Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin

Journal of Bone and Mineral Research

Volumn 15, Issue 4, 2000, Pages 663-673

  Abe, Etsuko ^a,c   Yamamoto, Matsuo ^a   Taguchi, Yasuto ^a   Lecka Czernik, Beata ^a   O'Brien, Charles A ^a   Economides, Aris N ^b   Stahl, Neil ^b   Jilka, Robert L ^a   Manolagas, Stavros C ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

BMP receptors; Bone cell progenitors; Bone remodeling; CFU osteoblast (CFU OB); Colony forming unit fibroblast (CFU F)

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE CELL; BONE MARROW CULTURE; BONE REMODELING; CELL MATURATION; COLONY FORMING UNIT; FIBROBLAST; GENE EXPRESSION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; STEM CELL;

EID: 0034103380     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.4.663     Document Type: Article

References (39)

1. Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling: Emerging insights into the pathophysiology of osteoporosis. N Eng J Med 332:305-311.
2. Parfitt AM 1994 Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55:273-286.
3. Jilka RL, Hangoc G, Girasole G, Passere G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas, SC 1992 Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science 257:88-91.
4. Jilka RL, Weinstein RS, Takahashi K, Parfitt AM, Manolagas SC 1996 Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest 97:1732-1740.
5. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC 1998 Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: Potential mechanisms of their deleterious effects on bone. J Clin Invest 102:274-282.
6. Parfitt AM 1990 Bone forming cells in clinical conditions. In: Hall BK (ed.) Bone, The Osteoblast and Osteocyte, vol. 1. Telford and CRC Press, Boca Raton, FL, U.S.A., pp. 351-429.
7. Mundy GR 1996 Role of cytokines, parathyroid hormone and growth factors in malignancy. In: Bilezekian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, U.S.A., pp. 827-836.
8. Jilka RL, Takahashi K, Munshi M, Williams DC, Roberson PK, Manolagas SC 1998 Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow: Evidence for autonomy from factors released during bone resorption. J Clin Invest 101:1942-1959.
9. Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF 1996 Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med 2:1132-1136.
10. Rosen V, Cox K, Hattersley G 1996 Bone morphogenetic proteins. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, U.S.A., pp. 661-671.
11. Kirker-Head CA, Gerhart TN, Schelling SH, Henng GE, Wang E, Holtrop ME 1995 Long-term healing of bone using recombinant human bone morphogenetic protein 2. Clin Orthop 318:222-230.
12. Nifuji A, Kellermann O, Kuboki Y, Wozney JM, Noda M 1997 Perturbation of BMP signaling in somitogenesis resulted in vertebral and rib malformations in the axial skeletal formation. J Bone Miner Res 12:332-334.
13. Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T 1998 Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273: 1872-1879.
14. Ducy P, Zhang R, Geoffriy Y, Ridall AL, Karsenty G 1997 Osf2/cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747-754.
15. Komori TH, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997 Targeted disruption of cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
16. Piccolo S, Sasai Y, Lu B, De Robertis EM 1996 Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86:589-598.
17. Zimmerman LB, DeJesus-Escobar JM, Harland RM 1996 The Spemann organizer signal, noggin binds and inactivates bone morphogenetic protein 4. Cell 86:599-606.
18. Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL 1996 The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell 86:607-617.
19. Re'em-Kalma Y, Lamb T, Frank D 1996 Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development. Proc Natl Acad Sci USA 92:12141-12145.
20. Valenzuela DM, Economides AN, Rojas E, Lamb TM, Numez L, Jones P, Ip NY, Espinosa III R, Brannan CI, Gilbert DJ, Copeland NG, Jenkins NA, Le Beau MM, Harland RM, Yancopoulos GD 1995 Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci 15:6077-6084.
21. Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM 1996 Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382:595-601.
22. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC 1997 The effect of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology 138:4013-4021.
23. Suda T, Takahashi N, Martin TJ 1995 Modulation of osteoclast differentiation: Update 1995. Endocr Rev 4:266-270.
24. Lacey DL, Timms E, Tan H-L, Kelley MJ, Dunstan CR, Burgess T, Elliot R, Colombero A, Elliot G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian Y-X, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176.
25. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S-I, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95:3597-3602.
26. Nagasaki N, Kinoshita M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashi K 1998 RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun 252:395-400.
27. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T 1994 Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755-1766.
28. Lecka-Czernik B, Gubrij I, Moerman EA, Kajkenova O, Lipschitz DA, Manolagas SC, Jilka RL 1999 Inhibition of Osf2/ Cbfa 1 expression and terminal osteoblast differentiation by PPARγ2. J Cell Biochem 74:357-371.
29. Lee KC, Tak KK, Park MO, Lee JT, Woo BH, Yoo SD, Lee HS, Deluca PP 1999 Preparation and characterization of polyethylene-glycol-modified salmon calcitonins. Pharm Dev Tech 4:269-275.
30. Lin S-C, Yamate T, Taguchi Y, Borba V, Girasole G, O'Brien CA, Bellido T, Abe E, Manolagas SC 1997 Regulation of the gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. J Clin Invest 100:1980-1990.
31. Inada M, Katagiri T, Akiyama S, Namiki M, Komaki M, Yamaguchi A, Komori K, Rosen V, Suda T 1996 Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but not induce their differentiation into osteoblasts. Biochem Biophys Res Commun 222:317-322.
32. Yamate T, Mocharla H, Taguchi Y, Igietseme JU, Manolagas SC, Abe E 1997 Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: Demonstration of its requirement for osteoclastogenesis and its increase following ovariectomy. Endocrinology 138:3047-3055.
33. Kanatani M, Sugimoto T, Kobayashi T, Nishiyama K, Fukase M, Kumegawa M, Chihara K 1995 Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity. J Bone Miner Res 10:1681-1190.
34. Hentunen TA, Lakkakorpi PT, Tuukkanen J, Lehenkari PP, Sampath TK, Vaananen HK 1995 Effects of recombinant human osteogenic protein-1 on the differentiation of osteoclast-like cells and bone resorption. Biochem Biophys Res Commun 209:433-443.
35. Gbriji I, Lecka-Czrnik B, Kajkenova O, O'Brien CA, Lipschitz D, Manolagas SC, Jilka RL 1997 Isolation of clonal cell lines with distinct differentiation potential of the osteoclasts, adipocytes, or both: Association of the osteoclast support function with bipotentiality [abstract]. J Bone Miner Res 12: S183.
36. Brunet LJ, McMahon JA, McMahon AP, Harland RM 1998 Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280:1455-1457.
37. Gazzerro E, Gangji V, Canalis E 1998 Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest 102:2106-2114.
38. Kimble RB, Liu X, Gannon FA, Caplan FS, Shore EM, Economides AN. Stahl N 1998 Noggin inhibits bone formation in a model of heterotopic ossification [abstract]. J Bone Miner Res 12:S244.
39. O'Brien CA, Farrar NC, Manolagas SC 1998 Identification of an OSF-2 binding site in the murine RANKL/OPGL gene promoter: A potential link between osteoblastogenesis and osteoclastogenesis [abstract]. J Bone Miner Res 12:S149.