Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites

Annals of the New York Academy of Sciences

Volumn 959, Issue , 2002, Pages 133-166

  Liu, Jiankang ^a,b   Atamna, Hani ^a,b   Kuratsune, Hirohiko ^c   Ames, Bruce N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Acetyl L carnitine; Aging; Brain; Lipoic acid; Memory; Mitochondria; N t butyl hydroxylamine; Neurotoxicity; Oxidative damage; phenyl N t butyl nitrone

Indexed keywords

ACETYLCARNITINE; ANTIOXIDANT; CARNITINE ACETYLTRANSFERASE; GLUTAMIC ACID; LIPID; N TERT BUTYL ALPHA PHENYLNITRONE; N TERT BUTYL HYDROXYLAMINE; NUCLEIC ACID; OXIDOPAMINE; PROTEIN; THIOCTIC ACID; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANTIOXIDANT ACTIVITY; BRAIN MITOCHONDRION; CELL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; MEMORY; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; SENESCENCE;

ANIMALIA;

EID: 0036240776     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb02090.x     Document Type: Conference Paper

References (153)

1. Oxidants, antioxidants, and the degenerative diseases of aging
2. Mitochondrial decay in aging
3. The free radical theory of aging matures
4. The free radical theory of aging: The effect of age on serum mercaptan levels
5. The biologic clock: The mitochondria?
6. The aging process
7. Oxidative damage and mitochondrial decay in aging
8. Protein oxidation and aging
9. Mitochondria and the pathogenesis of ALS
10. Mitochondria, oxygen radicals, and apoptosis
11. Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse
12. A centry of mitochondrial research: Achievements and perspectives
13. The spin-trap N-tert-alpha-phenylbutylnitrone prolongs the life span of the senescence accelerated mouse
14. Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): A comparison with ddY mice
15. Oxidative damage in the senescence-accelerated mouse
16. Stress, aging, and brain oxidative damage
17. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats
18. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
19. Feeding acetyl-L-carnitine combined with lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
20. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo
21. Mitochondrial decay in aging: Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone
22. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
23. Mitochondrial metabolites, acetyl-L-carnitine and lipoic acid, improve age-associated memory decline and inhibit brain oxidative damage in old rats
24. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes: Reversal with (R)-alpha-lipoic acid supplementation
25. Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria
26. Decreased activity of the phosphate carrier and modification of lipids in cardiac mitochondria from senescent rats
27. Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria
28. The effect of aging and acetyl-L-carnitine on the function and on the lipid composition of rat heart mitochondria
29. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: The effect of acetyl-L-carnitine
30. Age-dependent changes in the activity of anion carriers and in the lipid composition in rat heart mitochondria
31. Possible confounding influence of strain, age and gender on cognitive performance in rats
32. Spatial memory in aged rats: Population heterogeneity and effect of levocarnitine acetyl
33. Effect of acetyl-L-carnitine chronic treatment on discrimination models in aged rats
34. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-α-lipoic acid
35. Motor and reflexive behavior in the aging rat
36. Animal models of declining memory in the aged: Short-term and spatial memory in the aged rat
37. Behavioral effects of acetyl-L-carnitine in the male rat
38. Active avoidance learning in old rats chronically treated with levocarnitine acetyl
39. The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria
40. The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria
41. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease
42. Creatine supplementation and age influence muscle metabolism during exercise
43. Acute creatine supplementation in older men
44. Nutritional supplements to increase muscle mass
45. Effects of 30 days of creatine ingestion in older men
46. Effects of oral creatine supplementation on maximal pedalling performance in older adults
47. Alpha-lipoic acid in liver metabolism and disease
48. Alpha-lipoic acid: A metabolic antioxidant and potential redox modulator of transcription
49. Alpha-Lipoic acid as a biological antioxidant
50. Determination of oxidized and reduced lipoic acid using high- performance liquid chromatography and coulometric detection
51. Neuroprotection by the metabolic antioxidant alpha-lipoic acid
52. Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia
53. Neuroprotective activity of lipoic and dihydrolipoic acid
54. Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death
55. Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue
56. A positively charged alpha-lipoic acid analogue with increased cellular uptake and more potent immunomodulatory activity
57. Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant?
58. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
59. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid
60. Alpha-lipoic acid as a new treatment option for Azheimer type dementia
61. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
62. Glutamate neurotoxicity and diseases of the nervous system
63. Excitotoxic cell death
64. NMDA receptors activate the arachidonic acid cascade system in striatal neurons
65. NMDA-dependent superoxide production and neurotoxicity
66. Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons an hypothesis for cell death in aging and disease
67. Excitatory amino acid uptake and N-methyl-D-aspartate-mediated secretion in a neural cell line
68. The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress
69. The role of monoamine metabolism in oxidative glutamate toxicity
70. The regulation of reactive oxygen species production during programmed cell death
71. Lipoic acid, a mitochondrial metabolite, counteracts the effect of neurotoxins on HT4 and HT22 hippocampal cell lines
72. Stress and brain oxidative damage: The role of monoamine transmitters, stress-related hormones, and antioxidants
73. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: P53 and Rb control G1 arrest but not cell replication
74. Oxidative DNA damage and senescence of human diploid fibroblast cells
75. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
76. Flow cytometric analysis of human epidermal cell ageing using two fluorescent mitochondrial probes
77. Human epidermal cells progressively lose their cardiolipins during ageing without change in mitochondrial transmembrane potential
78. N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro
79. N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts
80. Carnitine
81. Carnitine function and requirements during the life cycle
82. Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA
83. The distribution and role of carnitine in the mammalian brain
84. Carnitine, carnitine acyltransferases, and rat brain function
85. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices
86. Age-dependent decrease of carnitine content in muscle of mice and humans
87. Levels of carnitines in brain and other tissues of rats of different ages: Effect of acetyl-L-carnitine administration
88. A review of nutrients and botanicals in the integrative management of cognitive dysfunction
89. Spatial memory and NGF levels in aged rats: Natural variability and effects of acetyl-L-carnitine treatment
90. Age-dependent deficits in radial maze performance in the rat: Effect of chronic treatment with acetyl-L-carnitine
91. Acetyl-L-carnitine. 2: Effects on learning and memory performance of aged rats in simple and complex mazes
92. Acetyl-L-carnitine. 1: Effects on mortality, pathology and sensory-motor performance in aging rats
93. Central cholinergic effects of leveo-acetylcarnitine
94. Differential effect of acetyl-L-carnitine on open field behavior in young and old rats
95. Effects of L-carnitine, L-acetylcarnitine and gangliosides on the regeneration of the transected sciatic nerve in rats
96. Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors
97. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion
98. Differential inhibition by hyperammonemia of the electron transport chain enzymes in synaptosomes and non-synaptic mitochondria in ornithine transcarbamylase-deficient spf-mice: Restoration by acetyl-L-carnitine
99. Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: Correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation
100. Acetyl-L-carnitine in dementia
101. Long-term acetyl-L-carnitine treatment in Alzheimer's disease
102. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's disease
103. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease
104. Acetyl-L-carnitine slows decline in younger patients with Alzheimer's disease: A reanalysis of a double-blind, placebo-controlled study using the trilinear approach
105. Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain
106. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease
107. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism
108. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss
109. Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases
110. Acylcarnitine deficiency in chronic fatigue syndrome
111. High uptake of [2-11C]acetyl-L-carnitine into the brain: A PET study
112. Protection from oxygen radical damage in human diploid fibroblasts by acetyl-L-carnitine
113. Effect of acetyl-L-carnitine on lipid peroxidation and xanthine oxidase activity in rat skeletal muscle
114. Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions
115. The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes
116. Protective action of acetylcarnitine on NADPH-induced lipid peroxidation of cardiac microsomes
117. Antioxidant action of acetyl-L-carnitine: In vitro study
118. Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: The possible role of iron chelation
119. Effect of L-carnitine on the status of liperoxidation and antioxidants in aging rats
120. L-carnitine attenuates doxorubicin-induced lipid peroxidation in rats
121. Protection of the ischemic diabetic heart by L-propionylcarnitine therapy
122. Carnitine and its acyl esters as secondary antioxidants?
123. Is the carnitine system part of the heart antioxidant network?
124. Delaying aging with mitochondrial micronutrients and antioxidants
125. Developments of a water-maze procedure for studying spatial learning in the rat
126. Timing and the control of variation
127. Delaying the mitochondrial decay of aging
128. Acetyl-L-carnitine, lipoic acid, or their combination improve age-associated memory decline and inhibit brain oxidative damage in old rats: An immunohistological study
129. Effect of aging on tryptophan hydroxylase in rat brain: Implications on serotonin level
130. The effects of dietary restriction on mitochondrial dysfunction in aging
131. Dietary supplementation with phospholipids and docosahexaenoic acid for age-related cognitive impairment
132. L-Acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus
133. Oxidative stress, caloric restriction, and aging
134. Aging and oxidative stress: Modulation by dietary restriction
135. Micronutrients prevent cancer and delay aging
136. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid
137. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone
138. Stress, hormones, oxidative damage, and neurodegeneration
139. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone
140. A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice
141. A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair
142. Prolongation of the normal lifespan and inhibition of spontaneous cancer by antioxidants
143. Free radical theory of aging: Effect of free radical reaction inhibitors on the mortality rate of male LAF mice
144. Free radical theory of aging