Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2

Journal of Bone and Joint Surgery - Series B

Volumn 84, Issue 1, 2002, Pages 120-127

  Musgrave, D S ^a   Pruchnic, R ^a   Bosch, P ^a   Ziran, B H ^a   Whalen, J ^a   Huard, J ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; BETA GALACTOSIDASE; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 2; NUCLEAR PROTEIN; RETROVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL LABELING; CELL NUCLEUS; CELL POPULATION; CELL SECRETION; CELL STIMULATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME SYNTHESIS; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE LOCATION; GENE THERAPY; GENETIC CODE; GENETIC ENGINEERING; GENETIC TRANSDUCTION; HINDLIMB; HISTOPATHOLOGY; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUSCLE CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SECRETION; RADIOGRAPHY;

EID: 0036151114     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.84B1.11708     Document Type: Article

References (25)

1. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: A correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model
2. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
3. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy
4. The efficiency of muscle-derived cell-mediated bone formation
5. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing
6. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents
7. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats
8. Gene therapy: Adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo
9. Expression of human bone morphogenetic protein 7 in primary rabbit periosteal cells: Potential utility in gene therapy for osteochondral repair
10. Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone
11. Ex vivo gene therapy to produce bone using different cell types
12. Osteoprogenitor cells within skeletal muscle
13. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
14. Repair of calvarial defects with flap tissue: Role of bone morphogenetic proteins and competent responding tissues
15. Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle and skin
16. Development of approaches to improve cell survival in myoblast transfer therapy
17. Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy
18. Construction of adenovirus vectors through Cre-lox recombination
19. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
20. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes
21. Osteogenetic competence
22. Recombinant human bone morphogenetic protein induces bone formation
23. Mesenchymal stem cells
24. Bone: Formation by autoinduction
25. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro