Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Guo, Qiang ^a   Subramanian, Hariharan ^a   Gupta, Kshitij ^a   Ali, Hydar ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; COMPLEMENT C3A RECEPTOR; COMPLEMENT COMPONENT C3A; COMPLEMENT RECEPTOR; SMALL INTERFERING RNA;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; LENTIVIRINAE; MAST CELL; MAST CELL DEGRANULATION; MEDIATOR RELEASE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; CELL LINE; CYTOLOGY; DEGRANULATION; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN TRANSPORT;

LENTIVIRUS;

CELL DEGRANULATION; CELL LINE; COMPLEMENT C3A; G-PROTEIN-COUPLED RECEPTOR KINASES; GENE KNOCKDOWN TECHNIQUES; HUMANS; LENTIVIRUS; MAST CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, COMPLEMENT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 79960710835     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022559     Document Type: Article

References (35)

1. Bautsch W, Hoymann HG, Zhang Q, Meier-Wiedenbach I, Raschke U, et al. (2000) Cutting edge: guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease: evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma. J Immunol 165: 5401-5405.
2. Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA, (2002) Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J Immunol 169: 5926-5933.
3. McNeil HP, Adachi R, Stevens RL, (2007) Mast Cell-restricted Tryptases: Structure and Function in Inflammation and Pathogen Defense. J Biol Chem 282: 20785-20789.
4. Ahamed J, Venkatesha RT, Thangam EB, Ali H, (2004) C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1. J Immunol 172: 6961-6968.
5. Fukuoka Y, Xia HZ, Sanchez-Munoz LB, Dellinger AL, Escribano L, et al. (2008) Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5. J Immunol 180: 6307-6316.
6. Venkatesha RT, Berla Thangam E, Zaidi AK, Ali H, (2005) Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase. Mol Immunol 42: 581-587.
7. Ahamed J, Haribabu B, Ali H, (2001) Cutting edge: Differential regulation of chemoattractant receptor-induced degranulation and chemokine production by receptor phosphorylation. J Immunol 167: 3559-3563.
8. Pitcher JA, Freedman NJ, Lefkowitz RJ, (1998) G protein-coupled receptor kinases. Annu Rev Biochem 67: 653-692.
9. Krupnick JG, Benovic JL, (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38: 289-319.
10. Ren XR, Reiter E, Ahn S, Kim J, Chen W, et al. (2005) Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A 102: 1448-1453.
11. Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, et al. (2005) Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A 102: 1442-1447.
12. DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Dery O, et al. (2000) The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex. Proc Natl Acad Sci U S A 97: 11086-11091.
13. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, et al. (1999) β-arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes. Science 283: 655-661.
14. Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, et al. (2010) Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem 285: 7805-7817.
15. Langkabel P, Zwirner J, Oppermann M, (1999) Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by "G protein-coupled receptor kinases. Eur J Immunol 29: 3035-3046.
16. Tomhave ED, Richardson RM, Didsbury JR, Menard L, Snyderman R, et al. (1994) Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. J Immunol 153: 3267-3275.
17. Settmacher B, Rheinheimer C, Hamacher H, Ames RS, Wise A, et al. (2003) Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling. Eur J Immunol 33: 920-927.
18. Ali H, Ahamed J, Hernandez-Munain C, Baron JL, Krangel MS, et al. (2000) Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. J Immunol 165: 7215-7223.
19. Kashem SW, Subramanian H, Collington S, Magotti P, Lambris J, et al. (2011) G Protein coupled Receptor Specificity for C3a and Compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2. Eur J Pharm doi:10.1016/j.ejphar.2011.06.027.
20. Tatemoto K, Nozaki Y, Tsuda R, Konno S, Tomura K, et al. (2006) Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. Biochem Biophys Res Commun 349: 1322-1328.
21. Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, et al. (2011) PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in Human mast cells. Mol Pharmacol 79: 1005-1013.
22. Penn RB, Pronin AN, Benovic JL, (2000) Regulation of G protein-coupled receptor kinases. Trends Cardiovasc Med 10: 81-89.
23. Barthet G, Carrat G, Cassier E, Barker B, Gaven F, et al. (2009) β-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J 28: 2706-2718.
24. Vibhuti A, Gupta K, Subramanian H, Guo Q, Ali H, (2011) Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. PLoS ONE 6: e19585.
25. Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, et al. (2002) β-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization. Nat Cell Biol 4: 547-555.
26. Brown FD, Thompson N, Saqib KM, Clark JM, Powner D, et al. (1998) Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr Biol 8: 835-838.
27. Choi WS, Kim YM, Combs C, Frohman MA, Beaven MA, (2002) Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells. J Immunol 168: 5682-5689.
28. Hitomi T, Zhang J, Nicoletti LM, Grodzki AC, Jamur MC, et al. (2004) Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation. Blood 104: 4122-4128.
29. Peng Z, Beaven MA, (2005) An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells. J Immunol 174: 5201-5208.
30. Corrotte M, Nyguyen AP, Harlay ML, Vitale N, Bader MF, et al. (2010) Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA. J Immunol 185: 2942-2950.
31. Kim JH, Lee SD, Han JM, Lee TG, Kim Y, et al. (1998) Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA. FEBS Lett 430: 231-235.
32. Tipping M, Kim Y, Kyriakakis P, Tong M, Shvartsman SY, et al. (2010) β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. EMBO J.29: 3222-3235.
33. Butterfield JH, Weiler DA, (1989) In vitro sensitivity of immature human mast cells to chemotherapeutic agents. Int Arch Allergy Appl Immunol 89: 297-300.
34. Kirshenbaum AS, Akin C, Wu Y, Rottem M, Goff JP, et al. (2003) Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI. Leuk Res 27: 677-682.
35. Ali H, Richardson RM, Tomhave ED, DuBose RA, Haribabu B, et al. (1994) Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. J Biol Chem 269: 24557-24563.