Oligomerization of ETO is obligatory for corepressor interaction

Molecular and Cellular Biology

Volumn 21, Issue 1, 2001, Pages 156-163

  Zhang, J ^a   Hug, B A ^a   Huang, E Y ^a   Chen, C W ^a   Gelmetti, V ^a   Maccarana, M ^a   Minucci, S ^a   Pelicci, P G ^a   Lazar, M A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; GENE PRODUCT; HYBRID PROTEIN; PROTEIN ETO; PROTEIN NHR2; PROTEIN NHR4; PROTEIN SMRT; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; EMBRYO; GENE EXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OLIGOMERIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSCRIPTION REGULATION;

BINDING SITES; CELL DIFFERENTIATION; DIMERIZATION; DNA-BINDING PROTEINS; HEMATOPOIESIS; HUMANS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRANSFECTION; U937 CELLS; ZINC FINGERS;

EID: 0034749349     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.1.156-163.2001     Document Type: Article

References (56)

1. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
2. Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb
3. A role for Groucho tetramerization in transcription repression
4. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein
5. Identification of break-points in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
6. ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: Implications for t(8;21) leukemogenesis and monitoring residual disease
7. Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue
8. Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein
9. AML1/ETO blocks transactivation of the GM-CSF promoter by AML1B
10. The partner gene of AML1 in t(16;21) myeloid malignancies in a novel member of the MTG8(ETO) family
11. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
12. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
13. A core SMRT corepressor complex containing HDAC3 and a WD40 repeat protein linked to deafness
14. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia
15. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
16. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
17. Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO
18. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia
19. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
20. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
21. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
22. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1
23. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
24. Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction
25. Functional domains of the t(8;21) fusion protein, AML-1/ETO
26. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
27. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
28. Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers
29. Role of the histone deacetylase complex in acute promyelocytic leukaemia
30. The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor
31. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein
32. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
33. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
34. A new class of yeast transcriptional activators
35. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
36. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
37. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
38. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
39. t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
40. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
41. Mechanism of corepressor binding and release from nuclear hormone receptors
42. Transcriptionally active chimeric gene derived from the fusion of the AML1 gone and a novel gene on chromosome 8 in t(8;21) leukemic cells
43. AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene
44. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
45. Unique forms of human and mouse nuclear receptor corepressor SMRT
46. Molecular determinants of nuclear receptor-corepressor interaction
47. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor (RAR α) and PLZF-RARe fusion proteins on retinoic acid signalling
48. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development
49. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/DAC1 complex
50. Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells
51. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
52. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase
53. Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: Evidence for cooperativity with c-Myb
54. Stoichiometric and steric principles governing repression by nuclear hormone receptors
55. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters
56. Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression