Chronic spinal nerve ligation induces microvascular permeability disturbances, astrocytic reaction, and structural changes in the rat spinal cord

Acta Neurochirurgica, Supplementum

Volumn , Issue 96, 2006, Pages 335-340

  Gordh, T ^a   Sharma, H S ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

blood spinal cord barrier; immunoreactivity; pain; Spinal nerve lesion

Indexed keywords

ADAPTATION; ANIMAL; ARTICLE; ASTROCYTE; CAPILLARY PERMEABILITY; CHRONIC DISEASE; HYPERALGESIA; LIGATION; MALE; MICROCIRCULATION; NERVE BLOCK; PATHOLOGY; RAT; SPINAL CORD; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ASTROCYTES; CAPILLARY PERMEABILITY; CHRONIC DISEASE; HYPERALGESIA; LIGATION; MALE; MICROCIRCULATION; NERVE BLOCK; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES;

EID: 33744997202     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/3-211-30714-1_70     Document Type: Article

References (36)

1. Aquino DA, Chiu FC, Brosnan CF, Norton WT (1988) Glial fibrillary acidic protein increases in the spinal cord of Lewis rats with acute experimental autoimmuno encephalomyelitis. J Neurochem 51:1085-1096
2. Beck DW, Roberts RL, Olson JJ (1986) Glial cells influence membrane-associated enzyme activity at the blood-brain barrier. Brain Res 381:131-137
3. Bernstein JJ, Goldberg WJ (1987) Injury-related spinal cord astrocytes are immunoglobulin-positive (IgM and/or IgG) at different time periods in the regenerative process. Brain Res 426:112-118
4. Bignami A, Dahl D, Rueger DC (1980) Glial fibrillary acidic protein (GFA) in normal neural cells and in pathological conditions. Adv Cell Neurobiol 1:285-319
5. Bologa L, Cole R, Chiappelli F, Saneto RP, De Villis J (1988) Expression of glial fibrillary acidic protein by differentiated astrocytes is regulated by serum antagonistic factors. Brain Res 457:295-302
6. Cervos-Navarro J, Sharma HS, Westman J, Bongcam-Rudloff E (1998) Glial reactions in the central nervous system following heat stress. Prog Brain Res 115:241-274 (Pubitemid 28264327)
7. Chung JM, Choi Y, Yoon YW, Na HS (1995) Effects of age on behavioral signs of neuropathic pain in an experimental rat model. Neurosci Lett 183:54-57
8. Chung JM, Kim HK, Chung K (2004) Segmental spinal nerve ligation model of neuropathic pain. Methods Mol Med 99:35-45
9. Dubner R, Ruda MA (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 15:96-103
10. Goldman JE, Abramson B (1990) Cyclic AMP-induced shape changes of astrocytes are accompanied by rapid depolymerization of actin. Brain Res 528:189-196
11. Gordh T, Sharma HS, Alm P, Westman J (1998) Spinal nerve lesion induces upregulation of neuronal nitric oxide synthase in the spinal cord. An immunohistochemical investigation in the rat. Amino Acids 14:105-112
12. Gordh T, Sharma HS, Azizi M, Alm P, Westman J (2000) Spinal nerve lesion induces upregulation of constitutive isoform of heme oxygenase in the spinal cord. An immunohistochemical investigation in the rat. Amino Acids 19:373-381
13. Gordh T, Chu H, Sharma HS (2005) Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes. An immunohistochemical study using albumin and glial fibrillary acidic protein in the rat. Pain (in press)
14. Goshgarian HG, Yu XJ, Rafols JA (1989) Neuronal and glial changes in the rat phrenic nucleus occurring within hours after spinal cord injury. J Comp Neurol 284:519-533
15. Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355-363
16. LaBuda CJ, Little PJ (2005) Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat. J Neurosci Methods 144:175-181
17. Murphy S, Pearce B (1987) Functional receptors for neurotransmitters on astroglial cells. Neuroscience 22:381-394
18. Polgar E, Hughes DI, Arham AZ, Todd AJ (2005) Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain. J Neurosci 25:6658-6666
19. Schmidt-Kastner R, Freund TF (1991) Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 40:599-636
20. Sharma HS (1998) Neurobiology of the nitric oxide in the nervous system. Basic and clinical perspectives. Amino Acids 14:83-85
21. Sharma HS (2004) Blood-brain and spinal cord barriers in stress. In: Sharma HS, Westman J (eds) Blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 231-298
22. Sharma HS (2004) Pathophysiology of the blood-spinal cord barrier in traumatic injury. In: Sharma HS, Westman J (eds) Blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 437-518
23. Sharma HS (2005) Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 11:1353-1389
24. Sharma HS, Westman J (2004) Blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 1-617
25. Sharma HS, Zimmer C, Westman J, Cervos-Navarro J (1992) Acute systemic heat stress increases glial fibrillary acidic protein immunoreactivity in brain: experimental observations in conscious normotensive young rats. Neuroscience 48:889-901
26. Sharma HS, Olsson Y, Cervós-Navarro J (1993) p- Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. An immunohistochemical investigation in the rat. Acta Neuropathol (Berl) 86:422-427
27. Sharma HS, Alm P, Westman J (1998) Nitric oxide and carbon monoxide in the brain pathology of heat stress. Prog Brain Res 115:297-333
28. Sharma HS, Nyberg F, Westman J, Alm P, Gordh T, Lindholm D (1998) Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat. Amino Acids 14:121-129
29. Sharma HS, Nyberg F, Gordh T, Alm P, Westman J (2000) Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat. Amino Acids 19:351-361
30. Sharma HS, Westman J, Gordh T, Alm P (2000) Topical application of brain derived neurotrophic factor influences upregulation of constitutive isoform of heme oxygenase in the spinal cord following trauma an experimental study using immunohistochemistry in the rat. Acta Neurochir [Suppl] 76:365-369
31. Sharma HS, Badgaiyan RD, Mohanty S, Alm P, Wiklund L (2005) Neuroprotective effects of nitric oxide synthase inhibitors in spinal cord injury induced pathophysiology and motor functions. An experimental study in the rat. Ann NY Acad Sci 1053 (in press)
32. Sharma HS, Wiklund L, Badgaiyan RD, Mohanty S, Alm P (2006) Intracerebral administration of neuronal nitric oxide synthase antiserum attenuates traumatic brain injury induced bloodbrain barrier permeability, brain edema and sensory motor disturbances in the rat. Acta Neurochir [Suppl] 96:288-294
33. Sharma HS, Nyberg F, Gordh T, Alm P (2006) Topical application of dynorphin A (1-17) antibodies attenuate neuronal nitric oxide synthase up-regulation, edema formation, and cell injury following a focal trauma to the rat spinal cord. Acta Neurochir [Suppl] 96:309-315
34. Solodkin A, Traub RJ, Gebhart GF (1992) Unilateral hindpaw inflammation produces a bilateral increase in NADPH-diaphorase histochemical staining in the rat lumbar spinal cord. Neuroscience 51:495-499
35. Tao-Cheng JH, Brightman MW (1988) Development of membrane interactions between brain endothelial cells and astrocytes in vitro. Int J Dev Neurosci 6:25-37
36. Yamamoto T, Shimoyama N (1995) Role of nitric oxide in the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat. Anesthesiology 82:1266-1273