D.C.2    Huang, C.F.3    Shih, Y.S.4    Wu, J.H.5    Lin, T.L.6    Shih, L.Y.7
  • 105
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • DOI 10.1126/science.278.5340.1059
    • Look, A T: Oncogenic transcription factors in the human acute leukemias. Science 278, 1059-1064 (1997). (Pubitemid 27517875)
    • (1997) Science , vol.278 , Issue.5340 , pp. 1059-1064
    • Look, A.T.1
  • 107
    • 2942682886 scopus 로고    scopus 로고
    • Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia
    • DOI 10.1038/sj.onc.1207672
    • Zelent, A, M. Greaves, & T. Enver: Role of the TELAML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene 23, 4275-4283 (2004). (Pubitemid 38765136)
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4275-4283
    • Zelent, A.1    Greaves, M.2    Enver, T.3
  • 108
    • 0023551998 scopus 로고
    • Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia
    • Rubin, C M, R. A. Larson, M. A. Bitter, J. J. Carrino, M. M. LeBeau, M. O. Diaz, & J. D. Rowley: Association of A Chromosomal 3-21 Translocation with the Blast Phase of Chronic Myelogenous Leukemia. Blood 70, 1338-1342 (1987). (Pubitemid 18026135)
    • (1987) Blood , vol.70 , Issue.5 , pp. 1338-1342
    • Rubin, C.M.1    Larson, R.A.2    Bitter, M.A.3    Carrino, J.J.4    Le Beau, M.M.5    Diaz, M.O.6    Rowley, J.D.7
  • 109
    • 0025689037 scopus 로고
    • T(3-21)(Q26-Q22) - A recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid-leukemia
    • Rubin, C M, R. A. Larson, J. Anastasi, J. N. Winter, M. Thangavelu, J. W. Vardiman, J. D. Rowley, & M. M. LeBeau: T(3-21)(Q26-Q22) - A Recurring Chromosomal Abnormality in Therapy-Related Myelodysplastic Syndrome and Acute Myeloid-Leukemia. Blood 76, 2594- 2598 (1990).
    • (1990) Blood , vol.76 , pp. 2594-2598
    • Rubin, C.M.1    Larson, R.A.2    Anastasi, J.3    Winter, J.N.4    Thangavelu, M.5    Vardiman, J.W.6    Rowley, J.D.7    Lebeau, M.M.8
  • 112
    • 0032101547 scopus 로고    scopus 로고
    • The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family
    • Gamou, T, E. Kitamura, F. Hosoda, K. Shimizu, K. Shinohara, Y. Hayashi, T. Nagase, Y. Yokoyama, & M. Ohki: The partner gene of AML1 in t(16, 21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood 91, 4028-4037 (1998). (Pubitemid 28261962)
    • (1998) Blood , vol.91 , Issue.11 , pp. 4028-4037
    • Gamou, T.1    Kitamura, E.2    Hosoda, F.3    Shimizu, K.4    Shinohara, K.5    Hayashi, Y.6    Nagase, T.7    Yokoyama, Y.8    Ohki, M.9
  • 114
    • 0026757174 scopus 로고
    • Identification of breakpoints in t(8, 21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • Erickson, P, J. Gao, K. S. Chang, T. Look, E. Whisenant, S. Raimondi, R. Lasher, J. Trujillo, J. Rowley, & H. Drabkin: Identification of breakpoints in t(8, 21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80, 1825-1831 (1992).
    • (1992) Blood , vol.80 , pp. 1825-1831
    • Erickson, P.1    Gao, J.2    Chang, K.S.3    Look, T.4    Whisenant, E.5    Raimondi, S.6    Lasher, R.7    Trujillo, J.8    Rowley, J.9    Drabkin, H.10
  • 115
    • 0027218725 scopus 로고
    • The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
    • Miyoshi, H, T. Kozu, K. Shimizu, K. Enomoto, N. Maseki, Y. Kaneko, N. Kamada, & M. Ohki: The t(8, 21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12, 2715-2721 (1993). (Pubitemid 23218321)
    • (1993) EMBO Journal , vol.12 , Issue.7 , pp. 2715-2721
    • Miyoshi, H.1    Kozu, T.2    Shimizu, K.3    Enomoto, K.4    Maseki, N.5    Kaneko, Y.6    Kamada, N.7    Ohki, M.8
  • 116
    • 0028136090 scopus 로고
    • Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative(8) chromosome in the t(8;21) of acute myeloid leukemia M2
    • Tighe, J E & F. Calabi: Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8, 21) of acute myeloid leukemia M2. Blood 84, 2115-2121 (1994). (Pubitemid 24296366)
    • (1994) Blood , vol.84 , Issue.7 , pp. 2115-2121
    • Tighe, J.E.1    Calabi, F.2
  • 117
    • 0029128001 scopus 로고
    • T(8, 21) breakpoints are clustered between alternatively spliced exons of MTG8
    • Tighe, J E & F. Calabi: t(8, 21) breakpoints are clustered between alternatively spliced exons of MTG8. Clin Sci (Lond) 89, 215-218 (1995).
    • (1995) Clin Sci (Lond) , vol.89 , pp. 215-218
    • Tighe, J.E.1    Calabi, F.2
  • 119
    • 34547941839 scopus 로고    scopus 로고
    • Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts
    • DOI 10.1182/blood-2006-11-019265
    • Peterson, L F, A. Boyapati, E. Y. Ahn, J. R. Biggs, O. A. Joo, M. C. Lo, M. Yan, & D. E. Zhang: Acute myeloid leukemia with the 8q22, 21q22 translocation: secondary mutational events and alternative t(8, 21) transcripts. Blood 110: 799-805 (2007). (Pubitemid 47267414)
    • (2007) Blood , vol.110 , Issue.3 , pp. 799-805
    • Peterson, L.F.1    Boyapati, A.2    Ahn, E.-Y.3    Biggs, J.R.4    Akiko, J.O.5    Lo, M.-C.6    Yan, M.7    Zhang, D.-E.8
  • 120
    • 0034928794 scopus 로고    scopus 로고
    • Gene targeting reveals a crucial role for MTG8 in the gut
    • DOI 10.1128/MCB.21.16.5658-5666.2001
    • Calabi, F, R. Pannell, & G. Pavloska: Gene targeting reveals a crucial role for MTG8 in the gut. Mol Cell Biol 21, 5658-5666 (2001). (Pubitemid 32702468)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.16 , pp. 5658-5666
    • Calabi, F.1    Pannell, R.2    Pavloska, G.3
  • 121
    • 0032554767 scopus 로고    scopus 로고
    • Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells
    • Sacchi, N, F. Tamanini, R. Willemsen, S. Denis- Donini, S. Campiglio, & A. T. Hoogeveen: Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells. Oncogene 16, 2609-2615 (1998). (Pubitemid 28264038)
    • (1998) Oncogene , vol.16 , Issue.20 , pp. 2609-2615
    • Sacchi, N.1    Tamanini, F.2    Willemsen, R.3    Denis-Donini, S.4    Campiglio, S.5    Hoogeveen, A.T.6
  • 122
    • 67650783203 scopus 로고    scopus 로고
    • Regional expression of MTG genes in the developing mouse central nervous system
    • Alishahi, A, N. Koyano-Nakagawa, & Y. Nakagawa: Regional Expression of MTG Genes in the Developing Mouse Central Nervous System. Developmental Dynamics 238, 2095-2102 (2009).
    • (2009) Developmental Dynamics , vol.238 , pp. 2095-2102
    • Alishahi, A.1    Koyano-Nakagawa, N.2    Nakagawa, Y.3
  • 123
    • 0032575037 scopus 로고    scopus 로고
    • Structure and expression of the human MTG8/ETO gene
    • DOI 10.1016/S0378-1119(98)00141-3, PII S0378111998001413
    • Wolford, J K & M. Prochazka: Structure and expression of the human MTG8/ETO gene. Gene 212, 103- 109 (1998). (Pubitemid 28269138)
    • (1998) Gene , vol.212 , Issue.1 , pp. 103-109
    • Wolford, J.K.1    Prochazka, M.2
  • 124
    • 0028267241 scopus 로고
    • The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor
    • Erickson, P F, M. Robinson, G. Owens, & H. A. Drabkin: The Eto Portion of Acute Myeloid-Leukemia T(8- 21) Fusion Transcript Encodes A Highly Evolutionarily Conserved, Putative Transcription Factor. Cancer Research 54, 1782-1786 (1994). (Pubitemid 24116186)
    • (1994) Cancer Research , vol.54 , Issue.7 , pp. 1782-1786
    • Erickson, P.F.1    Robinson, M.2    Owens, G.3    Drabkin, H.A.4
  • 125
    • 51649109222 scopus 로고    scopus 로고
    • T(8, 21)(q22, q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNAbinding sequences to differentially regulate gene expression
    • Okumura, A J, L. F. Peterson, F. Okumura, A. Boyapati, & D. E. Zhang: t(8, 21)(q22, q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNAbinding sequences to differentially regulate gene expression. Blood 112, 1392-1401 (2008).
    • (2008) Blood , vol.112 , pp. 1392-1401
    • Okumura, A.J.1    Peterson, L.F.2    Okumura, F.3    Boyapati, A.4    Zhang, D.E.5
  • 126
    • 0029042845 scopus 로고
    • Identification of homeotic target genes in Drosophila melanogaster including nervy, a protooncogene homologue
    • Feinstein, P G, K. Kornfeld, D. S. Hogness, & R. S. Mann: Identification of homeotic target genes in Drosophila melanogaster including nervy, a protooncogene homologue. Genetics 140, 573-586 (1995).
    • (1995) Genetics , vol.140 , pp. 573-586
    • Feinstein, P.G.1    Kornfeld, K.2    Hogness, D.S.3    Mann, R.S.4
  • 127
    • 1242284592 scopus 로고    scopus 로고
    • Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion
    • DOI 10.1126/science.1092121
    • Terman, J R & A. L. Kolodkin: Nervy links protein kinase a to plexin-mediated semaphorin repulsion. Science 303, 1204-1207 (2004). (Pubitemid 38233588)
    • (2004) Science , vol.303 , Issue.5661 , pp. 1204-1207
    • Therman, J.R.1    Kolodkin, A.L.2
  • 128
    • 0035959806 scopus 로고    scopus 로고
    • MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes
    • DOI 10.1038/sj.onc.1204794
    • Fukuyama, T, E. Sueoka, Y. Sugio, T. Otsuka, Y. Niho, K. Akagi, & T. Kozu: MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMPdependent protein kinase in lymphocytes. Oncogene 20, 6225-6232 (2001). (Pubitemid 32964435)
    • (2001) Oncogene , vol.20 , Issue.43 , pp. 6225-6232
    • Fukuyama, T.1    Sueoka, E.2    Sugio, Y.3    Otsuka, T.4    Niho, Y.5    Akagi, K.6    Kozu, T.7
  • 130
    • 34249812945 scopus 로고    scopus 로고
    • Structural Basis for Recognition of SMRT/N-CoR by the MYND Domain and Its Contribution to AML1/ETO's Activity
    • DOI 10.1016/j.ccr.2007.04.010, PII S1535610807001171
    • Liu, Y, W. Chen, J. Gaudet, M. D. Cheney, L. Roudaia, T. Cierpicki, R. C. Klet, K. Hartman, T. M. Laue, N. A. Speck, & J. H. Bushweller: Structural Basis for Recognition of SMRT/N-CoR by the MYND Domain and Its Contribution to AML1/ETO's Activity. Cancer Cell 11, 483-497 (2007). (Pubitemid 46856906)
    • (2007) Cancer Cell , vol.11 , Issue.6 , pp. 483-497
    • Liu, Y.1    Chen, W.2    Gaudet, J.3    Cheney, M.D.4    Roudaia, L.5    Cierpicki, T.6    Klet, R.C.7    Hartman, K.8    Laue, T.M.9    Speck, N.A.10    Bushweller, J.H.11
  • 131
    • 4344669438 scopus 로고    scopus 로고
    • E protein silencing by the leukemogenic AML1-ETO fusion protein
    • DOI 10.1126/science.1097937
    • Zhang, J, M. Kalkum, S. Yamamura, B. T. Chait, & R. G. Roeder: E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 305, 1286-1289 (2004). (Pubitemid 39129232)
    • (2004) Science , vol.305 , Issue.5688 , pp. 1286-1289
    • Zhang, J.1    Kalkum, M.2    Yamamura, S.3    Chait, B.T.4    Roeder, R.G.5
  • 138
    • 0027944548 scopus 로고
    • Molecular diversity in AML1/ETO fusion transcripts in patients with t(8;21) positive acute myeloid leukaemia
    • van de Locht, L T, T. F. Smetsers, S. Wittebol, R. A. Raymakers, & E. J. Mensink: Molecular diversity in AML1/ETO fusion transcripts in patients with t(8, 21) positive acute myeloid leukaemia. Leukemia 8, 1780-1784 (1994). (Pubitemid 24323799)
    • (1994) Leukemia , vol.8 , Issue.10 , pp. 1780-1784
    • Van De Locht, L.T.F.1    Smetsers, T.F.C.M.2    Wittebol, S.3    Raymakers, R.A.P.4    Mensink, E.J.B.M.5
  • 139
    • 0034252564 scopus 로고    scopus 로고
    • Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse
    • Buchholz, F, Y. Refaeli, A. Trumpp, & J. M. Bishop: Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Reports 1, 133-139 (2000).
    • (2000) EMBO Reports , vol.1 , pp. 133-139
    • Buchholz, F.1    Refaeli, Y.2    Trumpp, A.3    Bishop, J.M.4
  • 140
    • 0036463950 scopus 로고    scopus 로고
    • Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
    • DOI 10.1016/S1535-6108(02)00016-8
    • Higuchi, M, D. O'Brien, P. Kumaravelu, N. Lenny, E. J. Yeoh, & J. R. Downing: Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8, 21) acute myeloid leukemia. Cancer Cell 1, 63-74 (2002). (Pubitemid 41039177)
    • (2002) Cancer Cell , vol.1 , Issue.1 , pp. 63-74
    • Higuchi, M.1    O'Brien, D.2    Kumaravelu, P.3    Lenny, N.4    Yeoh, E.-J.5    Downing, J.R.6
  • 143
    • 77950959049 scopus 로고    scopus 로고
    • NHR4 domain mutations of ETO are probably very infrequent in AML1-ETO positive myeloid leukemia cells
    • Hackanson, B, M. Abdelkarim, J. H. Jansen, & M. Lubbert: NHR4 domain mutations of ETO are probably very infrequent in AML1-ETO positive myeloid leukemia cells. Leukemia 24, 860-861 (2010).
    • (2010) Leukemia , vol.24 , pp. 860-861
    • Hackanson, B.1    Abdelkarim, M.2    Jansen, J.H.3    Lubbert, M.4
  • 144
    • 43249104204 scopus 로고    scopus 로고
    • Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARα
    • DOI 10.1096/fj.06-8050com
    • Kramer, O H, S. Muller, M. Buchwald, S. Reichardt, & T. Heinzel: Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. FASEB J 22, 1369-1379 (2008). (Pubitemid 351656778)
    • (2008) FASEB Journal , vol.22 , Issue.5 , pp. 1369-1379
    • Kramer, O.H.1    Muller, S.2    Buchwald, M.3    Reichardt, S.4    Heinzel, T.5
  • 145
    • 39149132106 scopus 로고    scopus 로고
    • Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity
    • DOI 10.1038/sj.leu.2405020, PII 2405020
    • Lu, Y, Z. G. Peng, T. T. Yuan, Q. Q. Yin, L. Xia, & G. Q. Chen: Multi-sites cleavage of leukemogenic AML1- ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. Leukemia 22, 378-386 (2008). (Pubitemid 351250543)
    • (2008) Leukemia , vol.22 , Issue.2 , pp. 378-386
    • Lu, Y.1    Peng, Z.-G.2    Yuan, T.-T.3    Yin, Q.-Q.4    Xia, L.5    Chen, G.-Q.6
  • 146
    • 67749147576 scopus 로고    scopus 로고
    • A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO
    • Osman, D, V. Gobert, F. Ponthan, O. Heidenreich, M. Haenlin, & L. Waltzer: A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO. Proc Natl Acad Sci USA 106, 12043- 12048 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12043-12048
    • Osman, D.1    Gobert, V.2    Ponthan, F.3    Heidenreich, O.4    Haenlin, M.5    Waltzer, L.6
  • 147
    • 38949180229 scopus 로고    scopus 로고
    • AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression
    • DOI 10.1242/dev.008904
    • Yeh, J R J, K. M. Munson, Y. L. Chao, Q. P. Peterson, C. A. Macrae, & R. T. Peterson: AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development 135, 401-410 (2008). (Pubitemid 351228431)
    • (2008) Development , vol.135 , Issue.2 , pp. 401-410
    • Yeh, J.-R.J.1    Munson, K.M.2    Chao, Y.L.3    Peterson, Q.P.4    MacRae, C.A.5    Peterson, R.T.6
  • 150
    • 0032079424 scopus 로고    scopus 로고
    • Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors
    • Okuda, T, Z. Cai, S. Yang, N. Lenny, C. Lyu, van Deursen JMA, H. Harada, & J. R. Downing: Expression of a knocked-In AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood 91, 3134-3143 (1998). (Pubitemid 28193861)
    • (1998) Blood , vol.91 , Issue.9 , pp. 3134-3143
    • Okuda, T.1    Cai, Z.2    Yang, S.3    Lenny, N.4    Lyu, C.-J.5    Van Deursen, J.M.A.6    Harada, H.7    Downing, J.R.8
  • 153
    • 0036317908 scopus 로고    scopus 로고
    • Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
    • DOI 10.1128/MCB.22.15.5506-5517.2002
    • de Guzman, C G, A. J. Warren, Z. Zhang, L. Gartland, P. Erickson, H. Drabkin, S. W. Hiebert, & C. A. Klug: Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol Cell Biol 22, 5506-5517 (2002). (Pubitemid 34755760)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.15 , pp. 5506-5517
    • De Guzman, C.G.1    Warren, A.J.2    Zhang, Z.3    Gartland, L.4    Erickson, P.5    Drabkin, H.6    Hiebert, S.W.7    Klug, C.A.8
  • 154
    • 0037020837 scopus 로고    scopus 로고
    • AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency
    • DOI 10.1084/jem.20020824
    • Schwieger, M, J. Lohler, J. Friel, M. Scheller, I. Horak, & C. Stocking: AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med 196, 1227-1240 (2002). (Pubitemid 35304188)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.9 , pp. 1227-1240
    • Schwieger, M.1    Lohler, J.2    Friel, J.3    Scheller, M.4    Horak, I.5    Stocking, C.6
  • 157
    • 0345167904 scopus 로고    scopus 로고
    • + hematopoietic cells using a single genetic element
    • DOI 10.1182/blood-2003-05-1762
    • Mulloy, J C, J. Cammenga, F. J. Berguido, K. Wu, P. Zhou, R. L. Comenzo, S. Jhanwar, M. A. Moore, & S. D. Nimer: Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. Blood 102, 4369-4376 (2003). (Pubitemid 37494097)
    • (2003) Blood , vol.102 , Issue.13 , pp. 4369-4376
    • Mulloy, J.C.1    Cammenga, J.2    Berguido, F.J.3    Wu, K.4    Zhou, P.5    Comenzo, R.L.6    Jhanwar, S.7    Moore, M.A.S.8    Nimer, S.D.9
  • 158
    • 13244292308 scopus 로고    scopus 로고
    • AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation
    • DOI 10.1080/10428190400010767
    • Basecke, J, M. Schwieger, F. Griesinger, B. Schiedlmeier, G. Wulf, L. Trumper, & C. Stocking: AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation. Leuk Lymphoma 46, 265-272 (2005). (Pubitemid 40185958)
    • (2005) Leukemia and Lymphoma , vol.46 , Issue.2 , pp. 265-272
    • Basecke, J.1    Schwieger, M.2    Griesinger, F.3    Schiedlmeier, B.4    Wulf, G.5    Trumper, L.6    Stocking, C.7
  • 161
    • 34248325702 scopus 로고    scopus 로고
    • Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO
    • DOI 10.1182/blood-2006-03-012575
    • Peterson, L F, M. Yan, & D. E. Zhang: The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8, 21) fusion protein AML1-ETO. Blood 109, 4392-4398 (2007). (Pubitemid 46743408)
    • (2007) Blood , vol.109 , Issue.10 , pp. 4392-4398
    • Peterson, L.F.1    Yan, M.2    Zhang, D.-E.3
  • 169
    • 0034817075 scopus 로고    scopus 로고
    • ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
    • DOI 10.1128/MCB.21.19.6470-6483.2001
    • Amann, J M, J. Nip, D. K. Strom, B. Lutterbach, H. Harada, N. Lenny, J. R. Downing, S. Meyers, & S. W. Hiebert: ETO, a target of t(8, 21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 21, 6470-6483 (2001). (Pubitemid 32927415)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.19 , pp. 6470-6483
    • Amann, J.M.1    Nip, J.2    Strom, D.K.3    Lutterbach, B.4    Harada, H.5    Lenny, N.6    Downing, J.R.7    Meyers, S.8    Hiebert, S.W.9
  • 172
    • 33846109370 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein
    • DOI 10.1038/sj.onc.1209760, PII 1209760
    • Yang, G, M. A. Thompson, S. J. Brandt, & S. W. Hiebert: Histone deacetylase inhibitors induce the degradation of the t(8, 21) fusion oncoprotein. Oncogene 26, 91-101 (2007). (Pubitemid 46067334)
    • (2007) Oncogene , vol.26 , Issue.1 , pp. 91-101
    • Yang, G.1    Thompson, M.A.2    Brandt, S.J.3    Hiebert, S.W.4
  • 175
    • 3142733632 scopus 로고    scopus 로고
    • MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias
    • DOI 10.1038/sj.leu.2403377
    • Lasa, A, M. J. Carnicer, A. Aventin, C. Estivill, S. Brunet, J. Sierra, & J. Nomdedeu: MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. Leukemia 18, 1231- 1237 (2004). (Pubitemid 39023133)
    • (2004) Leukemia , vol.18 , Issue.7 , pp. 1231-1237
    • Lasa, A.1    Carnicer, M.J.2    Aventin, A.3    Estivill, C.4    Brunet, S.5    Sierra, J.6    Nomdedeu, J.F.7
  • 176
    • 33846820578 scopus 로고    scopus 로고
    • Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines
    • DOI 10.1016/j.leukres.2006.08.008, PII S0145212606003122
    • Berg, T, Y. Guo, M. Abdelkarim, M. Fliegauf, & M. Lubbert: Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. Leukemia Research 31, 497-506 (2007). (Pubitemid 46206089)
    • (2007) Leukemia Research , vol.31 , Issue.4 , pp. 497-506
    • Berg, T.1    Guo, Y.2    Abdelkarim, M.3    Fliegauf, M.4    Lubbert, M.5
  • 179
    • 21044450858 scopus 로고    scopus 로고
    • The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor
    • DOI 10.1242/dev.01824
    • Wildonger, J & R. S. Mann: The t(8, 21) translocation converts AML1 into a constitutive transcriptional repressor. Development 132, 2263-2272 (2005). (Pubitemid 40872797)
    • (2005) Development , vol.132 , Issue.10 , pp. 2263-2272
    • Wildonger, J.1    Mann, R.S.2
  • 180
    • 78649463826 scopus 로고    scopus 로고
    • Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model
    • Sinenko, S A, T. Hung, T. Moroz, Q. M. Tran, S. Sidhu, M. D. Cheney, N. A. Speck, & U. Banerjee: Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116, 4612-4620 (2010).
    • (2010) Blood , vol.116 , pp. 4612-4620
    • Sinenko, S.A.1    Hung, T.2    Moroz, T.3    Tran, Q.M.4    Sidhu, S.5    Cheney, M.D.6    Speck, N.A.7    Banerjee, U.8


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