Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-Oxo-2′ - deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7, 8-dione

Journal of Biological Chemistry

Volumn 284, Issue 43, 2009, Pages 29725-29734

  Park, Jong Heum ^a   Mangal, Dipti ^a   Frey, Alexander J ^a   Harvey, Ronald G ^b   Blair, Ian A ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8-OXOGUANINE; ALDO-KETO REDUCTASE; ARYL HYDROCARBON RECEPTOR; BENZO [A] PYRENE; COMET ASSAYS; DNA LESIONS; DNA STRAND BREAK; ELECTROSPRAYS; GENOTOXINS; GLYCOSYLASE; HUMAN LUNG CELLS; IMMUNOAFFINITY; OXIDATIVE DNA DAMAGE; REACTIVE OXYGEN SPECIES; SINGLE CELL GEL ELECTROPHORESIS; SINGLE-STRAND BREAKS; STABLE ISOTOPE DILUTION; STRAND BREAKS; TRANSLOCATORS; WILD TYPES;

AROMATIC HYDROCARBONS; BIOMOLECULES; BIOSENSORS; CELL MEMBRANES; CHROMATOGRAPHIC ANALYSIS; CYTOLOGY; ELECTROPHORESIS; ENZYME ACTIVITY; GENES; ISOTOPES; LIGANDS; LIQUID CHROMATOGRAPHY; NUCLEIC ACIDS; ORGANIC COMPOUNDS; OXYGEN; POLYCYCLIC AROMATIC HYDROCARBONS;

DNA;

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; ALDO KETO REDUCTASE; ALPHA NAPHTHOFLAVONE; ALPHA TOCOPHEROL; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE 7,8 DIONE; BENZO[A]PYRENE DERIVATIVE; DEFEROXAMINE MESYLATE; DNA; HYPOXIA INDUCIBLE FACTOR 1BETA; OXIDOREDUCTASE; POLYCYCLIC AROMATIC HYDROCARBON; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ELECTROSPRAY MASS SPECTROMETRY; GENE SILENCING; GENOTOXICITY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LUNG ALVEOLUS CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; WILD TYPE;

ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BENZOPYRENES; CELL LINE; CELL LINE, TUMOR; DEFEROXAMINE; DEOXYGUANOSINE; DNA BREAKS; DNA GLYCOSYLASES; HUMANS; MICE; REACTIVE OXYGEN SPECIES; RECEPTORS, ARYL HYDROCARBON; SIDEROPHORES;

MURINAE;

EID: 70350351227     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.042143     Document Type: Article

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