Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation

Neuroscience

Volumn 169, Issue 2, 2010, Pages 843-854

  Horvath, R J ^a,b   Landry, R P ^a,c   Romero Sandoval, E A ^a,b,c   DeLeo, J A ^a,b,c  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Neuroscience Center at Dartmouth   (United States)

^c DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Chronic pain; Glia; MAPK; Microglial memory; Opioids; Paw incision

Indexed keywords

ADAPTOR PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; IONIZED CALCIUM BINDING ADAPTOR PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; SODIUM CHLORIDE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; GENE ACTIVATION; HYPERALGESIA; IMMUNOFLUORESCENCE; LONG TERM EXPOSURE; MALE; MICROGLIA; MORPHINE TOLERANCE; MOUSE; NERVE CELL; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

ANIMALS; CALCIUM-BINDING PROTEINS; DRUG TOLERANCE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLIAL FIBRILLARY ACIDIC PROTEIN; HOT TEMPERATURE; MALE; MICROFILAMENT PROTEINS; MORPHINE; NARCOTICS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TOUCH;

EID: 77954624044     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.05.030     Document Type: Article

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