Novel muscarinic receptor mutant mouse models

Handbook of Experimental Pharmacology

Volumn 208, Issue , 2012, Pages 95-117

  Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Beta cells; Bone mass; Cognition; Cre loxP technology; Glucose homeostasis; Longitudinal growth; Muscarinic receptor knockin mice; Muscarinic receptor knockout mice; Seizure activity; Transgenic mice

Indexed keywords

GLUCOSE; LIVER PROTEIN; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; MUTANT PROTEIN; NERVE PROTEIN; PROTEIN INHIBITOR; RECEPTOR ACTIVATED SOLELY BY SYNTHETIC LIGAND; RGS4 PROTEIN; UNCLASSIFIED DRUG; INSULIN;

ADENOHYPOPHYSIS; BEHAVIOR CHANGE; BONE MASS; BONE METABOLISM; BRAIN ELECTROPHYSIOLOGY; BRAIN REGION; COGNITIVE DEFECT; CORPUS STRIATUM; DEPRESSION; DISEASE DURATION; DRUG DEPENDENCE; DRUG EFFECT; DRUG TARGETING; EXPERIMENTAL MODEL; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HIPPOCAMPAL CA3 REGION; HUMAN; INSULIN RELEASE; KNOCKOUT MOUSE; MOTOR DYSFUNCTION; MOUSE MUTANT; MUSCARINIC ACETYLCHOLINE RECEPTOR GENE; MUSCARINIC M3 RECEPTOR GENE; NEGATIVE FEEDBACK; NERVE PROJECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORGANOGENESIS; PANCREAS ISLET BETA CELL; PARKINSON DISEASE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR GENE; REVIEW; SCHIZOPHRENIA; TRANSGENIC MOUSE; ANIMAL; ANIMAL BEHAVIOR; BRAIN; COGNITION; GENETICS; GENOTYPE; LIVER CELL; METABOLISM; MOUSE; NERVE CELL; PHENOTYPE; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BEHAVIOR, ANIMAL; BLOOD GLUCOSE; BRAIN; COGNITION; GENOTYPE; HEPATOCYTES; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; NEURONS; PHENOTYPE; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION;

EID: 84856668794     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-23274-9_6     Document Type: Review

References (90)

1. Abramow-Newerly M, Roy AA, Nunn C, Chidiac P (2006) RGS proteins have a signaling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. Cell Signal 18:579-591 (Pubitemid 43113289)
2. Abrams P, Andersson KE, Buccafusco JJ et al (2006) Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Br J Pharmacol 148:565-578 (Pubitemid 43993048)
3. Ahren B (2000) Autonomic regulation of islet hormone secretion - implications for health and disease. Diabetologia 2000(43):393-410 (Pubitemid 30237947)
4. Ahrén B (2009) Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov 8:369-385
5. Alexander GM, Rogan SC, Abbas AI et al (2009) Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63:27-39
6. Anagnostaras SG, Murphy GG, Hamilton SE et al (2003) Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci 6:51-58 (Pubitemid 36026332)
7. Armbruster BN, Li X, Pausch MH et al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A 104:5163-5168 (Pubitemid 47186193)
8. Auerbach JM, Segal M (1996) Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus. J Physiol 492(Pt 2):479-493 (Pubitemid 26137757)
9. Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157 (Pubitemid 46711096)
10. Bansal G, Druey KM, Xie Z (2007) R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther 116:473-495 (Pubitemid 350116944)
11. Bear MF, Huber KM, Warren ST (2004) The mGluR theory of fragile X mental retardation. Trends Neurosci 27:370-377 (Pubitemid 38829251)
12. Bernard V, Normand E, Bloch B (1992) Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes. J Neurosci 12:3591-3600
13. Brady AE, Jones CK, Bridges TM et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther 327:941-953
14. Brown BS, Yu SP (2000) Modulation and genetic identification of the M channel. Prog Biophys Mol Biol 73:135-166
15. Budd DC, McDonald JE, Tobin AB (2000) Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1a. J Biol Chem 275:19667-19675 (Pubitemid 30441562)
16. Caulfield MP, Birdsall NJM (1998) International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50:279-290 (Pubitemid 28304029)
17. Chan WY, McKinzie DL, Bose S et al (2008) Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. Proc Natl Acad Sci U S A 105:10978-10983
18. Conklin BR, Hsiao EC, Claeysen S et al (2008) Engineering GPCR signaling pathways with RASSLs. Nat Methods 5:673-678
19. Del Prato S, Marchetti P, Bonadonna RC (2002) Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes 51(Suppl 1):S109-S116 (Pubitemid 34761504)
20. Di Chiara G, Morelli M, Consolo S (1994) Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions. Trends Neurosci 17:228-233 (Pubitemid 24150555)
21. Dong S, Rogan SC, Roth BL (2010) Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs. Nat Protoc 5:561-573
22. Doyle ME, Egan JM (2007) Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther 113:546-593 (Pubitemid 46365961)
23. Duttaroy A, Zimliki CL, Gautam D et al (2004) Muscarinic stimulation of pancreatic insulin and glucagon release is abolished inM3 muscarinic acetylcholine receptor-deficient mice. Diabetes 53:1714-1720 (Pubitemid 38857029)
24. Eglen RM (2005) Muscarinic receptor subtype pharmacology and physiology. Prog Med Chem 43:105-136 (Pubitemid 40605496)
25. Elefteriou F, Ahn JD, Takeda S et al (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514-520 (Pubitemid 40477060)
26. Felder CC, Porter AC, Skillman TL et al (2001) Elucidating the role of muscarinic receptors in psychosis. Life Sci 68:2605-2613 (Pubitemid 32455701)
27. Frohman LA, Kineman RD (2002) Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis. Trends Endocrinol Metab 13:299-303 (Pubitemid 36733960)
28. Fu L, Patel MS, Bradley A et al (2005) The molecular clock mediates leptin-regulated bone formation. Cell 122:803-815 (Pubitemid 41242643)
29. Gautam D, Gavrilova O, Jeon J et al (2006a) Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metab 4:363-375 (Pubitemid 44645070)
30. Gautam D, Han SJ, Hamdan FF et al (2006b) A critical role for b cellM3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 3:449-461 (Pubitemid 43811775)
31. Gautam D, Jeon J, Starost MF et al (2009) Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A 106:6398-6403
32. Gerber DJ, Sotnikova TD, Gainetdinov RR et al (2001) Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc Natl Acad Sci U S A 98:15312-15317 (Pubitemid 34014011)
33. Gilon P, Henquin JC (2001) Mechanisms and physiological significance of the cholinergic control of pancreatic b-cell function. Endocr Rev 22:565-604 (Pubitemid 32958576)
34. Giustina A, Veldhuis JD (1998) Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19:717-797 (Pubitemid 128506521)
35. Gomeza J, Zhang L, Kostenis E et al (1999) Enhancement of D1 dopamine receptor-mediated locomotor stimulation inM4 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 96:10483-10488 (Pubitemid 29422585)
36. Guettier JM, Gautam D, Scarselli M et al (2009) A chemical-genetic approach to study G protein regulation of b cell function in vivo. Proc Natl Acad Sci U S A 106:19197-19202
37. Hamilton SE, Loose MD, Qi M et al (1997) Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci U S A 94:13311-13316 (Pubitemid 27518518)
38. Hollinger S, Hepler JR (2002) Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev 54:527-559
39. Ince E, Ciliax BJ, Levey AI (1997) Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neurons. Synapse 27:357-366 (Pubitemid 27479473)
40. Iwasato T, Nomura R, Ando R et al (2004) Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis 38:130-138 (Pubitemid 38506850)
41. Jeon J, Dencker D, Wörtwein G et al (2010) A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci 30:2396-2405
42. Jetté L, Léger R, Thibaudeau K et al (2005) Human growth hormone-releasing factor (hGRF)1-29- albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology 146:3052-3058 (Pubitemid 41002813)
43. Kahn CR (1994) Insulin action, diabetogenes, and the cause of type II diabetes (Banting Lecture). Diabetes 43:1066-1084 (Pubitemid 24230714)
44. Kamsler A, McHugh TJ, Gerber D et al (2010) Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus. Proc Natl Acad Sci U S A 107:1618-1623
45. Koob GF, Sanna PP, Bloom FE (1998) Neuroscience of addiction. Neuron 21:467-476 (Pubitemid 28475499)
46. Lam TK, Pocai A, Gutierrez-Juarez R et al (2005) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11:320-327 (Pubitemid 40460561)
47. Le Tissier PR, Carmignac DF, Lilley S et al (2005) Hypothalamic growth hormone-releasing hormone (GHRH) deficiency: targeted ablation of GHRH neurons in mice using a viral ion channel transgene. Mol Endocrinol 19:1251-1262 (Pubitemid 40594122)
48. Lefkowitz RJ, Rajagopal K, Whalen EJ (2006) New roles for b-arrestins in cell signaling: not just for seven-transmembrane receptors. Mol Cell 24:643-652 (Pubitemid 44839219)
49. Lemberger T, Parlato R, Dassesse D et al (2007) Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci 8:4
50. Levey AI, Kitt CA, Simonds WF et al (1991) Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218-3226
51. Levey AI, Edmunds SM, Heilman CJ et al (1994) Localization of muscarinic m3 receptor protein and M3 receptor binding in rat brain. Neuroscience 63:207-221 (Pubitemid 24333962)
52. Li JH, Gautam D, Han SJ et al (2009) Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice. Diabetes 58:2776-2787
53. Lingohr MK, Briaud I, Dickson LM et al (2006) Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet b-cells. J Biol Chem 281:15884-15892 (Pubitemid 43848480)
54. Matsui M, Yamada S, Oki T et al (2004) Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sci 75:2971-2981 (Pubitemid 39330580)
55. Mayford M, Bach ME, Huang YY et al (1996) Control of memory formation through regulated expression of a CaMKII transgene. Science 274:1678-1683 (Pubitemid 26414891)
56. McCutchen E, Scheiderer CL, Dobrunz LE, McMahon LL (2006) Coexistence of muscarinic longterm depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. J Neurophysiol 96:3114-3121 (Pubitemid 44837857)
57. McGinty JF (1999) Regulation of neurotransmitter interactions in the ventral striatum. Ann N Y Acad Sci 877:129-139 (Pubitemid 29351855)
58. Miyakawa T, Yamada M, Duttaroy A, Wess J (2001) Hyperactivity and intact hippocampusdependent learning in mice lacking the M1 muscarinic acetylcholine receptor. J Neurosci 21:5239-5250 (Pubitemid 32622949)
59. Nesher R, Cerasi E (2002) Modeling phasic insulin release: immediate and time-dependent effects of glucose. Diabetes 51(Suppl 1):S53-S59 (Pubitemid 34761495)
60. Niessen M (2006) On the role of IRS2 in the regulation of functional b-cell mass. Arch Physiol Biochem 112:65-73 (Pubitemid 44384774)
61. Oki T, Takagi Y, Inagaki S et al (2005) Quantitative analysis of binding parameters of 3H]Nmethylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice. Brain Res Mol Brain Res 133:6-11 (Pubitemid 40127486)
62. Pocai A, Lam TK, Gutierrez-Juarez R et al (2005a) Hypothalamic KATP channels control hepatic glucose production. Nature 434:1026-1031 (Pubitemid 40586051)
63. Pocai A, Obici S, Schwartz GJ, Rossetti L (2005b) A brain-liver circuit regulates glucose homeostasis. Cell Metab 1:53-61 (Pubitemid 43960581)
64. Poulin B, Butcher A, McWilliams P et al (2010) The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A 107:9440-9445
65. Regard JB, Kataoka H, Cano DA et al (2007) Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 117:4034-4043 (Pubitemid 350224112)
66. Ross EM, Wilkie TM (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795-827
67. Ruiz de Azua I, Scarselli M, Rosemond E et al (2010) RGS4 is a negative regulator of insulin release from pancreatic b-cells in vitro and in vivo. Proc Natl Acad Sci U S A 107:7999-8004
68. Scearce-Levie K, Coward P, Redfern CH, Conklin BR (2001) Engineering receptors activated solely by synthetic ligands (RASSLs). Trends Pharmacol Sci 22:414-420 (Pubitemid 32718633)
69. Shekhar A, Potter WZ, Lightfoot J et al (2008) Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry 165:1033-1039
70. Shi Y, Oury F, Yadav VK et al (2010) Signaling through the M3 muscarinic receptor favors bone mass accrual by decreasing sympathetic activity. Cell Metab 11:231-238
71. Takeda S, Elefteriou F, Levasseur R et al (2002) Leptin regulates bone formation via the sympathetic nervous system. Cell 111:305-317 (Pubitemid 35345151)
72. Torrecilla I, Spragg EJ, Poulin B et al (2007) Phosphorylation and regulation of a G proteincoupled receptor by protein kinase CK2. J Cell Biol 177:127-137 (Pubitemid 46588407)
73. Tronche F, Kellendonk C, Kretz O et al (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103 (Pubitemid 29418797)
74. Tzavara ET, Bymaster FP, Davis RJ et al (2004)M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J 18:1410-1412 (Pubitemid 39561597)
75. Vatamaniuk MZ, Horyn OV, Vatamaniuk OK, Doliba NM (2003) Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes. Life Sci 72:1871-1882 (Pubitemid 36174023)
76. Vilaro MT, Mengod G, Palacios JM (1993) Advances and limitations of the molecular neuroanatomy of cholinergic receptors: the example of multiple muscarinic receptors. Prog Brain Res 98:95-101 (Pubitemid 23305634)
77. Volpicelli LA, Levey AI (2004) Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus. Prog Brain Res 145:59-66 (Pubitemid 37442934)
78. Wang PY, Caspi L, Lam CK et al (2008) Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature 452:1012-1016 (Pubitemid 351589616)
79. Wess J (1996) Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 10:69-99 (Pubitemid 26283956)
80. Wess J (2004) Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu Rev Pharmacol Toxicol 44:423-450 (Pubitemid 38263848)
81. Wess J, Eglen RM, Gautam D (2007) Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721-733 (Pubitemid 47342315)
82. Wettschureck N, Moers A, Wallenwein B et al (2005) Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice. Mol Cell Biol 25:1942-1948 (Pubitemid 40280156)
83. White MF (2006) Regulating insulin signaling and b-cell function through IRS proteins. Can J Physiol Pharmacol 84:725-737 (Pubitemid 44897893)
84. Wise RA (1996) Neurobiology of addiction. Curr Opin Neurobiol 6:243-251 (Pubitemid 26168484)
85. Woolley ML, Carter HJ, Gartlon JE et al (2009) Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice. Eur J Pharmacol 603:147-149
86. Yadav VK, Oury F, Suda N et al (2009) A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 138:976-989
87. Zawalich WS, Zawalich KC, Tesz GJ et al (2004) Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses. Biochem Biophys Res Commun 315:872-876 (Pubitemid 38249384)
88. Zhang W, Yamada M, Gomeza J et al (2002) Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci 22:6347-6352 (Pubitemid 35386389)
89. Zhang H, Craciun LC, Mirshahi T et al (2003) PIP2 activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 37:963-975 (Pubitemid 36398301)
90. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787 (Pubitemid 34000780)