ETS-core binding factor: A common composite motif in antigen receptor gene enhancers

Molecular and Cellular Biology

Volumn 18, Issue 3, 1998, Pages 1322-1330

  Erman, Batu ^a   Cortes, Marta ^a   Nikolajczyk, Barbara S ^a   Speck, Nancy A ^b   Sen, Ranjan ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; IMMUNOGLOBULIN MU CHAIN; LEUCINE ZIPPER PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ARTICLE; B CELL LEUKEMIA; ENHANCER REGION; GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031951663     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.3.1322     Document Type: Article

References (45)

1. Cameron, S., D. S. Taylor, E. C. TePas, N. A. Speck, and B. Mathet-Prevot. 1994. Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting. Blood 83:2851-2859.
2. Carvajal, I., and R. Sen. Unpublished observations.
3. H locus. EMBO J. 12:4635-4645.
4. Crute, B., A. Lewis, Z. Wu, J. Bushweller, and N. Speck. 1996. Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain. J. Biol. Chem. 271:26251-26260.
5. Ephrussi, A., G. M. Church, S. Tonegawa, and W. Gilbert. 1985. B lineage specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134-140.
6. Erman, B., and R. Sen. 1996. Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer. EMBO J. 15:4565-4575.
7. Ernst, P., and S. T. Smale. 1995. Combinatorial regulation of transcription II: the immunoglobulin heavy chain gene. Immunity 2:427-438.
8. Giese, K., C. Kingsley, J. Kirshner, and R. Grosschedl. 1995. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9:995-1008.
9. Gillies, S. D., S. L. Morrison, V. T. Oi, and S. Tonegawa. 1983. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 33:717-728.
10. Golub, T. R., G. F. Barker, S. K. Bohlander, S. Hiebert, D. C. Ward, P. Bray-Ward, E. Morgan, S. C. Raimondi, J. D. Rowley, and D. G. Gilliland. 1995. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 92:4917-4921.
11. Hallberg, B., A. Thornell, M. Holm, and T. Grundstrom. 1992. SEF1 binding is important for T cell specific enhancers of genes for T cell receptor-CD3 subunits. Nucleic Acids Res. 20:6495-6499.
12. Hayday, A. C., S. D. Gillies, H. Saito, C. Wood, C. Wiman, W. S. Hayward, and S. Tonegawa. 1984. Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus. Nature 307:334-340.
13. Hernandez-Munain, C., and M. Krangel. 1995. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. Mol. Cell. Biol. 15:3090-3099. (Erratum, 15:4659.)
14. Hiebert, S. W., W. Sun, N. Davis, T. Golub, S. Shurtleff, A. Buijs, J. R. Downing, G. Grosveld, M. F. Roussel, D. G. Gilliland, N. Lenny, and S. Meyers. 1996. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol. Cell. Biol. 16:1349-1355.
15. Hsiang, Y. H., D. Spencer, S. Wang, N. A. Speck, and D. H. Raulet. 1993. The role of viral "core" motif-related sequences in regulating T cell receptor γ and 8 gene expression. J. Immunol. 150:3905-3916.
16. Kamachi, Y., E. Ogawa, M. Asano, S. Ishida, Y. Murakami, M. Satake, Y. Ito, and K. Shigesada. 1990. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J. Virol. 64:4808-4819.
17. Lenardo, M., J. W. Pierce, and D. Baltimore. 1987. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236:1573-1577.
18. Libermann, T. A., and D. Baltimore. 1990. Transcriptional regulation of immunoglobulin gene expression. Mol. Aspects Cell. Regul. 6:399-421.
19. Matthias, P., M. M. Müller, E. Schreiber, S. Rusconi, and W. Shaffner. 1989. Eukaryotic expression vectors for the analysis of mutant proteins. Nucleic Acids Res. 17:6418.
20. Melnikova, I., B. Crute, S. Wang, and N. Speck. 1993. Sequence specificity of the core-binding factor. J. Virol. 67:2408-2411.
21. Merrell, K., S. Wells, A. Henderson, J. Gorman, F. Alt, A. Stall, and K. Calame. 1997. The absence of the transcription activator TFE3 impairs activation of B cells in vivo. Mol. Cell. Biol. 17:3335-3344.
22. Meyers, S., J. Downing, and S. Hiebert. 1993. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336-6345.
23. Meyers, S., N. Lenny, W. Sun, and S. Hiebert. 1996. AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia. Oncogene 13:303-312.
24. Nelsen, B., and R. Sen. 1992. Regulation of immunoglobulin gene transcription. Int. Rev. Cytol. 133:121-149.
25. Nelsen, B., G. Tian, B. Erman, J. Gregoire, R. Maki, B. Graves, and R. Sen. 1993. Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins. Science 261:82-86.
26. Nikolajczyk, B., B. Nelsen, and R. Sen. 1996. Precise alignment of sites required for mu enhancer activation in B cells. Mol. Cell. Biol. 16:4544-4554.
27. Nikolajczyk, B. S., M. Cortes, R. Feinman, and R. Sen. 1997. Combinatorial determinants of tissue-specific transcription in B cells and macrophages. Mol. Cell. Biol. 17:3527-3535.
28. Nuchprayoon, I., S. Meyers, L. Scott, J. Suzow, S. Hiebert, and A. Friedman. 1994. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol. Cell. Biol. 14:5558-5568.
29. Nye, J. A., J. Tersen, C. V. Gunther, M. D. Jonsen, and B. J. Graves. 1992. Interaction of murine Ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev. 6:975-990.
30. Okuda, T., J. van Deursen, S. Hiebert, G. Grosveld, and J. Downing. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-330.
31. Oltz, E. M., F. W. Alt, W. Lin, J. Chen, G. Taccioli, S. Desiderio, and G. Rathbun. 1993. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol. Cell. Biol. 13:6223-6230.
32. Romana, S. P., H. Poirel, M. Leconiat, M.-A. Flexor, M. Mauchauffe, P. Jonveaux, E. A. Macintyre, R. Berger, and O. A. Bernard. 1995. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 86:4263-4269.
33. Serwe, M., and F. Sablitzky. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321-2327.
34. Shurtleff, S. A., A. Buijs, F. G. Behm, J. E. Rubnitz, S. C. Raimondi, M. L. Hancock, G. C.-F. Chan, C.-H. Pui, G. Grosveld, and J. R. Downing. 1995. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9:1985-1989.
35. Speck, N. A., B. Renjifo, and N. Hopkins. 1990. Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. Genes Dev. 4:233-242.
36. Sun, W., B. Graves, and N. Speck. 1995. Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by CBF and ETS requires intact binding sites for both proteins. J. Virol. 69:4941-4949.
37. Takahashi, A., M. Satake, Y. Yamaguchi-Iwai, S.-C. Bae, J. Lu, M. Maruyama, Y. W. Zhang, H. Oka, N. Arai, K. Arai, and Y. Ito. 1995. Positive and negative regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter activity by AML1-related transcription factor, PEBP2. Blood 86:607-616.
38. Thurnell, A., B. Hallberg, and T. Grundström. 1988. Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3. Mol. Cell. Biol. 8:1625-1637.
39. van de Watering, M., M. Oosterwegel, D. Dooijes, and H. Clevers. 1991. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J. 10:123-132.
40. Wang, S., Q. Wang, B. Crute, I. Melnikova, S. Keller, and N. Speck. 1993. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol. Cell. Biol. 13:3324-3339.
41. Waterman, M., W. Fischer, and K. Jones. 1991. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Genes Dev. 5:656-669.
42. Wotton, D., J. Ghysdael, S. Wang, N. Speck, and M. Owen. 1994. Cooper-ative binding of Ets-1 and core binding factor to DNA. Mol. Cell. Biol. 14:840-850.
43. H gene segments. Cell 40:271-281.
44. Zaiman, A., A. Lewis, B. Crute, N. Speck, and J. Lenz. 1495. Transcriptional activity of core binding factor alpha (AML1) and beta subunits on murine leukemia virus enhancer cores. J. Virol. 69:2898-2906.
45. Zhang, D., C. Hetherington, S. Meyers, K. Rhoades, C. Larson, H. Chen, S. Hiebert, and D. Tenen. 1996. CCAAT enhancer-binding protein (CVEBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol. Cell. Biol. 16:1231-1240.