In vitro and in vivo induction of bone formation based on adeno-associated virus-mediated BMP-7 gene therapy using human adipose-derived mesenchymal stem cells

Acta Pharmacologica Sinica

Volumn 28, Issue 6, 2007, Pages 839-849

  Kang, Yan ^a   Liao, Wei Ming ^a   Yuan, Zhen Hua ^b   Sheng, Pu Yi ^a   Zhang, Long Juan ^a   Yuan, Xiang Wei ^a   Lei, Lei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Adeno associated virus; Adipose derived mesenchymal stem cells; Bone morphogenetic protein; Ectopic bone formation; Gene therapy

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; GREEN FLUORESCENT PROTEIN; OSTEOCALCIN; OSTEOGENIC PROTEIN 1;

ADENO ASSOCIATED VIRUS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIPOSUCTION; MALE; MESENCHYMAL STEM CELL; MINERALIZATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN SYNTHESIS; QUALITATIVE ANALYSIS; SCID MOUSE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADIPOSE TISSUE; ANIMALS; BONE MORPHOGENETIC PROTEIN 7; CELL LINE; CELL SHAPE; CELL TRANSPLANTATION; DEPENDOVIRUS; GENE THERAPY; HUMANS; IMMUNOPHENOTYPING; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, SCID; OSTEOCALCIN; OSTEOGENESIS;

EID: 34249329627     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00583.x     Document Type: Article

References (46)

1. Colterjohn NR, Bednar DA. Procurement of bone graft from the iliac crest: an operative approach with decreased morbidity. J Bone Joint Surg Am, 1997 79 : 756 9.
2. Gamradt, SC, Lieberman JR. Bone graft for revision hip arthroplasty: biology and future applications. Clin Orthop Relat Res 2003 417 183 94.
3. Hannallah D, Peterson B, Lieberman JR, Fu FH, Huard J. Gene therapy in orthopaedic surgery. J Bone Joint Surg Am, 2002 84A : 1046 61.
4. Wozney, JM. Bone morphogenetic proteins. Prog Growth Factor Res, 1989 1 : 267 80.
5. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al. Novel regulators of bone formation: molecular clones and activities. Science, 1988 242 : 1528 34.
6. Philips FM, Turner AS, Seim HB 3rd., MacLeay J, Toth CA, Pierce AR, et al. In vivo BMP-7 (OP-1) enhacement of osteoporotic vertebral bodies in an ovine model. Spine J, 2006 6 : 500 6.
7. Sugiyama O, An DS, Kung SPK, Feeley BT, Gamradt S, Liu NQ, et al. Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo. Mol Ther 2005 11 : 390 8.
8. Pluhar GE, Turner AS, Pierce AR, Toth CA, Wheeler DL. A comparison of two biomaterial carriers for osteogenic protein-1 (BMP-7) in an ovine critical defect model. J Bone Surg Br, 2006 88 : 960 6.
9. Abe N, Lee YP, Sato M, Zhang X, Wu J, Mitani K, et al. Enhancement of bone repair with a helper-dependent adenoviral transfer of bone morphogenetic protein-2. Biochem Biophys Res Commun, 2002 297 : 523 7.
10. Lee JY, Peng H, Usas A, Musgrave D, Cummins J, Pelinkovic D, et al. Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum Gene Ther, 2002 13 : 1201 11.
11. Sugiyama O, Orimo H, Suzuki S, Yamashita K, Ito H, Shimada T, et al. Bone formation following transplantation of genetically modified primary bone marrow stromal cells. J Orthop Res, 2003 21 : 630 7.
12. Wilson JM. Adenoviruses as gene-delivery vehicles. N Engl J Med, 1996 334 : 1185 7.
13. Anderson WF. Human gene therapy. Nature, 1998 392 : 25 30.
14. Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol, 1992 158 : 97 129.
15. Samulski RJ, Chang LS, Shenk T. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol, 1989 63 : 3822 8.
16. Stiehler M, Duch M, Mygind T, Li H, Ulrich-Vinther M, Modin C, et al. Optimizing viral and non-viral gene transfer methods for genetic modification of porcine mesenchymal stem cells. Adv Exp Med Biol, 2006 585 : 31 48.
17. Monahan PE, Samulski RJ. AAV vectors: is clinical success on the horizon Gene Ther 2000 7 : 24 30.
18. Chen Y, Luk KD, Cheung KM, Xu R, Lin MC, Lu WW, et al. Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors. Gene Ther, 2003 10 : 1345 53.
19. Luk KD, Chen Y, Cheung KM, Kung HF, Lu WW, Leong JC. Adeno-associated virus-mediated bone morphogenetic protein-4 gene therapy for in vivo bone formation. Biochem Biophys Res Commun, 2003 308 : 636 45.
20. Gafni Y, Pelled G, Zilberman Y, Turgeman G, Apparailly F, Yotvat H, et al. Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system. Mol Ther, 2004 9 : 587 95.
21. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng, 2001 7 : 211 28.
22. De Ugarte DA, Ashjian PH, Elbarbary A, Hedrick MH. Future of fat as raw material for tissue regeneration. Ann Plast Surg, 2003 50 : 215 9.
23. Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol, 2001 189 : 54 63.
24. Lee JA, Parrett BM, Conejero JA, Laser J, Chen J, Kogon AJ, et al. Biological alchemy: engineering bone and fat from fat-derived mesenchymal stem cells. Ann Plast Surg, 2003 50 : 610 7.
25. Aust L, Devlin B, Foster SJ, Halvorsen YD, Hicok K, du Laney T, et al. Yield of human adipose-derived mesenchymal stem cells from liposuction aspirates. Cytotherapy, 2004 6 : 7 10.
26. Ponnazhagan S, Yoder MC, Srivastava A. Adeno-associated virus type 2-mediated transduction of murine hematopoietic cells with long-term repopulating ability and sustained expression of a human globin gene in vivo. J Virol 1997 71 : 3098 104.
27. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent mesenchymal stem cells. Mol Biol Cell, 2002 13 : 4279 95.
28. Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol, 2001 189 : 54 63.
29. Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC. Human adipose tissue-derived mesenchymal stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun 2005 332 : 370 9.
30. Li R, Wozney J. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol, 2001 19 : 255 65.
31. Dragoo JL, Choi JY, Lieberman JR, Huang J, Zuk PA, Zhang J, et al. Bone induction by BMP-2 transduced mesenchymal stem cells derived from human fat. J Orthop Res, 2003 21 : 622 9.
32. Kawai M, Bessho K, Kaihara S, Sonobe J, Oda K, Iizuka T, et al. Ectopic bone formation by human bone morphogenetic protein-2 gene transfer to skeletal muscle using transcutaneous electroporation. Hum Gene Ther, 2003 14 : 1547 56.
33. Park J, Ries J, Gelse K, Kloss F, von der Mark K, Wiltfang J, et al. Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther, 2003 10 : 1089 98.
34. Betz OB, Betz VM, Nazarian A, Egermann M, Gerstenfeld LC, Einhorn TA, et al. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther 2007 Apr 26 : [Epub ahead of print].
35. Lieberman JR, Daluiski A, Stevenson S, Wu L, McAllister P, Lee YP, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am, 1999 81 : 905 17.
36. Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG. Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine, 2003 28 : 2049 57.
37. Wang JC, Kanim LE, Yoo S, Campbell PA, Berk AJ, Lieberman JR. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am, 2003 85 : 905 11.
38. Amalfitano A, Parks RJ. Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy. Curr Gene Ther, 2002 2 : 111 33.
39. Yang M, Ma QJ, Dang GT, Ma K, Chen P, Zhou CY. In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived mesenchymal stem cells expressing BMP-7. Cytotherapy, 2005 7 : 273 81.
40. Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat Genet, 2000 24 : 257 61.
41. Aubert D, Pichard V, Durand S, Moullier P, Ferry N. Cytotoxic immune response after retroviral-mediated hepatic gene transfer in rat does not preclude expression from adeno-associated virus 1 transduced muscles. Hum Gene Ther, 2003 14 : 473 81.
42. Asahina I, Sampath TK, Hauschka PV. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res, 1996 222 : 38 47.
43. Lee JY, Musgrave D, Pelinkovic D, Fukushima K, Cummins J, Usas A, et al. Effect of bone morphogenetic protein-2-express-ing muscle-derived cells on healing of critical-sized bone defects in mice. J Bone Joint Surg Am, 2001 83 : 1032 9.
44. Noel D, Gazit D, Bouquet C, Apparailly F, Bony C, Plence P, Millet V, et al. Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal mesenchymal stem cells. Mesenchymal Stem Cells, 2004 22 : 74 85.
45. Moutsatsos IK, Turgeman G, Zhou S, Kurkalli BG, Pelled G, Tzur L, et al. Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther, 2001 3 : 449 61.
46. Peng H, Usas A, Gearhart B, Young B, Olshanski A, Huard J, et al. Development of a self-inactivating Tet-On retroviral vector expressing bone morphogenetic protein 4 to achieve regulated bone formation. Mol Ther, 2004 9 : 885 94.