Genotoxic differences by sex in nasal epithelium and blood leukocytes in subjects residing in a highly polluted area

Environmental Research

Volumn 94, Issue 3, 2004, Pages 243-248

  Fortoul, T I ^a   Valverde, M ^b   Lopez M C ^b   Avila Costa, M R ^c   Avila Casado, M C ^a   Mussali Galante, P ^a   Gonzalez Villalva, A ^a   Rojas, E ^b   Ostrosky Shejet, P ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Air pollution; Comet assay; Genotoxicity; Leukocytes; Nasal epithelium; Sex; Single cell gel electrophoresis

Indexed keywords

AIR QUALITY; ATMOSPHERIC POLLUTION; GENOTOXICITY; POLLUTION EFFECT;

ADULT; AIR POLLUTION; ARTICLE; ATMOSPHERE; BLOOD; BLOOD TOXICITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; FEMALE; GEL ELECTROPHORESIS; GENOTOXICITY; HISTOLOGY; HUMAN; HUMAN CELL; LEUKOCYTE; LOWER RESPIRATORY TRACT; MALE; MEDICAL STUDENT; NOSE MUCOSA; NOSE SMEAR; OXIDATION; POPULATION RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; SQUAMOUS CELL;

ADULT; AIR POLLUTANTS; ANALYSIS OF VARIANCE; COMET ASSAY; DNA DAMAGE; FEMALE; HISTOLOGICAL TECHNIQUES; HUMANS; LEUKOCYTES; MALE; METAPLASIA; MEXICO; NASAL MUCOSA; OZONE; SEX FACTORS; URBAN HEALTH;

EID: 1542351672     PISSN: 00139351     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0013-9351(03)00093-8     Document Type: Article

References (31)

1. Asai K., Hiki N., Mimura Y., Ogawa T., Unou K., Kaminishi M. Gender differences in cytokine secretion by human peripheral blood mononuclear cells. role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model Shock. 16:2001;340-343.
2. Bajpayee M., Dhawn A., Parmar D., Pandey A.K., Mathur N., Seth P.K. Gender-related differences in basal DNA damage in lymphocytes of healthy Indian population using the alkaline comet assay. Mutat. Res. 520:2002;83-91.
3. Behl C., Holsboer F. The female sex hormone oestrogen as a neuroprotectant. Trends Pharmacol. Sci. 20:1999;441-444.
4. Betti C., Davini T., Giannessi L., Loprieno N., Barale R. Comparative studies by comet test and SCE analysis in human lymphocytes from 200 healthy subjects. Mutat. Res. 343:1995;201-207.
5. Bodel P., Dillard G.M., Kaplan S.S., Malawista S.E. Anti-inflammatory effects of estradiol on human blood leukocytes. J. Lab. Clin. Med. 80:1972;373-384.
6. Bravo, H., Roy-Ocotla, G., Sosa, R., Torres, R., 1991. Report of the historical trends (1986-1990) in the levels of ozone monitored by the University of Mexico at Mexico City. Proceedings of the 84th Annual Meeting and Exhibition, Vol. 2. Vancouver, BC, P. 11.
7. Calderon-Garciduenas L., Lian W.W., Zhang Y.J., Rodriguez-Alcaraz A., Osnaya N., Villarreal-Calderon A., Santella R.M. 8-Hydroxy-2′- deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ. Health Perspect. 107:1999;469-474.
8. Collins R.A., Gedik M.C., Olmedilla B., Southon S., Bellizzi M. Oxidative DNA damage measured in human lymphocytes. large differences between sexes and between countries, and correlations with heart disease mortality rates FASEB J. 12:1998;1397-1402.
9. Committee of the environmental and Occupational Health Assembly of the American Thoracic Society, 1996. Health effects of outdoor air pollution. State of the art. Am. J. Respir. Crit. Care Med. 53, 3-27.
10. Daniel W.W. Bioestadistica. Base para el Análisis de las Ciencias de la Salud:1999;UTHEA, Mexico.
11. Fortoul T.I., Saldivar O.I., Tovar T.A., Salazar D., Castilla M.E., Olaiz-Fernandez G. Metals in lung tissue from autopsy cases in Mexico City residents. Comparison of cases from the 1950s and the 1980s. Environ. Health Perspect. 104:1996;630-632.
12. Gluck U., Gebbers J.O. The comet assay of nasal epithelia. measurement of DNA damage for the assessment of genotoxic air pollution Laryngoscope. 110:2000;123-125.
13. Harada H., Pavlick K.P., Hines I.N., Hoffman J.M., Bharwani S., Gray L., Wolf R.E., Grisham M.B. Effects of gender on reduced-size liver ischemia and reperfusion injury. J. Appl. Physiol. 91:2001;2816-2822.
14. Hartmann A., Pfhuler S., Dennog C., Germandik D., Pilger A., Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2-deoxyguanosine or induction of micronuclei. Free Radical. Biol. Med. 24:1998;245-251.
15. Hayashi M., Sornberg G.C., Huber G.L. Differential response in the male and female tracheal epithelium following exposure to tobacco smoke. Chest. 73:1978;515-519.
16. Hodgkin J.B., Knowles J.W., Hyung-Suk K., Smithies O., Maeda N. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J. Clin. Invest. 109:2002;541-548.
17. Ide T., Tsutsui H., Ohashi N., Hayashidani S., Suematsu N., Tsuchihashi M., Tamai H., Takeshita A. Greater oxidative stress in healthy young men compared with premenopausal women. Arterioscler. Thromb. Vasc. Biol. 22:2002;438-442.
18. Kassie F., Parzefall W., Knasmuller S. Single cell gel electrophoresis assay. a new technique for human biomonitoring studies Mutat. Res. 463:2000;13-31.
19. Koss, L.G., 1979. Diagnostic Cytology and its Histopathologic Bases, 3rd Edition. Lippinocott, Philadelphia, pp. 541-542.
20. McEwen B.S. Estrogen effects on the brain. multiple sites and molecular mechanisms J. Appl. Physiol. 91:2001;2785-2801.
21. Mustafa M.G., Tierney D.F. Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity. Am. Rev. Respir. Dis. 118:1978;1061-1072.
22. Nikula K.J., Novak R.F., Chang I.Y., Dahl A.R., Kracko D.A., Zangar R.C., Kim S.G., Lewis J.L. Induction of nasal carboxylesterases in F55 rats following inhalation exposure to pyridine. Drug Metab. Dispos. 23:1995;529-535.
23. Piperaki M.S., Petrakou E., Tsilimigaki S. Effects of air pollution and smoking on DNA damage of human lymphocytes. Environ. Mol. Mutagenesis. 36:2000;243-249.
24. Plappert G.U., Stocker B., Fender H., Fliedner M.T. Changes in the repair capacity of blood cells as a biomarker for chronic low-dose exposure to ionizing radiation. Environ. Mol. Mutagenesis. 30:1997;153-160.
25. Rojas E., Valverde M., Sordo M., Ostrosky-Wegman P. DNA damage in the exfoliated buccal cells of smokers assessed by the single cell gel electrophoresis assay. Mutat. Res. 370:1996;115-120.
26. Rojas E., Lopez M.C., Valverde M. Single cell gel electrophoresis assay. methodology and applications J. Chromatogr. B. 722:1999;225-254.
27. Rojas E., Valverde M., Lopez M.C., Naufal I., Sanchez I., Bizarro P., Lopez I., Fortoul T.I., Ostrosky-Wegman P. Evaluation of DNA damage in exfoliated tear duct epithelial cells from individuals exposed to air pollution assessed by single cell gel electrophoresis assay. Mutat. Res. 468:2000;11-17.
28. Sharma R.V., Gurjar M.V., Bhalla R.C. Selected contribution. estrogen receptor-alpha gene transfer inhibits proliferation and NF-kappaB activation in VSM cells from female rats J. Appl. Physiol. 91:2001;2400-2406.
29. Tan M., Tan U. Sex differences in susceptibility to epileptic seizures in rats. importance of estrous cycle Int. J. Neurosci. 108:2001;175-191.
30. Valverde M., Lopez M.C., Lopez I., Sanchez I., Fortoul T.I., Ostrosky-Wegman P., Rojas E. DNA damage in leukocytes and buccal and nasal epithelial cells of individuals exposed to air pollution in Mexico City. Environ. Mol. Mutagenesis. 30:1997;147-152.
31. Xin H.B., Senbonmatsu T., Cheng D.S., Wang Y.X., Copello J.A., Ji G.J., Collier M.L., Deng K.Y., Jeyakumar L.H., Magnuson M.A., Inagami T., Kotlikoff M.I., Fleischer S. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature. 416:2002;334-338.