The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family

Blood

Volumn 91, Issue 11, 1998, Pages 4028-4037

  Gamou, Toshie ^b   Kitamura, Eiko ^b   Hosoda, Fumie ^a   Shimizu, Kimiko ^b   Shinohara, Kenji ^b   Hayashi, Yasuhide ^b   Nagase, Takahiro ^b   Yokoyama, Yasunobu ^b   Ohki, Misao ^b  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B LYMPHOCYTE ACTIVATION; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; GENE ISOLATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MULTIGENE FAMILY; MYELOID LEUKEMIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ANALYSIS;

EID: 0032101547     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.11.4028.411a45_4028_4037     Document Type: Article

References (50)

1. Rabbitts TH: Chromosomal translocations in human cancer. Nature 372:143, 1994
2. Barr Fg: The malevolence of matchmaking. Nat Genet 12:113, 1996
3. Pedersen-Bjergaad J, Rowley JD: The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood 83:2780, 1994
4. Miyoshi H, Shimizu K, KUZU T, Maseki N, Kaneko Y, Ohki M: t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 88:10431, 1991
5. Mitelman F, Heim S: Quantitative acute leukemia cytogenetics. Genes Chromosomes Cancer 5:57, 1992
6. Nucifora G, Rowley JD: AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86:1, 1995
7. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M: The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12:2715, 1993
8. Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M: Junction of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 82:1270, 1993
9. Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H: Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825, 1992
10. Nisson PE, Watkins PC, Sacchi N: Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. Cancer Genet Cytogenet 63:81, 1992
11. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917, 1995
12. Romana SP, Mauchauffe M, Le Coniet M, Chumakov I, Le Paslier D, Berger R, Bernard OA: The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood 85:3662, 1995
13. Rubin CM, Larson RA, Anastasi J, Winter JN, Thangavelu M, Vardiman J, Rowley JD, LeBeau MM: t(3;21)(q26;q22): A recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood 76:2594, 1990
14. Nucifora G, Birn DJ, Espinosa R III, Erickson P, LeBeau MM, Roulston D, McKeithan TW, Drabkin H,. Rowley JD: Involvement of the AML1 gene in the t(3;21 ) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood 81:2728, 1993
15. Nucifora G, Begy CR, Erickson P, Drabkin HA, Rowley JD: The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. Proc Natl Acad Sci USA 90:7784, 1993
16. Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, Yazaki Y, Ohki M, Hirai H: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 13:504, 1994
17. Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton D, Pedersen-Bjergaad J, Parganas E. Ihle JN, Rowley JD: Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc Natl Acad Sci USA 91:4004, 1994
18. Shimada M, Ohtsuka E, Shimizu T, Matsumoto T, Matsushita K, Tanimoto F, Kajii T: A recurrent translocation, t(16;21)(q24;q22), associated with acute myelogenous Leukemia: Identification by fluorescence in situ hybridization. Cancer Genet Cytogenet 96:102, 1997
19. Takeda K, Shinohara K, Kameda N, Ariyoshi K: A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkyiating agent, cyclophosphamide. Int J Hematol (in press)
20. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chroloform extraction. Anal Biochem 162:156, 1987
21. Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N: Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. DNA Res 4:53, 1997
22. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayashi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res 1:27, 1994
23. Ohira M, Ichikawa H, Suzuki E, Iwaki M, Suzuki K, Saito-Ohara F, Ikeuchi T, Chumakov I, Tanahashi H, Tashiro K, Sakaki Y, Ohki M: A 1.6-Mb P1-based physical map of the down syndrome region on chromosome 21. Genomics 33:65, 1996
24. Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D: Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818, 1992
25. Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E, Ohki M: Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Res 23:2762, 1995
26. Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M: The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG(ETO/CDR) family, MTGR1. Mol Cell Biol 18:846, 1998
27. Feinstein PG, Kornfeld K, Hogness DS, Mann RS: Identification of homeotic target genes in Drosophila melanogasler including nervy, a proto-oncogene homologue. Genetics 140:573, 1995
28. Shapiro MB, Senapathy P: RNA splice junctions of different classes of eukaryotes: Sequence statistics and functional implications in gene expression. Nucleic Acids Res 15:7155, 1987
29. Berger R, Coniat ML, Romana SP, Jonveaux P: Secondary acute myeloblastic leukemia with t(16;21)(q24;q22) involving the AML1 gene. Hematol Cell Ther 38:183, 1996
30. Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M. Shigesada K, Ito Y: PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA 90:6859, 1993
31. Ogawa E, Inuzuka M, Maruyama M, Satake M, NAito-Fujimoto M, Ito Y, Shigesada K: Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314, 1993
32. Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13:3324, 1993
33. Mayers S, Dowing JR, Hiebert SW: Identification of AML-1 and the (8;21) translocation protein (AML1-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 13:6336, 1993
34. Prosser HM, Wotton D, Gegonne A, Ghysdael J, Wang S, Speck NA, Owen MJ: A phorbol ester response element within the human T-cell receptor β-chain enhancer. Proc Natl Acad Sci USA 89:9934, 1992
35. Redondo JM, Pfohl JL, Hernandez-Munain C, Wang S, Speck NA, Krangel MS: Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor δ and murine leukemia virus enhancers. Mol Cell Biol 12:4817, 1992
36. Zhang DE, Fujioka K, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG: Identification of a region which, directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol 14:8085, 1994
37. Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14:5558, 1994
38. Takahashi A, Satake M, Yamaguchi-Iwai Y, Bae SC, Lu J, Maruyama M, Zhang YM, Oka H, Arai N, Arai K, Ito Y: Positive and negative regulation of granulocyte macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood 86:607, 1995
39. Frank R, Zhang J, Meyers S, Hiebert SW, Mimer SD: The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 11:2667, 1995
40. Wargnier A, Legros-Maida S, Bosselut R, Bourge JF, Lafaurie C, Ghysdael J, Sasportes M, Paul P: Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: Implication of Ikaros and CBF binding sites in promoter activation. Proc Natl Acad Sci USA 92:6930, 1995
41. Okuda T, van Deusen J, Hiebert SW, Grosveld G, Downing JR: AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321, 1996
42. Sasaki K, Yagi H, Bronson RT, Tominaga K, Matsunashi T, Deguchi K, Tani Y, Kishimoto T, Komori T: Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor β. Proc Natl Acad Sci USA 93:12359, 1996
43. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA: Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444, 1996
44. Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marin-Padilla M, Sharpe AH, Speck NA: The CBFβ subunit is essential for CBFα2 (AML1) function in vivo. Cell 87:697, 1996
45. Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, Asano S, Ito Y, Satake M, Noda T: Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc Natl Acad Sci USA 94:5697, 1997
46. Negrini M, Felix CA, Martin C, Lange BJ, Nakamura T, Canaani E, Croce CM: Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia. Cancer Res 53:4489, 1993
47. Gu Y, Alder H, Nakamura T, Schichman SA, Prasad R, Canaani O, Saito H, Croce CM, Canaani E: Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia. Cancer Res 54:2327, 1994
48. Pamela L, Broeker S, Super HG, Thirman MJ, Pomykala H, Yonebayashi Y, Tanabe S, Zeleznik-Le N, Rowley JD: Distribution of IIq23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scafford attachment regions and topoisomerase II consensus binding sites. Blood 87:1912, 1996
49. Cimino G, Rapanotti MC, Biondi A, Elia L, Lo Coco F, Price C, Rossi V, Rivoita A, Canaani E, Croce CM, Mandelli F, Greaves M: Infant acute leukemia show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias. Cancer Res 57:2879, 1997
50. Tighe JE, Calabi F: t(8;21) breakpoints are clustered between alternatively spliced exons of MTG8. Clin Sci 89:215, 1995