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Volumn 13, Issue 6, 2011, Pages

β1-integrins signaling and mammary tumor progression in transgenic mouse models: Implications for human breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; BETA LACTOGLOBULIN; BETA1 INTEGRIN; CD31 ANTIGEN; CD98 ANTIGEN; CRK ASSOCIATED SUBSTRATE PROTEIN; CRK LIKE PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; FLUOROURACIL; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; KALININ; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; PAXILLIN; PROTEIN P130; PROTEIN P85; TENASCIN; TRASTUZUMAB; VITRONECTIN; VOLOCIXIMAB;

EID: 84855829745     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2905     Document Type: Review
Times cited : (84)

References (106)
  • 1
    • 77955462853 scopus 로고    scopus 로고
    • Global patterns of cancer incidence and mortality rates and trends
    • 10.1158/1055-9965.EPI-10-0437, 20647400
    • Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 2010, 19:1893-1907. 10.1158/1055-9965.EPI-10-0437, 20647400.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 1893-1907
    • Jemal, A.1    Center, M.M.2    DeSantis, C.3    Ward, E.M.4
  • 2
    • 54749102754 scopus 로고    scopus 로고
    • Cause and consequences of genetic and epigenetic alterations in human cancer
    • 10.2174/138920208785699580, 2691666, 19506729
    • Sadikovic B, Al-Romaih K, Squire JA, Zielenska M. Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics 2008, 9:394-408. 10.2174/138920208785699580, 2691666, 19506729.
    • (2008) Curr Genomics , vol.9 , pp. 394-408
    • Sadikovic, B.1    Al-Romaih, K.2    Squire, J.A.3    Zielenska, M.4
  • 3
    • 68449084678 scopus 로고    scopus 로고
    • Metastatic breast cancer: therapeutic options according to molecular subtypes and prior adjuvant therapy
    • 10.1634/theoncologist.2009-0078, 19608638
    • Guarneri V, Conte P. Metastatic breast cancer: therapeutic options according to molecular subtypes and prior adjuvant therapy. Oncologist 2009, 14:645-656. 10.1634/theoncologist.2009-0078, 19608638.
    • (2009) Oncologist , vol.14 , pp. 645-656
    • Guarneri, V.1    Conte, P.2
  • 4
    • 50849102685 scopus 로고    scopus 로고
    • The relevance of mouse models to understanding the development and progression of human breast cancer
    • 10.1007/s10911-008-9093-5, 18704660
    • Allred DC, Medina D. The relevance of mouse models to understanding the development and progression of human breast cancer. J Mammary Gland Biol Neoplasia 2008, 13:279-288. 10.1007/s10911-008-9093-5, 18704660.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 279-288
    • Allred, D.C.1    Medina, D.2
  • 5
    • 73749085492 scopus 로고    scopus 로고
    • Molecular interactions in cancer cell metastasis
    • 10.1016/j.acthis.2008.11.022, 19162308
    • Brooks SA, Lomax-Browne HJ, Carter TM, Kinch CE, Hall DM. Molecular interactions in cancer cell metastasis. Acta Histochem 2010, 112:3-25. 10.1016/j.acthis.2008.11.022, 19162308.
    • (2010) Acta Histochem , vol.112 , pp. 3-25
    • Brooks, S.A.1    Lomax-Browne, H.J.2    Carter, T.M.3    Kinch, C.E.4    Hall, D.M.5
  • 6
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • 10.1038/nrm1490, 15459662
    • Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004, 5:816-826. 10.1038/nrm1490, 15459662.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 7
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: bidirectional, allosteric signaling machines
    • 10.1016/S0092-8674(02)00971-6, 12297042
    • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687. 10.1016/S0092-8674(02)00971-6, 12297042.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 8
    • 34547606042 scopus 로고    scopus 로고
    • Functional atlas of the integrin adhesome
    • 10.1038/ncb0807-858, 2735470, 17671451
    • Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol 2007, 9:858-867. 10.1038/ncb0807-858, 2735470, 17671451.
    • (2007) Nat Cell Biol , vol.9 , pp. 858-867
    • Zaidel-Bar, R.1    Itzkovitz, S.2    Ma'ayan, A.3    Iyengar, R.4    Geiger, B.5
  • 9
    • 61449220945 scopus 로고    scopus 로고
    • Genetic and cell biological analysis of integrin outside-in signaling
    • 10.1101/gad.1758709, 19240129
    • Legate KR, Wickstrom SA, Fassler R. Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 2009, 23:397-418. 10.1101/gad.1758709, 19240129.
    • (2009) Genes Dev , vol.23 , pp. 397-418
    • Legate, K.R.1    Wickstrom, S.A.2    Fassler, R.3
  • 10
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: biological implications and therapeutic opportunities
    • 10.1038/nrc2748, 20029421
    • Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010, 10:9-22. 10.1038/nrc2748, 20029421.
    • (2010) Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 11
    • 79954414698 scopus 로고    scopus 로고
    • The tail of integrin activation
    • 10.1016/j.tibs.2010.11.002, 21216149
    • Anthis NJ, Campbell ID. The tail of integrin activation. Trends Biochem Sci 2011, 36:191-198. 10.1016/j.tibs.2010.11.002, 21216149.
    • (2011) Trends Biochem Sci , vol.36 , pp. 191-198
    • Anthis, N.J.1    Campbell, I.D.2
  • 12
    • 34247891506 scopus 로고    scopus 로고
    • Structural basis of integrin regulation and signaling
    • 10.1146/annurev.immunol.25.022106.141618, 1952532, 17201681
    • Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu Rev Immunol 2007, 25:619-647. 10.1146/annurev.immunol.25.022106.141618, 1952532, 17201681.
    • (2007) Annu Rev Immunol , vol.25 , pp. 619-647
    • Luo, B.H.1    Carman, C.V.2    Springer, T.A.3
  • 13
    • 35648978998 scopus 로고    scopus 로고
    • Structure and mechanics of integrinbased cell adhesion
    • 10.1016/j.ceb.2007.08.002, 2443699, 17928215
    • Arnaout MA, Goodman SL, Xiong JP. Structure and mechanics of integrinbased cell adhesion. Curr Opin Cell Biol 2007, 19:495-507. 10.1016/j.ceb.2007.08.002, 2443699, 17928215.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 495-507
    • Arnaout, M.A.1    Goodman, S.L.2    Xiong, J.P.3
  • 14
    • 66849101632 scopus 로고    scopus 로고
    • Adhesion signaling - crosstalk between integrins, Src and Rho
    • Huveneers S, Danen EH. Adhesion signaling - crosstalk between integrins, Src and Rho. J Cell Sci 2009, 122(Pt 8):1059-1069.
    • (2009) J Cell Sci , vol.122 , Issue.PART 8 , pp. 1059-1069
    • Huveneers, S.1    Danen, E.H.2
  • 15
    • 77953513171 scopus 로고    scopus 로고
    • Crosstalk between integrin and receptor tyrosine kinase signaling in breas t carcinoma progression
    • 10.5483/BMBRep.2010.43.5.311, 20510013
    • Soung YH, Clifford JL, Chung J. Crosstalk between integrin and receptor tyrosine kinase signaling in breas t carcinoma progression. BMB Rep 2010, 43:311-318. 10.5483/BMBRep.2010.43.5.311, 20510013.
    • (2010) BMB Rep , vol.43 , pp. 311-318
    • Soung, Y.H.1    Clifford, J.L.2    Chung, J.3
  • 16
    • 70549101138 scopus 로고    scopus 로고
    • Integrins: masters and slaves of endocytic transport
    • 10.1038/nrm2799, 19904298
    • Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat Rev Mol Cell Biol 2009, 10:843-853. 10.1038/nrm2799, 19904298.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 843-853
    • Caswell, P.T.1    Vadrevu, S.2    Norman, J.C.3
  • 17
    • 27644470059 scopus 로고    scopus 로고
    • Beta1 integrin function in vivo: adhesion, migration and more
    • 10.1007/s10555-005-5132-5, 16258728
    • Brakebusch C, Fassler R. Beta1 integrin function in vivo: adhesion, migration and more. Cancer Metastasis Rev 2005, 24:403-411. 10.1007/s10555-005-5132-5, 16258728.
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 403-411
    • Brakebusch, C.1    Fassler, R.2
  • 19
    • 0141483387 scopus 로고    scopus 로고
    • Beta1 integrins regulate chondrocyte rotation, G1 progress ion, and cytokinesis
    • 10.1101/gad.277003, 218082, 14522949
    • Aszodi A, Hunziker EB, Brakebusch C, Fassler R. Beta1 integrins regulate chondrocyte rotation, G1 progress ion, and cytokinesis. Genes Dev 2003, 17:2465-2479. 10.1101/gad.277003, 218082, 14522949.
    • (2003) Genes Dev , vol.17 , pp. 2465-2479
    • Aszodi, A.1    Hunziker, E.B.2    Brakebusch, C.3    Fassler, R.4
  • 20
    • 0035911960 scopus 로고    scopus 로고
    • Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice
    • 10.1083/jcb.152.6.1207, 2199213, 11257121
    • Burkin DJ, Wallace GQ, Nicol KJ, Kaufman DJ, Kaufman SJ. Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. J Cell Biol 2001, 152:1207-1218. 10.1083/jcb.152.6.1207, 2199213, 11257121.
    • (2001) J Cell Biol , vol.152 , pp. 1207-1218
    • Burkin, D.J.1    Wallace, G.Q.2    Nicol, K.J.3    Kaufman, D.J.4    Kaufman, S.J.5
  • 21
    • 0038561092 scopus 로고    scopus 로고
    • β1 integrins regulate myoblast fusion and sarcomere assembly
    • 10.1016/S1534-5807(03)00118-7, 12737803
    • Schwander M, Leu M, Stumm M, Dorchies OM, Ruegg UT, Schittny J, Muller U. β1 integrins regulate myoblast fusion and sarcomere assembly. Dev Cell 2003, 4:673-685. 10.1016/S1534-5807(03)00118-7, 12737803.
    • (2003) Dev Cell , vol.4 , pp. 673-685
    • Schwander, M.1    Leu, M.2    Stumm, M.3    Dorchies, O.M.4    Ruegg, U.T.5    Schittny, J.6    Muller, U.7
  • 23
    • 37249047911 scopus 로고    scopus 로고
    • Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex
    • 10.1523/JNEUROSCI.4494-07.2007, 18077697
    • Belvindrah R, Graus-Porta D, Goebbels S, Nave KA, Muller U. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 2007, 27:13854-13865. 10.1523/JNEUROSCI.4494-07.2007, 18077697.
    • (2007) J Neurosci , vol.27 , pp. 13854-13865
    • Belvindrah, R.1    Graus-Porta, D.2    Goebbels, S.3    Nave, K.A.4    Muller, U.5
  • 24
    • 33644959471 scopus 로고    scopus 로고
    • Distinct roles of β1 integrins during angiogenesis
    • 10.1016/j.ejcb.2005.09.010, 16546568
    • Mettouchi A, Menegu zzi G. Distinct roles of β1 integrins during angiogenesis. Eur J Cell Biol 2006, 85:243-247. 10.1016/j.ejcb.2005.09.010, 16546568.
    • (2006) Eur J Cell Biol , vol.85 , pp. 243-247
    • Mettouchi, A.1    Menegu zzi, G.2
  • 26
    • 0028979154 scopus 로고
    • Consequences of lack of beta 1 integrin gene expression in mice
    • 10.1101/gad.9.15.1896, 7544313
    • Fassler R, Meyer M. Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 1995, 9:1896-1908. 10.1101/gad.9.15.1896, 7544313.
    • (1995) Genes Dev , vol.9 , pp. 1896-1908
    • Fassler, R.1    Meyer, M.2
  • 27
    • 0028979153 scopus 로고
    • Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
    • 10.1101/gad.9.15.1883, 7544312
    • Stephens LE, Sutherla nd AE, Klimanskaya IV, Andrieux A, Meneses J, Pedersen RA, Damsky CH. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev 1995, 9:1883-1895. 10.1101/gad.9.15.1883, 7544312.
    • (1995) Genes Dev , vol.9 , pp. 1883-1895
    • Stephens, L.E.1    Sutherla nd, A.E.2    Klimanskaya, I.V.3    Andrieux, A.4    Meneses, J.5    Pedersen, R.A.6    Damsky, C.H.7
  • 28
    • 61449213806 scopus 로고    scopus 로고
    • Mechanisms that regulate adaptor binding to betaintegrin cytoplasmic tails
    • Legate KR, Fassler R. Mechanisms that regulate adaptor binding to betaintegrin cytoplasmic tails. J Cell Sci 2009, 122(Pt 2):187-198.
    • (2009) J Cell Sci , vol.122 , Issue.PART 2 , pp. 187-198
    • Legate, K.R.1    Fassler, R.2
  • 29
    • 0033731119 scopus 로고    scopus 로고
    • Integrin cytoplasmic domain-binding proteins
    • Liu S, Calderwood DA, Ginsberg MH. Integrin cytoplasmic domain-binding proteins. J Cell Sci 2000, 113(Pt 20):3563-3571.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3563-3571
    • Liu, S.1    Calderwood, D.A.2    Ginsberg, M.H.3
  • 31
    • 11244258882 scopus 로고    scopus 로고
    • Focal adhesion kinase: in command and control of cell motility
    • 10.1038/nrm1549, 15688067
    • Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005, 6:56-68. 10.1038/nrm1549, 15688067.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 56-68
    • Mitra, S.K.1    Hanson, D.A.2    Schlaepfer, D.D.3
  • 32
    • 0033942173 scopus 로고    scopus 로고
    • The cytoplasmic tyrosines of integrin subunit β1 are involved in focal adhesion kinase activation
    • 10.1128/MCB.20.15.5758-5765.2000, 86053, 10891511
    • Wennerberg K, Armulik A, Sakai T, Karlsson M, Fassler R, Schaefer EM, Mosher DF, Johansson S. The cytoplasmic tyrosines of integrin subunit β1 are involved in focal adhesion kinase activation. Mol Cell Biol 2000, 20:5758-5765. 10.1128/MCB.20.15.5758-5765.2000, 86053, 10891511.
    • (2000) Mol Cell Biol , vol.20 , pp. 5758-5765
    • Wennerberg, K.1    Armulik, A.2    Sakai, T.3    Karlsson, M.4    Fassler, R.5    Schaefer, E.M.6    Mosher, D.F.7    Johansson, S.8
  • 33
    • 0029150292 scopus 로고
    • Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
    • 10.1083/jcb.130.5.1181, 2120552, 7657702
    • Schaller MD, Otey CA, Hildebrand JD, Parsons JT. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol 1995, 130:1181-1187. 10.1083/jcb.130.5.1181, 2120552, 7657702.
    • (1995) J Cell Biol , vol.130 , pp. 1181-1187
    • Schaller, M.D.1    Otey, C.A.2    Hildebrand, J.D.3    Parsons, J.T.4
  • 34
    • 4644328892 scopus 로고    scopus 로고
    • Paxillin: adapting to change
    • 10.1152/physrev.00002.2004, 15383653
    • Brown MC, Turner CE. Paxillin: adapting to change. Physiol Rev 2004, 84:1315-1339. 10.1152/physrev.00002.2004, 15383653.
    • (2004) Physiol Rev , vol.84 , pp. 1315-1339
    • Brown, M.C.1    Turner, C.E.2
  • 35
    • 0033579448 scopus 로고    scopus 로고
    • The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin
    • 10.1074/jbc.274.51.36684, 10593973
    • Thomas JW, Cooley MA, Broome JM, Salgia R, Griffin JD, Lombardo CR, Schaller MD. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin. J Biol Chem 1999, 274:36684-36692. 10.1074/jbc.274.51.36684, 10593973.
    • (1999) J Biol Chem , vol.274 , pp. 36684-36692
    • Thomas, J.W.1    Cooley, M.A.2    Broome, J.M.3    Salgia, R.4    Griffin, J.D.5    Lombardo, C.R.6    Schaller, M.D.7
  • 36
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-Src signaling in normal and cancer cells
    • 10.1016/j.ceb.2006.08.011, 16919435
    • Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 2006, 18:516-523. 10.1016/j.ceb.2006.08.011, 16919435.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 37
    • 7944233251 scopus 로고    scopus 로고
    • The interplay between Src and integrins in normal and tumor biology
    • 10.1038/sj.onc.1208080, 15489911
    • Playford MP, Schaller MD. The interplay between Src and integrins in normal and tumor biology. Oncogene 2004, 23:7928-7946. 10.1038/sj.onc.1208080, 15489911.
    • (2004) Oncogene , vol.23 , pp. 7928-7946
    • Playford, M.P.1    Schaller, M.D.2
  • 39
    • 3543023861 scopus 로고    scopus 로고
    • Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway
    • 10.1074/jbc.M313265200, 15166238
    • Xia H, Nho RS, Kahm J, Kleidon J, Henke CA. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J Biol Chem 2004, 279:33024-33034. 10.1074/jbc.M313265200, 15166238.
    • (2004) J Biol Chem , vol.279 , pp. 33024-33034
    • Xia, H.1    Nho, R.S.2    Kahm, J.3    Kleidon, J.4    Henke, C.A.5
  • 40
    • 2542492064 scopus 로고    scopus 로고
    • Temporal dissection of β1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation
    • 10.1074/jbc.M309693200, 15044442
    • Gustavsson A, Yuan M, Fallman M. Temporal dissection of β1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation. J Biol Chem 2004, 279:22893-22901. 10.1074/jbc.M309693200, 15044442.
    • (2004) J Biol Chem , vol.279 , pp. 22893-22901
    • Gustavsson, A.1    Yuan, M.2    Fallman, M.3
  • 41
    • 0034194714 scopus 로고    scopus 로고
    • Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
    • 10.1083/jcb.149.3.741, 2174844, 10791986
    • Almeida EA, Ilic D, Han Q, Hauck CR, Jin F, Kawakatsu H, Schlaepfer DD, Damsky CH. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol 2000, 149:741-754. 10.1083/jcb.149.3.741, 2174844, 10791986.
    • (2000) J Cell Biol , vol.149 , pp. 741-754
    • Almeida, E.A.1    Ilic, D.2    Han, Q.3    Hauck, C.R.4    Jin, F.5    Kawakatsu, H.6    Schlaepfer, D.D.7    Damsky, C.H.8
  • 42
  • 43
    • 21244502580 scopus 로고    scopus 로고
    • Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli
    • 10.1038/sj.emboj.7600674, 1142608, 15889143
    • Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH, Hynes NE. Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J 2005, 24:1942-1953. 10.1038/sj.emboj.7600674, 1142608, 15889143.
    • (2005) EMBO J , vol.24 , pp. 1942-1953
    • Li, N.1    Zhang, Y.2    Naylor, M.J.3    Schatzmann, F.4    Maurer, F.5    Wintermantel, T.6    Schuetz, G.7    Mueller, U.8    Streuli, C.H.9    Hynes, N.E.10
  • 45
    • 61949193776 scopus 로고    scopus 로고
    • Integrins in mammary-stem-cell biology and breastcancer progression - a role in cancer stem cells?
    • 2714417, 19118213
    • Pontier SM, Muller WJ. Integrins in mammary-stem-cell biology and breastcancer progression - a role in cancer stem cells?. J Cell Sci 2009, 122(Pt 2):207-214. 2714417, 19118213.
    • (2009) J Cell Sci , vol.122 , Issue.PART 2 , pp. 207-214
    • Pontier, S.M.1    Muller, W.J.2
  • 47
    • 0033201938 scopus 로고    scopus 로고
    • Integrin function in breast carcinoma progression
    • 10.1023/A:1018766317055, 10705920
    • Shaw LM. Integrin function in breast carcinoma progression. J Mammary Gland Biol Neoplasia 1999, 4:367-376. 10.1023/A:1018766317055, 10705920.
    • (1999) J Mammary Gland Biol Neoplasia , vol.4 , pp. 367-376
    • Shaw, L.M.1
  • 48
    • 33745947286 scopus 로고    scopus 로고
    • Current insights into the formation and breakdown of hemidesmosomes
    • 10.1016/j.tcb.2006.05.004, 16757171
    • Litjens SH, de Pereda JM, S onnenberg A. Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol 2006, 16:376-383. 10.1016/j.tcb.2006.05.004, 16757171.
    • (2006) Trends Cell Biol , vol.16 , pp. 376-383
    • Litjens, S.H.1    de Pereda, J.M.2    S onnenberg, A.3
  • 49
    • 85047683109 scopus 로고    scopus 로고
    • Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland
    • 10.1210/en.142.7.3214, 11416044
    • Woodward TL, Mienaltowski A S, Modi RR, Bennett JM, Haslam SZ. Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland. Endocrinology 2001, 142:3214-3222. 10.1210/en.142.7.3214, 11416044.
    • (2001) Endocrinology , vol.142 , pp. 3214-3222
    • Woodward, T.L.1    Mienaltowski A, S.2    Modi, R.R.3    Bennett, J.M.4    Haslam, S.Z.5
  • 50
    • 0042671256 scopus 로고    scopus 로고
    • Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells
    • 2933217, 12808020
    • Novaro V, Roskelley CD, Bissell MJ. Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells. J Cell Sci 2003, 116(Pt 14):2975-2986. 2933217, 12808020.
    • (2003) J Cell Sci , vol.116 , Issue.PART 14 , pp. 2975-2986
    • Novaro, V.1    Roskelley, C.D.2    Bissell, M.J.3
  • 51
    • 0029894277 scopus 로고    scopus 로고
    • Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion
    • 10.1006/dbio.1996.0116, 8626034
    • Gardner H, Kreidberg J, Koteliansky V, Jaenisch R. Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Dev Biol 1996, 175:301-313. 10.1006/dbio.1996.0116, 8626034.
    • (1996) Dev Biol , vol.175 , pp. 301-313
    • Gardner, H.1    Kreidberg, J.2    Koteliansky, V.3    Jaenisch, R.4
  • 53
    • 0036314793 scopus 로고    scopus 로고
    • The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis
    • 10.1016/S0002-9440(10)64185-5, 1850700, 12107118
    • Chen J, Diacovo TG, Grenach e DG, Santoro SA, Zutter MM. The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis. Am J Pathol 2002, 161:337-344. 10.1016/S0002-9440(10)64185-5, 1850700, 12107118.
    • (2002) Am J Pathol , vol.161 , pp. 337-344
    • Chen, J.1    Diacovo, T.G.2    Grenach e, D.G.3    Santoro, S.A.4    Zutter, M.M.5
  • 54
    • 38049098089 scopus 로고    scopus 로고
    • Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
    • 10.1073/pnas.0710091104, 2154426, 18056629
    • Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, Frame MC, Muller WJ. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci USA 2007, 104:20302-20307. 10.1073/pnas.0710091104, 2154426, 18056629.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20302-20307
    • Lahlou, H.1    Sanguin-Gendreau, V.2    Zuo, D.3    Cardiff, R.D.4    McLean, G.W.5    Frame, M.C.6    Muller, W.J.7
  • 55
    • 5144235557 scopus 로고    scopus 로고
    • Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    • 10.1016/j.ccr.2004.06.025, 15324699
    • White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 2004, 6:159-170. 10.1016/j.ccr.2004.06.025, 15324699.
    • (2004) Cancer Cell , vol.6 , pp. 159-170
    • White, D.E.1    Kurpios, N.A.2    Zuo, D.3    Hassell, J.A.4    Blaess, S.5    Mueller, U.6    Muller, W.J.7
  • 56
    • 0026730017 scopus 로고
    • Alteration of stromal protein and integrin expression in breast - a marker of premalignant change?
    • 10.1002/path.1711670409, 1383484
    • Jones JL, Critchley DR, Walker RA. Alteration of stromal protein and integrin expression in breast - a marker of premalignant change?. J Pathol 1992, 167:399-406. 10.1002/path.1711670409, 1383484.
    • (1992) J Pathol , vol.167 , pp. 399-406
    • Jones, J.L.1    Critchley, D.R.2    Walker, R.A.3
  • 57
    • 0027383908 scopus 로고
    • Expression of beta-1 integrins on tumor cells of invasive ductal breast carcinoma
    • 10.1016/S0344-0338(11)80668-0, 7508107
    • Jonjic N, Lucin K, Krstulja M, Iternicka Z, Mustac E. Expression of beta-1 integrins on tumor cells of invasive ductal breast carcinoma. Pathol Res Pract 1993, 189:979-984. 10.1016/S0344-0338(11)80668-0, 7508107.
    • (1993) Pathol Res Pract , vol.189 , pp. 979-984
    • Jonjic, N.1    Lucin, K.2    Krstulja, M.3    Iternicka, Z.4    Mustac, E.5
  • 58
    • 0026040340 scopus 로고
    • Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules
    • 1886301, 1928301
    • Koukoulis GK, Virtanen I, Korhonen M, Laitinen L, Quaranta V, Gould VE. Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules. Am J Pathol 1991, 139:787-799. 1886301, 1928301.
    • (1991) Am J Pathol , vol.139 , pp. 787-799
    • Koukoulis, G.K.1    Virtanen, I.2    Korhonen, M.3    Laitinen, L.4    Quaranta, V.5    Gould, V.E.6
  • 59
    • 0026644051 scopus 로고
    • Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors
    • 10.1016/0046-8177(92)90034-Z, 1383121
    • Pignatelli M, Cardillo MR, Hanby A, Stamp GW. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Hum Pathol 1992, 23:1159-1166. 10.1016/0046-8177(92)90034-Z, 1383121.
    • (1992) Hum Pathol , vol.23 , pp. 1159-1166
    • Pignatelli, M.1    Cardillo, M.R.2    Hanby, A.3    Stamp, G.W.4
  • 60
    • 0027772194 scopus 로고
    • Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization
    • 1886906, 8388172
    • Zutter MM, Krigman HR, Santoro SA. Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization. Am J Pathol 1993, 142:1439-1448. 1886906, 8388172.
    • (1993) Am J Pathol , vol.142 , pp. 1439-1448
    • Zutter, M.M.1    Krigman, H.R.2    Santoro, S.A.3
  • 61
    • 2542552635 scopus 로고    scopus 로고
    • Integrin expression and survival in human breast cancer
    • 10.1016/j.ejso.2004.01.016, 15135474
    • Berry MG, Gui GP, Wells CA, Carpenter R. Integrin expression and survival in human breast cancer. Eur J Surg Oncol 2004, 30:484-489. 10.1016/j.ejso.2004.01.016, 15135474.
    • (2004) Eur J Surg Oncol , vol.30 , pp. 484-489
    • Berry, M.G.1    Gui, G.P.2    Wells, C.A.3    Carpenter, R.4
  • 62
    • 0032998843 scopus 로고    scopus 로고
    • An immunohistochemical examination of the expression of E-cadherin, α- and β/γ-catenins, and α2- and β1-integrins in invasive breast cancer
    • 10.1002/(SICI)1096-9896(199904)187:5<523::AID-PATH296>3.0.CO;2-3, 10398116
    • Gonzalez MA, Pinder SE, Wencyk PM, Bell JA, Elston CW, Nicholson RI, Robertson JF, Blamey RW, Ellis IO. An immunohistochemical examination of the expression of E-cadherin, α- and β/γ-catenins, and α2- and β1-integrins in invasive breast cancer. J Pathol 1999, 187:523-529. 10.1002/(SICI)1096-9896(199904)187:5<523::AID-PATH296>3.0.CO;2-3, 10398116.
    • (1999) J Pathol , vol.187 , pp. 523-529
    • Gonzalez, M.A.1    Pinder, S.E.2    Wencyk, P.M.3    Bell, J.A.4    Elston, C.W.5    Nicholson, R.I.6    Robertson, J.F.7    Blamey, R.W.8    Ellis, I.O.9
  • 63
    • 1842455077 scopus 로고    scopus 로고
    • Integrin β1-mediated invasion of human breast cancer cells: an ex vivo assay for invasiveness
    • 10.1007/BF02966720, 12955033
    • Berry MG, Goode AW, Puddefoot J R, Vinson GP, Carpenter R. Integrin β1-mediated invasion of human breast cancer cells: an ex vivo assay for invasiveness. Breast Cancer 2003, 10:214-219. 10.1007/BF02966720, 12955033.
    • (2003) Breast Cancer , vol.10 , pp. 214-219
    • Berry, M.G.1    Goode, A.W.2    Puddefoot J, R.3    Vinson, G.P.4    Carpenter, R.5
  • 64
    • 32944469169 scopus 로고    scopus 로고
    • Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
    • 10.1158/0008-5472.CAN-05-3071, 2933188, 16452209
    • Park CC, Zhang H, Pallavicini M, Gray JW, Baehner F, Park CJ, Bissell MJ. Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 2006, 66:1526-1535. 10.1158/0008-5472.CAN-05-3071, 2933188, 16452209.
    • (2006) Cancer Res , vol.66 , pp. 1526-1535
    • Park, C.C.1    Zhang, H.2    Pallavicini, M.3    Gray, J.W.4    Baehner, F.5    Park, C.J.6    Bissell, M.J.7
  • 65
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
    • 10.1083/jcb.137.1.231, 2139858, 9105051
    • Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 1997, 137:231-245. 10.1083/jcb.137.1.231, 2139858, 9105051.
    • (1997) J Cell Biol , vol.137 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 66
    • 33846653542 scopus 로고    scopus 로고
    • Increased β1 integrin is associated with decreased survival in invasive breast cancer
    • 10.1158/0008-5472.CAN-06-2768, 17234776
    • Yao ES, Zhang H, Chen YY, Lee B, Chew K, Moore D, Park C. Increased β1 integrin is associated with decreased survival in invasive breast cancer. Cancer Res 2007, 67:659-664. 10.1158/0008-5472.CAN-06-2768, 17234776.
    • (2007) Cancer Res , vol.67 , pp. 659-664
    • Yao, E.S.1    Zhang, H.2    Chen, Y.Y.3    Lee, B.4    Chew, K.5    Moore, D.6    Park, C.7
  • 67
    • 72249105509 scopus 로고    scopus 로고
    • Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer
    • 10.1158/0008-5472.CAN-09-1591, 19887601
    • Lesniak D, Xu Y, Deschenes J, Lai R, Thoms J, Murray D, Gosh S, Mackey JR, Sabri S, Abdulkarim B. Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer. Cancer Res 2009, 69:8620-8628. 10.1158/0008-5472.CAN-09-1591, 19887601.
    • (2009) Cancer Res , vol.69 , pp. 8620-8628
    • Lesniak, D.1    Xu, Y.2    Deschenes, J.3    Lai, R.4    Thoms, J.5    Murray, D.6    Gosh, S.7    Mackey, J.R.8    Sabri, S.9    Abdulkarim, B.10
  • 70
    • 33847141029 scopus 로고    scopus 로고
    • The expression of the cytoskeletal focal adhesion protein paxillin in breast cancer correlates with HER2 overexpression and may help predict response to chemotherapy: a retrospective immunohistochemical study
    • 10.1111/j.1524-4741.2007.00389.x, 17319853
    • Short SM, Yoder BJ, Tarr SM, Prescott NL, Laniauskas S, Coleman KA, Downs-Kelly E, Pettay JD, Choueiri TK, Crowe JP, Tubbs RR, Budd TG, Hicks DG. The expression of the cytoskeletal focal adhesion protein paxillin in breast cancer correlates with HER2 overexpression and may help predict response to chemotherapy: a retrospective immunohistochemical study. Breast J 2007, 13:130-139. 10.1111/j.1524-4741.2007.00389.x, 17319853.
    • (2007) Breast J , vol.13 , pp. 130-139
    • Short, S.M.1    Yoder, B.J.2    Tarr, S.M.3    Prescott, N.L.4    Laniauskas, S.5    Coleman, K.A.6    Downs-Kelly, E.7    Pettay, J.D.8    Choueiri, T.K.9    Crowe, J.P.10    Tubbs, R.R.11    Budd, T.G.12    Hicks, D.G.13
  • 72
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • 10.1016/S0002-9440(10)63568-7, 1892434, 14578209
    • Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, Pollard JW. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003, 163:2113-2126. 10.1016/S0002-9440(10)63568-7, 1892434, 14578209.
    • (2003) Am J Pathol , vol.163 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, L.4    Whitney, K.D.5    Muller, W.J.6    Pollard, J.W.7
  • 73
    • 50849107639 scopus 로고    scopus 로고
    • Signal transduction in transgenic mouse models of human breast cancer - implications for human breast cancer
    • 10.1007/s10911-008-9087-3, 18651209
    • Marcotte R, Muller WJ. Signal transduction in transgenic mouse models of human breast cancer - implications for human breast cancer. J Mammary Gland Biol Neoplasia 2008, 13:323-335. 10.1007/s10911-008-9087-3, 18651209.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 323-335
    • Marcotte, R.1    Muller, W.J.2
  • 74
    • 52049111209 scopus 로고    scopus 로고
    • Integrins in breast cancer dormancy
    • 10.1111/j.1600-0463.2008.01026.x, 18834411
    • Pontier SM, Muller WJ. Integrins in breast cancer dormancy. APMIS 2008, 116:677-684. 10.1111/j.1600-0463.2008.01026.x, 18834411.
    • (2008) APMIS , vol.116 , pp. 677-684
    • Pontier, S.M.1    Muller, W.J.2
  • 75
    • 58349108303 scopus 로고    scopus 로고
    • Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells
    • 10.1158/0008-5472.CAN-08-3078, 3039129, 19147559
    • Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan JL. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 2009, 69:466-474. 10.1158/0008-5472.CAN-08-3078, 3039129, 19147559.
    • (2009) Cancer Res , vol.69 , pp. 466-474
    • Luo, M.1    Fan, H.2    Nagy, T.3    Wei, H.4    Wang, C.5    Liu, S.6    Wicha, M.S.7    Guan, J.L.8
  • 76
    • 55349105491 scopus 로고    scopus 로고
    • Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer
    • 10.2353/ajpath.2008.080308, 2570144, 18845837
    • Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol 2008, 173:1551-1565. 10.2353/ajpath.2008.080308, 2570144, 18845837.
    • (2008) Am J Pathol , vol.173 , pp. 1551-1565
    • Provenzano, P.P.1    Inman, D.R.2    Eliceiri, K.W.3    Beggs, H.E.4    Keely, P.J.5
  • 77
    • 61749094852 scopus 로고    scopus 로고
    • Rasand PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling
    • 2631302, 19147981
    • Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG. Rasand PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 2009, 119:252-266. 2631302, 19147981.
    • (2009) J Clin Invest , vol.119 , pp. 252-266
    • Pylayeva, Y.1    Gillen, K.M.2    Gerald, W.3    Beggs, H.E.4    Reichardt, L.F.5    Giancotti, F.G.6
  • 78
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/H ER2/neu in breast cancer progression and metastasis
    • 10.1023/A:1014730829872, 12013529
    • Eccles SA. The role of c-erbB-2/H ER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol Neoplasia 2001, 6:393-406. 10.1023/A:1014730829872, 12013529.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 393-406
    • Eccles, S.A.1
  • 79
    • 34247499539 scopus 로고    scopus 로고
    • Insights from transgenic mouse models of ERBB2-induced breast cancer
    • 10.1038/nrc2127, 17446858
    • Ursini-Siegel J, Schade B, Cardiff RD, Muller WJ. Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer 2007, 7:389-397. 10.1038/nrc2127, 17446858.
    • (2007) Nat Rev Cancer , vol.7 , pp. 389-397
    • Ursini-Siegel, J.1    Schade, B.2    Cardiff, R.D.3    Muller, W.J.4
  • 80
    • 77957283664 scopus 로고    scopus 로고
    • Beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression
    • 10.1073/pnas.1003034107, 2932605, 20713705
    • Huck L, Pontier SM, Zuo DM, Muller WJ. Beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression. Proc Natl Acad Sci USA 2010, 107:15559-15564. 10.1073/pnas.1003034107, 2932605, 20713705.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15559-15564
    • Huck, L.1    Pontier, S.M.2    Zuo, D.M.3    Muller, W.J.4
  • 81
    • 40949130063 scopus 로고    scopus 로고
    • ShcA signalling is essential for tumour progression in mouse models of human breast cancer
    • 10.1038/emboj.2008.22, 2274931, 18273058
    • Ursini-Siegel J, Hardy WR, Zuo D, Lam SH, Sanguin-Gendreau V, Cardiff RD, Pawson T, Muller WJ. ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J 2008, 27:910-920. 10.1038/emboj.2008.22, 2274931, 18273058.
    • (2008) EMBO J , vol.27 , pp. 910-920
    • Ursini-Siegel, J.1    Hardy, W.R.2    Zuo, D.3    Lam, S.H.4    Sanguin-Gendreau, V.5    Cardiff, R.D.6    Pawson, T.7    Muller, W.J.8
  • 83
    • 53749092962 scopus 로고    scopus 로고
    • Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments
    • 10.1083/jcb.200804140, 2557049, 18838556
    • Caswell PT, Chan M, Lindsay AJ, McCaffrey MW, Boettiger D, Norman JC. Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol 2008, 183:143-155. 10.1083/jcb.200804140, 2557049, 18838556.
    • (2008) J Cell Biol , vol.183 , pp. 143-155
    • Caswell, P.T.1    Chan, M.2    Lindsay, A.J.3    McCaffrey, M.W.4    Boettiger, D.5    Norman, J.C.6
  • 84
    • 68149159378 scopus 로고    scopus 로고
    • Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway
    • 10.1038/onc.2009.132, 2861141, 19483730
    • Liu Y, Pixley R, Fusaro M, Godoy G, Kim E, Bromberg ME, Colman RW. Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene 2009, 28:2756-2765. 10.1038/onc.2009.132, 2861141, 19483730.
    • (2009) Oncogene , vol.28 , pp. 2756-2765
    • Liu, Y.1    Pixley, R.2    Fusaro, M.3    Godoy, G.4    Kim, E.5    Bromberg, M.E.6    Colman, R.W.7
  • 85
    • 0031914189 scopus 로고    scopus 로고
    • Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells
    • Tagliabue E, Ghirelli C, Squicciarini P, Aiello P, Colnaghi MI, Menard S. Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clin Cancer Res 1998, 4:407-410.
    • (1998) Clin Cancer Res , vol.4 , pp. 407-410
    • Tagliabue, E.1    Ghirelli, C.2    Squicciarini, P.3    Aiello, P.4    Colnaghi, M.I.5    Menard, S.6
  • 86
    • 3442897659 scopus 로고    scopus 로고
    • Contributions of the alpha6 integrins to breast carcinoma survival and progression
    • Chung J, Mercurio AM. Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol Cells 2004, 17:203-209.
    • (2004) Mol Cells , vol.17 , pp. 203-209
    • Chung, J.1    Mercurio, A.M.2
  • 87
    • 67949097338 scopus 로고    scopus 로고
    • Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer
    • 10.1186/1756-9966-28-67, 2694164, 19470173
    • Gilcrease MZ, Zhou X, Lu X, Woodwar d WA, Hall BE, Morrissey PJ. Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. J Exp Clin Cancer Res 2009, 28:67-76. 10.1186/1756-9966-28-67, 2694164, 19470173.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 67-76
    • Gilcrease, M.Z.1    Zhou, X.2    Lu, X.3    Woodwar d, W.A.4    Hall, B.E.5    Morrissey, P.J.6
  • 88
    • 33746764457 scopus 로고    scopus 로고
    • Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
    • 10.1016/j.cell.2006.05.047, 16901783
    • Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006, 126:489-502. 10.1016/j.cell.2006.05.047, 16901783.
    • (2006) Cell , vol.126 , pp. 489-502
    • Guo, W.1    Pylayeva, Y.2    Pepe, A.3    Yoshioka, T.4    Muller, W.J.5    Inghirami, G.6    Giancotti, F.G.7
  • 91
    • 28544452516 scopus 로고    scopus 로고
    • A direct test of potential roles for β3 and β5 integrins in growth and metastasis of murine mammary carcinomas
    • 10.1158/0008-5472.CAN-04-4098, 16288021
    • Taverna D, Crowley D, Connolly M, Bronson RT, Hynes RO. A direct test of potential roles for β3 and β5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Res 2005, 65:10324-10329. 10.1158/0008-5472.CAN-04-4098, 16288021.
    • (2005) Cancer Res , vol.65 , pp. 10324-10329
    • Taverna, D.1    Crowley, D.2    Connolly, M.3    Bronson, R.T.4    Hynes, R.O.5
  • 94
    • 77957363101 scopus 로고    scopus 로고
    • Integrins as therapeutic targets: lessons and opportunities
    • 10.1038/nrd3266, 20885411
    • Cox D, Brennan M, Moran N. Integrins as therapeutic targets: lessons and opportunities. Nat Rev Drug Discov 2010, 9:804-820. 10.1038/nrd3266, 20885411.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 804-820
    • Cox, D.1    Brennan, M.2    Moran, N.3
  • 95
    • 39049171151 scopus 로고    scopus 로고
    • A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo
    • 10.1186/1479-5876-5-61, 2235829, 18042290
    • Bhaskar V, Zhang D, Fox M, Seto P, Wong M H, Wales PE, Powers D, Chao DT, Dubridge RB, Ramakrishnan V. A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo. J Transl Med 2007, 5:61-71. 10.1186/1479-5876-5-61, 2235829, 18042290.
    • (2007) J Transl Med , vol.5 , pp. 61-71
    • Bhaskar, V.1    Zhang, D.2    Fox, M.3    Seto, P.4    Wong M, H.5    Wales, P.E.6    Powers, D.7    Chao, D.T.8    Dubridge, R.B.9    Ramakrishnan, V.10
  • 97
    • 38149086091 scopus 로고    scopus 로고
    • Volociximab, a chimeric integrin α5β1 antibody, inhibits the growth of VX2 tumors in rabbits
    • 10.1007/s10637-007-9078-z, 17786386
    • Bhaskar V, Fox M, Breinberg D, Wong MH, Wales PE, Rhodes S, DuBridge RB, Ramakrishnan V. Volociximab, a chimeric integrin α5β1 antibody, inhibits the growth of VX2 tumors in rabbits. Invest New Drugs 2008, 26:7-12. 10.1007/s10637-007-9078-z, 17786386.
    • (2008) Invest New Drugs , vol.26 , pp. 7-12
    • Bhaskar, V.1    Fox, M.2    Breinberg, D.3    Wong, M.H.4    Wales, P.E.5    Rhodes, S.6    DuBridge, R.B.7    Ramakrishnan, V.8
  • 98
    • 42249084453 scopus 로고    scopus 로고
    • Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a Ushaped dose-response curve in several preclinical models of angiogenesis and tumor growth
    • 10.1158/1078-0432.CCR-07-4530, 18381955
    • Donate F, Parry GC, Shaked Y, Hensley H, Guan X, Beck I, Tel-Tsur Z, Plunkett ML, Manuia M, Shaw DE, Kerbel RS, Mazar AP. Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a Ushaped dose-response curve in several preclinical models of angiogenesis and tumor growth. Clin Cancer Res 2008, 14:2137-2144. 10.1158/1078-0432.CCR-07-4530, 18381955.
    • (2008) Clin Cancer Res , vol.14 , pp. 2137-2144
    • Donate, F.1    Parry, G.C.2    Shaked, Y.3    Hensley, H.4    Guan, X.5    Beck, I.6    Tel-Tsur, Z.7    Plunkett, M.L.8    Manuia, M.9    Shaw, D.E.10    Kerbel, R.S.11    Mazar, A.P.12
  • 100
    • 0037457423 scopus 로고    scopus 로고
    • Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice
    • 10.1002/ijc.10958, 12584749
    • Stoeltzing O, Liu W, Reinmuth N, Fan F, Parry GC, Parikh AA, McCarty MF, Bucana CD, Mazar AP, Ellis LM. Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer 2003, 104:496-503. 10.1002/ijc.10958, 12584749.
    • (2003) Int J Cancer , vol.104 , pp. 496-503
    • Stoeltzing, O.1    Liu, W.2    Reinmuth, N.3    Fan, F.4    Parry, G.C.5    Parikh, A.A.6    McCarty, M.F.7    Bucana, C.D.8    Mazar, A.P.9    Ellis, L.M.10
  • 101
    • 70449507354 scopus 로고    scopus 로고
    • Beta1 integrin targeting to enhance radiation therapy
    • 10.3109/09553000903232876, 19895268
    • Nam JM, Chung Y, Hsu HC, Park CC. Beta1 integrin targeting to enhance radiation therapy. Int J Radiat Biol 2009, 85:923-928. 10.3109/09553000903232876, 19895268.
    • (2009) Int J Radiat Biol , vol.85 , pp. 923-928
    • Nam, J.M.1    Chung, Y.2    Hsu, H.C.3    Park, C.C.4
  • 102
    • 49249107671 scopus 로고    scopus 로고
    • Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts
    • 10.1158/0008-5472.CAN-07-6390, 18519702
    • Park CC, Zhang HJ, Yao ES, Park CJ, Bissell MJ. Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res 2008, 68:4398-4405. 10.1158/0008-5472.CAN-07-6390, 18519702.
    • (2008) Cancer Res , vol.68 , pp. 4398-4405
    • Park, C.C.1    Zhang, H.J.2    Yao, E.S.3    Park, C.J.4    Bissell, M.J.5
  • 103
    • 38349112349 scopus 로고    scopus 로고
    • Mouse mammary tumor virus integration site selection in human and mouse genomes
    • 10.1128/JVI.02098-07, 2224419, 18032509
    • Faschinger A, Rouault F, Sollner J, Lukas A, Salmons B, Gunzburg WH, Indik S. Mouse mammary tumor virus integration site selection in human and mouse genomes. J Virol 2008, 82:1360-1367. 10.1128/JVI.02098-07, 2224419, 18032509.
    • (2008) J Virol , vol.82 , pp. 1360-1367
    • Faschinger, A.1    Rouault, F.2    Sollner, J.3    Lukas, A.4    Salmons, B.5    Gunzburg, W.H.6    Indik, S.7
  • 104
    • 0034724314 scopus 로고    scopus 로고
    • Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
    • 10.1073/pnas.050408497, 16259, 10716706
    • Andrechek ER, Hardy WR, Siegel PM, Rudnicki MA, Cardiff RD, Muller WJ. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci USA 2000, 97:3444-3449. 10.1073/pnas.050408497, 16259, 10716706.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3444-3449
    • Andrechek, E.R.1    Hardy, W.R.2    Siegel, P.M.3    Rudnicki, M.A.4    Cardiff, R.D.5    Muller, W.J.6
  • 105
    • 59449094255 scopus 로고    scopus 로고
    • Volociximab, a chimeric monoclonal antibody that specifically binds α5β1 integrin: a phase I, pharmacokinetic, and biological correlative study
    • 10.1158/1078-0432.CCR-08-0378, 19047123
    • Ricart AD, Tolcher AW, Liu G, Holen K, Schwartz G, Albertini M, Weiss G, Yazji S, Ng C, Wilding G. Volociximab, a chimeric monoclonal antibody that specifically binds α5β1 integrin: a phase I, pharmacokinetic, and biological correlative study. Clin Cancer Res 2008, 14:7924-7929. 10.1158/1078-0432.CCR-08-0378, 19047123.
    • (2008) Clin Cancer Res , vol.14 , pp. 7924-7929
    • Ricart, A.D.1    Tolcher, A.W.2    Liu, G.3    Holen, K.4    Schwartz, G.5    Albertini, M.6    Weiss, G.7    Yazji, S.8    Ng, C.9    Wilding, G.10


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