Protective role of metallothionein in benzo[a]pyrene-induced DNA damage

Journal of Toxicological Sciences

Volumn 34, Issue 5, 2009, Pages 449-458

  Takaishi, Masaki ^a   Sawada, Masumi ^b   Shimada, Akinori ^b   Suzuki, Junko S ^c   Satoh, Masahiko ^a,d   Nagase, Hisamitsu ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^d AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

8 OHdG; B a P; Comet assay; EROD activity; Micronucleus test; MT

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A; DEOXYGUANOSINE DERIVATIVE; ETHOXYRESORUFIN DEETHYLASE; METALLOTHIONEIN I; METALLOTHIONEIN II;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME ABERRATION; COMET ASSAY; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENOTOXICITY; LIVER; MALE; METABOLIC ACTIVATION; MOUSE; MOUSE STRAIN; NONHUMAN; NULL ALLELE; OXIDATIVE STRESS; RETICULOCYTE; WILD TYPE;

MUS;

EID: 70349895554     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.449     Document Type: Article

References (39)

1. Cai, L., Klein, J.B. and Kang, Y.J. (2000): Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage. J. Biol. Chem., 275, 38957-38960.
2. Cai, L., Satoh, M., Tohyama, C. and Cherian, M.G. (1999): Metallothionein in radiation exposure: its induction and protective role. Toxicology, 132, 85-98. (Pubitemid 29121947)
3. Cheng, K.C., Cahill, D.S., Kasai, H., Nishimura, S. and Loeb, L.A. (1992): 8-hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem., 267, 166-172.
4. Cherian, M.G., Howell, S.B., Imura, N., Klaassen, C.D., Koropatnick, J., Lazo, J.S. and Waalkes, M.P. (1994): Contemporary Issues in Toxicology : Role of metallothionein in carcinogenesis. Toxicol. Appl. Pharmacol., 126, 1-5.
5. Cherian, M.G., Jayasurya, A. and Bay, B.H. (2003): Metallothioneins in human tumors and potential roles in carcinogenesis. Mutat. Res., 533, 201-209.
6. 3. Cancer Lett., 74, 141-145. (Pubitemid 23346329)
7. Conney, A.H. (1982): Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res., 42, 4875-4917.
8. Culp, S.J. and Beland, F.A. (1994): Comparison of DNA adduct formation in mice fed coal tar or benzo[a]pyrene. Carcinogenesis, 15, 247-252.
9. Duncan, J.R. and Dreosti, I.E. (1975): Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice. J. Natl. Cancer Inst., 55, 195-196.
10. Fairbairn, D.W., Olive, P.L. and O'Neill, K.L. (1995): The comet assay: a comprehensive review. Mutat. Res., 339, 37-59.
11. Hayashi, M., Morita, T., Kodama, Y., Sofuni, T. and Ishidate, M.Jr. (1990): The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res., 245, 245-249.
12. IARC working group on the evaluation of carcinogenic risks to humans. Air pollution, Part 1, some non-heterocyclic polycyclic aromatic hydrocarbons and some related industrial exposure. IARC Monogr. Eval. Carcinog. Risks Hum. 92. in preparation.
13. Itoh, S. and Shimada, H. (1996): Micronucleus induction by chromium and selenium, and suppression by metallothionein inducer. Mutat. Res., 367, 233-236.
14. Jia, G., Sone, H., Nishimura, N., Satoh, M. and Tohyama, C. (2004): Metallothionein (I/II) suppresses genotoxicity caused by dimethylarsinic acid. Int. J. Oncol., 25, 325-333.
15. Kasai, H., Nishimura, S., Kurokawa, Y. and Hayashi, Y. (1987): Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis, 8, 1959-1961. (Pubitemid 17163965)
16. Kim, K.B. and Lee, B.M. (1997): Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene. Cancer Lett., 113, 205-212.
17. Kondo, Y., Himeno, S., Endo, W., Mita, M., Suzuki, Y., Nemoto, K., Akimoto, M., Lazo, J.S. and Imura, N. (1999): Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice. Carcinogenesis, 20, 1625-1627.
18. Michalska, A.E. and Choo, K.H. (1993): Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. PNAS, 90, 8088-8092. (Pubitemid 23260860)
19. Miles, A.T., Hawksworth, G.M., Beattie, J.H. and Rodilla, V. (2000): Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit. Rev. Biochem. Mol. Biol., 35, 35-70.
20. Naganuma, A., Satoh, M. and Imura, N. (1987): Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum (II) by induction of metallothionein synthesis without compromising its antitumor activity in mice. Cancer Res., 47, 983-987. (Pubitemid 17027915)
21. Nakagawa, I., Nishi, E., Naganuma, A. and Imura, N. (1995): Effect of preinduction of metallothionein synthesis on clastogenicity of anticancer drugs in mice. Mutat. Res., 348, 37-43.
22. Nishimura, H., Nishimura, N. and Tohyama, C. (1990): Localization of metallothionein in the genital organs of the male rat. J. Histochem. Cytochem., 38, 927-933.
23. Park, J.D., Liu, Y. and Klassen, C.D. (2001): Protective effect of metallothionein against the toxicity of cadmium and other metals. Toxicology, 163, 93-100. (Pubitemid 32539280)
24. Penning, T.M., Ohnishi, S.T., Ohnishi, T. and Harvey, R.G. (1996): Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase. Chem. Res. Toxicol., 9, 84-92.
25. Poswillo, D.E. and Cohen, B. (1971): Inhibition of carcinogenesis by dietary zinc. Nature (London, U. K.), 231, 447-448.
26. Poulsen, H.E., Prieme, H. and Loft, S. (1998): Role of oxidative DNA damage in cancer initiation and promotion. Eur. J. Cancer Prev., 7, 9-16.
27. Sasaki, Y.F., Nishidate, E., Izumiyama, F., Matsusaka, N. and Tsuda, S. (1997): Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutat. Res., 391, 215-231. (Pubitemid 27308704)
28. Sato, M. and Bremner, I. (1993): Oxygen free radicals and metallothionein. Free Radic. Biol. Med., 14, 325-337.
29. Satoh, M., Kondo, Y., Mita, M., Nakagawa, I., Naganuma, A. and Imura, N. (1993): Prevention of carcinogenicity of anticancer drugs by metallothionein induction. Cancer Res., 53, 4767-4768. (Pubitemid 23326162)
30. Satoh, M., Naganuma, A. and Imura, N. (1988): Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart. Toxicology, 53, 231-237. (Pubitemid 19023799)
31. Satoh, M., Naganuma, A. and Imura, N. (1992): Effect of preinduction of metallothionein on paraquat toxicity in mice. Arch. Toxicol., 66, 145-148.
32. Shimada, H., Suzuki, H., Itoh, S., Hattori, C., Matsuura, Y., Tada, S. and Watanabe, C. (1992): The micronucleus test of benzo[a]pyrene with mouse and rat peripheral blood reticulocytes. Mutat. Res., 278, 165-168.
33. Shimada, T., Inoue, K., Suzuki, Y., Kawai, T., Azuma, E., Nakajima, T., Shindo, M., Kurose, K., Sugie, A., Yamagishi, Y., Fujii-Kuriyama, Y. and Hashimoto, M. (2002): Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinigenesis, 23, 1199-1207. (Pubitemid 34814779)
34. Shimada, T., Wunsch, R.M., Hanna, I.H., Sutter, T.R., Guengerich, F.P. and Gillam, E.M.J. (1998): Recombinant human cytochrome P450 1B1 expression in Escherichia coli. Arch. Biochem. Biophys., 357, 111-120.
35. Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988): A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res., 175, 184-191.
36. Suzuki, J.S., Nishimura, N., Zhang, B., Nakatsuru, Y., Kobayashi, S., Satoh, M. and Tohyama, C. (2003): Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz [a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice. Carcinogenesis, 24, 1123-1132.
37. Tohyama, C. and Shaikh, Z.A. (1981): Metallothionein in plasma and urine of cadmium-exposed rats determined by a single-antibody radioimmunoassay. Fundam. Appl. Toxicol., 1, 1-7.
38. Waalkes, M.P., Liu, J., Goyer, R. and Diwan, B.A. (2004): Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation. Cancer Res., 64, 7766-7772. (Pubitemid 39446908)
39. Zhang, B., Satoh, M., Nishimura, N., Suzuki, J.S., Sone, H., Aoki, Y. and Tohyama, C. (1998): Metallothionein deficiency promotes mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anth racene. Cancer Res., 58, 4044-4046. (Pubitemid 28440551)