Ca2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells

European Journal of Biochemistry

Volumn 265, Issue 3, 1999, Pages 1075-1084

  Kreideweiß, Stefan ^a,b,c   Ahlers, Christoph ^a   Nordheim, Alfred ^a,b   Rühlmann, Andreas ^a,b,d  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Ca2+ mediated signal transduction; Cyclosporin A; Immunosuppression; Mitogen activated protein kinase (MAPK) network

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM; CYCLOSPORIN A; DNA DIRECTED DNA POLYMERASE BETA; IMMUNOSUPPRESSIVE AGENT; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; THREONINE; TRANSCRIPTION FACTOR; ACTIVATING TRANSCRIPTION FACTOR 2; ATF2 PROTEIN, HUMAN; CALCINEURIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOSPORIN; DNA; MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; MAP2K6 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; BINDING SITE; CALCIUM SIGNALING; DRUG EFFECT; ENZYMOLOGY; GENETICS; IN VITRO STUDY; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; STRUCTURAL GENE;

ACTIVATING TRANSCRIPTION FACTOR 2; BASE SEQUENCE; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCINEURIN; CALCIUM SIGNALING; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOSPORINE; DNA; ENZYME ACTIVATION; GENES, POL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IONOMYCIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKOCYTES, MONONUCLEAR; MAP KINASE KINASE 6; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 0033216535     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00830.x     Document Type: Article

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