Mesenchymal stem cells expressing insulin-like growth factor-I (MSC IGF) promote fracture healing and restore new bone formation in irs1 knockout mice: Analyses of MSC IGF autocrine and paracrine regenerative effects

Stem Cells

Volumn 29, Issue 10, 2011, Pages 1537-1548

  Granero Moltó, Froilán ^a   Myers, Timothy J ^a   Weis, Jared A ^a   Longobardi, Lara ^a   Tieshi, Li ^a   Yan, Yun ^a   Case, Natasha ^a   Rubin, Janet ^a   Spagnoli, Anna ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Fracture healing; Insulin like growth factor; Mesenchymal stem cells; Mouse models

Indexed keywords

BETA GALACTOSIDASE; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BONE MARROW CULTURE; BONE MINERALIZATION; BONE REGENERATION; BONE STRENGTH; CALLUS; CELL DIFFERENTIATION; CONTROLLED STUDY; FRACTURE HEALING; FRACTURE NONUNION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOPATHOLOGY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; PARACRINE SIGNALING; PROTEIN EXPRESSION; TIBIA FRACTURE;

ANIMALS; BONY CALLUS; CELL DIFFERENTIATION; CELL MIGRATION ASSAYS; FEMALE; FRACTURE HEALING; GENETIC VECTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; OSTEOGENESIS; RECOMBINANT PROTEINS; RETROVIRIDAE; TRANSFECTION;

MUS;

EID: 80053267201     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.697     Document Type: Article

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