Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion

Science

Volumn 303, Issue 5661, 2004, Pages 1204-1207

  Terman, Jonathan R ^a   Kolodkin, Alex L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXONAL REPULSION; MOLECULAR EVENTS;

GENES; LIVING SYSTEMS STUDIES; MOLECULAR BIOLOGY; NEUROLOGY; NUCLEIC ACIDS;

ENZYMES;

CARRIER PROTEIN; CELL SURFACE RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; DROSOPHILA PROTEIN; NERVE PROTEIN; NERVY PROTEIN, DROSOPHILA; PLEXIN; PLEXIN A; PLEXIN A PROTEIN; PROTEIN; PROTEIN NERVY; SEMAPHORIN; SEMAPHORIN 1A; UNCLASSIFIED DRUG;

ENZYME;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ANIMAL EMBRYO; ARTICLE; ASSOCIATION; CENTRAL NERVOUS SYSTEM; CHEMISTRY; CYTOLOGY; DROSOPHILA; EMBRYOLOGY; GENE CONTROL; GENETICS; INNERVATION; METABOLISM; MOLECULAR GENETICS; MOTONEURON; MULTIGENE FAMILY; MUSCLE; MUTATION; NERVE FIBER; NERVE TRACT; NONHUMAN; PHENOTYPE; PHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC ANIMAL; ULTRASTRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM; CUES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; MOLECULAR SEQUENCE DATA; MOTOR NEURONS; MUSCLES; MUTATION; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; PHENOTYPE; RECEPTORS, CELL SURFACE; SEMAPHORINS; SIGNAL TRANSDUCTION; TRANSGENES;

ANIMALIA;

EID: 1242284592     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092121     Document Type: Article

References (20)

1. R. J. Pasterkamp, A. L. Kolodkin, Curr. Opin. Neurobiol. 13, 79 (2003).
2. P. G. Feinstein, K. Kornfeld, D. S. Hogness, R. S. Mann, Genetics 140, 573 (1995).
3. T. Fukuyama et al., Oncogene 20, 6225 (2001).
4. R. V. Schillace, S. F. Andrews, G. A. Liberty, M. P. Davey, D. W. Carr, J. Immunol. 168, 1590 (2002).
5. A. Feliciello, M. E. Gottesman, E. V. Avvedimento, J. Mol. Biol. 308, 99 (2001).
6. H.-j. Song et al., Science 281, 1515 (1998).
7. H. J. Song, M. M. Poo, Curr. Opin. Neurobiol. 9, 355 (1999).
8. V. D. Dontchev, P. C. Letourneau, J. Neurosci. 22, 6659 (2002).
9. S. H. Chalasani, K. A. Sabelko, M. J. Sunshine, D. R. Littman, J. A. Raper, J. Neurosci. 23, 1360 (2003).
10. J. R. Terman, T. Mao, R. J. Pasterkamp, H. H. Yu, A. L. Kolodkin, Cell 109, 887 (2002).
11. M. L. Winberg et al., Cell 95, 903 (1998).
12. H. H. Yu, H. H. Araj, S. A. Ralls, A. L. Kolodkin, Neuron 20, 207 (1998).
13. M. L. Winberg et al., Neuron 32, 53 (2001).
14. S. K. Park, S. A. Sedore, C. Cronmiller, J. Hirsh, J. Biol. Chem. 275, 20588 (2000).
15. N. Sacchi et al., Oncogene 16, 2609 (1998).
16. W. D. Snider, F. Q. Zhou, J. Zhong, A. Markus, Neuron 35, 13 (2002).
17. V. Corset et al., Nature 407, 747 (2000).
18. Y. Xiang et al., Nature Neurosci. 5, 843 (2002).
19. M. Nishiyama et al., Nature 424, 990 (2003).
20. We thank H.-H. Yu for help with the yeast screen; J. Ayoob and T. Mao for discussions; J. Ayoob, D. Ginty, D. Kantor, R. Kuruvilla, G.-I. Ming, J. Pasterkamp, A. Sahay, and H.-j. Song for comments on the manuscript; and H. Araj, C. Goodman, Bloomington Stock Center, Drosophila Genetic Research Center, D. Van Vactor, D. Kalderon, K. Peer, and the Berkeley Drosophila Genome Project for reagents. Supported by NIH/National Institute of Mental Health and the Paralyzed Veterans of America Spinal Cord Research Foundation (J.R.T), and The Kirsch Foundation and NIH/National Institute of Neurological Disorders and Stroke (A.L.K).