메뉴 건너뛰기




Volumn 19, Issue 5, 2005, Pages 1251-1262

Hypothalamic growth hormone-releasing hormone (GHRH) deficiency: Targeted ablation of GHRH neurons in mice using a viral ion channel transgene

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CATION CHANNEL; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; ION CHANNEL; PROLACTIN; PROTEIN M2; RIMANTADINE; THYROTROPIN; VIRUS PROTEIN;

EID: 17844391242     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0223     Document Type: Article
Times cited : (41)

References (56)
  • 2
    • 0021828930 scopus 로고
    • Independent effects of growth-hormone releasing-factor on hormone release and gene-transcription
    • Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM 1985 Independent effects of growth-hormone releasing-factor on hormone release and gene-transcription. Nature 314:279-281
    • (1985) Nature , vol.314 , pp. 279-281
    • Barinaga, M.1    Bilezikjian, L.M.2    Vale, W.W.3    Rosenfeld, M.G.4    Evans, R.M.5
  • 4
    • 0021847770 scopus 로고
    • Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth
    • Hammer RE, Brinster RL, Rosenfeld MG, Evans RM, Mayo KE 1985 Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315:413-416
    • (1985) Nature , vol.315 , pp. 413-416
    • Hammer, R.E.1    Brinster, R.L.2    Rosenfeld, M.G.3    Evans, R.M.4    Mayo, K.E.5
  • 5
    • 0020428780 scopus 로고
    • Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
    • Rivier J, Spiess J, Thorner M, Vale W 1982 Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 300:276-278
    • (1982) Nature , vol.300 , pp. 276-278
    • Rivier, J.1    Spiess, J.2    Thorner, M.3    Vale, W.4
  • 6
    • 4344649944 scopus 로고    scopus 로고
    • A mouse with targeted ablation of the GHRH gene: A new model of isolated GH deficiency
    • Alba M, Salvatori R 2004 A mouse with targeted ablation of the GHRH gene: a new model of isolated GH deficiency. Endocrinology 145:4134-4143
    • (2004) Endocrinology , vol.145 , pp. 4134-4143
    • Alba, M.1    Salvatori, R.2
  • 7
    • 0029783602 scopus 로고    scopus 로고
    • Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons
    • Flavell DM, Wells T, Wells SE, Carmignac DF, Thomas GB, Robinson ICAF 1996 Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J 15:3871-3879
    • (1996) EMBO J , vol.15 , pp. 3871-3879
    • Flavell, D.M.1    Wells, T.2    Wells, S.E.3    Carmignac, D.F.4    Thomas, G.B.5    Robinson, I.C.A.F.6
  • 8
    • 0037508542 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: A ventral hypothalamic network
    • Balthasar N, Mery PF, Magoulas CB, Mathers KE, Martin A, Mollard P, Robinson IC 2003 Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: a ventral hypothalamic network. Endocrinology 144:2728-2740
    • (2003) Endocrinology , vol.144 , pp. 2728-2740
    • Balthasar, N.1    Mery, P.F.2    Magoulas, C.B.3    Mathers, K.E.4    Martin, A.5    Mollard, P.6    Robinson, I.C.7
  • 10
    • 0036758648 scopus 로고    scopus 로고
    • Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels
    • Slimko EM, McKinney S, Anderson DJ, Davidson N, Lester HA 2002 Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. J Neurosci 22:7373-7379
    • (2002) J Neurosci , vol.22 , pp. 7373-7379
    • Slimko, E.M.1    McKinney, S.2    Anderson, D.J.3    Davidson, N.4    Lester, H.A.5
  • 12
    • 0029816765 scopus 로고    scopus 로고
    • Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells
    • Chizhmakov IV, Geraghty FM, Ogden DC, Hayhurst A, Antoniou M, Hay AJ 1996 Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells. J Physiol 494:329-336
    • (1996) J Physiol , vol.494 , pp. 329-336
    • Chizhmakov, I.V.1    Geraghty, F.M.2    Ogden, D.C.3    Hayhurst, A.4    Antoniou, M.5    Hay, A.J.6
  • 14
    • 0037131381 scopus 로고    scopus 로고
    • The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue
    • Tang Y, Zaitseva F, Lamb RA, Pinto LH 2002 The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue. J Biol Chem 277:39880-39886
    • (2002) J Biol Chem , vol.277 , pp. 39880-39886
    • Tang, Y.1    Zaitseva, F.2    Lamb, R.A.3    Pinto, L.H.4
  • 18
    • 0027236844 scopus 로고
    • Molecular-basis of the little mouse phenotype and implications for cell-type-specific growth
    • Lin SC, Lin C, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG 1993 Molecular-basis of the little mouse phenotype and implications for cell-type-specific growth. Nature 364:208-213
    • (1993) Nature , vol.364 , pp. 208-213
    • Lin, S.C.1    Lin, C.2    Gukovsky, I.3    Lusis, A.J.4    Sawchenko, P.E.5    Rosenfeld, M.G.6
  • 19
    • 0027265595 scopus 로고
    • GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
    • Godfrey P, Rahal J, Beamer W, Copeland N, Jenkins N, Mayo K 1993 GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nature Genet 4:227-232
    • (1993) Nature Genet , vol.4 , pp. 227-232
    • Godfrey, P.1    Rahal, J.2    Beamer, W.3    Copeland, N.4    Jenkins, N.5    Mayo, K.6
  • 20
    • 0031732361 scopus 로고    scopus 로고
    • Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh
    • Maheshwari H, Silverman B, JD, GB 1998 Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: dwarfism of Sindh. J Clin Endocrinol Metab 83:4065-4074
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 4065-4074
    • Maheshwari, H.1    Silverman, B.2
  • 21
    • 0020569661 scopus 로고
    • A noninvasive functional lesion of the hypothalamo-pituitary axis for the study of growth hormone-releasing factor
    • Wehrenberg WB, Brazeau P, Luben R, Ling N, Guillemin R 1983 A noninvasive functional lesion of the hypothalamo-pituitary axis for the study of growth hormone-releasing factor. Neuroendocrinology 36:489-491
    • (1983) Neuroendocrinology , vol.36 , pp. 489-491
    • Wehrenberg, W.B.1    Brazeau, P.2    Luben, R.3    Ling, N.4    Guillemin, R.5
  • 22
    • 0021183450 scopus 로고
    • Specific depletion of immunoreactive growth hormone-releasing factor by monosodium glutamate in rat median eminence
    • Bloch B, Ling N, Benoit R, Wehrenberg WB, Guillemin R 1984 Specific depletion of immunoreactive growth hormone-releasing factor by monosodium glutamate in rat median eminence. Nature 307:272-273
    • (1984) Nature , vol.307 , pp. 272-273
    • Bloch, B.1    Ling, N.2    Benoit, R.3    Wehrenberg, W.B.4    Guillemin, R.5
  • 23
    • 0030022021 scopus 로고    scopus 로고
    • Gsh-1, an orphan Hox gene, is required for normal pituitary development
    • Li H, Zeitler PS, Valerius MT, Small K, Potter SS 1996 Gsh-1, an orphan Hox gene, is required for normal pituitary development. EMBO J 15:714-724
    • (1996) EMBO J , vol.15 , pp. 714-724
    • Li, H.1    Zeitler, P.S.2    Valerius, M.T.3    Small, K.4    Potter, S.S.5
  • 25
    • 0024424678 scopus 로고
    • A dominant phenocopy of hypopituitarism in transgenic mice resulting from central nervous system synthesis of human growth hormone
    • Hollingshead PG, Martin L, Pitts SL, Stewart TA 1989 A dominant phenocopy of hypopituitarism in transgenic mice resulting from central nervous system synthesis of human growth hormone. Endocrinology 125:1556-1564
    • (1989) Endocrinology , vol.125 , pp. 1556-1564
    • Hollingshead, P.G.1    Martin, L.2    Pitts, S.L.3    Stewart, T.A.4
  • 29
    • 0026612385 scopus 로고
    • Influenza virus M2 protein has ion channel activity
    • Pinto LH, Holsinger LJ, Lamb RA 1992 Influenza virus M2 protein has ion channel activity. Cell 69:517-528
    • (1992) Cell , vol.69 , pp. 517-528
    • Pinto, L.H.1    Holsinger, L.J.2    Lamb, R.A.3
  • 30
    • 0027339698 scopus 로고
    • Influenza virus M2 protein: A molecular modelling study of the ion channel
    • Sansom MS, Kerr ID 1993 Influenza virus M2 protein: a molecular modelling study of the ion channel. Protein Eng 6:65-74
    • (1993) Protein Eng , vol.6 , pp. 65-74
    • Sansom, M.S.1    Kerr, I.D.2
  • 31
    • 0028100022 scopus 로고
    • Direct measurement of the influenza A virus M2 protein ion channel activity in mammalian cells
    • Wang C, Lamb RA, Pinto LH 1994 Direct measurement of the influenza A virus M2 protein ion channel activity in mammalian cells. Virology 205:133-140
    • (1994) Virology , vol.205 , pp. 133-140
    • Wang, C.1    Lamb, R.A.2    Pinto, L.H.3
  • 34
    • 0028915559 scopus 로고
    • Presence of a spermatogenic-specific promoter in the rat growth hormone-releasing hormone gene
    • Srivastava CH, Monts BS, Rothrock JK, Peredo MJ, Pescovitz OH 1995 Presence of a spermatogenic-specific promoter in the rat growth hormone-releasing hormone gene. Endocrinology 136:1502-1508
    • (1995) Endocrinology , vol.136 , pp. 1502-1508
    • Srivastava, C.H.1    Monts, B.S.2    Rothrock, J.K.3    Peredo, M.J.4    Pescovitz, O.H.5
  • 35
    • 0029121045 scopus 로고
    • Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues
    • Matsubara S, Sato M, Mizobuchi M, Niimi M, Takahara J 1995 Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues. Endocrinology 136:4147-4150
    • (1995) Endocrinology , vol.136 , pp. 4147-4150
    • Matsubara, S.1    Sato, M.2    Mizobuchi, M.3    Niimi, M.4    Takahara, J.5
  • 36
    • 0023793510 scopus 로고
    • Identification of a rat GHRH-like substance and its messenger RNA in rat testis
    • Berry SA, Pescovitz OH 1988 Identification of a rat GHRH-like substance and its messenger RNA in rat testis. Endocrinology 123:661-663
    • (1988) Endocrinology , vol.123 , pp. 661-663
    • Berry, S.A.1    Pescovitz, O.H.2
  • 37
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 38
    • 0030464704 scopus 로고    scopus 로고
    • The growth-hormone-releasing hormone receptor: Signal transduction, gene expression, and physiological function in growth regulation
    • Mayo K, Miller T, DeAlmeida V, Zheng J, Godfrey P 1996 The growth-hormone-releasing hormone receptor: signal transduction, gene expression, and physiological function in growth regulation. Ann NY Acad Sci 26:184-203
    • (1996) Ann NY Acad Sci , vol.26 , pp. 184-203
    • Mayo, K.1    Miller, T.2    DeAlmeida, V.3    Zheng, J.4    Godfrey, P.5
  • 39
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic peptide that acts on the pituitary to specifically release growth hormone
    • Bowers CY, Momany FA, Reynolds GA, Hong A 1984 On the in vitro and in vivo activity of a new synthetic peptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114:1537-1545
    • (1984) Endocrinology , vol.114 , pp. 1537-1545
    • Bowers, C.Y.1    Momany, F.A.2    Reynolds, G.A.3    Hong, A.4
  • 40
    • 0025267776 scopus 로고
    • Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone
    • Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO 1990 Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab 70:975-982
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 975-982
    • Bowers, C.Y.1    Reynolds, G.A.2    Durham, D.3    Barrera, C.M.4    Pezzoli, S.S.5    Thorner, M.O.6
  • 41
    • 0024453883 scopus 로고
    • The effects of a growth hormone-releasing peptide and growth hormone releasing factor in conscious and anaesthetized rats
    • Clark RG, Carlsson LMS, Trojnar J, Robinson ICAF 1989 The effects of a growth hormone-releasing peptide and growth hormone releasing factor in conscious and anaesthetized rats. J Neuroendocrinol 1:249-255
    • (1989) J Neuroendocrinol , vol.1 , pp. 249-255
    • Clark, R.G.1    Carlsson, L.M.S.2    Trojnar, J.3    Robinson, I.C.A.F.4
  • 42
    • 0021799343 scopus 로고
    • Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats
    • Clark RG, Robinson IC 1985 Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats. Nature 314:281-283
    • (1985) Nature , vol.314 , pp. 281-283
    • Clark, R.G.1    Robinson, I.C.2
  • 44
    • 0034974980 scopus 로고    scopus 로고
    • Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: Evidence for a role for non-GHRH inputs into the generation of GH pulses
    • Roelfsema F, Biermasz NR, Veldman RG, Veldhuis JD, Frolich M, Stokvis-Brantsma WH, Wit JM 2001 Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses. J Clin Endocrinol Metab 86:2459-2464
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2459-2464
    • Roelfsema, F.1    Biermasz, N.R.2    Veldman, R.G.3    Veldhuis, J.D.4    Frolich, M.5    Stokvis-Brantsma, W.H.6    Wit, J.M.7
  • 45
    • 0025853062 scopus 로고
    • Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant
    • Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR 1991 Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350:622-624
    • (1991) Nature , vol.350 , pp. 622-624
    • Struthers, R.S.1    Vale, W.W.2    Arias, C.3    Sawchenko, P.E.4    Montminy, M.R.5
  • 46
    • 0036855316 scopus 로고    scopus 로고
    • Increased lactotrophs despite decreased somatotrophs in the dwarf (dw/dw) rat: A defect in the regulation of lactotroph/somatotroph cell fate?
    • Tierney T, Robinson IC 2002 Increased lactotrophs despite decreased somatotrophs in the dwarf (dw/dw) rat: a defect in the regulation of lactotroph/somatotroph cell fate? J Endocrinol 175:435-446
    • (2002) J Endocrinol , vol.175 , pp. 435-446
    • Tierney, T.1    Robinson, I.C.2
  • 47
    • 0025014024 scopus 로고
    • Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
    • Li S, Crenshaw 3rd EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG 1990 Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347:528-533
    • (1990) Nature , vol.347 , pp. 528-533
    • Li, S.1    Crenshaw III, E.B.2    Rawson, E.J.3    Simmons, D.M.4    Swanson, L.W.5    Rosenfeld, M.G.6
  • 48
    • 0034465457 scopus 로고    scopus 로고
    • Pituitary hormone gene expression and secretion in human growth hormone-releasing hormone transgenic mice: Focus on lactotroph function
    • Moore JR JP, Cai A, Hostettler ME, Arbogast LA, Voogt JL, Hyde JF 2000 Pituitary hormone gene expression and secretion in human growth hormone-releasing hormone transgenic mice: focus on lactotroph function. Endocrinology 141:81-90
    • (2000) Endocrinology , vol.141 , pp. 81-90
    • Moore Jr., J.P.1    Cai, A.2    Hostettler, M.E.3    Arbogast, L.A.4    Voogt, J.L.5    Hyde, J.F.6
  • 49
    • 0036316517 scopus 로고    scopus 로고
    • Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo
    • Wojtkiewicz PW, Phelps CJ, Hurley DL 2002 Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo. Endocrine 18:67-74
    • (2002) Endocrine , vol.18 , pp. 67-74
    • Wojtkiewicz, P.W.1    Phelps, C.J.2    Hurley, D.L.3
  • 50
    • 0033054121 scopus 로고    scopus 로고
    • Galanin within the normal and hyperplastic anterior pituitary gland: Localization, secretion, and functional analysis in normal and human growth hormone-releasing hormone transgenic mice
    • Moore Jr JP, Cai A, Maley BE, Jennes L, Hyde JF 1999 Galanin within the normal and hyperplastic anterior pituitary gland: localization, secretion, and functional analysis in normal and human growth hormone-releasing hormone transgenic mice. Endocrinology 140:1789-1799
    • (1999) Endocrinology , vol.140 , pp. 1789-1799
    • Moore Jr., J.P.1    Cai, A.2    Maley, B.E.3    Jennes, L.4    Hyde, J.F.5
  • 52
    • 0033305490 scopus 로고    scopus 로고
    • Posttranslational processing of progrowth hormone-releasing hormone
    • Nillni EA, Steinmetz R, Pescovitz OH 1999 Posttranslational processing of progrowth hormone-releasing hormone. Endocrinology 140:5817-5827
    • (1999) Endocrinology , vol.140 , pp. 5817-5827
    • Nillni, E.A.1    Steinmetz, R.2    Pescovitz, O.H.3
  • 53
    • 0033921442 scopus 로고    scopus 로고
    • Effects of growth hormone-releasing hormone-related peptide on stem cell factor expression in cultured rat Sertoli cells
    • Steinmetz R, Lazzaro N, Rothrock JK, Pescovitz OH 2000 Effects of growth hormone-releasing hormone-related peptide on stem cell factor expression in cultured rat Sertoli cells. Endocrine 12:323-327
    • (2000) Endocrine , vol.12 , pp. 323-327
    • Steinmetz, R.1    Lazzaro, N.2    Rothrock, J.K.3    Pescovitz, O.H.4
  • 54
    • 0034871822 scopus 로고    scopus 로고
    • Peptides derived from pro-growth hormone-releasing hormone activate p38 mitogen-activated protein kinase in GH3 pituitary cells
    • Steinmetz R, Zeng P, King DW, Walvoord E, Pescovitz OH 2001 Peptides derived from pro-growth hormone-releasing hormone activate p38 mitogen-activated protein kinase in GH3 pituitary cells. Endocrine 15:119-127
    • (2001) Endocrine , vol.15 , pp. 119-127
    • Steinmetz, R.1    Zeng, P.2    King, D.W.3    Walvoord, E.4    Pescovitz, O.H.5
  • 55
    • 0022448018 scopus 로고
    • Ontogenesis of growth hormone-releasing hormone neurons in the rat hypothalamus
    • Ishikawa K, Katakami H, Jansson JO, Frohman LA 1986 Ontogenesis of growth hormone-releasing hormone neurons in the rat hypothalamus. Neuroendocrinology 43:537-542
    • (1986) Neuroendocrinology , vol.43 , pp. 537-542
    • Ishikawa, K.1    Katakami, H.2    Jansson, J.O.3    Frohman, L.A.4
  • 56
    • 0037320980 scopus 로고    scopus 로고
    • Prolactin replacement must be continuous and initiated prior to 21 d of age to maintain hypothalamic dopaminergic neurons in hypopituitary mice
    • Phelps CJ, Romero MI, Hurley DL 2003 Prolactin replacement must be continuous and initiated prior to 21 d of age to maintain hypothalamic dopaminergic neurons in hypopituitary mice. Endocrine 20:139-148
    • (2003) Endocrine , vol.20 , pp. 139-148
    • Phelps, C.J.1    Romero, M.I.2    Hurley, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.