Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect

Journal of Bone and Joint Surgery

Volumn 85, Issue 10, 2003, Pages 1927-1935

  Arinzeh, Treena Livingston ^a,b   Peter, Susan J ^a,c   Archambault, Michael P ^a,d   Van Den Bos, Christian ^a,d   Gordon, Steve ^a,d   Kraus, Karl ^a,d   Smith, Alan ^a,e   Kadiyala, Sudha ^a,e  

^a OSIRIS THERAPEUTICS INC   (United States)

^b NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^c Medtronic Sofamor Danek   (United States)

^d TUFTS UNIVERSITY   (United States)

^e Synthes Technical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCIUM PHOSPHATE; HYDROXYAPATITE; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE; BONE ALLOGRAFT; BONE DEFECT; BONE MARROW; BONE RADIOGRAPHY; CALLUS; CARTILAGE; CONNECTIVE TISSUE; CONTROLLED STUDY; DIAPHYSIS; DOG; FEMUR; HEALING; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IMPLANT; LYMPHOCYTIC INFILTRATION; MESENCHYME CELL; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; STEM CELL;

EID: 0141889330     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/00004623-200310000-00010     Document Type: Article

References (33)

1. Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG. Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone. Biomaterials. 1996;17:175-85.
2. Gazdag AR, Lane JM, Glaser D, Forster RA. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg. 1995;3:1-8.
3. Li XQ, Stevenson S, Klein L, Davy DT, Shaffer JW, Goldberg VM. Differential patterns of incorporation and remodeling among various types of bone grafts. Acta Anat (Basel). 1991;140:236-44.
4. Ehrler DM, Vaccaro AR. The use of allograft bone in lumbar spine surgery. Clin Orthop. 2000;371:38-45.
5. Head WC, Emerson RH Jr, Malinin TI. Structural bone grafting for femoral reconstruction. Clin Orthop. 1999;369:223-9.
6. Garbuz DS, Masri BA, Czitrom AA. Biology of allografting. Orthop Clin North Am. 1998;29:199-204.
7. Aho AJ, Ekfors T, Dean PB, Aro HT, Ahonen A, Nikkanen V. Incorporation and clinical results of large allografts of the extremities and pelvis. Clin Orthop. 1994;307:200-13.
8. Pittenger MF, Mackay AM, Beck SC, Jalswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-7.
9. Caplan AI, Fink DJ, Goto T, Linton AE, Young RG, Wakitani S, Goldberg VM, Haynesworth SE. Mesenchymal stem cells and tissue repair. In: Jackson DW, Arnoczky SP, Woo SL, Frank CB, Simon TM, editors. The anterior cruciate ligament: current and future concepts. New York: Raven Press; 1993. p 405-17.
10. Jaiswai N, Haynesworth SE, Caplan AI, Bruder SP. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997;64:295-312.
11. Friedenstein AJ, Challakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987;20:263-72.
12. Lennon DP, Haynesworth SE, Bruder SP, Jalswal NJ, Caplan AI. Human and animal mesenchymal progenitor cells from bone marrow: identification of serum for optimal selection and proliferation. In Vitro Cell Dev Biol. 1996; 32:602-11.
13. Beresford JN. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop. 1989;240:270-80.
14. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992;13:69-80.
15. Bruder SP, Horowitz MC, Mosca JD, Haynesworth SE. Monoclonal antibodies reactive with human osteogenic cell surface antigens. Bone. 1997; 21:225-35.
16. Bruder SP, Jalswal N, Haynesworth SE. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem. 1997;64:278-94.
17. Bruder SP, Kraus KH, Goldberg VM, Kadiyala S. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am. 1998;80:985-96.
18. Kadiyala S, Jalswal N, Bruder SP. Culture-expanded, bone marrow-derived mesenchymal stem cells can regenerate a critical-sized segmental bone defect. Tissue Eng. 1997;3:173-85.
19. Bruder SP, Kurth AA, Shea M, Hayes WC, Jalswal N, Kadiyala S. Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res. 1998;16:155-62.
20. Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patll S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;30:42-8.
21. Di Nicola M, Carlo-Steila C, Magni M, Milanesi M, Longonl PD, Matteucci P, Grisanti S, Gianni AM. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002;99:3838-43.
22. Devine SM, Peter S, Martin BJ, Barry F, McIntosh KR. Mesenchymal stem cells: stealth and suppression. Cancer J. 2001;7(Suppl 2):S76-82.
23. McIntosh K, Bartholomew A. Stromal cell modulation of the immune system. A potential role for mesenchymal stem cells. Graft. 2000;3;324-8.
24. Wagner JL, Burnett RC, DeRose SA, Francisco LV, Storb R, Ostrander EA. Histocompatibility testing of dog families with highly polymorphic microsatellite markers. Transplantation. 1996;62:876-7.
25. Marquet RL, de Bruin RW, Ijzermans JN. Induction of specific inhibition of alloreactivity in beagle dogs by intrathymic injection of donor splenocytes. Transpl Int. 1996;9(Suppl 1):S379-81.
26. Hartner WC, Markees TG, De Fazio SR, Khouri W, Maki T, Monaco AP, Gozzo JJ. The effect of antilymphocyte serum, fractionated donor bone marrow, and cyclosporine on renal allograft survival in mongrel dogs. Transplantation. 1991;52:784-9.
27. Colombe BW. Histocompatibility testing. In: Stites DP, Terr AI, editors. Basic and clinical immunology. 7th ed. Norwalk: Appleton and Lange; 1991. p 295-311.
28. Clcclarelll J, Helstab K, Mendez R. Flow cytometry PRA, a new test that is highly correlated with graft survival. Clin Transplant. 1992;6:159-64.
29. Gazit D, Turgeman G, Kelley P, Wang E, Jalenak M, Zilberman Y, Moutsatsos I. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med. 1999; 1:121-33.
30. Hock JM, Krishnan V, Onyla JE, Bidweil JP, Milas J, Stanislaus D. Osteoblast apoptosis and bone turnover. J Bone Miner Res. 2001;16:975-84.
31. Krebsbach PH, Kuznetsov SA, Satomura K, Emmons RV, Rowe DW, Robey PG. Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation. 1997;63:1059-69.
32. Gosain AK, Song L, Riordan P, Amarante MT, Nagy PG, Wilson CR, Toth JM, Ricci JL. A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: part I. Plast Reconstr Surg. 2002;109:619-30.
33. Livingston TL, Gordon S, Archambault M, McIntosh K, Kadiyala S, Smith A, Peter S. Mesenchymal stem cells and biphasic calcium phosphate ceramics. J Mater Sci Mater Med. 2003;14:211-8.