Pathobiology of neuropathic pain

European Journal of Pharmacology

Volumn 429, Issue 1-3, 2001, Pages 23-37

  Zimmermann, Manfred ^a  

^a Neuroscience and Pain Research Institute   (Germany)

Author keywords

Allodynia; Animal pain model; Apoptosis; Autotomy; Deafferentation; Hyperalgesia; Na+ channel; Nerve injury; Nerve trauma; Neuropathy; Opioid; Phantom pain; Sensitization; TNF (tumor necrosis factor ); Transcription

Indexed keywords

ALCOHOL; ANTICONVULSIVE AGENT; CANNABINOID DERIVATIVE; CLONIDINE; DEXMEDETOMIDINE; GLYCEROL; INTERLEUKIN 1; KETOPROFEN; MAGNESIUM SULFATE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE; PROTEIN KINASE C; SODIUM CHANNEL; TUMOR NECROSIS FACTOR ALPHA;

ALLODYNIA; ANIMAL BEHAVIOR; APOPTOSIS; AUTOTOMY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME PHOSPHORYLATION; GENE INDUCTION; HUMAN; HYPERALGESIA; IMMEDIATE EARLY GENE; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NERVE FIBER TRANSECTION; NERVE INJURY; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; THERMAL STIMULATION; WITHDRAWAL REFLEX;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MONONEUROPATHIES; PAIN; POLYNEUROPATHIES;

EID: 0035840825     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01303-6     Document Type: Review

References (106)

1. Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats
2. Use of an animal model to evaluate the origin of and protection against deafferentation pain
3. Sex-dependent effects of formalin and restraint on c-fos expression in the septum and hippocampus on the rat
4. Peripheral nerve insult induces NMDA-receptor-mediated, delayed degeneration in spinal neurons
5. Peripheral neuropathic pain: From mechanisms to symptoms
6. Postherpetic neuralgia: Are C-nociceptors involved in signalling and maintenance of tactile allodynia?
7. Mechanical allodynia in postherpetic neuralgia: Evidence for central mechanisms depending on nociceptive C-fiber degeneration
8. Animal models of neuropathic pain. Proceedings of the 7th World Congress on Pain
9. Neuropathic pain
10. A peripheral mononeuropathie in rat that produces disorders of pain sensation like those seen in man
11. The influence of housing condition on autotomy following dorsal rhizotomy in rats
12. Characteristics of spinal dorsal horn neurons after partial chronic deafferentation by dorsal root transection
13. Effects of nerve injury on sympathetic excitation of A delta mechanical nociceptors
14. Sympathectomy induces adrenergic excitability of cutaneous C-fiber nociceptors
15. Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat model
16. Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate
17. Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain
18. Characteristics of ectopic discharges in a rat neuropathic pain model
19. Deafferentation and chronic pain in animals: An evaluation of evidence suggesting autotomy is related to pain
20. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states
21. What is the signal for chromatolysis?
22. Sodium channels and the molecular pathophysiology of pain
23. Evidence for involvement of N-methyl-D-aspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat
24. The pathophysiology of damaged peripheral nerves
25. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
26. The development in regenerating cutaneous nerves of C-fibre receptors responding to noxious heating of the skin
27. Initial characterization of the transplant of immortalized chromaffin cells for the attenuation of chronic neuropathic pain
28. TNF-alpha expression in painful and nonpainful neuropathies
29. Sodium channel accumulation in humans with painful neuromas
30. Programmed cell death in virus infections of the nervous system
31. Magnesium sulphate injected subcutaneously suppresses autotomy in peripherally deafferented rats
32. Phantom-pain as a perceptual correlate of cortical reorganization following arm amputation
33. The role of central and peripheral Cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain
34. Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat
35. Subarachnoid spinal cord transplantation of adrenal medulla suppresses chronic neuropathic pain behavior in rats
36. A clinical approach to complex regional pain syndrome
37. The excitation of cutaneous nerve endings in a neuroma by capsaicin
38. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
39. AP-1 proteins in the adult brain: Facts and fiction about effectors of neuroprotection and neurodegeneration
40. Mechanosensitivity of dorsal root ganglia and chronically injured axons: A physiological basis for the radicular pain of nerve root compression
41. Brain-derived TNFalpha mediates neuropathic pain
42. Autotomy following nerve injury: Genetic factors in the development of chronic pain
43. Pathophysiology of nerve following mechanical injury
44. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain
45. Correlation between autotomy-behavior and current theories of neuropathic pain
46. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
47. Infection by human varicella-zoster virus confers norepinephrine sensitivity to sensory neurons from rat dorsal root ganglia
48. N- and L- but not P/Q-type calcium channels contribute to neuropeptide release from rat skin in vitro
49. An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy
50. The expression of sensory receptors on regenerating and regenerated cutaneous C fibres
51. Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-D-aspartic acid receptor blockage
52. Attempts to gauge the relative importance of pre- and postsynaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord
53. Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain
54. Protein kinase subtypes involved in injury-induced nociception
55. Experimental mononeuropathy reduces the antinociceptive effects of morphine: Implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain
56. The development of morphine tolerance and dependence is associated with translocation of protein kinase C
57. Changing pattern of c-Fos expression in spinal cord neurons after electrical stimulation of the chronically injured sciatic nerve in the rat
58. The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles
59. Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: Evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia
60. Autotomy and central nervous system neuropeptides after section of the sciatic nerve in rats of different strains
61. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the μ-opioid receptor
62. The differential effects of morphine and the alpha2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain
63. Responses of nerve fibres of the rat saphenous nerve neuroma to mechanical and chemical stimulation: An in vitro study
64. Deafferentation in animals as a model for the study of pain: An alternative hypothesis
65. Mechanoreceptors in rat glabrous skin: Redevelopment of function after nerve crush
66. Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury
67. Effects of lowering ambient temperature on pain-related behaviors in a rat model of neuropathic pain
68. Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice
69. A chronically implanted delivery system of drugs to a nerve-end neuroma: Effects on a behavioural chronic pain model
70. Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline
71. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
72. The role of injury discharge in the induction of neuropathic pain behavior in rats
73. Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse
74. Soy-containing diet suppresses chronic neuropathic sensory disorders in rats
75. Correlation of intact sensibility and neuropathic pain-related behaviors in eight inbred and outbred rat strains and selection lines
76. Pathological studies of spinal nerve ganglia in relation to intractable intercostal pain
77. Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1
78. Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy
79. Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat
80. Complex regional pain syndrome (type I, RSD; type II, causalgia): Controversies
81. Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy
82. Endorphins in chronic pain
83. ω-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats
84. Preoperative open field behavior predicts levels of neuropathic pain-related behavior in mice
85. Properties of afferent nerve impulses originating from a neuroma
86. Autotomy following peripheral nerve lesions: Experimental anesthesia dolorosa
87. Postherpetic neuralgia: Further post-mortem studies of cases with and without pain
88. Characteristics of A- and C-fibers ending in a sensory nerve neuroma in the rat
89. The bradykinin-induced release of substance P from nerve fibre endings in the rat saphenous nerve neuroma is not related to electrophysiological excitation
90. Stress-related pain behaviour in rats with peripheral nerve injuries
91. Peripheral nerve injury triggers central sprouting of myelinated afferents
92. A mouse model for varicella-zoster latency
93. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat
94. The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autotomy after sciatic nerve section in rats
95. Immunoisolating encapsulation of intrathecally implanted bovine chromaffin cells prolongs their survival and produces anti-allodynic effect in spinally injured rats
96. Risk and prognostic factors of postherpetic neuralgia and focal sensory denervation: A prospective evaluation in acute herpes zoster ophthalmicus
97. Autoradiographic study of mu and delta opioid binding sites and neutral endopeptidase-24.11 in rat after dorsal root rhizotomy
98. Functional characteristics of sensory fibres in regenerating cutaneous nerves
99. Central nervous mechanisms modulating pain-related information: Do they become deficient after lesions of the peripheral or central nervous system?
100. Control of gene transcription by Jun and Fos proteins in the nervous system
101. Plasticity of the nervous system at the systemic, cellular and molecular levels: A mechanism of chronic pain and hyperalgesia
102. Chemosensitivity of nerve sprouts in experimental neuroma of cutaneous nerves of the cat