메뉴 건너뛰기




Volumn 12, Issue 4, 2012, Pages 411-423

Cell-mediated and direct gene therapy for bone regeneration

Author keywords

Bone morphogenetic protein; Bone regeneration; Gene therapy; Stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 2; OSTEOGENIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; TRANSCRIPTION FACTOR RUNX2;

EID: 84858690327     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.661709     Document Type: Review
Times cited : (18)

References (98)
  • 1
    • 34848839211 scopus 로고    scopus 로고
    • Prevalence of long-bone non-unions
    • DOI 10.1016/j.injury.2007.02.005, PII S0020138307800039
    • Tzioupis C, Giannoudis PV. Prevalence of long-bone non-unions. Injury 2007;38(Suppl 2):S3-9 (Pubitemid 47498401)
    • (2007) Injury , vol.38 , Issue.SUPPL. 2
    • Tzioupis, C.1    Giannoudis, P.V.2
  • 2
    • 60849106318 scopus 로고    scopus 로고
    • The challenge of establishing preclinical models for segmental bone defect research
    • Reichert JC, Saifzadeh S, Wullschleger ME, et al. The challenge of establishing preclinical models for segmental bone defect research. Biomaterials 2009;30:2149-63
    • (2009) Biomaterials , vol.30 , pp. 2149-2163
    • Reichert, J.C.1    Saifzadeh, S.2    Wullschleger, M.E.3
  • 4
    • 58149316260 scopus 로고    scopus 로고
    • Advances in limb lengthening and reconstruction: Alessandro codivilla MD 1861 - 1912
    • Brand RA. Advances in limb lengthening and reconstruction: alessandro Codivilla, MD, 1861 - 1912. Clin Orthop Relat Res 2008;466:2901-2
    • (2008) Clin. Orthop. Relat. Res. , vol.466 , pp. 2901-2902
    • Brand, R.A.1
  • 6
    • 18244395555 scopus 로고    scopus 로고
    • Time for treating bone fracture using rhBMP-2: A randomised placebo controlled mouse fracture trial
    • DOI 10.1016/j.orthres.2004.12.008, PII S073602660500063X
    • Murnaghan M, McIlmurray L, Mushipe MT, Li G. Time for treating bone fracture using rhBMP-2: a randomized placebo controlled mouse fracture trial. J Orthop Res 2005;23:625-31 (Pubitemid 40631335)
    • (2005) Journal of Orthopaedic Research , vol.23 , Issue.3 , pp. 625-631
    • Murnaghan, M.1    McILmurray, L.2    Mushipe, M.T.3    Li, G.4
  • 7
    • 30944432386 scopus 로고    scopus 로고
    • Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects
    • Han DK, Kim CS, Jung UW, et al. Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects. J Periodontol 2005;76:221:6-22
    • (2005) J. Periodontol. , vol.76 , pp. 2216-2222
    • Han, D.K.1    Kim, C.S.2    Jung, U.W.3
  • 8
    • 21844477311 scopus 로고    scopus 로고
    • Osteogenic protein-1 in treatment of tibial nonunions: Current status
    • Friedlaender GE. Osteogenic protein-1 in treatment of tibial nonunions: current status. Surg Technol Int 2004;13:249-52
    • (2004) Surg. Technol. Int. , vol.13 , pp. 249-252
    • Friedlaender, G.E.1
  • 10
    • 84862899040 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways
    • published online 7 January 2012;10.1007/s00418-011-0908-
    • Yu Y, Mu J, Fan Z, et al. Insulin-like growth factor 1 enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways. Histochem Cell Biol 2012;published online 7 January 2012; doi:10.1007/s00418-011-0908-
    • (2012) Histochem Cell Biol.
    • Yu, Y.1    Mu, J.2    Fan, Z.3
  • 11
    • 81755189075 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the wnt signaling pathway
    • Fei Y, Xiao L, Doetschman T, et al. Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway. J Biol Chem 2011;286:40575-83
    • (2011) J. Biol. Chem. , vol.286 , pp. 405745-83
    • Fei, Y.1    Xiao, L.2    Doetschman, T.3
  • 12
    • 80955178835 scopus 로고    scopus 로고
    • PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs
    • Caplan AI, Correa D. PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs. Orthop Res 2011;29:1795-803
    • (2011) Orthop. Res. , vol.29 , pp. 1795-1803
    • Caplan, A.I.1    Correa, D.2
  • 13
    • 80053104201 scopus 로고    scopus 로고
    • VEGF expression in mesenchymal stem cells promotes bone formation of tissue-engineered bones
    • Liu B, Li X, Liang G, Liu X. VEGF expression in mesenchymal stem cells promotes bone formation of tissue-engineered bones. Mol Med Rep 2011;4:1121-6
    • (2011) Mol. Med. Rep. , vol.4 , pp. 1121-1126
    • Liu, B.1    Li, X.2    Liang, G.3    Liu, X.4
  • 14
    • 12344291865 scopus 로고    scopus 로고
    • Bone morphogenetic proteins
    • DOI 10.1080/08977190412331279890
    • Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth Factors 2004;22:233-41 (Pubitemid 40136452)
    • (2004) Growth Factors , vol.22 , Issue.4 , pp. 233-241
    • Chen, D.1    Zhao, M.2    Mundy, G.R.3
  • 16
    • 77954856587 scopus 로고    scopus 로고
    • Effects of adenoviral-mediated coexpression of bone morphogenetic protein-7 and insulin-like growth factor-1 on human periodontal ligament cells
    • Yang L, Zhang Y, Dong R, et al. Effects of adenoviral-mediated coexpression of bone morphogenetic protein-7 and insulin-like growth factor-1 on human periodontal ligament cells. J Periodontal Res 2010;45:532-40
    • (2010) J. Periodontal. Res. , vol.45 , pp. 532-540
    • Yang, L.1    Zhang, Y.2    Dong, R.3
  • 17
    • 48249095121 scopus 로고    scopus 로고
    • Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells
    • Rider DA, Dombrowski C, Sawyer AA, et al. Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells 2008;26:1598-608
    • (2008) Stem Cells , vol.26 , pp. 1598-608
    • Rider, D.A.1    Dombrowski, C.2    Sawyer, A.A.3
  • 19
    • 79957797244 scopus 로고    scopus 로고
    • Gene therapy for the regeneration of bone
    • Evans CH. Gene therapy for the regeneration of bone. Injury 2011;42:599-604
    • (2011) Injury , vol.42 , pp. 599-604
    • Evans, C.H.1
  • 22
    • 33646946177 scopus 로고    scopus 로고
    • Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep
    • DOI 10.1089/hum.2006.17.507
    • Egermann M, Baltzer AW, Adamaszek S, et al. Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep. Hum Gene Ther 2006;17:507-17 (Pubitemid 43794490)
    • (2006) Human Gene Therapy , vol.17 , Issue.5 , pp. 507-517
    • Egermann, M.1    Baltzer, A.W.2    Adamaszek, S.3    Evans, C.4    Robbins, P.5    Schneider, E.6    Lill, C.A.7
  • 24
    • 1842740302 scopus 로고    scopus 로고
    • Combination of adeno-associated virus and adenovirus vectors expressing bone morphogenetic protein-2 produces enhanced osteogenic activity in immunocompetent rats
    • DOI 10.1016/j.bbrc.2004.03.098, PII S0006291X04005583
    • Chen Y, Luk KD, Cheung KM, et al. Combination of adeno-associated virus and adenovirus vectors expressing bone morphogenetic protein-2 produces enhanced osteogenic activity in immunocompetent rats. Biochem Biophys Res Commun 2004;317:675-81 (Pubitemid 38481425)
    • (2004) Biochemical and Biophysical Research Communications , vol.317 , Issue.3 , pp. 675-681
    • Chen, Y.1    Luk, K.D.K.2    Cheung, K.M.C.3    Lu, W.W.4    An, X.-M.5    Ng, S.S.M.6    Lin, M.C.7    Kung, H.-F.8
  • 26
    • 4844223862 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model
    • DOI 10.1016/j.orthres.2004.03.014, PII S0736026604000592
    • Bertone AL, Pittman DD, Bouxsein ML, et al. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy mmodel. J Orthop Res 2004;22:1261-70 (Pubitemid 39317917)
    • (2004) Journal of Orthopaedic Research , vol.22 , Issue.6 , pp. 1261-1270
    • Bertone, A.L.1    Pittman, D.D.2    Bouxsein, M.L.3    Li, J.4    Clancy, B.5    Seeherman, H.J.6
  • 28
    • 52649114788 scopus 로고    scopus 로고
    • LMP-1 retroviral gene therapy influences osteoblast differentiation and fracture repair: A preliminary study
    • Strohbach CA, Rundle CH, Wergedal JE, et al. LMP-1 retroviral gene therapy influences osteoblast differentiation and fracture repair: a preliminary study. Calcif Tissue Int 2008;83:202-11
    • (2008) Calcif. Tissue Int. , vol.83 , pp. 202-211
    • Strohbach, C.A.1    Rundle, C.H.2    Wergedal, J.E.3
  • 30
    • 33646337916 scopus 로고    scopus 로고
    • Bone regeneration by modified gene-activated matrix: Effectiveness in segmental tibial defects in rats
    • Endo M, Kuroda S, Kondo H, et al. Bone regeneration by modified gene-activated matrix: effectiveness in segmental tibial defects in rats. Tissue Eng 2006;12:489-97 (Pubitemid 43673454)
    • (2006) Tissue Engineering , vol.12 , Issue.3 , pp. 489-497
    • Endo, M.1    Kuroda, S.2    Kondo, H.3    Maruoka, Y.4    Ohya, K.5    Kasugai, S.6
  • 31
    • 15444381040 scopus 로고    scopus 로고
    • Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4)
    • DOI 10.1038/sj.gt.3302439
    • Huang YC, Simmons C, Kaigler D, et al. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther 2005;12:418-26 (Pubitemid 40394294)
    • (2005) Gene Therapy , vol.12 , Issue.5 , pp. 418-426
    • Huang, Y.-C.1    Simmons, C.2    Kaigler, D.3    Rice, K.G.4    Mooney, D.J.5
  • 32
    • 33947192399 scopus 로고    scopus 로고
    • The effect on bone regeneration of a liposomal vector to deliver BMP-2 gene to bone grafts in peri-implant bone defects
    • DOI 10.1016/j.biomaterials.2007.02.009, PII S0142961207001470
    • Park J, Lutz R, Felszeghy E, et al. The effect on bone regeneration of liposomal vector to deliver BMP-2 gene to bone grafts in peri-implant bon e defects. Biomaterials 2007;28:2772-82 (Pubitemid 46415761)
    • (2007) Biomaterials , vol.28 , Issue.17 , pp. 2772-2782
    • Park, J.1    Lutz, R.2    Felszeghy, E.3    Wiltfang, J.4    Nkenke, E.5    Neukam, F.W.6    Schlegel, K.A.7
  • 33
    • 68949211767 scopus 로고    scopus 로고
    • Osteoinduction by microbubble-enhanced transcutaneous sonoporation of human bone morphogenetic protein-2
    • Osawa K, Okubo Y, Nakao K, et al. Osteoinduction by microbubble-enhanced transcutaneous sonoporation of human bone morphogenetic protein-2. J Gene Med 2009;11:633-41
    • (2009) J. Gene. Med. , vol.11 , pp. 633-641
    • Osawa, K.1    Okubo, Y.2    Nakao, K.3
  • 34
    • 34250886203 scopus 로고    scopus 로고
    • Review: Gene- and stem cell-based therapeutics for bone regeneration and repair
    • DOI 10.1089/ten.2007.0096
    • Kimelman N, Pelled G, Helm GA, et al. Review: gene- and stem cell-based therapeutics for bone regeneration and repair. Tissue Eng 2007;13:113:5-50 (Pubitemid 46986715)
    • (2007) Tissue Engineering , vol.13 , Issue.6 , pp. 1135-1150
    • Kimelman, N.1    Pelled, G.2    Helm, G.A.3    Huard, J.4    Schwarz, E.M.5    Gazit, D.6
  • 35
    • 4544233119 scopus 로고    scopus 로고
    • Response of induced bone defects in horses to collagen matrix containing the human parathyroid hormone gene
    • DOI 10.2460/ajvr.2004.65.1223
    • Backstrom KC, Bertone AL, Wisner ER, Weisbrode SE. Response of induced bone defects in horses to collagen matrix containing the human paratahyroid hormone gene. Am J Vet Res 2004;65:1223-32 (Pubitemid 39232596)
    • (2004) American Journal of Veterinary Research , vol.65 , Issue.9 , pp. 1223-1232
    • Backstrom, K.C.1    Bertone, A.L.2    Wisner, E.R.3    Weisbrode, S.E.4
  • 37
    • 27644463397 scopus 로고    scopus 로고
    • Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber-mutant adenoviral BMP2 gene
    • DOI 10.1002/jgm.777
    • Tsuda H, Wada T, Yamashita T, Hamada H. Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber-mutant adenoviral rBMP2 gene. J Gene Med 2005;7:1322-34 (Pubitemid 41555438)
    • (2005) Journal of Gene Medicine , vol.7 , Issue.10 , pp. 1322-1334
    • Tsuda, H.1    Wada, T.2    Yamashita, T.3    Hamada, H.4
  • 39
    • 67749114142 scopus 로고    scopus 로고
    • Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs
    • Jiang X, Zhao J, Wang S, et al. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs. Biomaterials 2009;30:452:2-32
    • (2009) Biomaterials , vol.30 , pp. 4522-4532
    • Jiang, X.1    Zhao, J.2    Wang, S.3
  • 40
    • 78449288291 scopus 로고    scopus 로고
    • Enhancement of bone formation by BMP-7 transduced MSCs on biomimetic nanohydroxyapatite/ polyamide composite scaffolds in repair of mandibular defects
    • Li J, Li Y, Ma S, et al. Enhancement of bone formation by BMP-7 transduced MSCs on biomimetic nanohydroxyapatite/ polyamide composite scaffolds in repair of mandibular defects. J Biomed Mater Res A 2010;95:973-81
    • (2010) J. Biomed. Mater Res. A , vol.95 , pp. 973-981
    • Li, J.1    Li, Y.2    Ma, S.3
  • 41
    • 0036771653 scopus 로고    scopus 로고
    • Systematically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing
    • DOI 10.1097/00005131-200210000-00007
    • Shen FH, Visger JM, Balian G, et al. Systemically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing. J Orthop Trauma 2002;16:651-9 (Pubitemid 35214856)
    • (2002) Journal of Orthopaedic Trauma , vol.16 , Issue.9 , pp. 651-659
    • Shen, F.H.1    Visger, J.M.2    Balian, G.3    Hurwitz, S.R.4    Diduch, D.R.5
  • 42
    • 80053267201 scopus 로고    scopus 로고
    • Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: Analyses of MSCIGF autocrine and paracrine regenerative effects
    • Granero-Molto F, Myers TJ, Weis JA, et al. Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects. Stem Cells 2011;29:153:7-48
    • (2011) Stem Cells , vol.29 , pp. 1537-1548
    • Granero-Molto, F.1    Myers, T.J.2    Weis, J.A.3
  • 43
    • 41949123855 scopus 로고    scopus 로고
    • Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model
    • Virk MS, Conduah A, Park SH, et al. Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model. Bone 2008;42:921-31
    • (2008) Bone , vol.42 , pp. 921-931
    • Virk, M.S.1    Conduah, A.2    Park, S.H.3
  • 45
    • 52049104885 scopus 로고    scopus 로고
    • The effects of lentiviral gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats
    • Miyazaki M, Sugiyama O, Tow B, et al. The effects of lentiviral gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Spinal Disord Tech 2008;21:372-9
    • (2008) J. Spinal. Disord. Tech. , vol.21 , pp. 372-379
    • Miyazaki, M.1    Sugiyama, O.2    Tow, B.3
  • 46
    • 73949153030 scopus 로고    scopus 로고
    • Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone
    • Lian Z, Chuanchang D, Wei L, et al. Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone. J Orthop Res 2010;28:412-18
    • (2010) J. Orthop. Res. , vol.28 , pp. 412-418
    • Lian, Z.1    Chuanchang, D.2    Wei, L.3
  • 47
    • 17144412168 scopus 로고    scopus 로고
    • Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue
    • DOI 10.1089/ten.2005.11.120
    • Peterson B, Zhang J, Iglesias R, et al. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng 2005;11:120-9 (Pubitemid 40515180)
    • (2005) Tissue Engineering , vol.11 , Issue.1-2 , pp. 120-129
    • Peterson, B.1    Zhang, J.2    Iglesias, R.3    Kabo, M.4    Hedrick, M.5    Benhaim, P.6    Lieberman, J.R.7
  • 48
    • 22944474955 scopus 로고    scopus 로고
    • In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7
    • DOI 10.1080/14653240510027244
    • Yang M, Ma QJ, Dang GT, et al. In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7. Cytotherapy 2005;7:273-81 (Pubitemid 41051370)
    • (2005) Cytotherapy , vol.7 , Issue.3 , pp. 273-281
    • Yang, M.1    Ma, Q.J.2    Dang, G.T.3    Ma, K.T.4    Chen, P.5    Zhou, C.Y.6
  • 49
    • 34249329627 scopus 로고    scopus 로고
    • In vitro and in vivo induction of bone formation based on adeno-associated virus-mediated BMP-7 gene therapy using human adipose-derived mesenchymal stem cells
    • DOI 10.1111/j.1745-7254.2007.00583.x
    • Kang Y, Liao WM, Yuan ZH, et al. In vitro and in vivo induction of bone formation based on adeno-associated virus-mediated BMP-7 gene therapy using human adipose-derived mesenchymal stem cells. Acta Pharmacol Sin 2007;28:839-49 (Pubitemid 46817445)
    • (2007) Acta Pharmacologica Sinica , vol.28 , Issue.6 , pp. 839-849
    • Kang, Y.1    Liao, W.-M.2    Yuan, Z.-H.3    Sheng, P.-Y.4    Zhang, L.-J.5    Yuan, X.-W.6    Lei, L.7
  • 50
    • 33748958848 scopus 로고    scopus 로고
    • Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose - Derived stem cells in vitro and in vivo
    • DOI 10.1007/s00223-006-0083-6
    • Zhang X, Yang M, Lin L, et al. Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo. Calcif Tissue Int 2006;79:169-78 (Pubitemid 44440445)
    • (2006) Calcified Tissue International , vol.79 , Issue.3 , pp. 169-178
    • Zhang, X.1    Yang, M.2    Lin, L.3    Chen, P.4    Ma, K.T.5    Zhou, C.Y.6    Ao, Y.F.7
  • 51
    • 48749124949 scopus 로고    scopus 로고
    • In vivo bone formation following transplantation of human adipose-derived stromal cells that are not differentiated osteogenically
    • Jeon O, Rhie JW, Kwon IK, et al. In vivo bone formation following transplantation of human adipose-derived stromal cells that are not differentianted osteogenically. Tissue Eng Part A 2008;14:1285-94
    • (2008) Tissue Eng. Part A , vol.14 , pp. 1285-1294
    • Jeon, O.1    Rhie, J.W.2    Kwon, I.K.3
  • 55
    • 42149139129 scopus 로고    scopus 로고
    • Comparison of human mesenchymal stem cells derived from adipose tissue and bone marrow for ex vivo gene therapy in rat spinal fusion model
    • DOI 10.1097/BRS.0b013e31816b45c3, PII 0000763220080415000007
    • Miyazaki M, Zuk PA, Zou J, et al. Comparison of human mesenchymal stem cells derived from adipose tissue and bone marrow for ex vivo gene therapy in rat spinal fusion model. Spine (Phila Pa 1976) 2008:33:863-9 (Pubitemid 351533854)
    • (2008) Spine , vol.33 , Issue.8 , pp. 863-869
    • Miyazaki, M.1    Zuk, P.A.2    Zou, J.3    Yoon, S.H.4    Wei, F.5    Morishita, Y.6    Sintuu, C.7    Wang, J.C.8
  • 58
    • 2942527680 scopus 로고    scopus 로고
    • Ex vivo gene therapy-induced endochondral bone formation: Comparison of muscle-derived stem cells and different subpopulations of primary muscle-derived cells
    • DOI 10.1016/j.bone.2004.01.028, PII S8756328204000195
    • Shen HC, Peng H, Usas A, et al. Ex vivo gene therapy-induced endochondral bone formation: comparison of muscle-derived stem cells and different subpopulations of primary muscle-derived cells. Bone 2004;34:982-92 (Pubitemid 38749235)
    • (2004) Bone , vol.34 , Issue.6 , pp. 982-992
    • Shen, H.-C.1    Peng, H.2    Usas, A.3    Gearhart, B.4    Cummins, J.5    Fu, F.H.6    Huard, J.7
  • 60
    • 3042734229 scopus 로고    scopus 로고
    • Development of a self-inactivating tet-on retroviral vector expressing bone morphogenetic protein 4 to achieve regulated bone formation
    • DOI 10.1016/j.ymthe.2004.02.023, PII S1525001604000991
    • Peng H, Usas A, Gearhart B, et al. Development of a self-inactivating tet-on retroviral vector expressing bone morphogenetic protein 4 to achieve regulated bone formation. Mol Ther 2004;9:885-94 (Pubitemid 38878134)
    • (2004) Molecular Therapy , vol.9 , Issue.6 , pp. 885-894
    • Peng, H.1    Usas, A.2    Gearhart, B.3    Young, B.4    Olshanski, A.5    Huard, J.6
  • 61
    • 22644434623 scopus 로고    scopus 로고
    • Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4
    • DOI 10.1016/j.ymthe.2005.02.027, PII S1525001605001115
    • Peng H, Usas A, Hannallah D, et al. Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4. Mol Ther 2005;12:239-46 (Pubitemid 41025093)
    • (2005) Molecular Therapy , vol.12 , Issue.2 , pp. 239-246
    • Peng, H.1    Usas, A.2    Hannallah, D.3    Olshanski, A.4    Cooper, G.M.5    Huard, J.6
  • 64
    • 73949150050 scopus 로고    scopus 로고
    • Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model
    • Ishihara A, Zekas LJ, Litsky AS, et al. Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model. J Orthop Res 2010;28:403-11
    • (2010) J. Orthop. Res. , vol.28 , pp. 403-411
    • Ishihara, A.1    Zekas, L.J.2    Litsky, A.S.3
  • 65
    • 77953479600 scopus 로고    scopus 로고
    • Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model
    • Ishihara A, Zekas LJ, Weisbrode SE, Bertone AL. Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model. Gene Ther 2010;17:733-44
    • (2010) Gene. Ther. , vol.17 , pp. 733-744
    • Ishihara, A.1    Zekas, L.J.2    Weisbrode, S.E.3    Bertone, A.L.4
  • 66
    • 67651173151 scopus 로고    scopus 로고
    • Autografts and xenografts of skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis
    • Wang R, Zou Y, Yuan Z, et al. Autografts and xenografts of skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis. Anat Rec (Hoboken) 2009;292:777-86
    • (2009) Anat. Rec. (Hoboken , vol.292 , pp. 777-786
    • Wang, R.1    Zou, Y.2    Yuan, Z.3
  • 67
    • 21844479582 scopus 로고    scopus 로고
    • Bone regeneration in cranial defects previously treated with radiation
    • DOI 10.1097/01.MLG.0000166513.74247.CC
    • Nussenbaum B, Rutherford RB, Krebsbach PH. Bone regeneration in cranial defects previously treated with radiation. Laryngoscope 2005;115:1170-7 (Pubitemid 40962351)
    • (2005) Laryngoscope , vol.115 , Issue.7 , pp. 1170-1177
    • Nussenbaum, B.1    Rutherford, R.B.2    Krebsbach, P.H.3
  • 68
    • 52049086443 scopus 로고    scopus 로고
    • Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models
    • Lattanzi W, Parrilla C, Fetoni A, et al. Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models. Gene Ther 2008;15:1330-43
    • (2008) Gene. Ther. , vol.15 , pp. 1330-1343
    • Lattanzi, W.1    Parrilla, C.2    Fetoni, A.3
  • 69
    • 0042025193 scopus 로고    scopus 로고
    • Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type
    • DOI 10.1038/sj.gt.3302006
    • Gugala Z, Olmsted-Davis EA, Gannon FH, et al. Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type. Gene Ther 2003;10:1289-96 (Pubitemid 36987119)
    • (2003) Gene Therapy , vol.10 , Issue.16 , pp. 1289-1296
    • Gugala, Z.1    Olmsted-Davis, E.A.2    Gannon, F.H.3    Lindsey, R.W.4    Davis, A.R.5
  • 71
    • 57349140321 scopus 로고    scopus 로고
    • Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs
    • Jang BJ, Byeon YE, Lim JH, et al. Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs. J Vet Sci 2008;9:387-93
    • (2008) J. Vet. Sci. , vol.9 , pp. 387-393
    • Jang, B.J.1    Byeon, Y.E.2    Lim, J.H.3
  • 72
    • 33644859570 scopus 로고    scopus 로고
    • Human circulating peripheral blood mononuclear cells for calvarial bone tissue engineering
    • DOI 10.1097/01.prs.0000201489.65811.e7, PII 0000653420060200000017
    • Chim H, Schantz JT. Human circulating peripheral blood mononuclear cells for calvarial bone tissue engineering. Plast Reconstr Surg 2006;117:468-78 (Pubitemid 44400633)
    • (2006) Plastic and Reconstructive Surgery , vol.117 , Issue.2 , pp. 468-478
    • Chim, H.1    Schantz, J.-T.2
  • 73
    • 0035002311 scopus 로고    scopus 로고
    • Stem cells and the promise of eternal youth: Embryonic versus adult stem cells
    • DOI 10.1016/S0753-3322(01)00057-9
    • Labat ML. Stem cells and the promise of eternal youth: embryonic versus adult stem cells. Biomed Pharmacother 2001;55:179-85 (Pubitemid 32429563)
    • (2001) Biomedicine and Pharmacotherapy , vol.55 , Issue.4 , pp. 179-185
    • Labat, M.L.1
  • 75
    • 21444445838 scopus 로고    scopus 로고
    • Percutaneous autologous bone-marrow grafting for nonunions: Influence of the number and concentration of progenitor cells
    • DOI 10.2106/JBJS.D.02215
    • Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 2005;87:1430-7 (Pubitemid 40917741)
    • (2005) Journal of Bone and Joint Surgery - Series A , vol.87 , Issue.7 , pp. 1430-1437
    • Hernigou, Ph.1    Poignard, A.2    Beaujean, F.3    Rouard, H.4
  • 77
    • 67650685844 scopus 로고    scopus 로고
    • Platelet-rich plasma and fibrin glue-coated bioactive ceramics enhance growth and differentiation of goat bone marrow-derived stem cells
    • Nair MB, Varma HK, John A. Platelet-rich plasma and fibrin glue-coated bioactive ceramics enhance growth and differentiation of goat bone marrowr-derived stem cells. Tissue Eng Part A 2009;15:1619-31
    • (2009) Tissue Eng. Part A , vol.15 , pp. 1619-1631
    • Nair, M.B.1    Varma, H.K.2    John, A.3
  • 78
    • 0242552104 scopus 로고    scopus 로고
    • Adipose-derived adult stem cells: Isolation, characterization, and differentiation potential
    • DOI 10.1080/14653240310003026
    • Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 2003;5:362-9 (Pubitemid 37369023)
    • (2003) Cytotherapy , vol.5 , Issue.5 , pp. 362-369
    • Gimble, J.M.1    Guilak, F.2
  • 80
    • 0034285013 scopus 로고    scopus 로고
    • The osteoblast: A sophisticated fibroblast under central surveillance
    • Ducy P, Schinke T, Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science 2000;289:1501-4
    • (2000) Science , vol.289 , pp. 1501-1504
    • Ducy, P.1    Schinke, T.2    Karsenty, G.3
  • 81
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72 (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 82
    • 77649136214 scopus 로고    scopus 로고
    • Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells
    • Kao CL, Tai LK, Chiou SH, et al. Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells. Stem Cells Dev 2010;19:247-58
    • (2010) Stem. Cells Dev. , vol.19 , pp. 247-258
    • Kao, C.L.1    Tai, L.K.2    Chiou, S.H.3
  • 83
    • 0034212434 scopus 로고    scopus 로고
    • US gene therapy in crisis
    • Teichler Zallen D. US gene therapy in crisis. Trends Genet 2000;16:272-5
    • (2000) Trends Genet. , vol.16 , pp. 272-275
    • Teichler Zallen, D.1
  • 85
    • 0037294039 scopus 로고    scopus 로고
    • Non-viral and hybrid vectors in human gene therapy: An update
    • DOI 10.1016/S1471-4914(03)00005-4
    • Schmidt-Wolf GD, Schmidt-Wolf IG. Non-viral and hybrid vectors in human gene therapy: an update. Trends Mol Med 2003;9:67-72 (Pubitemid 36313867)
    • (2003) Trends in Molecular Medicine , vol.9 , Issue.2 , pp. 67-72
    • Schmidt-Wolf, G.D.1    Schmidt-Wolf, I.G.H.2
  • 88
    • 30544438742 scopus 로고    scopus 로고
    • Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture
    • DOI 10.1080/14653240500363216, PII N7748614010732
    • Wang Y, Huso DL, Harrington J, et al. Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy 2005;7:509-19 (Pubitemid 43078081)
    • (2005) Cytotherapy , vol.7 , Issue.6 , pp. 509-519
    • Wang, Y.1    Huso, D.I.2    Harrington, J.3    Kellner, J.4    Jeong, D.K.5    Turney, J.6    McNiece, I.K.7
  • 89
    • 53249090261 scopus 로고    scopus 로고
    • Retrovirus-induced oncogenesis and safety of retroviral vectors
    • Nair V. Retrovirus-induced oncogenesis and safety of retroviral vectors. Curr Opin Mol Ther 2008;10:431-8
    • (2008) Curr. Opin. Mol. Ther. , vol.10 , pp. 431-438
    • Nair, V.1
  • 90
    • 0038700553 scopus 로고    scopus 로고
    • Selective ablation of human embryonic stem cells expressing a "suicide" gene
    • Schuldiner M, Itskovitz-Eldor J, Benvenisty N. Selective ablation of human embryonic stem cells expressing a "suicide" gene. Stem Cells 2003;21:257-65 (Pubitemid 36623167)
    • (2003) Stem Cells , vol.21 , Issue.3 , pp. 257-265
    • Schuldiner, M.1    Itskovitz-Eldor, J.2    Benvenisty, N.3
  • 91
    • 48349106268 scopus 로고    scopus 로고
    • Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1
    • Choo AB, Tan HL, Ang SN, et al. Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxiny-like protein-1. Stem Cells 2008;26:1454-63
    • (2008) Stem Cells , vol.26 , pp. 1454-1463
    • Choo, A.B.1    Tan, H.L.2    Ang, S.N.3
  • 92
    • 77954026714 scopus 로고    scopus 로고
    • Guided bone regeneration: Biological principle and therapeutic applications
    • Retzepi M, Donos N. Guided Bone Regeneration: biological principle and therapeutic applications. Clin Oral Implants Res 2010;21:567-76
    • (2010) Clin. Oral. Implants. Res. , vol.21 , pp. 567-576
    • Retzepi, M.1    Donos, N.2
  • 93
    • 0034150961 scopus 로고    scopus 로고
    • A histochemical investigation of the bone formation process by guided bone regeneration in rat jaws effect of PTFE membrane application periods on newly formed bone
    • Ohnishi H, Fujii N, Futami T, et al. A histochemical investigation of the bone formation process by guided bone regeneration in rat jaws. Effect of PTFE membrane application periods on newly formed bone. J Periodontol 2000;71:341-52
    • (2000) J. Periodontol. , vol.71 , pp. 341-352
    • Ohnishi, H.1    Fujii, N.2    Futami, T.3
  • 94
    • 66649136744 scopus 로고    scopus 로고
    • Comparison of dermal matrix and polytetrafluoroethylene membrane for socket bone augmentation: A clinical and histologic study
    • Fotek PD, Neiva RF, Wang HL. Comparison of dermal matrix and polytetrafluoroethylene membrane for socket bone augmentation: a clinical and histologic study. J Periodontol 2009;80:776-85
    • (2009) J. Periodontol. , vol.80 , pp. 776-785
    • Fotek, P.D.1    Neiva, R.F.2    Wang, H.L.3
  • 96
    • 77950657693 scopus 로고    scopus 로고
    • Safety, tolerability, and clinical outcomes after intraarticular injection of arecombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: Results of a Phase I/II Study
    • Mease PJ, Wei N, Fudman EJ, et al. Safety, tolerability, and clinical outcomes after intraarticular injection of arecombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a Phase I/II Study. J Rheumatol 2010;37:692-703
    • (2010) J. Rheumatol. , vol.37 , pp. 692-703
    • Mease, P.J.1    Wei, N.2    Fudman, E.J.3
  • 97
    • 58849159153 scopus 로고    scopus 로고
    • Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis
    • Wehling P, Reinecke J, Baltzer AW, et al. Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther 2009;20:97-101
    • (2009) Hum. Gene. Ther. , vol.20 , pp. 97-101
    • Wehling, P.1    Reinecke, J.2    Baltzer, A.W.3
  • 98
    • 66149096522 scopus 로고    scopus 로고
    • Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use
    • Chang PC, Cirelli JA, Jin Q, et al. Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use. Hum Gene Ther 2009;20:486-96
    • (2009) Hum. Gene. Ther. , vol.20 , pp. 486-496
    • Chang, P.C.1    Cirelli, J.A.2    Jin, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.