DNA adduct formation in mammalian cell cultures by polycyclic aromatic hydrocarbons (PAH) and nitro-PAH in coke oven emission extract

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 419, Issue 1-3, 1998, Pages 91-105

  Topinka, J ^a   Schwarz, L R ^b   Kiefer, F ^b   Wiebel, F J ^b   Gajdos O ^c   Vidova P ^c   Dobias L ^d   Fried, M ^e   Sram R J ^a   Wolff, T ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Spec Inst of Hyg and Epidemiology   (Slovakia)

^d Regional Institute of Hygiene   (Czech Republic)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

32P postlabeling; Coke oven emission; DNA adduct; Genotoxicity testing; Mammalian cell; Nitroaromatic compound; Polycyclic aromatic hydrocarbon

Indexed keywords

BENZ[A]ANTHRACENE; BENZO[A]PYRENE; INDUSTRIAL TOXIC SUBSTANCE; NITRO DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON;

AIR POLLUTION; ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CELL CULTURE; CONTROLLED STUDY; DNA ADDUCT; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; LIVER CELL; LUNG TUMOR; MAMMAL CELL; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; TUMOR CELL LINE;

AIR POLLUTANTS; ANIMALS; CELLS, CULTURED; COKE; CRICETINAE; CRICETULUS; DNA ADDUCTS; HUMANS; LIVER; MALE; MUTAGENICITY TESTS; MUTAGENS; NITRO COMPOUNDS; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; RATS, WISTAR; TETRACHLORODIBENZODIOXIN;

CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0001870825     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(98)00127-2     Document Type: Article

References (35)

1. IARC Evaluation of the carcinogenic risk of chemicals to humans: polynuclear aromatic compounds. IARC Monogr. 34:1984;101-131.
2. 32P -postlabeling and HPLC separation of DNA adducts formed by diesel exhaust extracts in vitro and in mouse skin and lung after topical treatment Carcinogenesis. 16:1995;2083-2089.
3. Imaida K., Hirose M., Tay L., Lee M.-S., Wang C.Y., King C.M. Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat. Cancer Res. 51:1991;2902-2907.
4. Qu S.X., Stacey N.H. Comparison of DNA adduct induction in vitro by PAHs and nitro-PAHs in freshly isolated rat hepatocytes. Toxicology in Vitro. 10:1996;685-692.
5. 32P -postlabeling analysis demonstrated by the selective formation and comparative analysis of nitrated-PAH-derived adducts arising from diesel particle extracts Carcinogenesis. 12:1991;1685-1691.
6. Williams R., Sparacino C., Petersen B., Bumgarner J., Jungers R.H., Lewtas J. Comparative characterization of organic emissions from diesel particles, coke oven mains, roofing tar vapors and cigarette smoke condensate. Intern. J. Environ. Anal. Chem. 26:1986;27-49.
7. K.M. Nauss and the HEI Diesel Working Group, Diesel Exhaust: A Critical Analysis of Emissions, Exposure, and Health Effects, A Special Report of the Institute's Diesel Working Group, Cambridge, MA, USA, 1995, pp. 223-242.
8. Hasegava N.M., Nishi Y., Tsuda H., Inui N., Morimoto K. Effect of diesel exhaust particles on chromosomal aberrations, sister chromatid exchanges, and morphological transformation in cultured mammalian cells. Cancer Lett. 42:1988;61-66.
9. Rogiers V., Vercruysse A. Rat hepatocytes cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology. 82:1993;193-208.
10. Monteith D.K., Gupta R.C. Carcinogen-DNA adducts in cultures of rat and human hepatocytes. Cancer Letters. 62:1992;87-93.
11. Pfau W., Brockstedt U., Schulze C., Neurath G., Marquardt H. Characterization of the major DNA adduct formed by the food mutagen 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) in primary rat hepatocytes. Carcinogenesis. 17:1996;2727-2732.
12. Topinka J., Binková B., Zhu H.K., Andrae U., Neumann I., Schwarz L.R., Wolff T. Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocytes cultures. Carcinogenesis. 14:1993;423-427.
13. Topinka J., Binková B., Zhu H.K., Andrae U., Neumann I., Schwarz L.R., Werner S., Wolff T. DNA-damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver. Carcinogenesis. 16:1995;1483-1487.
14. P. Moldeus, P. Jernstrom, J.R. Dawson, The use of freshly isolated or cultured hepatocytes in studies of the metabolism of polycyclic aromatic hydrocarbons and other carcinogens, in: E. Hodgson, E. Bend, R.M. Philpot (Eds.), Reviews in Biochemical Toxicology Vol. 5, Elsevier, Amsterdam, 1983, pp. 239-266 .
15. Kiefer F., Wiebel F.J. V79 Chinese hamster cells express cytochrome P-450 activity after simultaneous exposure to polycyclic aromatic hydrocarbons and aminophyline. Toxicol. Lett. 48:1989;265-273.
16. Wiebel F.J., Kiefer F., Krupski G., Schuller H.M. Expression of glutathione S-transferase and phenol sulfotransferase but not of UDP-glucuronosyltransferase, in the human lung tumor cell lines NCl-H322 and NCl-H358. Biochem. Pharmacol. 35:1986;1337-1343.
17. Stanley L.A., Carmichael J., Wolf C.R. Cytochrome P-450 induction in human lung tumor-derived cell lines. Eur. J. Biochem. 280:1992;521-529.
18. Carmichael J., Mitchell J.B., Friedman N., Gazdar A.F., Russo A. Glutathione and related enzyme activity in human lung cancer cell line. Br. J. Cancer. 58:1988;437-440.
19. Lewis A.D., Hickson J.D., Robson C.N., Harris A.L., Hayes J.D., Griffiths S.A., Manson M.M., Moss J.E., Wolf C.R. Amplification and increase expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc. Natl. Acad. Sci. U.S.A. 85:1988;8511-8515.
20. Perchermeier M.M., Kiefer F., Wiebel F.J. Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines. Toxicol. Lett. 48:1989;265-273.
21. Stephen F.D., Drahushuk A.D., Olson J.R. Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C. Toxicology. 124:1997;39-51.
22. Lewtas J. Bioassay-directed fractionation of the organic extract of SRM 1649 urban air particulate matter. Intern. J. Anal. Chem. 39:1990;245-256.
23. Scheepers P.T.J. Gas chromatographic-mass spectrometric determination of nitro-polycyclic aromatic hydrocarbons in airborne particulate matter from workplace atmospheres contaminated with diesel exhaust. J. Chromatography. A 677:1994;107-121.
24. Schwarz L.R., Watkins J.B. Uptake of taurocholate, a vecuronium like organic cation, ORG 9426 and ouabain into carcinogen-induced diploid and polyploid hepatocytes obtained by centrifugal elutriation. Biochem. Pharmacol. 43:1992;1195-1201.
25. Burke M.D., Mayer R.T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2:1974;583-588.
26. Wiebel F.J., Brown S., Waters H.L., Selkirk J.K. Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tools. Arch. Toxicol. 39:1977;133-148.
27. Gupta R.C. Non-random binding of the carcinogen hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc. Natl. Acad. Sci. U.S.A. 81:1984;6943-6947.
28. 32P -postlabeling analysis of aromatic carcinogen adducts Cancer Res. 45:1985;5656-5662.
29. M. Hall, P.L. Grover, Polycyclic aromatic hydrocarbons: metabolism, activation and tumour initiation, in: C.S. Cooper, P.L. Grover (Eds.), Chemical Carcinogenesis and Mutagenesis, Springer, Heidelberg, Germany, 1990, pp. 327-372.
30. Fu P.P. Metabolic activation of nitro-polycyclic aromatic hydrocarbons. Drug Metab. Rev. 22:1990;209-268.
31. Rogiers V., Vercruysse A. Rat hepatocytes cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology. 82:1993;193-208.
32. Schrenk D., Lipp H.-P., Wiesmuller T., Hagenmaier H., Bock K.W. Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins: comparison between defined mixtures and their constituents. Arch. Toxicol. 65:1991;114-118.
33. Silvers K.J., Couch L.H., Rorke E.A., Howard P.C. Role of nitroreductases but not cytochromes P450 in the metabolic activation of 1-nitropyrene in the HepG2 human hepatoblastoma cell line. Biochem. Pharmacol. 54:1997;927-936.
34. Nishioka M.G., Howard C.C., Contos D.A., Ball L.M., Lewtas J. Detection of hydroxylated nitroaromatic and hydroxylated nitro polycyclic aromatic compounds in an ambient air particulate extract using bioassay-directed fractionation. Environ. Sci. Technol. 22:1988;908-915.
35. Nishioka M.G., Lewtas J. Quantification of nitro- and hydroxylated nitro-aromatic/polycyclic aromatic hydrocarbons in selected ambient air daytime winter samples. Atmospheric Environment. 26A:1992;2077-2087.