메뉴 건너뛰기




Volumn 91, Issue 9, 1998, Pages 3134-3143

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 8; EMBRYO; GENE EXPRESSION REGULATION; GENE TARGETING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032079424     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.9.3134.3134_3134_3143     Document Type: Article
Times cited : (319)

References (43)
  • 2
    • 0025746321 scopus 로고
    • t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
    • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M: t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 88:10431, 1991
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10431
    • Miyoshi, H.1    Shimizu, K.2    Kozu, T.3    Maseki, N.4    Kaneko, Y.5    Ohki, M.6
  • 3
    • 0026757174 scopus 로고
    • Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • Erickson PF, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H: Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825, 1992
    • (1992) Blood , vol.80 , pp. 1825
    • Erickson, P.F.1    Gao, J.2    Chang, K.S.3    Look, T.4    Whisenant, E.5    Raimondi, S.6    Lasher, R.7    Trujillo, J.8    Rowley, J.9    Drabkin, H.10
  • 4
    • 0026496547 scopus 로고
    • Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells
    • published erratum appears in Cancer Genet Cytogenet 66:81, 1993.
    • Nisson PE, Watkins PC, Sacchi N: Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells [published erratum appears in Cancer Genet Cytogenet 66:81, 1993]. Cancer Genet Cytogenet 63:81, 1992
    • (1992) Cancer Genet Cytogenet , vol.63 , pp. 81
    • Nisson, P.E.1    Watkins, P.C.2    Sacchi, N.3
  • 5
    • 0029019659 scopus 로고
    • AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia
    • Nucifora G, Rowley JD: AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86:1, 1995
    • (1995) Blood , vol.86 , pp. 1
    • Nucifora, G.1    Rowley, J.D.2
  • 6
    • 0027383818 scopus 로고
    • Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as a sequence-specific DNA-binding proteins: The runt homology domain is required for DNa binding and protein-protein interactions
    • Meyers S, Downing JR, Hiebert SW: Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as a sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 13:6336, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 6336
    • Meyers, S.1    Downing, J.R.2    Hiebert, S.W.3
  • 7
    • 0029583960 scopus 로고
    • A new transcription factor family associated with human leukemia
    • Speck NA, Terryl S: A new transcription factor family associated with human leukemia. Crit Rev Eukaryot Gene Expr 5: 337, 1995
    • (1995) Crit Rev Eukaryot Gene Expr , vol.5 , pp. 337
    • Speck, N.A.1    Terryl, S.2
  • 8
    • 0027256023 scopus 로고
    • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13:3324, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 3324
    • Wang, S.1    Wang, Q.2    Crute, B.E.3    Melnikova, I.N.4    Keller, S.R.5    Speck, N.A.6
  • 9
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha
    • Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K: Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology 194:314, 1993
    • (1993) Virology , vol.194 , pp. 314
    • Ogawa, E.1    Inuzuka, M.2    Maruyama, M.3    Satake, M.4    Naito-Fujimoto, M.5    Ito, Y.6    Shigesada, K.7
  • 10
    • 0028925282 scopus 로고
    • The t(8;21) fusion protein interferes with AML-1B-dependent transcriptiona activation
    • Meyers S, Lenny N, Hiebert SW: The t(8;21) fusion protein interferes with AML-1B-dependent transcriptiona activation. Mol Cell Biol 15:1974, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 1974
    • Meyers, S.1    Lenny, N.2    Hiebert, S.W.3
  • 11
    • 0029042845 scopus 로고
    • Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue
    • Feinstein PG, Kornfeld K, Hogness DS, Mann RS: Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue. Genetics 140:573, 1995
    • (1995) Genetics , vol.140 , pp. 573
    • Feinstein, P.G.1    Kornfeld, K.2    Hogness, D.S.3    Mann, R.S.4
  • 13
    • 0025694765 scopus 로고
    • Transcriptional regulation of interleukin 3 gene expression in T lymphocytes
    • Shoemaker SG, Hromas R, Kaushansky K: Transcriptional regulation of interleukin 3 gene expression in T lymphocytes. Proc Natl Acad Sci USA 87:9650, 1990
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9650
    • Shoemaker, S.G.1    Hromas, R.2    Kaushansky, K.3
  • 14
    • 0028998584 scopus 로고
    • Positive and negative regulation of granulocyte-macrophage colony stimulating factor promoter activity by AML1-related transcription factor, PEBP2
    • Takahashi A, Satake M, Yamaguchi-Iwai Y, Bae SC, Lu J, Maruyama M, Zhang YW, Oka H, Arai N, Arai K, Ito Y: Positive and negative regulation of granulocyte-macrophage colony stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood 86:607, 1995
    • (1995) Blood , vol.86 , pp. 607
    • Takahashi, A.1    Satake, M.2    Yamaguchi-Iwai, Y.3    Bae, S.C.4    Lu, J.5    Maruyama, M.6    Zhang, Y.W.7    Oka, H.8    Arai, N.9    Arai, K.10    Ito, Y.11
  • 15
    • 0027984233 scopus 로고
    • Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
    • Zhang DE, Fujioka K, Hetherington CJ, Shapiro LH, Chen HN, Look AT, Tenen DG: Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol 14:8085, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 8085
    • Zhang, D.E.1    Fujioka, K.2    Hetherington, C.J.3    Shapiro, L.H.4    Chen, H.N.5    Look, A.T.6    Tenen, D.G.7
  • 16
    • 0028066779 scopus 로고
    • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
    • Nuchprayoon I, Meyers S, Scott LM, SUZOW J, Hiebert S, Friedman AD: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14:5558, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 5558
    • Nuchprayoon, I.1    Meyers, S.2    Scott, L.M.3    Suzow, J.4    Hiebert, S.5    Friedman, A.D.6
  • 17
    • 0027158441 scopus 로고
    • The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression
    • Hsiang YH, Spencer D, Wang S, Speck NA, Raulet DH: The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression. J Immunol 150:3905, 1993
    • (1993) J Immunol , vol.150 , pp. 3905
    • Hsiang, Y.H.1    Spencer, D.2    Wang, S.3    Speck, N.A.4    Raulet, D.H.5
  • 18
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR: AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321, 1996
    • (1996) Cell , vol.84 , pp. 321
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 19
    • 0029918597 scopus 로고    scopus 로고
    • Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    • Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA: Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3444
    • Wang, Q.1    Stacy, T.2    Binder, M.3    Marin-Padilla, M.4    Sharpe, A.H.5    Speck, N.A.6
  • 22
    • 0027183945 scopus 로고
    • The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA, EBER 1
    • Nucifora G, Begy CR, Erickson P, Drabkin HA, Rowley JD: The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA, EBER 1. Proc Natl Acad Sci USA 90:7784, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7784
    • Nucifora, G.1    Begy, C.R.2    Erickson, P.3    Drabkin, H.A.4    Rowley, J.D.5
  • 24
    • 0028069226 scopus 로고
    • Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia
    • Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, Yazaki Y, Ohki M, Hirai H: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 13:504, 1994
    • (1994) EMBO J , vol.13 , pp. 504
    • Mitani, K.1    Ogawa, S.2    Tanaka, T.3    Miyoshi, H.4    Kurokawa, M.5    Mano, H.6    Yazaki, Y.7    Ohki, M.8    Hirai, H.9
  • 28
    • 13344282725 scopus 로고
    • TEL/ AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
    • Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC, Pui CH, Grosveld G, Downing JR: TEL/ AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9:1985, 1995
    • (1995) Leukemia , vol.9 , pp. 1985
    • Shurtleff, S.A.1    Buijs, A.2    Behm, F.G.3    Rubnitz, J.E.4    Raimondi, S.C.5    Hancock, M.L.6    Chan, G.C.7    Pui, C.H.8    Grosveld, G.9    Downing, J.R.10
  • 31
    • 0029616633 scopus 로고
    • The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
    • Frank R, Zhang J, Uchida H, Meyers S, Hiebert SW, Nimer SD: The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 11:2667, 1995
    • (1995) Oncogene , vol.11 , pp. 2667
    • Frank, R.1    Zhang, J.2    Uchida, H.3    Meyers, S.4    Hiebert, S.W.5    Nimer, S.D.6
  • 32
    • 0028786125 scopus 로고
    • Functional domains of the t(8;21) fusion protein, AML-1/ETO
    • Lenny N, Meyers S, Hiebert SW: Functional domains of the t(8;21) fusion protein, AML-1/ETO. Oncogene 11:1761, 1995
    • (1995) Oncogene , vol.11 , pp. 1761
    • Lenny, N.1    Meyers, S.2    Hiebert, S.W.3
  • 34
    • 0029810924 scopus 로고    scopus 로고
    • AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia
    • Meyers S, Lenny N, Sun W, Hiebert SW: AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia. Oncogene 13:303, 1996
    • (1996) Oncogene , vol.13 , pp. 303
    • Meyers, S.1    Lenny, N.2    Sun, W.3    Hiebert, S.W.4
  • 35
    • 0028274940 scopus 로고
    • Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
    • Bodrug SE, Warner BJ, Bath ML, Lindeman GJ, Harris AW, Adams JM: Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO 13:2124, 1994
    • (1994) EMBO , vol.13 , pp. 2124
    • Bodrug, S.E.1    Warner, B.J.2    Bath, M.L.3    Lindeman, G.J.4    Harris, A.W.5    Adams, J.M.6
  • 36
  • 37
    • 0027236954 scopus 로고
    • Production of high titer helper-free retroviruses by transient transfection
    • Pear W, Nolan G, Scott M, Baltimore D: Production of high titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90:8392, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8392
    • Pear, W.1    Nolan, G.2    Scott, M.3    Baltimore, D.4
  • 39
    • 0022479617 scopus 로고
    • Properties of the earliest clonogenic hematopoietic precursors to appear in the developing murine yolk sac
    • Wong PMC, Chung SW, Chui DHK, Eaves CJ: Properties of the earliest clonogenic hematopoietic precursors to appear in the developing murine yolk sac. Proc Natl Acad Sci USA 83:3851, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3851
    • Wong, P.M.C.1    Chung, S.W.2    Chui, D.H.K.3    Eaves, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.