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Volumn 1822, Issue 5, 2012, Pages 685-689

Antioxidants in the canine model of human aging

Author keywords

Alzheimer's disease; Beta amyloid; Cognition; Dog; Lipoic acid; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CARNITINE; THIOCTIC ACID;

EID: 84858156551     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.09.020     Document Type: Review
Times cited : (27)

References (120)
  • 2
    • 0032751048 scopus 로고    scopus 로고
    • Stress, aging, and brain oxidative damage
    • Liu J., Mori A. Stress, aging, and brain oxidative damage. Neurochem. Res. 1999, 24:1479-1497.
    • (1999) Neurochem. Res. , vol.24 , pp. 1479-1497
    • Liu, J.1    Mori, A.2
  • 3
    • 0027096062 scopus 로고
    • Oxidants are a major contributor to aging
    • Ames B.N., Shigenaga M.K. Oxidants are a major contributor to aging. Ann. N. Y. Acad. Sci. 1992, 663:85-96.
    • (1992) Ann. N. Y. Acad. Sci. , vol.663 , pp. 85-96
    • Ames, B.N.1    Shigenaga, M.K.2
  • 5
    • 3242737585 scopus 로고    scopus 로고
    • Energetic basis of brain activity: implications for neuroimaging
    • Shulman R.G., Rothman D.L., Behar K.L., Hyder F. Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci. 2004, 27:489-495.
    • (2004) Trends Neurosci. , vol.27 , pp. 489-495
    • Shulman, R.G.1    Rothman, D.L.2    Behar, K.L.3    Hyder, F.4
  • 7
    • 0036751954 scopus 로고    scopus 로고
    • Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
    • Floyd R.A., Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 2002, 23:795-807.
    • (2002) Neurobiol. Aging , vol.23 , pp. 795-807
    • Floyd, R.A.1    Hensley, K.2
  • 8
    • 1542563727 scopus 로고    scopus 로고
    • The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
    • Perez-Campo R., Lopez-Torres M., Cadenas S., Rojas C., Barja G. The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach. J. Comp. Physiol. B 1998, 168:149-158.
    • (1998) J. Comp. Physiol. B , vol.168 , pp. 149-158
    • Perez-Campo, R.1    Lopez-Torres, M.2    Cadenas, S.3    Rojas, C.4    Barja, G.5
  • 9
    • 0036240776 scopus 로고    scopus 로고
    • Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites
    • Liu J., Atamna H., Kuratsune H., Ames B.N. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann. N. Y. Acad. Sci. 2002, 959:133-166.
    • (2002) Ann. N. Y. Acad. Sci. , vol.959 , pp. 133-166
    • Liu, J.1    Atamna, H.2    Kuratsune, H.3    Ames, B.N.4
  • 10
  • 12
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • Mecocci P., MacGarvey U., Beal M.F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 1994, 36:747-751.
    • (1994) Ann. Neurol. , vol.36 , pp. 747-751
    • Mecocci, P.1    MacGarvey, U.2    Beal, M.F.3
  • 13
    • 2542505678 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • Wei Y.H. Oxidative stress and mitochondrial DNA mutations in human aging. Proc. Soc. Exp. Biol. Med. 1998, 217:53-63.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.217 , pp. 53-63
    • Wei, Y.H.1
  • 17
    • 0026587335 scopus 로고
    • Mitochondrial genetics: a paradigm for aging and degenerative diseases?
    • Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases?. Science 1992, 256:628-632.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 18
    • 21644490218 scopus 로고    scopus 로고
    • Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain - potential role of L-Carnitine
    • Haripriya D., Devi M.A., Kokilavani V., Sangeetha P., Panneerselvam C. Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain - potential role of L-Carnitine. Biogerontology 2004, 5:355-364.
    • (2004) Biogerontology , vol.5 , pp. 355-364
    • Haripriya, D.1    Devi, M.A.2    Kokilavani, V.3    Sangeetha, P.4    Panneerselvam, C.5
  • 22
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • Stadtman E.R. Protein oxidation and aging. Science 1992, 257:1220-1224.
    • (1992) Science , vol.257 , pp. 1220-1224
    • Stadtman, E.R.1
  • 23
    • 0031010333 scopus 로고    scopus 로고
    • Reactive oxygen-mediated protein oxidation in aging and disease
    • Stadtman E.R., Berlett B.S. Reactive oxygen-mediated protein oxidation in aging and disease. Chem. Res. Toxicol. 1997, 10:485-494.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 485-494
    • Stadtman, E.R.1    Berlett, B.S.2
  • 24
    • 0030841350 scopus 로고    scopus 로고
    • Protein oxidation in aging, disease, and oxidative stress
    • Berlett B.S., Stadtman E.R. Protein oxidation in aging, disease, and oxidative stress. JBC 1997, 272:20313-20316.
    • (1997) JBC , vol.272 , pp. 20313-20316
    • Berlett, B.S.1    Stadtman, E.R.2
  • 25
    • 0028854465 scopus 로고
    • Studies on lipid peroxidation and protein oxidation in the aging brain
    • Cini M., Moretti A. Studies on lipid peroxidation and protein oxidation in the aging brain. Neurobiol. Aging 1995, 16:53-57.
    • (1995) Neurobiol. Aging , vol.16 , pp. 53-57
    • Cini, M.1    Moretti, A.2
  • 26
    • 0031980065 scopus 로고    scopus 로고
    • Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
    • Markesbery W.R., Lovell M.A. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiol. Aging 1998, 19:33-36.
    • (1998) Neurobiol. Aging , vol.19 , pp. 33-36
    • Markesbery, W.R.1    Lovell, M.A.2
  • 27
    • 0032904412 scopus 로고    scopus 로고
    • An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
    • Cassarino D.S., Bennett J.P. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res. Brain Res. Rev. 1999, 29:1-25.
    • (1999) Brain Res. Brain Res. Rev. , vol.29 , pp. 1-25
    • Cassarino, D.S.1    Bennett, J.P.2
  • 28
    • 0032845895 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain activity in the human brain as a function of age
    • Ojaimi J., Masters C.L., Opeskin K., McKelvie P., Byrne E. Mitochondrial respiratory chain activity in the human brain as a function of age. Mech. Ageing Dev. 1999, 111:39-47.
    • (1999) Mech. Ageing Dev. , vol.111 , pp. 39-47
    • Ojaimi, J.1    Masters, C.L.2    Opeskin, K.3    McKelvie, P.4    Byrne, E.5
  • 29
    • 0030881686 scopus 로고    scopus 로고
    • Oxidative damage during aging targets mitochondrial aconitase
    • Yan L.-J., Levine R.L., Sohal R.S. Oxidative damage during aging targets mitochondrial aconitase. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:11168-11172.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 11168-11172
    • Yan, L.-J.1    Levine, R.L.2    Sohal, R.S.3
  • 30
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y., Mazzucchelli F., Bresolin N., Scarlato G., Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999, 286:774-779.
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 31
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 1997, 23:134-147.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 32
    • 0033765735 scopus 로고    scopus 로고
    • Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease
    • Pratico D., Delanty N. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am. J. Med. 2000, 109:577-585.
    • (2000) Am. J. Med. , vol.109 , pp. 577-585
    • Pratico, D.1    Delanty, N.2
  • 33
    • 0032890439 scopus 로고    scopus 로고
    • Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches
    • Behl C. Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches. Prog. Neurobiol. 1999, 57:301-323.
    • (1999) Prog. Neurobiol. , vol.57 , pp. 301-323
    • Behl, C.1
  • 34
    • 0030700593 scopus 로고    scopus 로고
    • The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary
    • Mirra S.S. The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary. Neurobiol. Aging 1997, 18:S91-S94.
    • (1997) Neurobiol. Aging , vol.18
    • Mirra, S.S.1
  • 35
    • 0035880007 scopus 로고    scopus 로고
    • Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins
    • Butterfield D.A., Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech. Ageing Dev. 2001, 122:945-962.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 945-962
    • Butterfield, D.A.1    Kanski, J.2
  • 37
    • 0031558654 scopus 로고    scopus 로고
    • Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's Disease brain
    • Su J.H., Deng G., Cotman C.W. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's Disease brain. Brain Res. 1997, 774:193-199.
    • (1997) Brain Res. , vol.774 , pp. 193-199
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 39
    • 0030898724 scopus 로고    scopus 로고
    • An assessment of oxidative damage to proteins, lipids and DNA in brain from patients with Alzheimer's disease
    • Lyras L., Cairns N.J., Jenner A., Jenner P., Halliwell B. An assessment of oxidative damage to proteins, lipids and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 1997, 68:2061-2069.
    • (1997) J. Neurochem. , vol.68 , pp. 2061-2069
    • Lyras, L.1    Cairns, N.J.2    Jenner, A.3    Jenner, P.4    Halliwell, B.5
  • 41
    • 0037101889 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1
    • Castegna A., Aksenov M., Aksenova M., Thongboonkerd V., Klein J.B., Pierce W.M., Booze R., Markesbery W.R., Butterfield D.A. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic. Biol. Med. 2002, 33:562-571.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 562-571
    • Castegna, A.1    Aksenov, M.2    Aksenova, M.3    Thongboonkerd, V.4    Klein, J.B.5    Pierce, W.M.6    Booze, R.7    Markesbery, W.R.8    Butterfield, D.A.9
  • 42
    • 0036733145 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71
    • Castegna A., Aksenov M., Thongboonkerd V., Klein J.B., Pierce W.M., Booze R., Markesbery W.R., Butterfield D.A. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J. Neurochem. 2002, 82:1524-1532.
    • (2002) J. Neurochem. , vol.82 , pp. 1524-1532
    • Castegna, A.1    Aksenov, M.2    Thongboonkerd, V.3    Klein, J.B.4    Pierce, W.M.5    Booze, R.6    Markesbery, W.R.7    Butterfield, D.A.8
  • 43
    • 0028181782 scopus 로고
    • Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease
    • Palmer A.M., Burns M.A. Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease. Brain Res. 1994, 645:338-342.
    • (1994) Brain Res. , vol.645 , pp. 338-342
    • Palmer, A.M.1    Burns, M.A.2
  • 44
    • 0030989545 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
    • Sayre L.M., Zelasko D.A., Harris P.L.R., Perry G., Salomon R.G., Smith M.A. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 1997, 68:2092-2097.
    • (1997) J. Neurochem. , vol.68 , pp. 2092-2097
    • Sayre, L.M.1    Zelasko, D.A.2    Harris, P.L.R.3    Perry, G.4    Salomon, R.G.5    Smith, M.A.6
  • 45
    • 0032238783 scopus 로고    scopus 로고
    • Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo
    • Pratico D., Lee M.Y., Trojanowski J.Q., Rokach J., Fitzgerald G.A. Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo. FASEB J. 1998, 12:1777-1783.
    • (1998) FASEB J. , vol.12 , pp. 1777-1783
    • Pratico, D.1    Lee, M.Y.2    Trojanowski, J.Q.3    Rokach, J.4    Fitzgerald, G.A.5
  • 46
    • 0033762711 scopus 로고    scopus 로고
    • Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity
    • Pratico D., Clark C.M., Lee V.M., Trojanowski J.Q., Rokach J., FitzGerald G.A. Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Ann. Neurol. 2000, 48:809-812.
    • (2000) Ann. Neurol. , vol.48 , pp. 809-812
    • Pratico, D.1    Clark, C.M.2    Lee, V.M.3    Trojanowski, J.Q.4    Rokach, J.5    FitzGerald, G.A.6
  • 47
    • 38049010515 scopus 로고    scopus 로고
    • Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
    • Lovell M.A., Markesbery W.R. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res. 2007, 35:7497-7504.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7497-7504
    • Lovell, M.A.1    Markesbery, W.R.2
  • 48
    • 0032933750 scopus 로고    scopus 로고
    • Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF
    • Lovell M.A., Gabbita S.P., Markesbery W.R. Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF. J. Neurochem. 1999, 72:771-776.
    • (1999) J. Neurochem. , vol.72 , pp. 771-776
    • Lovell, M.A.1    Gabbita, S.P.2    Markesbery, W.R.3
  • 49
    • 0031754202 scopus 로고    scopus 로고
    • Increased nuclear DNA oxidation in the brain in Alzheimer's disease
    • Gabbita S.P., Lovell M.A., Markesbery W.R. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J. Neurochem. 1998, 71:2034-2040.
    • (1998) J. Neurochem. , vol.71 , pp. 2034-2040
    • Gabbita, S.P.1    Lovell, M.A.2    Markesbery, W.R.3
  • 50
    • 38149087424 scopus 로고    scopus 로고
    • Oxidatively modified RNA in mild cognitive impairment
    • Lovell M.A., Markesbery W.R. Oxidatively modified RNA in mild cognitive impairment. Neurobiol. Dis. 2008, 29:169-175.
    • (2008) Neurobiol. Dis. , vol.29 , pp. 169-175
    • Lovell, M.A.1    Markesbery, W.R.2
  • 52
    • 0026823074 scopus 로고
    • Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease
    • Pappolla M.A., Omar R.A., Kim K.S., Robakis N.K. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. Am. J. Pathol. 1992, 140:621-628.
    • (1992) Am. J. Pathol. , vol.140 , pp. 621-628
    • Pappolla, M.A.1    Omar, R.A.2    Kim, K.S.3    Robakis, N.K.4
  • 53
    • 1842505677 scopus 로고    scopus 로고
    • Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain
    • Butterfield D.A. Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain. Brain Res. 2004, 1000:1-7.
    • (2004) Brain Res. , vol.1000 , pp. 1-7
    • Butterfield, D.A.1
  • 54
    • 0031737226 scopus 로고    scopus 로고
    • Abnormalities of mitochondrial enzymes in Alzheimer disease
    • Gibson G.E., Sheu K.F., Blass J.P. Abnormalities of mitochondrial enzymes in Alzheimer disease. J. Neural Transm. 1998, 105:855-870.
    • (1998) J. Neural Transm. , vol.105 , pp. 855-870
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3
  • 55
    • 0036231792 scopus 로고    scopus 로고
    • Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease
    • Bosetti F., Brizzi F., Barogi S., Mancuso M., Siciliano G., Tendi E.A., Murri L., Rapoport S.I., Solaini G. Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol. Aging 2002, 23:371-376.
    • (2002) Neurobiol. Aging , vol.23 , pp. 371-376
    • Bosetti, F.1    Brizzi, F.2    Barogi, S.3    Mancuso, M.4    Siciliano, G.5    Tendi, E.A.6    Murri, L.7    Rapoport, S.I.8    Solaini, G.9
  • 56
    • 3242668604 scopus 로고    scopus 로고
    • Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
    • Coskun P.E., Beal M.F., Wallace D.C. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:10726-10731.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10726-10731
    • Coskun, P.E.1    Beal, M.F.2    Wallace, D.C.3
  • 57
    • 0035399655 scopus 로고    scopus 로고
    • Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration
    • Valla J., Berndt J.D., Gonzalez-Lima F. Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration. J. Neurosci. 2001, 21:4923-4930.
    • (2001) J. Neurosci. , vol.21 , pp. 4923-4930
    • Valla, J.1    Berndt, J.D.2    Gonzalez-Lima, F.3
  • 61
    • 22144483112 scopus 로고    scopus 로고
    • Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia
    • Maxwell C.J., Hicks M.S., Hogan D.B., Basran J., Ebly E.M. Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement. Geriatr. Cogn. Disord. 2005, 20:45-51.
    • (2005) Dement. Geriatr. Cogn. Disord. , vol.20 , pp. 45-51
    • Maxwell, C.J.1    Hicks, M.S.2    Hogan, D.B.3    Basran, J.4    Ebly, E.M.5
  • 62
    • 0037320324 scopus 로고    scopus 로고
    • Antioxidant vitamin intake and risk of Alzheimer disease
    • Luchsinger J.A., Tang M.X., Shea S., Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch. Neurol. 2003, 60:203-208.
    • (2003) Arch. Neurol. , vol.60 , pp. 203-208
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 64
    • 33845511770 scopus 로고    scopus 로고
    • A randomized trial of vitamin E supplementation and cognitive function in women
    • Kang J.H., Cook N., Manson J., Buring J.E., Grodstein F. A randomized trial of vitamin E supplementation and cognitive function in women. Arch. Intern. Med. 2006, 166:2462-2468.
    • (2006) Arch. Intern. Med. , vol.166 , pp. 2462-2468
    • Kang, J.H.1    Cook, N.2    Manson, J.3    Buring, J.E.4    Grodstein, F.5
  • 68
    • 0037133319 scopus 로고    scopus 로고
    • Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid
    • Liu J., Killilea D.W., Ames B.N. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:1876-1881.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 1876-1881
    • Liu, J.1    Killilea, D.W.2    Ames, B.N.3
  • 69
    • 0024786493 scopus 로고
    • Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia
    • Rai G., Wright G., Scott L., Beston B., Rest J., Exton-Smith A.N. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr. Med. Res. Opin. 1990, 11:638-647.
    • (1990) Curr. Med. Res. Opin. , vol.11 , pp. 638-647
    • Rai, G.1    Wright, G.2    Scott, L.3    Beston, B.4    Rest, J.5    Exton-Smith, A.N.6
  • 72
    • 0022494388 scopus 로고
    • Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain
    • Bonavita E. Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain. Int. J. Clin. Pharmacol. Ther. Toxicol. 1986, 24:511-516.
    • (1986) Int. J. Clin. Pharmacol. Ther. Toxicol. , vol.24 , pp. 511-516
    • Bonavita, E.1
  • 73
    • 0034718466 scopus 로고    scopus 로고
    • A 1-year controlled trial of acetyl-l-carnitine in early-onset AD
    • Thal L.J., Calvani M., Amato A., Carta A. A 1-year controlled trial of acetyl-l-carnitine in early-onset AD. Neurology 2000, 55:805-810.
    • (2000) Neurology , vol.55 , pp. 805-810
    • Thal, L.J.1    Calvani, M.2    Amato, A.3    Carta, A.4
  • 74
    • 0031927848 scopus 로고    scopus 로고
    • Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach
    • Brooks J.O., Yesavage J.A., Carta A., Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int. Psychogeriatr. 1998, 10:193-203.
    • (1998) Int. Psychogeriatr. , vol.10 , pp. 193-203
    • Brooks, J.O.1    Yesavage, J.A.2    Carta, A.3    Bravi, D.4
  • 76
    • 0037347231 scopus 로고    scopus 로고
    • Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
    • Montgomery S.A., Thal L.J., Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int. Clin. Psychopharmacol. 2003, 18:61-71.
    • (2003) Int. Clin. Psychopharmacol. , vol.18 , pp. 61-71
    • Montgomery, S.A.1    Thal, L.J.2    Amrein, R.3
  • 77
    • 0038681645 scopus 로고    scopus 로고
    • Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors
    • Bianchetti A., Rozzini R., Trabucchi M. Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors. Curr. Med. Res. Opin. 2003, 19:350-353.
    • (2003) Curr. Med. Res. Opin. , vol.19 , pp. 350-353
    • Bianchetti, A.1    Rozzini, R.2    Trabucchi, M.3
  • 79
    • 38449099641 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a new treatment option for Alzheimer's disease-a 48 months follow-up analysis
    • Hager K., Kenklies M., McAfoose J., Engel J., Munch G. Alpha-lipoic acid as a new treatment option for Alzheimer's disease-a 48 months follow-up analysis. J. Neural Transm. Suppl. 2007, 189-193.
    • (2007) J. Neural Transm. Suppl. , pp. 189-193
    • Hager, K.1    Kenklies, M.2    McAfoose, J.3    Engel, J.4    Munch, G.5
  • 80
    • 57349180534 scopus 로고    scopus 로고
    • Antioxidants in central nervous system diseases: preclinical promise and translational challenges
    • Kamat C.D., Gadal S., Mhatre M., Williamson K.S., Pye Q.N., Hensley K. Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J. Alzheimers Dis. 2008, 15:473-493.
    • (2008) J. Alzheimers Dis. , vol.15 , pp. 473-493
    • Kamat, C.D.1    Gadal, S.2    Mhatre, M.3    Williamson, K.S.4    Pye, Q.N.5    Hensley, K.6
  • 81
    • 57649221161 scopus 로고    scopus 로고
    • Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows
    • Pratico D. Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann. N. Y. Acad. Sci. 2008, 1147:70-78.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 70-78
    • Pratico, D.1
  • 84
    • 0034738347 scopus 로고    scopus 로고
    • Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention
    • Joseph J.A., Denisova N.A., Bielinski D., Fisher D.R., Shukitt-Hale B. Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention. Mech. Ageing Dev. 2000, 116:141-153.
    • (2000) Mech. Ageing Dev. , vol.116 , pp. 141-153
    • Joseph, J.A.1    Denisova, N.A.2    Bielinski, D.3    Fisher, D.R.4    Shukitt-Hale, B.5
  • 85
    • 28444463999 scopus 로고    scopus 로고
    • The beneficial effects of fruit polyphenols on brain aging
    • Lau F.C., Shukitt-Hale B., Joseph J.A. The beneficial effects of fruit polyphenols on brain aging. Neurobiol. Aging 2005, 26(Suppl. 1):128-132.
    • (2005) Neurobiol. Aging , vol.26 , Issue.SUPPL. 1 , pp. 128-132
    • Lau, F.C.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 86
    • 14944372848 scopus 로고    scopus 로고
    • NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models
    • Cole G.M., Morihara T., Lim G.P., Yang F., Begum A., Frautschy S.A. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann. N. Y. Acad. Sci. 2004, 1035:68-84.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1035 , pp. 68-84
    • Cole, G.M.1    Morihara, T.2    Lim, G.P.3    Yang, F.4    Begum, A.5    Frautschy, S.A.6
  • 88
    • 79959257484 scopus 로고    scopus 로고
    • Analysis of postmortem ventricular cerebrospinal fluid from patients with and without dementia indicates association of vitamin E with neuritic plaques and specific measures of cognitive performance
    • Hensley K., Barnes L.L., Christov A., Tangney C., Honer W.G., Schneider J.A., Bennett D.A., Morris M.C. Analysis of postmortem ventricular cerebrospinal fluid from patients with and without dementia indicates association of vitamin E with neuritic plaques and specific measures of cognitive performance. J. Alzheimers Dis. 2011, 24:767-774.
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 767-774
    • Hensley, K.1    Barnes, L.L.2    Christov, A.3    Tangney, C.4    Honer, W.G.5    Schneider, J.A.6    Bennett, D.A.7    Morris, M.C.8
  • 89
    • 79953743040 scopus 로고    scopus 로고
    • A potential design flaw of randomized trials of vitamin supplements
    • Morris M.C., Tangney C.C. A potential design flaw of randomized trials of vitamin supplements. JAMA 2011, 305:1348-1349.
    • (2011) JAMA , vol.305 , pp. 1348-1349
    • Morris, M.C.1    Tangney, C.C.2
  • 92
    • 0037178579 scopus 로고    scopus 로고
    • Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
    • Morris M.C., Evans D.A., Bienias J.L., Tangney C.C., Bennett D.A., Aggarwal N., Wilson R.S., Scherr P.A. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 2002, 287:3230-3237.
    • (2002) JAMA , vol.287 , pp. 3230-3237
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Bennett, D.A.5    Aggarwal, N.6    Wilson, R.S.7    Scherr, P.A.8
  • 93
    • 0034837151 scopus 로고    scopus 로고
    • Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects
    • Chandra R.K. Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects. Nutrition 2001, 17:709-712.
    • (2001) Nutrition , vol.17 , pp. 709-712
    • Chandra, R.K.1
  • 94
    • 77957205468 scopus 로고    scopus 로고
    • Preventing Alzheimer's Disease and Cognitive Decline. Evidence Report/Technology Assessment No. 193 (Prepared by the Duke Evidence-based Practice Center under Contract No. HHSA 290-2007-10066-I.)
    • Agency for Healthcare Research and Quality, Rockville, MD
    • Williams J.W., Plassman B.L., Burke J., Holsinger T., Benjamin S. Preventing Alzheimer's Disease and Cognitive Decline. Evidence Report/Technology Assessment No. 193 (Prepared by the Duke Evidence-based Practice Center under Contract No. HHSA 290-2007-10066-I.). AHRQ Publication No. 10-E005 2010, Agency for Healthcare Research and Quality, Rockville, MD.
    • (2010) AHRQ Publication No. 10-E005
    • Williams, J.W.1    Plassman, B.L.2    Burke, J.3    Holsinger, T.4    Benjamin, S.5
  • 95
    • 77950361072 scopus 로고    scopus 로고
    • Insights into the disappointing clinical trials of antioxidants in neurodegenerative diseases
    • Shen L., Ji H.F. Insights into the disappointing clinical trials of antioxidants in neurodegenerative diseases. J Alzheimers Dis 2010, 19:1141-1142.
    • (2010) J Alzheimers Dis , vol.19 , pp. 1141-1142
    • Shen, L.1    Ji, H.F.2
  • 96
    • 58149380028 scopus 로고    scopus 로고
    • The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches
    • Cotman C.W., Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J. Alzheimers Dis. 2008, 15:685-707.
    • (2008) J. Alzheimers Dis. , vol.15 , pp. 685-707
    • Cotman, C.W.1    Head, E.2
  • 98
    • 0038580535 scopus 로고    scopus 로고
    • The role of free radicals in canine counterpart of senile dementia of the Alzheimer type
    • Skoumalova A., Rofina J., Schwippelova Z., Gruys E., Wilhelm J. The role of free radicals in canine counterpart of senile dementia of the Alzheimer type. Exp. Gerontol. 2003, 38:711-719.
    • (2003) Exp. Gerontol. , vol.38 , pp. 711-719
    • Skoumalova, A.1    Rofina, J.2    Schwippelova, Z.3    Gruys, E.4    Wilhelm, J.5
  • 99
    • 0031475121 scopus 로고    scopus 로고
    • Immunohistochemical detection of anti-oxidative stress enzymes in the dog brain
    • Kiatipattanasakul W., Nakamura S., Kuroki K., Nakayama H., Doi K. Immunohistochemical detection of anti-oxidative stress enzymes in the dog brain. Neuropathology 1997, 17:307-312.
    • (1997) Neuropathology , vol.17 , pp. 307-312
    • Kiatipattanasakul, W.1    Nakamura, S.2    Kuroki, K.3    Nakayama, H.4    Doi, K.5
  • 100
    • 36049026787 scopus 로고    scopus 로고
    • Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease
    • Opii W.O., Joshi G., Head E., Milgram N.W., Muggenburg B.A., Klein J.B., Pierce W.M., Cotman C.W., Butterfield D.A. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol. Aging 2008, 29:51-70.
    • (2008) Neurobiol. Aging , vol.29 , pp. 51-70
    • Opii, W.O.1    Joshi, G.2    Head, E.3    Milgram, N.W.4    Muggenburg, B.A.5    Klein, J.B.6    Pierce, W.M.7    Cotman, C.W.8    Butterfield, D.A.9
  • 101
    • 42149166594 scopus 로고    scopus 로고
    • Differences in lipid peroxidation and Cu, Zn-superoxide dismutase in the hippocampal CA1 region between adult and aged dogs
    • Hwang I.K., Yoon Y.S., Yoo K.Y., Li H., Choi J.H., Kim D.W., Yi S.S., Seong J.K., Lee I.S., Won M.H. Differences in lipid peroxidation and Cu, Zn-superoxide dismutase in the hippocampal CA1 region between adult and aged dogs. J. Vet. Med. Sci. 2008, 70:273-277.
    • (2008) J. Vet. Med. Sci. , vol.70 , pp. 273-277
    • Hwang, I.K.1    Yoon, Y.S.2    Yoo, K.Y.3    Li, H.4    Choi, J.H.5    Kim, D.W.6    Yi, S.S.7    Seong, J.K.8    Lee, I.S.9    Won, M.H.10
  • 102
    • 0035093896 scopus 로고    scopus 로고
    • Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques
    • Papaioannou N., Tooten P.C.J., van Ederen A.M., Bohl J.R.E., Rofina J., Tsangaris T., Gruys E. Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques. Amyloid: J Protein Folding Disord. 2001, 8:11-21.
    • (2001) Amyloid: J Protein Folding Disord. , vol.8 , pp. 11-21
    • Papaioannou, N.1    Tooten, P.C.J.2    van Ederen, A.M.3    Bohl, J.R.E.4    Rofina, J.5    Tsangaris, T.6    Gruys, E.7
  • 103
    • 4544285567 scopus 로고    scopus 로고
    • Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine
    • Rofina J.E., Singh K., Skoumalova-Vesela A., van Ederen A.M., van Asten A.J., Wilhelm J., Gruys E. Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine. Amyloid 2004, 11:90-100.
    • (2004) Amyloid , vol.11 , pp. 90-100
    • Rofina, J.E.1    Singh, K.2    Skoumalova-Vesela, A.3    van Ederen, A.M.4    van Asten, A.J.5    Wilhelm, J.6    Gruys, E.7
  • 105
    • 0036751980 scopus 로고    scopus 로고
    • Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
    • Cotman C.W., Head E., Muggenburg B.A., Zicker S., Milgram N.W. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol. Aging 2002, 23:809-818.
    • (2002) Neurobiol. Aging , vol.23 , pp. 809-818
    • Cotman, C.W.1    Head, E.2    Muggenburg, B.A.3    Zicker, S.4    Milgram, N.W.5
  • 107
    • 2342544886 scopus 로고    scopus 로고
    • Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs
    • Milgram N.W., Head E., Zicker S.C., Ikeda-Douglas C., Murphey H., Muggenberg B.A., Siwak C.T., Dwight Tapp P., Lowry S.R., Cotman C.W. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp. Gerontol. 2004, 39:753-765.
    • (2004) Exp. Gerontol. , vol.39 , pp. 753-765
    • Milgram, N.W.1    Head, E.2    Zicker, S.C.3    Ikeda-Douglas, C.4    Murphey, H.5    Muggenberg, B.A.6    Siwak, C.T.7    Dwight, T.P.8    Lowry, S.R.9    Cotman, C.W.10
  • 109
    • 33947592137 scopus 로고    scopus 로고
    • Enhanced spatial ability in aged dogs following dietary and behavioural enrichment
    • Nippak P.M., Mendelson J., Muggenburg B., Milgram N.W. Enhanced spatial ability in aged dogs following dietary and behavioural enrichment. Neurobiol. Learn. Mem. 2007, 87:610-623.
    • (2007) Neurobiol. Learn. Mem. , vol.87 , pp. 610-623
    • Nippak, P.M.1    Mendelson, J.2    Muggenburg, B.3    Milgram, N.W.4
  • 110
    • 15744365212 scopus 로고    scopus 로고
    • Cognitive and behavioral assessment in dogs and pet food market applications
    • Zicker S.C. Cognitive and behavioral assessment in dogs and pet food market applications. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29:455-459.
    • (2005) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.29 , pp. 455-459
    • Zicker, S.C.1
  • 113
    • 78651324323 scopus 로고    scopus 로고
    • Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes
    • Calabrese V., Cornelius C., Stella A.M., Calabrese E.J. Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. Neurochem. Res. 2010, 35:1880-1915.
    • (2010) Neurochem. Res. , vol.35 , pp. 1880-1915
    • Calabrese, V.1    Cornelius, C.2    Stella, A.M.3    Calabrese, E.J.4
  • 114
    • 77958126450 scopus 로고    scopus 로고
    • Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders
    • Calabrese V., Cornelius C., Dinkova-Kostova A.T., Calabrese E.J., Mattson M.P. Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid. Redox Signal. 2010, 13:1763-1811.
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 1763-1811
    • Calabrese, V.1    Cornelius, C.2    Dinkova-Kostova, A.T.3    Calabrese, E.J.4    Mattson, M.P.5
  • 115
    • 70349736400 scopus 로고    scopus 로고
    • Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging
    • Head E., Nukala V.N., Fenoglio K.A., Muggenburg B.A., Cotman C.W., Sullivan P.G. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp. Neurol. 2009, 220:171-176.
    • (2009) Exp. Neurol. , vol.220 , pp. 171-176
    • Head, E.1    Nukala, V.N.2    Fenoglio, K.A.3    Muggenburg, B.A.4    Cotman, C.W.5    Sullivan, P.G.6
  • 117
    • 84862534586 scopus 로고    scopus 로고
    • BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog
    • doi:10.1016/j.neurobiolaging.2010.03.019
    • Fahnestock M., Marchese M., Head E., Pop V., Michalski B., Milgram W.N., Cotman C.W. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol. Aging 2010, doi:10.1016/j.neurobiolaging.2010.03.019.
    • (2010) Neurobiol. Aging
    • Fahnestock, M.1    Marchese, M.2    Head, E.3    Pop, V.4    Michalski, B.5    Milgram, W.N.6    Cotman, C.W.7
  • 118
    • 33947270478 scopus 로고    scopus 로고
    • Effects of antioxidants on the aging inner ear
    • Le T., Keithley E.M. Effects of antioxidants on the aging inner ear. Hear. Res. 2007, 226:194-202.
    • (2007) Hear. Res. , vol.226 , pp. 194-202
    • Le, T.1    Keithley, E.M.2
  • 119
    • 70449705892 scopus 로고    scopus 로고
    • Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles
    • Christie L.A., Opii W.O., Head E., Araujo J.A., de Rivera C., Milgram N.W., Cotman C.W. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp. Gerontol. 2009, 44:752-759.
    • (2009) Exp. Gerontol. , vol.44 , pp. 752-759
    • Christie, L.A.1    Opii, W.O.2    Head, E.3    Araujo, J.A.4    de Rivera, C.5    Milgram, N.W.6    Cotman, C.W.7
  • 120
    • 42649127765 scopus 로고    scopus 로고
    • Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine
    • Araujo J.A., Landsberg G.M., Milgram N.W., Miolo A. Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. Can. Vet. J. 2008, 49:379-385.
    • (2008) Can. Vet. J. , vol.49 , pp. 379-385
    • Araujo, J.A.1    Landsberg, G.M.2    Milgram, N.W.3    Miolo, A.4


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