G Protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation

Journal of Biological Chemistry

Volumn 284, Issue 49, 2009, Pages 34103-34115

  Namkung, Yoon ^a   Dipace, Concetta ^b   Urizar, Eneko ^b   Javitch, Jonathan A ^b   Sibley, David R ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ACTIVITIES; CELL SURFACES; DIFFERENT MECHANISMS; G PROTEIN COUPLED RECEPTORS; G PROTEIN-COUPLED RECEPTOR KINASE; IMMUNOPRECIPITATES; IN-CELL; INACTIVE MUTANTS; KINASE ACTIVITY; N-TERMINALS; OVER-EXPRESSION; PRE-TREATMENT; RECEPTOR COMPLEX; RECEPTOR EXPRESSION; RECEPTOR MUTANTS; RECEPTOR SIGNALING; REGULATORY EFFECTS; SHORT INTERFERING RNA;

BRAIN; CELL MEMBRANES; NUCLEIC ACIDS; PROTEINS; RNA; SIGNALING;

PHOSPHORYLATION;

ADENYLATE CYCLASE; CELL SURFACE RECEPTOR; CYCLIC AMP; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; MUTANT PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOCYTOSIS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, DOPAMINE D2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 71749113078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.055707     Document Type: Article

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