Structural analyses of DNA recognition by the AML1/Runx-1 runt domain and its allosteric control by CBFβ

Cell

Volumn 104, Issue 5, 2001, Pages 755-767

  Tahirov, Tahir H ^a,b,d   Inoue Bungo, Taiko ^a,b   Morii, Hisayuki ^c   Fujikawa, Atsushi ^a,b   Sasaki, Motoko ^a,b,d   Kimura, Kazumi ^a,b   Shiina, Masaaki ^a,b   Sato, Ko ^a,b   Kumasaka, Takashi ^e   Yamamoto, Masaki ^e   Ishii, Shunsuke ^f,g   Ogata, Kazuhiro ^a,b,d  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c NATL INST BIOSCI HUM TECHNOL   (Japan)

^d Bio Crystallography Technology Division   (Japan)

^e RIKEN HARIMA INSTITUTE   (Japan)

^f RIKEN TSUKUBA INSTITUTE   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORE BINDING FACTOR; DNA; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX 1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE LEUKEMIA; ALLOSTERISM; ARTICLE; CLEIDOCRANIAL DYSPLASIA; CRYSTAL STRUCTURE; DNA PROTEIN COMPLEX; HYDROGEN BOND; MOLECULAR RECOGNITION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; REGULATORY MECHANISM; STRUCTURE ANALYSIS;

EID: 0035831044     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00271-9     Document Type: Article

References (57)

1. A simple screening for mutant DNA binding proteins: Application to murine transcription factor PEBP2α subunit, a founding member of the Runt domain protein family
2. Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues
3. The structure of GABPα/β: An ETS domain-ankyrin repeat heterodimer bound to DNA
4. AML1 haploinsufficiency, gene dosage, and the predisposition to acute leukemia
5. Three-dimensional structure of the Stat3β homodimer bound to DNA
6. The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains
7. Crystallography and NMR system: A new software suite for macromolecular structure determination
8. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
9. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
10. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
11. A novel DNA recognition mode by the NF-kB p65 homodimer
12. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
13. A new angle on a pervasive oncogene
14. Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution
15. Biochemical and biophysical properties of the core-binding factor α2 (AML1) DNA-binding domain
16. Structure of NF-kappa B p50 homodimer bound to a kappa B site
17. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
18. Molecular insights into PEBP2/CBF β-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF β
19. Auto-inhibition and partner proteins, core-binding factor β (CBFβ) and Ets-1, modulate DNA binding by CBFα2 (AML1)
20. Somatic point mutations in the p53 gene of human tumors and cell lines: Updated compilation
21. Solution structure of core binding factor β and map of the CBF α binding site
22. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis
23. Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF
24. The Runt domain identifies a new family of heteromeric transcriptional regulators
25. Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity
26. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer
27. Cbfa1 in bone development
28. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
29. Functional domains of the t(8;21) fusion protein, AML-1/ETO
30. Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye
31. Oncogenic transcription factors in the human acute leukemias
32. Acute myeloid leukemia
33. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
34. Sequence specificity of the core-binding factor
35. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
36. Structure of the NF-kappa B p50 homodimer bound to DNA
37. Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
38. Molecular cloning and characterization of PEBP2 β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 α
39. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
40. Identification of the regions involved in DNA binding by the mouse PEBP2α protein
41. Multiple functional domains of AML1: PU.1 and C/EBPα synergize with different regions of AML1
42. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
43. Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia
44. Role of cysteine residues in regulation of p53 function
45. The critical role of chromosome translocations in human leukemias
46. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
47. A new transcription factor family associated with human leukemias
48. Core-binding factor: A central player in hematopoiesis and leukemia
49. Crystallization and preliminary X-ray analyses of quaternary, ternary and binary protein-DNA complexes with involvement of AML1/Runx-1 Runt domain, CBFβ and the C/EBPβ bZip region
50. Biophysical characterization of interactions between the core binding factor α and β subunits and DNA
51. Energetic and functional contribution of residues in the core binding factor β (CBFβ) subunit to heterodimerization with CBFα
52. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFβ
53. Runt domains take the lead in hematopoiesis and osteogenesis
54. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter
55. PEBP2αA/CBFA1 mutations in Japanese cleidocranial dysplasia patients
56. Solution structure of the core NFATC1/DNA complex
57. CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia