Contributions of the α6 integrins to breast carcinoma survival and progression

Molecules and Cells

Volumn 17, Issue 2, 2004, Pages 203-209

  Chung, Jun ^a   Mercurio, Arthur M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Breast carcinoma; Integrin; Survival; VEGF

Indexed keywords

ALPHA6 INTEGRIN; ALPHA6BETA4 INTEGRIN; RNA; VASCULOTROPIN; VERY LATE ACTIVATION ANTIGEN 6; DNA BINDING PROTEIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; NUCLEAR PROTEIN; PROTEIN KINASE; TRANSCRIPTION FACTOR; VASCULOTROPIN A;

AUTOCRINE EFFECT; BREAST CARCINOMA; CANCER GROWTH; CARCINOMA CELL; CELL SURVIVAL; GENETIC TRANSCRIPTION; HUMAN; HYPOTHESIS; MICROENVIRONMENT; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; STRESS; BREAST TUMOR; DISEASE COURSE; FEMALE; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SURVIVAL RATE;

BREAST NEOPLASMS; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTEGRIN ALPHA6BETA1; INTEGRIN ALPHA6BETA4; NUCLEAR PROTEINS; PROTEIN KINASES; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 3442897659     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. Bachelder, R. E., Crago, A., Chung, J., Wendt, M. A., Shaw, L. M., Robinson, G., and Mercurio, A. M. (2001) Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 61, 5736-5740.
2. Bachelder, R. E., Ribick, M. J., Marchetti, A., Falcioni, R., Soddu, S., Davis, K. R., and Mercurio, A. M. (1999) p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J. Cell Biol. 147, 1063-1072.
3. Bachelder, R. E., Wendt, M. A., and Mercurio, A. M. (2002) Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res. 62, 7203-7206.
4. Bates, R. C., Goldsmith, J. D., Bachelder, R. E., Brown, C., Shibuya, M., Oettgen, P., and Mercurio, A. M. (2003) Flt-1 (VEGFR-1)-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr. Biol. (in press).
5. Beasley, N. J., Leek, R., Alam, M., Turley, H., Cox, G. J., Gatter, K., Millard, P., Fuggle, S., and Harris, A. L. (2002) Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 62, 2493-2497.
6. Berkel, H. J., Turbat-Herrera, E. A., Shi, R., and de Benedetti, A. (2001) Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon. Cancer Epidemiol Biomarkers Prev. 10, 663-666.
7. Bissell, M. J., Weaver, V. M., Lelievre, S. A., Wang, F., Petersen, O. W., and Schmeichel, K. L. (1999) Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res. 59, 1757-1763s; discussion 1763s-1764s.
8. Blouw, B., Song, H., Tihan, T., Bosze, J., Ferrara, N., Gerber, H. P., Johnson, R. S., and Bergers, G. (2003) The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4, 133-146.
9. Boudreau, N. and Bissell, M. J. (1998) Extracellular matrix signaling: integration of form and function in normal and malignant cells. Curr. Opin. Cell. Biol. 10, 640-646.
10. Brizel, D. M., Scully, S. P., Harrelson, J. M., Layfield, L. J., Bean, J. M., Prosnitz, L. R., and Dewhirst, M. W. (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56, 941-943.
11. Brown, J. M. (1999) The hypoxic cell: a target for selective cancer therapy - eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res. 59, 5863-5870.
12. Brown, L. F., Guidi, A. J., Schnitt, S. J., Van De Water, L., Iruela-Arispe, M. L., Yeo, T. K., Tognazzi, K., and Dvorak, H. F. (1999) Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin. Cancer Res. 5, 1041-1056.
13. Caro, J. (2001) Hypoxia regulation of gene transcription. High Alt. Med. Biol. 2, 145-154.
14. Chen, M. S., Almeida, E. A., Huovila, A. P., Takahashi, Y., Shaw, L. M., Mercurio, A. M., and White, J. M. (1999) Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM. J. Cell Biol. 144, 549-561.
15. Chung, J., Bachelder, R. E., Lipscomb, E. A., Shaw, L. M., and Mercurio, A. M. (2002) Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J. Cell Biol. 158, 165-174.
16. Chung, J., Yoon, S., Kaustubh, D., Bachelder, R. E., and Mercurio, A. M. (2004) Hypoxia induced VEGF transcription and survival is dependent on a6 integrin expression in breast carcinoma cells. Cancer Res. (under review).
17. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927.
18. De Benedetti, A. and Harris, A. L. (1999) eIF4E expression in tumors: its possible role in progression of malignancies. Int. J. Biochem. Cell. Biol. 31, 59-72.
19. DeFatta, R. J., Nathan, C. A., and De Benedetti, A. (2000) Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line. Laryngoscope 110, 928-933.
20. Dennis, P. B., Fumagalli, S., and Thomas, G. (1999) Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation. Curr. Opin. Genet. Dev. 9, 49-54.
21. Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., and Thomas, G. (2001) Mammalian TOR: a homeostatic ATP sensor. Science 294, 1102-1105.
22. Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., and Dvorak, A. M. (1999) Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr. Top Microbiol. Immunol. 237, 97-132.
23. Fearon, E. R. (1999) Cancer progression. Curr. Biol. 9, R873-875.
24. Freedman, S. J., Sun, Z. Y., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G., and Eck, M. J. (2002) Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc. Natl. Acad. Sci. USA 99, 5367-5372.
25. Friedrichs, K., Ruiz, P., Franke, F., Gille, I., Terpe, H. J., and Imhof, B. A. (1995) High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res. 55, 901-906.
26. Frisch, S. M. and Francis, H. (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
27. Gambaletta, D., Marchetti, A., Benedetti, L., Mercurio, A. M., Sacchi, A., and Falcioni, R. (2000) Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J. Biol. Chem. 275, 10604-10610.
28. Gingras, A. C., Raught, B., and Sonenberg, N. (2001) Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15, 807-826.
29. Gradin, K., Takasaki, C., Fujii-Kuriyama, Y., and Sogawa, K. (2002) The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine. J. Biol. Chem. 277, 23508-23514.
30. Hagios, C., Lochter, A., and Bissell, M. J. (1998) Tissue architecture: the ultimate regulator of epithelial function? Philos. Trans. R. Soc. Lond B Biol. Sci. 353, 857-870.
31. Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70.
32. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., and Vaupel, P. (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56, 4509-4515.
33. Huang, S. and Houghton, P. J. (2002) Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr. Opin. Investig. Drugs 3, 295-304.
34. Huang, L. E., Gu, J., Schau, M., and Bunn, H. F. (1998) Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 95, 7987-7992.
35. Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
36. Jauliac, S., Lopez-Rodriguez, C., Shaw, L. M., Brown, L. F., Rao, A., and Toker, A. (2002) The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat. Cell. Biol. 4, 540-544.
37. Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. Adv. Exp. Med. Biol. 502, 365-376.
38. McKendrick, L., Pain, V. M., and Morley, S. J. (1999) Translation initiation factor 4E. Int. J. Biochem. Cell. Biol. 31, 31-35.
39. McNeill, L. A., Hewitson, K. S., Claridge, T. D., Seibel, J. F., Horsfall, L. E., and Schofield, C. J. (2002) Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem. J. 367, 571-575.
40. Mercurio, A. M. and Rabinovitz, I. (2001) Towards a mechanistic understanding of tumor invasion - lessons from the alpha6beta 4 integrin. Semin. Cancer Biol. 11, 129-141.
41. Mercurio, A. M., Rabinovitz, I., and Shaw, L. M. (2001) The alpha 6 beta 4 integrin and epithelial cell migration. Curr. Opin. Cell Biol. 13, 541-545.
42. Meredith, J. E., Jr., Fazeli, B., and Schwartz, M. A. (1993) The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
43. Minet, E., Michel, G., Mottet, D., Raes, M., and Michiels, C. (2001) Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation. Free Radical Biol. Med. 31, 847-855.
44. Mukhopadhyay, R., Theriault, R. L., and Price, J. E. (1999) Increased levels of alpha6 integrins are associated with the metastatic phenotype of human breast cancer cells. Clin. Exp. Metastasis 17, 325-332.
45. Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z. (1999) Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22.
46. O'Connor, K. L., Shaw, L. M., and Mercurio, A. M. (1998) Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. J. Cell Biol. 143, 1749-1760.
47. Parise, L. V., Lee, J., and Juliano, R. L. (2000) New aspects of integrin signaling in cancer. Semin. Cancer Biol. 10, 407-414.
48. Petersen, O. W., Ronnov-Jessen, L., Weaver, V. M., and Bissell, M. J. (1998) Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv. Cancer Res. 75, 135-161.
49. Rabinovitz, I. and Mercurio, A. M. (1997) The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin- containing motility structures. J. Cell Biol. 139, 1873-1884.
50. Richard, D. E., Berra, E., and Pouyssegur, J. (1999) Angiogenesis: how a tumor adapts to hypoxia. Biochem. Biophys. Res. Commun. 266, 718-722.
51. Salceda, S. and Caro, J. (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272, 22642-22647.
52. Schmelzle, T. and Hall, M. N. (2000) TOR, a central controller of cell growth. Cell 103, 253-262.
53. Schwartz, M. A. (1997) Integrins, oncogenes, and anchorage independence. J. Cell Biol. 139, 575-578.
54. Semenza, G. L. (2002) Involvement of hypoxia-inducible factor 1 in human cancer. Int. Med. 41, 79-83.
55. Senger, D. R. and Van De Water, L. (2000) VEGF expression by epithelial and stromal cell compartments: resolving a controversy. Am. J. Pathol. 157, 1-3.
56. Shaw, L. M., Chao, C., Wewer, U. M., and Mercurio, A. M. (1996) Function of the integrin alpha6beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor. Cancer Res. 56, 959-963.
57. Shaw, L. M., Rabinovitz, I., Wang, H. H., Toker, A., and Mercurio, A. M. (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91, 949-960.
58. Shweiki, D., Itin, A., Soffer, D., and Keshet, E. (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845.
59. Soker, S., Fidder, H., Neufeld, G., and Klagsbrun, M. (1996) Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J. Biol. Chem. 271, 5761-5767.
60. Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., and Klagsbrun, M. (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform- specific receptor for vascular endothelial growth factor. Cell 92, 735-745.
61. Tagliabue, E., Ghirelli, C., Squicciarini, P., Aiello, P., Colnaghi, M. I., and Menard, S. (1998) Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clin. Cancer Res. 4, 407-410.
62. Takahashi, T., Fournier, A., Nakamura, F., Wang, L. H., Murakami, Y., Kalb, R. G., Fujisawa, H., and Strittmatter, S. M. (1999) Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors [in process citation]. Cell 99, 59-69 [MEDLINE record in process].
63. Tamagnone, L., Artigiani, S., Chen, H., He, Z., Ming, G. I., Song, H., Chedotal, A., Winberg, M. L., Goodman, C. S., Poo, M., Tessier-Lavigne, M., and Comoglio, P. M. (1999) Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99, 71-80.
64. Wang, G. L., Jiang, B. H., Rue, E. A., and Semenza, G. L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92, 5510-5514.
65. Wewer, U. M., Shaw, L. M., Albrechtsen, R., and Mercurio, A. M. (1997) The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice. Am. J. Pathol. 151, 1191-1198.
66. Zhu, H., Jackson, T., and Bunn, H. F. (2002) Detecting and responding to hypoxia. Nephrol. Dial. Transplant 17 (Suppl. 1), 3-7.