Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome

Leukemia

Volumn 20, Issue 6, 2006, Pages 1002-1008

  Xu, G ^a   Kanezaki, R ^a   Toki, T ^a   Watanabe, S ^a   Takahashi, Y ^a   Terui, K ^a   Kitabayashi, I ^b   Ito, Eturou ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Acute megakaryoblastic leukemia; Down syndrome; GATA1; RUNX1; Transient myeloproliferative disorder

Indexed keywords

TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR RUNX1; ZINC FINGER PROTEIN;

ACUTE MEGAKARYOCYTIC LEUKEMIA; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; GENE MUTATION; MEGAKARYOCYTE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

EID: 33744458176     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404223     Document Type: Article

References (33)

1. Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol 2000; 110: 512-524.
2. Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet 2002; 32: 148-152.
3. Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood 2003; 101: 4298-4300.
4. Hitzler JK, Cheung J, Li Y, Scherer SW, Zipursky A. GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood 2003; 101: 4301-4304.
5. Rainis L, Bercovich D, Strehl S, Teigler-Schlegel A, Stark B, Trka J et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood 2003; 102: 981-986.
6. Groet J, McElwaine S, Spinelli M, Rinaldi A, Burtscher I, Mulligan C et al. Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Lancet 2003; 361: 1617-1620.
7. Xu G, Nagano M, Kanezaki R, Toki T, Hayashi Y, Taketani T et al. Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down's syndrome. Blood 2003; 102: 2960-2968.
8. Look AT. A leukemogenic twist for GATA1. Nat Genet 2002; 32: 83-84.
9. Speck NA, Gilliland DG. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002; 2: 502-513.
10. Ichikawa M, Asai T, Saito T, Seo S, Yamazaki I, Yamagata T et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med 2004; 10: 299-304.
11. Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 1999; 23: 166-175.
12. Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN. RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood 2003; 101: 4333-4341.
13. Yanagida M, Osato M, Yamashita N, Liqun H, Jacob B, Wu F et al. Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Oncogene 2005; 24: 4477-4485.
14. Hitzler JK, Zipursky A. Origins of leukaemia in children with Down syndrome. Nat Rev Cancer 2005; 5: 11-20.
15. Waltzer L, Ferjoux G, Bataille L, Haenlin M. Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis. EMBO J 2003; 22: 6516-6525.
16. Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K et al. The AML1-MTG8 leukemic Fusion protein forms a complex with a novel member of the MTG8 (ETO/CDR) family, MTGR1. Mol Cell Biol 1998; 18: 846-858.
17. Hashimoto Y, Ware J. Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein Ib alpha gene. J Biol Chem 1995; 270: 24532-24539.
18. Sato T, Fuse A, Eguchi M, Hayashi Y, Ryo R, Adachi M et al. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia. Br J Haematol 1989; 72: 184-190.
19. Toki T, Katsuoka F, Kanezaki R, Xu G, Kurotaki H, Sun J et al. Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Blood 2005; 105: 3100-3108.
20. Toki T, Arai K, Terui K, Komatsu N, Yokoyama M, Katsuoka F et al. Functional characterization of the two alternative promoters of human p45 NF-E2 gene. Exp Hematol 2000; 28: 1113-1119.
21. Kanezaki R, Toki T, Yokoyama M, Yomogida K, Sugiyama K, Yamamoto M et al. Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform. J Biol Chem 2001; 276: 7278-7284.
22. Eisbacher M, Holmes ML, Newton A, Hogg PJ, Khachigian LM, Crossley M et al. Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol Cell Biol 2003; 23: 3427-3441.
23. Visvader JE, Crossley M, Hill J, Orkin SH, Adams JM. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol Cell Biol 1995; 15: 634-641.
24. Muntean AG, Crispino JD. Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood 2005; 106: 1223-1231.
25. Martin DI, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev 1990; 4: 1886-1898.
26. Waltzer L, Bataille L, Peyrefitte S, Haenlin M. Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis. EMBO J 2002; 21: 5477-5486.
27. Trainor CD, Omichinski JG, Vandergon TL, Gronenborn AM, Clore GM, Felsenfeld G. A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mol Cell Biol 1996; 16: 2238-2247.
28. Ferreira R, Ohneda K, Yamamoto M, Philipsen S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol 2005; 25: 1215-1227.
29. Barrett DM, Gustafson KS, Wang J, Wang SZ, Ginder GD. A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon. Mol Cell Biol 2004; 24: 6194-6204.
30. Kim WY, Sieweke M, Ogawa E, Wee HJ, Englmeier U, Graf T et al. Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. EMBO J 1999; 18: 1609-1620.
31. Deveaux S, Filipe A, Lemarchandel V, Ghysdael J, Romeo P-H, Mignotte V. Analysis of the thrombopoietin receptor (mpl) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood 1996; 87: 4678-4685.
32. Deveaux S, Cohen-Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I et al. p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J 1997; 16: 5654-5661.
33. Zhang C, Gadue P, Scott E, Atchison M, Poncz M. Activation of the megakaryocyte-specific gene platelet basic protein (PBP) by the Ets family factor PU.1. J Biol Chem 1997; 272: 26236-26246.