Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors

Journal of Biological Chemistry

Volumn 279, Issue 26, 2004, Pages 27030-27038

  Lin, Z Ping ^a   Belcourt, Michael F ^b   Cory, Joseph G ^c   Sartorelli, Alan C ^a,d  

^a YALE CANCER CENTER   (United States)

^b Vion Pharmaceuticals Incorporated   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOSYNTHESIS; CATALYSIS; CELLS; CLONING; DNA; ENZYMES; TOXICITY;

HOMODIMERS; RIBONUCLEOTIDE REDUCTASE (RNR);

BIOCHEMISTRY;

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; CISPLATIN; DEOXYADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA; DOXORUBICIN; ENZYME INHIBITOR; HYDROXYUREA; MESSENGER RNA; PROTEIN P53; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL SURVIVAL; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA INTERFERENCE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COLONIC NEOPLASMS; DEOXYRIBONUCLEOTIDES; DNA DAMAGE; DOWN-REGULATION; DOXORUBICIN; ENZYME INHIBITORS; ETOPOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; HYDROXYUREA; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS; PYRIDINES; RECOMBINANT PROTEINS; RIBONUCLEOTIDE REDUCTASES; RNA, SMALL INTERFERING; THIOSEMICARBAZONES; TUMOR SUPPRESSOR PROTEIN P53; VINCRISTINE;

MAMMALIA; VECTORS;

EID: 3042595897     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402056200     Document Type: Article

References (43)

1. Thelander, L., and Reichard, P. (1979) Annu. Rev. Biochem. 48, 133-158
2. Kunz, B. A., Kohalmi, S. E., Kunkel, T. A., Mathews, C. K., McIntosh, E. M., and Reidy, J. A. (1994) Mutat. Res. 318, 1-64
3. Eriksson, S., Graslund, A., Skog, S., Thelander, L., and Tribukait, B. (1984) J. Biol. Chem. 259, 11695-11700
4. Engstrom, Y., Eriksson, S., Jildevik, I., Skog, S., Thelander, L., and Tribukait, B. (1985) J. Biol. Chem. 260, 9114-9116
5. Bjorklund, S., Skog, S., Tribukait, B., and Thelander, L. (1990) Biochemistry 29, 5452-5458
6. Mann, G. J., Musgrove, E. A., Fox, R. M., and Thelander, L. (1988) Cancer Res. 48, 5151-5156
7. Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y., and Nakamura, Y. (2000) Nature 404, 42-49
8. Nakano, K., Balint, E., Ashcroft, M., and Vousden, K. H. (2000) Oncogene 19, 4283-4289
9. Guittet, O., Hakansson, P., Voevodskaya, N., Fridd, S., Graslund, A., Arakawa, H., Nakamura, Y., and Thelander, L. (2001) J. Biol. Chem. 276, 40647-40651
10. Yamaguchi, T., Matsuda, K., Sagiya, Y., Iwadate, M., Fujmo, M. A., Nakamura, Y., and Arakawa, H. (2001) Cancer Res. 61, 8256-8262
11. Elford, H. L., Freese, M., Passamani, E., and Morris, H. P. (1970) J. Biol. Chem. 245, 5228-5233
12. Weber, G. (1980) Oncology 37, 19-24
13. Cory, J. G., Cory, A. H., Rappa, G., Lorico, A., Liu, M. C., Lin, T. S., and Sartorelli, A. C. (1994) Biochem. Pharmacol. 48, 335-344
14. Finch, R. A., Liu, M. C., Cory, A. H., Cory, J. G., and Sartorelli, A. C. (1999) Adv. Enzyme Regul. 39, 3-12
15. Fritzer-Szekeres, M., Salamon, A., Grusch, M., Horvath, Z., Hochtl, T., Steinbrugger, R., Jager, W., Krupitza, G., Elford, H. L., and Szekeres, T. (2002) Biochem. Pharmacol. 64, 481-485
16. Inayat, M. S., Chendil, D., Mohiuddin, M., Elford, H. L., Gallicchio, V. S., and Ahmed, M. M. (2002) Cancer Biol. Ther. 1, 539-545
17. Liu, M. C., Lin, T. S., and Sartorelli, A. C. (1992) J. Med. Chem. 35, 3672-3677
18. Finch, R. A., Liu, M., Grill, S. P., Rose, W. C., Loomis, R., Vasquez, K. M., Cheng, Y., and Sartorelli, A. C. (2000) Biochem. Pharmacol. 59, 983-991
19. Kimura, M., Takatsuki, A., and Yamaguchi, I. (1994) Biochim. Biophys. Acta 1219, 653-659
20. Mulsant, P., Gatignol, A., Dalens, M., and Tiraby, G. (1988) Somat. Cell Mol. Genet. 14, 243-252
21. Das, G., Henning, D., Wright, D., and Reddy, R. (1988) EMBO J. 7, 503-512
22. Sherman, P. A., and Fyfe, J. A. (1989) Anal. Biochem. 180, 222-226
23. Gao, W. Y., Johns, D. G., and Mitsuya, H. (1994) Anal. Biochem. 222, 116-122
24. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., and Vogelstein, B. (1997) Nature 389, 300-305
25. Blagosklonny, M. V., Schulte, T. W., Nguyen, P., Mimnaugh, E. G., Trepel, J., and Neckers, L. (1995) Cancer Res. 55, 4623-4626
26. Sablina, A. A., Chumakov, P. M., Levine, A. J., and Kopnin, B. P. (2001) Oncogene 20, 899-909
27. Fan, S., Smith, M. L., Rivet, D. J., II, Duba, D., Zhan, Q., Kohn, K. W., Fornace, A. J., Jr., and O'Connor, P. M. (1995) Cancer Res. 55, 1649-1654
28. Hawkins, D. S., Demers, G. W., and Galloway, D. A. (1996) Cancer Res. 56, 892-898
29. Elledge, S. J., and Davis, R. W. (1987) Mol. Cell. Biol. 7, 2783-2793
30. Elledge, S. J., and Davis, R. W. (1989) Mol. Cell. Biol. 9, 4932-4940
31. Hurta, R. A., and Wright, J. A. (1992) J. Biol. Chem. 267, 7066-7071
32. Filatov, D., Bjorklund, S., Johansson, E., and Thelander, L. (1996) J. Biol. Chem. 271, 23698-23704
33. Kuo, M. L., and Kinsella, T. J. (1998) Cancer Res. 58, 2245-2252
34. Chabes, A., and Thelander, L. (2000) J. Biol. Chem. 275, 17747-17753
35. Chabes, A. L., Pfleger, C. M., Kirschner, M. W., and Thelander, L. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 3925-3929
36. Pinto, A. L., and Lippard, S. J. (1985) Biochim. Biophys. Acta 780, 167-180
37. Chaney, S. G., and Sancar, A. (1996) J. Natl. Cancer Inst. 88, 1346-1360
38. Furuta, T., Ueda, T., Aune, G., Sarasin, A., Kraemer, K. H., and Pommier, Y. (2002) Cancer Res. 62, 4899-4902
39. Chabes, A., Georgieva, B., Domkin, V., Zhao, X., Rothstein, R., and Thelander, L. (2003) Cell 112, 391-401
40. Thelander, M., Graslund, A., and Thelander, L. (1985) J. Biol. Chem. 260, 2737-2741
41. Shao, J., Zhou, B., Zhu, L., Qiu, W., Yuan, Y. C., Xi, B., and Yen, Y. (2004) Cancer Res. 64, 1-6
42. Zhou, B., Liu, X., Mo, X., Xue, L., Darwish, D., Qiu, W., Shih, J., Hwu, E. B., Luh, F., and Yen, Y. (2003) Cancer Res. 63, 6583-6594
43. Lee, Y., Vassilakos, A., Feng, N., Lam, V., Xie, H., Wang, M., Jin, H., Xiong, K., Liu, C., Wright, J., and Young, A. (2003) Cancer Res. 63, 2802-2811