Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice

Diabetes

Volumn 58, Issue 12, 2009, Pages 2776-2787

  Li, Jian H ^a   Gautam, Dinesh ^a   Han, Sung Jun ^a,c   Guettier, Jean Marc ^a   Cui, Yinghong ^a   Lu, Huiyan ^a   Deng, Chuxia ^a   O'Hare, James ^b   Jou, William ^a   Gavrilova, Oksana ^a   Buettner, Christoph ^b   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Institute Pasteur Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; GENE EXPRESSION REGULATION; GENE TARGETING; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; IN VIVO STUDY; LIPID DIET; LIVER CELL; MALE; METABOLIC REGULATION; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; GLUCOSE; HEPATOCYTES; KUPFFER CELLS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PHENOTYPE; RECEPTOR, MUSCARINIC M3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 73249150588     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0522     Document Type: Article

References (34)

1. Taylor SI. Deconstructing type 2 diabetes. Cell 1999;97:9-12
2. Lautt WW. Afferent and efferent neural roles in liver function. Prog Neurobiol 1983;21:323-348
3. Gardemann A, Jungermann K. Control of glucose balance in the perfused rat liver by the parasympathetic innervation. Biol Chem Hoppe Seyler 1986;367:559-566
4. Matsuhisa M, Yamasaki Y, Shiba Y, Nakahara I, Kuroda A, Tomita T, Iida M, Ikeda M, Kajimoto Y, Kubota M, Hori M. Important role of the hepatic vagus nerve in glucose uptake and production by the liver. Metabolism 2000;49:11-16
5. Shimazu T, Fujimoto T. Regulation of glycogen metabolism in liver by the autonomic nervous system: IV. Neural control of glycogen biosynthesis. Biochim Biophys Acta 1971;252:18-27
6. Xue C, Aspelund G, Sritharan KC, Wang JP, Slezak LA, Andersen DK. Isolated hepatic cholinergic denervation impairs glucose and glycogen metabolism. J Surg Res 2000;90:19-25
7. Stümpel F, Jungermann K. Sensing by intrahepatic muscarinic nerves of a portal-arterial glucose concentration gradient as a signal for insulin-dependent glucose uptake in the perfused rat liver. FEBS Lett 1997;406:119-122
8. Shiota M, Jackson P, Galassetti P, Scott M, Neal DW, Cherrington AD. Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake. Am J Physiol Endocrinol Metab 2000;278:E544-E552
9. Akpan JO, Gardner R, Wagle SR. Studies on the effects of insulin and acetylcholine on activation of glycogen synthase and on glycogenesis in hepatocytes. Biochem Biophys Res Commun 1974;61:222-229
10. Vatamaniuk MZ, Horyn OV, Vatamaniuk OK, Doliba NM. Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes. Life Sci 2003;72:1871-1882
11. Pocai A, Obici S, Schwartz GJ, Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metab 2005;1:53-61
12. Pocai A, Lam TK, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J, Aguilar-Bryan L, Rossetti L. Hypothalamic KATP channels control hepatic glucose production. Nature 2005;434:1026-1031
13. Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005;11:320-327
14. Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK. Upper intestinal lipids trigger a gut-brainliver axis to regulate glucose production. Nature 2008;452:1012-1016
15. Caulfield MP, Birdsall NJ. International Union of Pharmacology: XVII. classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998;50:279-290
16. Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 2007;6:721-733
17. Jaruga B, Hong F, Kim WH, Gao B. IFN-γ/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol 2004;287:G1044-G1052
18. Horiguchi N, Wang L, Mukhopadhyay P, Park O, Jeong WI, Lafdil F, Osei-Hyiaman D, Moh A, Fu XY, Pacher P, Kunos G, Gao B. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 2008;134:1148-1158
19. 3 muscarinic acetylcholine receptor-deficient mice. Diabetes 2004;53:1714-1720
20. Li JH, Han SJ, Hamdan FF, Kim SK, Jacobson KA, Bloodworth LM, Zhang X, Wess J. Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands. J Biol Chem 2007;282:26284-26293
21. Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA. Regulation of fasted blood glucose by resistin. Science 2004;303:1195-1198
22. Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A 2003;100:1438-1443
23. Rossetti L, Stenbit AE, Chen W, Hu M, Barzilai N, Katz EB, Charron MJ. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. J Clin Invest 1997;100:1831-1839
24. 3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 2006;3:449-461
25. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305-315
26. Lefebvre PJ. Glucagon and its family revisited. Diabetes Care 1995;18:715-730
27. Ahren B. Autonomic regulation of islet hormone secretion: implications for health and disease. Diabetologia 2000;43:393-410
28. Gilon P, Henquin JC. Mechanisms and physiological significance of the cholinergic control of pancreatic β-cell function. Endocr Rev 2001;22:565-604
29. Kawamura T, Furusaka A, Koziel MJ, Chung RT, Wang TC, Schmidt EV, Liang TJ. Transgenic expression of hepatitis C virus structural proteins in the mouse. Hepatology 1997;25:1014-1021
30. Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y. Regulation of pancreatic β cell mass by neuronal signals from the liver. Science 2008;322:1250-1254
31. Horton RA, Ceppi ED, Knowles RG, Titheradge MA. Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock. Biochem J 1994;299:735-739
32. 2 on parenchymal liver cells. Biochem J 1989;262:195-201
33. Yerkovich ST, Rigby PJ, Fournier PA, Olynyk JK, Yeoh GC. Kupffer cell cytokines interleukin-1β and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes. Int J Biochem Cell Biol 2004;36:1462-1472
34. Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga M. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 2006;3:267-275