Evaluation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct levels and DNA strand breaks in human peripheral blood lymphocytes exposed in vitro to polycyclic aromatic hydrocarbons with or without animal metabolic activation

Toxicology Mechanisms and Methods

Volumn 22, Issue 3, 2012, Pages 170-183

  Isabel, Rodrguez Romero María ^a   Sandra, Gómez Arroyo ^a   Rafael, Villalobos Pietrini ^a   Carmen, Martínez Valenzuela ^b   Josefina, Cortés Eslava ^a   Del Carmen, Calderón Ezquerro María ^a   Rocío, García Martínez ^a   Francisco, Arenas Huertero ^c   Elena, Calderón Segura María ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b Universidad de Occidente   (Mexico)

^c HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

Author keywords

8 OHdG; DNA strand breaks; Human peripheral lymphocytes; Oxidative DNA damage; Polycyclic aromatic hydrocarbons

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BENZO[A]PYRENE; BENZO[B]FLUORANTHENE; BENZO[GHI]PERYLENE; DIBENZ[A,H]ANTHRACENE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ARTICLE; CELL VIABILITY; CITY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTOXICITY; HUMAN; HUMAN CELL; METABOLIC ACTIVATION; MEXICO; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

AIR POLLUTANTS; ANIMALS; BIOTRANSFORMATION; CELL SURVIVAL; CELLS, CULTURED; COMET ASSAY; DEOXYGUANOSINE; DNA ADDUCTS; DNA BREAKS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIVER; LYMPHOCYTES; OXIDATIVE STRESS; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; RISK ASSESSMENT; VEHICLE EMISSIONS;

ANIMALIA;

EID: 84856890063     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2011.623330     Document Type: Article

References (107)

1. Akçay T, Saygili I, Andican G, Yalçin V. 2003. Increased formation of 8-hydroxy-2'-deoxyguanosine in peripheral blood leukocytes in bladder cancer. Urol Int 71:271-274. (Pubitemid 37186742)
2. Anwar WA, Kamal AA. 1988. Cytogenetic efects in a group of trafc policemen in Cairo. Mutat Res 208:225-231.
3. Altman SA, Randers L, Rao G. 1993. Comparison of trypan blue dye exclusion and fuorometric assays for mammalian cell viability determinations. Biotechnol Prog 9:671-674. (Pubitemid 2022153)
4. Altuntas I, Osmanagaoglu Ö, Dagdelen S, Isildak M, Durusoy M, Erbas T. 2009. The availability of 8-oHdG, an oxidative DNA damage marker, in the diagnosis and treatment of autoimmune thryroiditis. Endocrinol Dialog 6:151-155.
5. Amador-Muñoz O, Villalobos-Pietrini R, Aragón-Piña A, Tran TC, Morrison P, Marriott PJ. 2008. Quantifcation of polycyclic aromatic hydrocarbons based on comprehensive two-dimensional gas chromatography-isotope dilution mass spectrometry. J Chromatogr A 1201:161-168.
6. Annas A, Brittebo E, Hellman B. 2000. Evaluation of benzo(a)pyrene- induced DNA damage in human endothelial cells using alkaline single cell gel electrophoresis. Mutat Res 471:145-155.
7. Baer-Dubowska W. 1999. Alternative pathways of polycyclic aromatic hydrocarbons activation: the formation of polar DNA adducts. Acta Biochim Pol 46:263-274.
8. Beland FA, Churchwell MI, Von Tungel LS, Chen S, Fu PP, Culp SJ, Schoket B, Györfy E, Minárovits J, Poirier MC, Bowman ED, Weston A, Doerge DR. 2005. High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo(a)pyrene-DNA adducts. Chem Res Toxicol 18:1306-1315. (Pubitemid 41170255)
9. Bialkowski K, Kowara R, Windorbska W, Olinski R. 1996. 8-Oxo-2'-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy. Cancer Lett 99:93-97.
10. Binková B, Srám RJ. 2004. The genotoxic efect of carcinogenic PAHs, their artifcial and environmental mixtures (EOM) on human diploid lung fbroblasts. Mutat Res 547:109-121. (Pubitemid 38324544)
11. Bonassi S, Neri M, Lando C, Ceppi M, Lin YP, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Fenech M; HUMN collaborative group. 2003. Efect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat Res 543:155-166. (Pubitemid 36324355)
12. Breton J, Sichel F, Bianchini F, Prevost V. 2003. Measurement of 8-Hydroxy-2'-deoxyguanosine by a commercially available ELISA test: comparison with HPLC/electrochemical detection in calf thymus DNA and determination in human serum. Anal Lett 36:123-134. (Pubitemid 36297120)
13. Briedé JJ, Godschalk RW, Emans MTG, De Kok TMC, van Agen E, van Maanen JMS, van Schooten F, Kleinjans JCS. 2004. In vitro and in vivo studies on oxygen free radical and DNA adduct formation in rat lung and liver during benzo(a)pyrene metabolism. Free Radic Res 38:995-1002. (Pubitemid 39341696)
14. Buening MK, Levin W, Wood AW, Chang RL, Yagi H, Karle JM, Jerina DM, Conney AH. 1979. Tumorigenicity of the dihydrodiols of dibenzo(a,h)anthracene on mouse skin and in newborn mice. Cancer Res 39:1310-1314. (Pubitemid 9183850)
15. Burchiel SW, Luster MI. 2001. Signaling by environmental polycyclic aromatic hydrocarbons in human lymphocytes. Clin Immunol 98:2-10.
16. Burdick AD, Davis JW 2nd, Liu KJ, Hudson LG, Shi H, Monske ML, Burchiel SW. 2003. Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells. Cancer Res 63:7825-7833. (Pubitemid 37466715)
17. Calderón-Garcidueñas L, Wen-Wang L, Zhang YJ, Rodriguez-Alcaraz A, Osnaya N, Villarreal-Calderón A, Santella RM. 1999. 8-hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ Health Perspect 107:469-474. (Pubitemid 29341371)
18. Calderón-Segura ME, Gómez-Arroyo S, Villalobos-Pietrini R, Butterworth FM, Amador-Muñoz O. 2004. The efects of seasonal weather on the genotoxicity, cytogenetic properties, cytotoxicity and organochemical content of extracts of airborne particulates in Mexico City. Mutat Res 558:7-17. (Pubitemid 38229630)
19. Carmichael PL, Platt KL, Shé MN, Lecoq S, Oesch F, Phillips DH, Grover PL. 1993. Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a,h]anthracene to DNA-binding species in mouse skin. Cancer Res 53:944-948. (Pubitemid 23087888)
20. Cavallo D, Ursini CL, Bavazzano P, Cassinelli C, Frattini A, Perniconi B, Di Francesco A, Ciervo A, Rondinone B, Iavicoli S. 2006. Sister chromatid exchange and oxidative DNA damage in paving workers exposed to PAHs. Ann Occup Hyg 50:211-218.
21. Cebulska-Wasilewska A, Wiechec A, Panek A, Binková B, Srám RJ, Farmer PB. 2005. Infuence of environmental exposure to PAHs on the susceptibility of lymphocytes to DNA-damage induction and on their repair capacity. Mutat Res 588:73-81. (Pubitemid 41785729)
22. Celi K A, Akbas E. 2005. Evaluation of sister chromatid exchange and chromosomal aberration frequencies in peripheral blood lymphocytes of gasoline station attendants. Ecotoxicol Environ Saf 60:106-112.
23. Chandrasekaran R, Samy PL, Murthy PB. 1996. Increased sister chromatid exchange (SCE) frequencies in lymphocytes from trafc policemen exposed to automobile exhaust pollution. Hum Exp Toxicol 15:301-304. (Pubitemid 26127319)
24. Chiou CC, Chang PY, Chan EC, Wu TL, Tsao KC, Wu JT. 2003. Urinary 8-hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: development of an ELISA and measurement in both bladder and prostate cancers. Clin Chim Acta 334:87-94. (Pubitemid 36836061)
25. Cheng YW, Tsai HJ, Wu JY, Hsu YF, Chen CY, Hao NJ, Lee H. 2007. A posible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cell and tumor tissues. Environ Mol Mut 48:14-21. (Pubitemid 46238554)
26. Cohen AJ. 2000. Outdoor air pollution and lung cancer. Environ Health Perspect 108 Suppl 4:743-750.
27. Cooke MS, Singh R, Hall GK, Mistry V, Duarte TL, Farmer P, Evans MD. 2006. Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine. Free Rad Biol Med 41:1829-1836. (Pubitemid 44842007)
28. Crohns M, Saarelainen S, Erhola M, Alho H, Kellokumpu-Lehtinen P. 2009. Impact of radiotherapy and chemotherapy on biomarkers of oxidative DNA damage in lung cancer patients. Clin Biochem 42:1082-1090.
29. Dreij K, Seidel A, Jernström B. 2005. Diferential renoval of DNA adducts derived from anti-diol epoxides of dibenzo(a,l)pyrene and benzo(a)pyrene in human cells. Chem Res Toxicol 18:655-664. (Pubitemid 40563279)
30. Dzepina K, Arey J, Marr LC, Worsnop DR, Salcedo QZ, Onasch TB, Molina LT, Molina MJ, Jimenez JL. 2007. Detection of particle-phase polycyclic aromatic hydrocarbons in Mexico City using an aerosol mass spectrometer. Int J Mass Spectrom 263:152-170.
31. Endo K, Miyashita Y, Sasaki H, Ebisuno M, Ohira M, Saiki A, Koide N, Oyama T, Takeyoshi M, Shirai K. 2006. Probucal and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and hypercholesterolemia. J Atheroscler Tromb 13:68-75.
32. Evans MD, Singh R, Mistry V, Sandhu K, Farmer P, Cooke MS. 2008. Analysis of urinary 8-oxo-7,8-dihydro-purine-2'-deoxyribonucleosides by LC-MS/MS and improved ELISA. Free Rad Res 42:831-840.
33. Foksinski M, Kotzbach R, Szymanski W, Olinski R. 2000. The level of typical biomarker of oxidative stress 8-hydroxy-2'-deoxyguanosine is higher in uterine myomas than in control tissues and correlates with the size of the tumor. Free Radic Biol Med 29:597-601.
34. Fortoul TI, Valverde M, López MC, Avila-Costa MR, Avila-Casado MC, Mussali-Galante P, Gonzalez-Villalva A, Rojas E, Ostrosky-Shejet P. 2004. Genotoxic diferences by sex in nasal epithelium and blood leukocytes in subjects residing in a highly polluted area. Environ Res 94:243-248. (Pubitemid 38328676)
35. Furukawa M, Nishimura M, Ogino D, Chiba R, Ikai I, Ueda N, Naito S, Kuribayashi S, Moustafa MA, Uchida T, Sawada H, Kamataki T, Funae Y, Fukumoto M. 2004. Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci 95:520-529. (Pubitemid 38832702)
36. Gackowski D, Rozalski R, Siomek A, Dziaman T, Nicpon K, Klimarczyk M, Araszkiewicz A, Olinski R. 2008. Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia. J Neurol Sci 266:57-62. (Pubitemid 351186523)
37. Garry S, Nesslany F, Aliouat E, Haguenoer JM, Marzin D. 2003. Assessment of genotoxic efect of benzo[a]pyrene in endotracheally treated rat using the comet assay. Mutat Res 534:33-43. (Pubitemid 36015837)
38. Geddie JE, Amin S, Huie K, Hecht SS. 1987. Formation and tumorigenicity of benzo[b]fuoranthene metabolites in mouse epidermis. Carcinogenesis 8:1579-1584.
39. Glen ACA. 1996. Measurement of DNA and RNA in human peripheral blood lymphocytes. Chem Clin 13:299-313.
40. Grzybowska E, Hemminki K, Szeliga J, Chorazy M. 1993. Seasonal variation of aromatic DNA adducts in human lymphocytes and granulocytes. Carcinogenesis 14:2523-2526. (Pubitemid 24016589)
41. Gutiérrez-Castillo ME, Roubicek DA, Cebrián-García ME, De Vizcaya-Ruíz A, Sordo-Cedeño M, Ostrosky-Wegman P. 2006. Efect of chemical composition on the induction of DNA damage by urban airborne particulate matter. Environ Mol Mutagen 47:199-211.
42. Gyorfy E, Anna L, Kovács K, Rudnai P, Schoket B. 2008. Correlation between biomarkers of human exposure to genotoxins with focus on carcinogen-DNA adducts. Mutagenesis 23:1-18. (Pubitemid 351161353)
43. Haghdoost S, Sjölander L, Czene S, Harms-Ringdahl M. 2006. The nucleotide pool is a signifcant target for oxidative stress. Free Radic Biol Med 41:620-626. (Pubitemid 44080509)
44. Harrigan JA, McGarrigle BP, Sutter TR, Olson JR. 2006. Tissue specifc induction of cytochrome P 450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro and in vivo exposure to benzo(a)pyrene. Toxicol In Vitro 20:426-438.
45. Harris CC, Vahakangas K, Newmant MJ, Trivers GE, Shamsuddin A, Sinopoli N, Mann D, Wright WE. 1985. Detection of benzo[a]pyrene diol epoxide DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci 82:6672-6676. (Pubitemid 16228882)
46. Hattori Y, Nishigori C, Tanaka T, Uchida K, Nikaido O, Osawa T, Hiai H, Imamura S, Toyokuni S. 1996. 8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol 107:733-737. (Pubitemid 26371090)
47. Helbock HJ, Beckman KB, Ames BN. 1999. 8-hydrodeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol 300:156-166.
48. Hsiao WL, Mo ZY, Fang M, Shi XM, Wang F. 2000. Cytotoxicity of PM(2.5) and PM(2.5-10) ambient air pollutants assessed by the MTT and the comet assays. Mutat Res 471:45-55.
49. Kim JY, Mukherjee S, Ngo LC, Christiani DC. 2004. Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to fne particulates. Environ Health Perspect 112:666-671. (Pubitemid 38628394)
50. Kleiner HE, Vulimiri SV, Hatten WB, Reed MJ, Nebert DW, Jefcoate CR, DiGiovanni J. 2004. Role of cytochrome P450 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis. Chem Res Toxicol 17:1667-1674. (Pubitemid 39665559)
51. Kondo S, Toyocuni S, Tanaka T, Hiai H, Onodera H, Kasai H, Imamura M. 2000. Overexpression of the hOGGI Gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. Clin Cancer Res 6:1394-1400. (Pubitemid 30226226)
52. Kuo H, Chou S, Hu T, Wu F. 2007. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients. Mutat Res 631:62-68. (Pubitemid 46809622)
53. Lecoq S, Pfau W, Grover PL, Phillips DH. 1992. HPLC separation of 32P-postlabelled DNA adducts formed from dibenz[a,h]anthracene in skin. Chem Biol Interact 85:173-185. (Pubitemid 23020428)
54. Lin P, Hu SW, Chang TH. 2003. Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon receptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human lymphocytes. Toxicol Sci 71:20-26. (Pubitemid 36163702)
55. Loft S, Høgh Danielsen P, Mikkelsen L, Risom L, Forchhammer L, Møller P. 2008. Biomarkers of oxidative damage to DNA and repair. Biochem Soc Trans 36:1071-1076.
56. Marczynski B, Rozynek P, Elliehausen HJ, Korn M, Baur X. 1997. Detection of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, in white blood cells of workers occupationally exposed to styrene. Arch Toxicol 71:496-500. (Pubitemid 27285938)
57. Marczynski B, Rihs HP, Rossbach B, Hölzer J, Angerer J, Scherenberg M, Hofmann G, Brüning T, Wilhelm M. 2002. Analysis of 8-oxo-7,8-dihydro-2'- deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Carcinogenesis 23:273-281. (Pubitemid 34224002)
58. Marczynski B, Pesch B, Wilhelm M, Rossbach B, Preuss R, Hahn JU, Rabstein S, Raulf-Heimsoth M, Seidel A, Rihs HP, Adams A, Scherenberg M, Erkes A, Engelhardt B, Straif K, Käferlein HU, Angerer J, Brüning T. 2009. Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany. Arch Toxicol 83:947-957.
59. Marie C, Ravanat JL, Badouard C, Marques M, Balducci F, Maître A. 2009. Urinary levels of oxidative DNA and RNA damage among workers exposed to polycyclic aromatic hydrocarbons in silicon production: comparison with 1-hydroxypyrene. Environ Mol Mutagen 50:88-95.
60. Marr LC, Grogan LA, Wöhrnschimmel H, Molina LT, Molina MJ, Smith TJ, Garshick E. 2004. Vehicle trafc as a source of particulate polycyclic aromatic hydrocarbon exposure in the Mexico City metropolitan area. Environ Sci Technol 38:2584-2592. (Pubitemid 38579858)
61. Marston CP, Pereira C, Ferguson J, Fischer K, Hedstrom O, Dashwood WM, Baird WM. 2001. Efect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis. Carcinogenesis 22:1077-1086. (Pubitemid 32633607)
62. Martí-Cid R, Llobet JM, Castell V, Domingo JL. 2008. Evolution of the dietary exposure to polycyclic aromatic hydrocarbons in Catalonia, Spain. Food Chem Toxicol 46:3163-3171.
63. Mass MJ, Abu-Shakra A, Roop BC, Nelson G, Galati AJ, Stoner GD, Nesnow S, Ross JA. 1996. Benzo[b]fuoranthene: tumorigenicity in strain A/J mouse lungs, DNA adducts and mutations in the Ki-ras oncogene. Carcinogenesis 17:1701-1704. (Pubitemid 26280395)
64. Maron DM, Ames BN. 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173-215. (Pubitemid 13120319)
65. Miyake H, Hara I, Kamidono S, Eto H. 2004. Prognostic signifcance of oxidative DNA damage evaluated by 8-hydroxy-2'-deoxyguanosine in patients undergoing radical nephrectomy for renal cell carcinoma. Urology 64:1057-1061. (Pubitemid 39469545)
66. Molina MJ, Molina LT. 2004. Megacities and atmospheric pollution. J Air Waste Manag Assoc 54:644-680. (Pubitemid 38747741)
67. Nilsson RI, Nordlinder RG, Tagesson C, Walles S, Järvholm BG. 1996. Genotoxic efects in workers exposed to low levels of benzene from gasoline. Am J Ind Med 30:317-324. (Pubitemid 26299967)
68. Park S, Lee S, Ye S, Yoon S, Chung M, Choi J. 2006. Benzo(a)pyrene- induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identifcation of potential biomarkers for PAH monitoring and risk assessment. Toxicol Lett 167:27-33. (Pubitemid 44548274)
69. Park JH, Mangal D, Frey AJ, Harvey RG, Blair IA, Penning TM. 2009. Aryl-hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'- deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8- dione. J Biol Chem 284:29725-29734.
70. Phillips DH. 1999. Polycyclic aromatic hydrocarbons in the diet. Mutat Res 443:139-147. (Pubitemid 29327272)
71. Phillips DH. 2005. DNA adducts as markers of exposure and risk. Mutat Res 577:284-292. (Pubitemid 41225507)
72. Platt KL, Grupe S. 2005. Microsomal biotransformation of benzo[ghi] perylene, a mutagenic polycyclic aromatic hydrocarbon withouth ̈classic̈ bay region. Chem Res Toxicol 18:700-710. (Pubitemid 40563284)
73. Platt KL, Grupe S, Fickler M. 2008. The 3,4-oxide is responsible for the DNA binding of benzo[ghi]perylene, a polycyclic aromatic hydrocarbon without a "classic" bay-region. Chem Biol Interact 176:179-187.
74. Poirier MC. 2004. Chemical-induced DNA damage and human cancer risk. Nat Rev Cancer 4:630-637. (Pubitemid 39025057)
75. Pope CA 3rd, Burnett RT, Tun MJ, Calle EE, Krewski D, Ito K, Turston GD. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fne particulate air pollution. JAMA 287:1132-1141. (Pubitemid 34252082)
76. Romano G, Sgambato A, Mancini R, Capelli G, Giovagnoli MR, Flamini G, Boninsegna A, Vecchione A, Cittadini A. 2000. 8-hydroxy-2'-deoxyguanosine in cervical cells: correlation with grade of dysplasia and human papillomavirus infection. Carcinogenesis 21:1143-1147. (Pubitemid 30389339)
77. Ross JA, Nelson GB, Holden KL, Kligerman AD, Erexson GL, Bryant MF, Earley K, Beach AC, Gupta RC, Nesnow S. 1992. DNA adducts and induction of sister chromatid exchanges in the rat following benzo[b]fuoranthene administration. Carcinogenesis 13:1731-1734.
78. Roszkowski K, Gackowski D, Rozalski R, Dziaman T, Siomek A, Guz J, Szpila A, Foksinski M, Olinski R. 2008. Small feld radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism. Int J Cancer 123:1964-1967.
79. Ruan Q, Gelhaus SL, Penning TM, Harvey RG, Blair IA. 2007. Aldo-keto reductase-and cytochrome p450-dependent formation of benzo[a]pyrene-derived dna adducts in human bronchoalveolar cells. Chem Res Toxicol 20:424-431. (Pubitemid 46548689)
80. Schins RP, Schilderman PA, Borm PJ. 1995. Oxidative DNA damage in peripheral blood lymphocytes of coal workers. Int Arch Occup Environ Health 67:153-157.
81. Shimada T, Guengerich FP. 2006. Inhibition of human cytochrome P450 1A1-, 1A2-and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. Chem Res Toxicol 19:288-294.
82. Shimoi K, Kasai H, Yokota N, Toyokuni S, Kinae N. 2002. Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine. Cancer Epidemiol Biomarkers Prev 11:767-770. (Pubitemid 34851912)
83. Singh N, McCoy M, Tice R, Schneider E. 1988. A simple technique for quantization of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
84. Singh R, Teichert F, Seidel A, Roach J, Cordell R, Cheng MK, Frank H, Steward WP, Manson MM, Farmer PB. 2010. Development of a targeted adductomic method for the determination of polycyclic aromatic hydrocarbon DNA adducts using online column-switching liquid chromatography/tandem mass spectro-metry. Rapid Commun Mass Spectrom 24:2329-2340.
85. Staal YC, van Herwijnen MH, Pushparajah DS, Umachandran M, Ioannides C, van Schooten FJ, van Delft JH. 2007. Modulation of gene expression and DNA-adduct formation in precision-cut liver slices exposed to polycyclic aromatic hydrocarbons of diferent carcinogenic potency. Mutagenesis 22:55-62. (Pubitemid 46058642)
86. Svihálková-Sindlerová L, Machala M, Pencíková K, Marvanová S, Neca J, Topinka J, Sevastyanova O, Kozubík A, Vondrácek J. 2007. Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells. Toxicology 232:147-159. (Pubitemid 46283182)
87. Takaishi M, Sawada M, Shimada A, Suzuki JS, Satoh M, Nagase H. 2009. Protective role of mellathionein in benzo(a)pyrene-induced DNA damage. Toxicol Sci 34:449-458.
88. Takahashi K, Pan G, Kasai H, Hanaoka T, Feng Y, Liu N, Zhang S, Xu Z, Tsuda T, Yamato H, Higashi T, Okubo T. 1997. Relationship between asbestos exposures and 8-hydroxydeoxyguanosine levels in leukocytes DNA of workers at a Chinese asbestos-material plant. Int J Occup Environ Health 3:111-119. (Pubitemid 127816932)
89. Tarantini A, Maitre A, Lefebvre E, Marques M, Marie C, Ravanat JL, Douki T. 2009. Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo(a)pyrene as a pure compound and in complex mixtures. Mutat Res 671:67-75.
90. Tornhill DA, Foy B, Herndon SC, Onasch TB, Wood EC, Zavala M, Molina LT, Gafney JS, Marley NA, Marr LC. 2008. Spatial and temporal variability of particulate polycyclic aromatic hydrocarbons in Mexico City. Atm Chem Phys 8:3093-3105.
91. Tice R, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki Y F. 2000. Single cell gel/comet assay: guidelines for in vivo genetic toxicology testing. Environ Mol Mutagen 35:206-221. (Pubitemid 30196665)
92. Topinka J, Schwarz LR, Kiefer F, Wiebel FJ, Gajdos O, Vidová P, Dobiás L, Fried M, Srám RJ, Wolf T. 1998. DNA adduct formation in mammalian cell cultures by polycyclic aromatic hydrocarbons (PAH) and nitro-PAH in coke oven emission extract. Mutat Res 419:91-105. (Pubitemid 28512975)
93. Topinka J, Marvanová S, Vondrácek J, Sevastyanova O, Nováková Z, Krcmár P, Pencíková K, Machala M. 2008. DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like' cells exposed to carcinogenic polycyclic aromatic hydrocarbons. Mutat Res 638:122-132.
94. Tsurudome Y, Hirano T, Yamato H, Tanaka I, Sagai M, Hirano H, Nagata N, Itoh H, Kasai H. 1999. Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles. Carcinogenesis 20:1573-1576. (Pubitemid 29385447)
95. Valverde M, del Carmen López M, López I, Sánchez I, Fortoul TI, Ostrosky-Wegman P, Rojas E. 1997. DNA damage in leukocytes and buccal and nasal epithelial cells of individuals exposed to air pollution in Mexico City. Environ Mol Mutagen 30:147-152. (Pubitemid 27440591)
96. van Duursen MB, Sanderson JT, van den Berg M. 2005. Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibility. Toxicol Sci 85:703-712.
97. Villalobos-Pietrini R, Amador-Muñoz O, Walisevski S, Hernández M, Munive C, Gómez A, Bravo C, Frías V. 2006. Mutagenicity and polycyclic aromatic hydrocarbons associated with extractable organic matter from airborne particles 10 μm in southwest México City. Atm Environ 40:5845-5857. (Pubitemid 44335856)
98. Weyand EH, Cai ZW, Wu Y, Rice JE, He ZM, LaVoie EJ. 1993. Detection of the major DNA adducts of benzo[b]fuoranthene in mouse skin: role of phenolic dihydrodiols. Chem Res Toxicol 6:568-577. (Pubitemid 23212530)
99. Wiencke JK, McDowell ML, Bodell WJ. 1990. Molecular dosimetry of DNA adducts and sister chromatid exchanges in human lymphocytes treated with benzo[a]pyrene. Carcinogenesis 11: 1497-1502. (Pubitemid 20281462)
100. Wiseman H, Kaur H, Halliwell B. 1995. DNA damage and cancer: measurement and mechanism. Cancer Lett 93:113-120.
101. Wu LL, Chiou CC, Chang PY, Wu JT. 2004. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 339:1-9. (Pubitemid 37542453)
102. Xue W, Warshawsky D. 2005. Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicol Appl Pharmacol 206:73-93. (Pubitemid 40800430)
103. Yoshida R, Ogawa Y, Kasai H. 2002. Urinary 8-oxo-7,8-dihydro-2'- deoxyguanosine values measured by an ELISA correlated well with measurements by high-performance liquid chromatography with electrochemical detection. Cancer Epidemiol Biomarkers Prev 11:1076-1081. (Pubitemid 35192660)
104. Yin B, Whyatt RM, Perera FP, Randall MC, Cooper TB, Santella M. 1995. Determination of hydroxydeoxyguanosine by an immunoafnity chromatography- monoclonal antibody-based ELISA. Free Radic Biol Med 18:1023-1032.
105. Zanesi N, Ferraro P, Pavanello S, Furlan D, Celotti L. 1994. Cytotoxic and mutagenic efects of anti-and syn-benzo[a]pyrene diol epoxide in human lymphocytes. Toxicol In Vitro 8:1269-1275. (Pubitemid 24366259)
106. Zhang J, Ichiba M, Hanaoka T, Pan G, Yamano Y, Hara K, Takahashi K, Tomokuni K. 2003. Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure. Int Arch Occup Environ Health 76:499-504. (Pubitemid 37254233)
107. Zavala M, Herndon SC, Wood EC, Onasch T V, Knighton WB, Marr LC, Kolb CE, Molina LT. 2009. Evaluation of mobile emission contributions to Mexico City's emissions inventory using on-road and cross-road emission measurements and ambient data. Atm Chem Phys 9:6305-6317.