Hydroxyurea Arrests DNA Replication by a Mechanism that Preserves Basal dNTP Pools

Journal of Biological Chemistry

Volumn 279, Issue 1, 2004, Pages 223-230

  Koç, Ahmet ^a   Wheeler, Linda J ^a   Mathews, Christopher K ^a   Merrill, Gary F ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DNA; GENES; YEAST;

REPLICATION INITIATION;

BIOCHEMISTRY;

DNA; HYDROXYUREA; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; BIOACCUMULATION; CELL DAMAGE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME INHIBITION; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; YEAST;

DEOXYRIBONUCLEOTIDES; DNA REPLICATION; DNA, FUNGAL; G1 PHASE; GENOTYPE; HYDROXYUREA; KINETICS; S PHASE; SACCHAROMYCES CEREVISIAE;

EID: 0345791546     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303952200     Document Type: Article

References (42)

1. Slater, M. L. (1973) J. Bacteriol. 113, 263-270
2. Skoog, L., and Nordenskjold, B. (1971) Eur. J. Biochem. 19, 81-89
3. Skoog, L., and Bjursell, G. (1974) J. Biol. Chem. 249, 6434-6438
4. Adams, R. L., Berryman, S., and Thomson, A. (1971) Biochim. Biophys. Acta 240, 455-462
5. Tyrsted, G. (1982) Biochem. Pharmacol. 31, 3107-3113
6. Snyder, R. D. (1984) Mutat. Res. 131, 163-172
7. Gandhi, V., Plunkett, W., Kantarjian, H., Talpaz, M., Robertson, L. E., and O'Brien, S. (1998) J. Clin. Oncol. 16, 2321-2331
8. Hereford, L. M., and Hartwell, L. H. (1974) J. Mol. Biol. 84, 445-461
9. Hartwell, L. H. (1976) J. Mol. Biol. 104, 803-817
10. Elledge, S. J. (1996) Science 274, 1664-1672
11. McIntosh, E. M., Atkinson, T., Storms, R. D., and Smith, M. (1991) Mol. Cell Biol. 11, 329-337
12. Lowndes, N. F., Johnson, A. L., and Johnston, L. H. (1991) Nature 350, 247-250
13. Merrill, G. F., Morgan, B. A., Lowndes, N. F., and Johnston, L. H. (1992) BioEssays 14, 823-830
14. McIntosh, E. M. (1993) Curr. Genet. 24, 185-192
15. Muller, E. G. D. (1994) J. Biol. Chem. 269, 24466-24471
16. Zhao, X., Muller, E. G., and Rothstein, R. (1998) Mol. Cell 2, 329-340
17. Kohalmi, S. E., Glattke, M., McIntosh, E. M., and Kunz, B. A. (1991) J. Mol. Biol. 220, 933-946
18. Koc, A., Wheeler, L. J., Mathews, C. K., and Merrill, G. F. (2003) J. Biol. Chem. 278, 9345-9352
19. Chabes, A., Georgieva, B., Domkin, V., Zhao, X., Rothstein, R., and Thelander, L. (2003) Cell 112, 391-401
20. Lagergren, J., and Reichard, P. (1987) Biochem. Pharmacol. 36, 2985-2991
21. Adams, R. L., and Lindsay, J. G. (1967) J. Biol. Chem. 242, 1314-1317
22. Eriksson, S., Skog, S., Tribukait, B., and Wallstrom, B. (1987) Exp. Cell Res. 168, 79-88
23. Sclafani, R. A. (2000) J. Cell Sci. 113, 2111-2117
24. Nordenskjold, B. A., Skoog, L., Brown, N. C., and Reichard, P. (1970) J. Biol. Chem. 245, 5360-5368
25. Bjursell, K. G., Reichard, P. A., and Skoog, K. L. (1972) Eur. J. Biochem. 29, 348-352
26. Leeds, J. M., Slabaugh, M. B., and Mathews, C. K. (1985) Mol. Cell Biol. 5, 3443-3450
27. Elledge, S. J., Zhou, Z., Allen, J. B., and Navas, T. A. (1993) BioEssays 15, 333-339
28. Yao, R., Zhang, Z., An, X., Bucci, B., Perlstein, D. L., Stubbe, J., and Huang, M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 6628-6633
29. Zhao, X., Chabes, A., Dornkin, V., Thelander, L., and Rothstein, R. (2001) EMBO J. 20, 3544-3553
30. Zhao, X., and Rothstein, R. (2002) Proc. Natl. Acad. Sci. U. S.A. 99, 3746-3751
31. Santocanale, C., and Diffley, J. F. (1998) Nature 395, 615-618
32. Lengronne, A., Pasero, P., Bensirnon, A., and Schwob, E. (2001) Nucleic Acids Res. 29, 1433-1442
33. North, T. W., Bestwick, R. K., and Mathews, C. K. (1980) J. Biol. Chem. 255, 6640-6645
34. Jorgensen, P., Nishikawa, J. L., Breitkreutz, B. J., and Tyers, M. (2002) Science 297, 395-400
35. Bundy, R., Marczin, N., Chester, A. H., and Yacoub, M. (1999) Am. J. Physiol. 277, H1799-H1807
36. Day, R. S, III (1993) Mutat. Res. 293, 215-223
37. Slabaugh, M. B., Howell, M. L., Wang, Y., and Mathews, C. K. (1991) J. Virol. 65, 2290-2298
38. Raghuraman, M. K., Winzeler, E. A., Collingwood, D., Hunt, S., Wodicka, L., Conway, A., Lockhart, D. J., Davis, R. W., Brewer, B. J., and Fangman, W. L. (2001) Science 294, 115-121
39. Snyder, R. D. (1988) Mutat. Res. 200, 193-199
40. Exinger, F., and Lacroute, F. (1992) Curr. Genet. 22, 9-11
41. Larsson, C., Nilsson, A., Blomberg, A., and Gustafsson, L. (1997) J. Bacteriol. 179, 7243-7250
42. Wallis, J. W., Chrebet, G., Brodsky, G., Rolfe, M., and Rothstein, R. (1989) Cell 58, 409-419