Signaling by environmental polycyclic aromatic hydrocarbons in human lymphocytes

Clinical Immunology

Volumn 98, Issue 1, 2001, Pages 2-10

  Burchiel, Scott W ^a   Luster, Michael I ^b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; POLYCYCLIC AROMATIC HYDROCARBON; XENOBIOTIC AGENT;

B LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; IMMUNOTOXICITY; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; METABOLISM; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0035188023     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4934     Document Type: Article

References (59)

1. Toxic responses of the immune system
2. Development of a testing battery to assess chemical-induced immunotoxicity: National Toxicology Program's guidelines for immunotoxicity evaluation in mice
3. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests
4. Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests
5. Use of animal studies in risk assessment for immunotoxicology
6. Target organs and systems: Methodologies to assess immune system function
7. Local lymph node assay: Use in hazard and risk assessment
8. Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity
9. Molecular mechanisms of toxicant-induced immunosuppression: Role of second messengers
10. Polycyclic aromatic hydrocarbons: A review
11. Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke
12. Biomonitoring of human genotoxicity induced by complex occupational exposures
13. Sources of fine organic aerosol. 2. Noncatalyst and catalyst-equipped automobiles and heavy duty trucks
14. Fine particle and gaseous emission rates from residential wood combustion
15. Mechanisms of polycyclic aromatic hydrocarbon immunotoxicity
16. Immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in B6C3F1 mice. I. Effects on humoral immunity and host resistance
17. Immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in B6C3F1 mice - II. Altered cell-mediated immunity and tumor resistance
18. Immunomodulation by polyaromatic hydrocarbons in mice and murine cells
19. Inhibition of IL-2 responsiveness following exposure to benzo(a)pyrene is due to alterations in accessory cell function
20. Persistent suppression of humoral and cell-mediated immunity in mice following exposure to the polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene
21. Persistent suppression of humoral immunity produced by 7,12-dimethylbenz(a)anthracene (DMBA) in B6C3F1 mice: Correlation with changes in spleen cell surface markers detected by flow cytometry
22. Inhibition of lymphocyte activation in splenic and gut-associated lymphoid tissues following oral exposure of mice to 7,12-dimethylbenz[a]anthracene
23. Suppression of local gut-associated and splenic mitogen responsiveness of lymphoid cells following oral exposure of B6C3F1 mice to 7,12-dimethylbenz[a]anthracene
24. Suppression of splenic lymphocyte function by 7,12-dimethylbenz[a]anthracene (DMBA) in vitro
25. Effects of benzo[a]pyrene on concanavalin-A-stimulated human peripheral blood mononuclear cells in vitro: Inhibition of proliferation but no effect on parameters related to the G1 phase of the cell cycle
26. Human T cells are highly sensitive to suppression of mitogenesis by polycyclic aromatic hydrocarbons and this effect is differentially reversed by α-naphthoflavone
27. Effects of 7,12-dimethylbenz[a]anthracene on the superantigen toxic shock syndrome toxin (TSST-1)-induced proliferation and antibody secretion by human lymphocytes
28. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis
29. Induction of preB cell apoptosis by 7,12-dimethylbenz[a]anthracene in long-term primary murine bone marrow cultures
30. DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma
31. Apoptosis in Daudi human B cells in response to benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol
32. Suppression of the in vitro humoral immune response of mouse splenocytes by 7,12-dimethylbenz[a]anthracene metabolites and inhibition of immunosuppression by alpha-naphthoflavone
33. Chemical carcinogenesis
34. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
35. Role of altered calcium homeostasis and signal transduction in polycyclic aromatic hydrocarbon-induced immunotoxicity in B cells, invited review
36. Alterations in mitogen-induced calcium mobilization and intracellular free calcium produced by 7,12-dimethylbenz(a)anthracene (DMBA) in the Jurkat human T cell line
37. 3 formation, and mobilization of intracellular calcium
38. Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons
39. Characterization of intracellular calcium responses produced by polycyclic aromatic hydrocarbons in surface marker-defined human peripheral blood mononuclear cells
40. 2+ in the MCF-10A human mammary epithelial cell line by carcinogenic polycyclic aromatic hydrocarbons
41. Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: Possible associations with cytochrome P450 metabolism and increased protein tyrosine kinase phosphorylation
42. Uses and future applications of flow cytometry in immunotoxicity testing
43. DNA adducts in human carcinogenesis: Etiological relevance and structure-activity relationship
44. Participation of p53 protein in the cellular response to DNA damage
45. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
46. Immunotoxic polycyclic aromatic hydrocarbons reduce intracellular glutathione levels in the A20.1 murine B cell lymphoma
47. Depletion of glutathione by benzo(a)pyrene metabolites, ionomycin, thapsigargin, and phorbol esters in human peripheral blood mononuclear cells
48. Characterization of benzo[a]pyrene quinone-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice: Potential role of mitochondrial dysfunction
49. Redox regulation of signal transduction in mammalian cells
50. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles
51. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern
52. The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease
53. The organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro
54. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system
55. Macrophage activation by polycyclic aromatic hydrocarbons: Evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements
56. Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa
57. Enhancement of allergic inflammation by diesel exhaust particles: Permissive role of reactive oxygen species
58. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages
59. Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IkappaB kinase cascade: Implications for exacerbation of allergic inflammation by environmental pollutants