Integrin Function in Breast Carcinoma Progression

Journal of Mammary Gland Biology and Neoplasia

Volumn 4, Issue 4, 1999, Pages 367-376

  Shaw, Leslie M ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Breast carcinoma; Extracellular matrix; Integrin receptors; Invasion; Phosphoinositide 3 OH kinase

Indexed keywords

INTEGRIN;

ANIMAL; BIOSYNTHESIS; BREAST TUMOR; DISEASE COURSE; EXPERIMENTAL NEOPLASM; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; BREAST NEOPLASMS; DISEASE PROGRESSION; HUMANS; INTEGRINS; MAMMARY NEOPLASMS, EXPERIMENTAL;

EID: 0033201938     PISSN: 10833021     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018766317055     Document Type: Article

References (70)

1. R. O. Hynes (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25.
2. C. C. Kumar (1998). Signaling by integrin receptors. Oncogene 17:1365-1373.
3. E. A. Clark and J. S. Brugge (1995). Integrins and signal transduction pathways: The road taken. Science 268:233-239.
4. J. C. Porter and N. Hogg (1998). Integrins take partners: Cross-talk between integrins and other membrane receptors. Trends in Cell Biol. 8:390-396.
5. M. A. Schwartz (1993). Signaling by integrins: Implications for tumorigenesis. Cancer Res. 53:1503-1506.
6. R. L. Juliano and J. A. Varner (1993). Adhesion molecules in cancer: The role of integrins. Curr. Opin. Cell Biol. 5:812-818.
7. V. E. Gould, G. K. Koukoulis, and I. Virtanen (1990). Extracellular matrix proteins and their receptors in the normal, hyperplastic and neoplastic breast. Cell Differ. Dev. 32:409-416.
8. G. K. Koukoulis, I. Virtanen, M. Korhonen, L. Laitinen, V. Quaranta, and V. E. Gould (1991). Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules. Am. J. Pathol. 139:787-799.
9. M. Pignatelli, M. R. Cardillo, A. Hanby, and G. W. Stamp (1992). Integrins and their accessory adhesion molecules in mammary carcinomas: Loss of polarization in poorly differentiated tumors. Human Pathol. 23:1159-1166.
10. M. M. Zutter, G. Mazoujian, and S. A. Santoro (1990). Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast. Am. J. Pathol. 137:863-870.
11. M. A. Deugnier, E. P. Moiseyeva, J. P. Thiery, and M. Glukhova (1995). Myoepithelial cell differentiation in the developing mammary gland: Progressive acquisition of smooth muscle phenotype. Dev. Dynam. 204:107-117.
12. M. E. Hemler, C. Crouse, and A. Sonnenberg (1989). Association of the VLA α6 subunit with a novel protein. A possible alternative to the common VLA β 1 subunit on certain cell lines. J. Biol. Chem. 264:6529-6535.
13. S. Kajiji, R. N. Tamura, and V. Quaranta (1989). A novel integrin (α E β 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. EMBO J. 8:673-680.
14. S. J. Kennel, L. J. Foote, R. Falcioni, A. Sonnenberg, C. D. Stringer, C. Crouse, and M. E. Hemler (1989). Analysis of the tumor-associated antigen TSP-180. Identity with α 6 β 4 in the integrin superfamily. J. Biol. Chem. 264:15515-15521.
15. K. J. Green, and J. C. R. Jones (1996). Desmosomes and hemidesmosomes - structure and function of molecular components. FASEB J. 10:871-881.
16. L. Borradori and A. Sonnenberg (1996). Hemidesmosomes - Roles in adhesion, signaling and human diseases. Curr. Opin. Cell Biol. 8:647-656.
17. L. M. Bergstraesser, G. Srinivasan, J. C. Jones, S. Stahl, and S. A. Weitzman (1995). Expression of hemidesmosomes and component proteins is lost by invasive breast cancer cells. Amer. J. Pathol. 147:1823-1839.
18. C. H. Streuli and M. J. Bissell (1991). Mammary epithelial cells, extracellular matrix, and gene expression. Cancer Treat. Res. 53:365-381.
19. N. Boudreau and M. J. Bissell (1998). Extracellular matrix signaling: Integration of form and function in normal and malignant cells. Curr. Opin. Cell Biol. 10:640-646.
20. C. H. Streuli, C. Schmidhauser, N. Bailey, P. Yurchenco, A. P. Skubitz, C. Roskelley, and M. J. Bissell (1995). Laminin mediates tissue-specific gene expression in mammary epithelia. J. Cell Biol. 129:591-603.
21. C. H. Streuli, N. Bailey, and M. J. Bissell (1991). Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J. Cell Biol. 115:1383-1395.
22. C. Q. Lin, P. J. Dempsey, R. J. Coffey, and M. J. Bissell (1995). Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-α in mouse mammary epithelial cells: Studies in culture and in transgenic mice. J. Cell Biol. 129:1115-1126.
23. C. H. Streuli, C. Schmidhauser, M. Kobrin, M. J. Bissell, and R. Derynck (1993). Extracellular matrix regulates expression of the TGF-β 1 gene. J. Cell Biol. 120:253-260.
24. C. H. Streuli, G. M. Edwards, M. Delcommenne, C. B. Whitelaw, T. G. Burdon, C. Schindler, and C. J. Watson (1995). Stat5 as a target for regulation by extracellular matrix. J. Biol. Chem. 270:21639-21644.
25. G. M. Edwards, F. H. Wilford, X. Liu, L. Hennighausen, J. Djiane, and C. H. Streuli (1998). Regulation of mammary differentiation by extracellular matrix involves protein-tyrosine phosphatases. J. Biol. Chem. 273:9495-9500.
26. T. Hunter (1997). Oncoprotein networks. Cell 88:333-346.
27. V. E. Gould, W. Jao, and H. Battifora (1980). Ultrastructural analysis in the differential diagnosis of breast tumors. The significance of myoepithelial cells, basal lamina, intracytoplasmic lumina and secretory granules. Pathol. Res. Practice 167:45-70.
28. G. K. Koukoulis, A. A. Howeedy, M. Korhonen, I. Virtanen, and V. E. Gould (1993). Distribution of tenascin, cellular fibronectins and integrins in the normal, hyperplastic and neoplastic breast. J. Submicroscopic Cytol. Pathol. 25:285-295.
29. B. E. Symington, Y. Takada, and W. G. Carter (1993). Interaction of integrins α3β1 and α2β1: Potential role in keratinocyte intercellular adhesion. J. Cell Biol. 120:523-535.
30. M. M. Zutter, H. R. Krigman, and S. A. Santoro (1993). Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization. Am. J. Pathol. 142:1439-1448.
31. P. J. Keely, A. M. Fong, M. M. Zutter, and S. A. Santoro (1995). Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense α 2 integrin mRNA in mammary cells. J. Cell Sci. 108:595-607.
32. M. M. Zutter, S. A. Santoro, W. D. Staatz, and Y. L. Tsung (1995). Re-expression of the α2β1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 92:7411-7415.
33. H. Sun, S. A. Santoro, and M. M. Zutter (1998). Downstream events in mammary gland morphogenesis mediated by reexpression of the α2β1 integrin: The role of the α6 and β4 integrin subunits. Cancer Res. 58:2224-2233.
34. R. Sager, A. Anisowicz, M. Neveu, P. Liang, and G. Sotiropoulou (1993). Identification by differential display of α6 integrin as a candidate tumor suppressor gene. FASEB J. 7:964-970.
35. P. G. Natali, M. R. Nicotra, C. Botti, M. Mottolese, A. Bigotti, and O. Segatto (1992). Changes in expression of α6β4 integrin heterodimer in primary and metastatic breast cancer. Brit. J. Cancer 66:318-322.
36. N. Jonjic, K. Lucin, M. Krstulja, Z. Iternicka, and E. Mustac (1993). Expression of β 1 integrins on tumor cells of invasive ductal breast carcinoma. Pathol. Res. Practice 189:979-984.
37. K. Friedrichs, P. Ruiz, F. Franke, I. Gille, H.-J. Terpe, and B. A. Imhof (1995). High expression level of α6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res. 55:901-906.
38. E. Tagliabue, C. Ghirelli, P. Squicciarini, P. Aiello, M. I. Colnaghi, and S. Menard (1998). Prognostic value of α6β4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clinical Cancer Res. 4:407-410.
39. L. M. Shaw, C. Chao, U. M. Wewer, and A. M. Mercurio (1996). Function of the integrin α6β1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor. Cancer Res. 56:959-963.
40. U. M. Wewer, L. M. Shaw, R. Albrechtsen, and A. M. Mercurio (1997). The integrin α 6 β 1 promotes the survival of metastatic human breast carcinoma cells in mice. Am. J. Pathol. 151:1191-1198.
41. R. D. Bliss, J. A. Kirby, D. A. Browell, and T. W. Lennard (1995). The role of β 1 integrins in adhesion of two breast carcinoma cell lines to a model endothelium. Clin. Exp. Metastasis 13:173-183.
42. N. Farrelly, Y.-J. Lee, J. Oliver, C. Dive, and C. H. Streuli (1999). Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling. J. Cell Biol. 144:1337-1347.
43. A. Khwaja, P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne, and J. Downward (1997). Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783-2793.
44. S. G. Kennedy, A. J. Wagner, S. D. Conzen, J. Jordan, A. Bellacosa, P. N. Tsichlis, and N. Hay (1997). The PI 3-kinase/ Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:701-713.
45. H. Dudek, S. R. Datta, T. F. Franke, M. J. Birnbaum, R. Yao, G. M. Cooper, R. A. Segal, D. R. Kaplan, and M. E. Greenberg (1997). Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
46. R. Baserga, M. Resnicoff, and M. Dews (1997). The IGF-I receptor and cancer. Endocrine 7:99-102.
47. R. Vanderneut, P. Krimpenfort, J. Calafat, C. M. Niessen, and A. Sonnenberg (1996). Epithelial detachment due to absence of hemidesmosomes in integrin β 4 null mice. Nature Genetics 13:366-369.
48. J. Dowling, Q. C. Yu, and E. Fuchs (1996). β 4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J. Cell Biol. 134:559-572.
49. I. Rabinovitz and A. M. Mercurio (1996). The integrin α 6 β 4 and the biology of carcinoma. Biochem. Cell Biol. 74:811-821.
50. L. M. Shaw, I. Rabinovitz, H. H. F. Wang, A. Toker, and A. M. Mercurio (1997). Activation of phosphoinositide 3-Oh kinase by the α 6 β 4 integrin promotes carcinoma invasion. Cell 91:949-960.
51. C. Chao, M. M. Lotz, A. C. Clarke, and A. M. Mercurio (1996). A function for the integrin α 6 β 4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 56:4811-4819.
52. I. Rabinovitz and A. M. Mercurio (1997). The integrin α6β4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J. Cell Biol. 139:1873-1884.
53. A. S. Clarke, M. M. Lotz, C. Chao, and A. M. Mercurio (1995). Activation of the p21 pathway of growth arrest and apoptosis by the β4 integrin cytoplasmic domain. J. Biol. Chem. 270:22673-22676.
54. R. Bachelder, A. Marchetti, R. Falcioni, S. Soddu, and A. M. Mercurio (Undated). Activation of p53 function in carcinoma cells by the α6β4 integrin. J. Biol. Chem. (in review).
55. L. A. Lesoon-Wood, W. H. Kim, H. K. Kleinman, B. D. Weintraub, and A. J. Mixson (1995). Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice. Human Gene Therapy 6:395-405.
56. P. J. Keely, J. K. Westwick, I. P. Whitehead, C. J. Der, and L. V. Parise (1997). Cdc42 and rac1 induce integrin-mediated cell motility and invasiveness through Pi(3)K. Nature 390:632-636.
57. C. D. Nobes and A. Hall (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
58. C. L. Sommers, S. W. Byers, E. W. Thompson, J. A. Torri, and E. P. Gelmann (1994). Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res. Treat. 31:325-335.
59. E. E. Sander, S. van Delft, J. P. ten Klooster, T. Reid, R. A. van der Kammen, F. Michiels, and J. G. Collard (1998). Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol. 143:1385-1398.
60. W. Birchmeier, J. Hulsken, and J. Behrens (1995). E-cadherin as an invasion suppressor. Ciba Foundation Symp. 189:124-136.
61. M. Takeichi (1993). Cadherins in cancer: Implications for invasion and metastasis. Curr. Opin. Cell Biol. 5:806-811.
62. K. L. O'Connor, L. M. Shaw, and A. M. Mercurio (1998). Release of cAMP gating by the α6β4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. J. Cell Biol. 143:1749-1760.
63. F. Mainiero, A. Pepe, K. K. Wary, L. Spinardi, M. Mohammadi, J. Schlessinger, and F. G. Giancotti (1995). Signal transduction by the α6β4 integrin: Distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14:4470-4481.
64. L. C. Cantley, and Z. Songyang (1994). Specificity in recognition of phosphopeptides by src-homology 2 domains. J. Cell Sci. Supplement. 18:121-126.
65. R. Falcioni, A. Antonini, P. Nistico, S. Di Stefano, M. Crescenzi, P. G. Natali, and A. Sacchi (1997). α6β4 and α6β1 integrins associate with ErbB-2 in human carcinoma cell lines. Exp. Cell Res. 236:76-85.
66. N. E. Hynes and D. F. Stern (1994). The biology of erbB-2/ neu/HER-2 and its role in cancer. Biochim. Biophys. Acta. 1198:165-184.
67. Baselga, D. Tripathy, J. Mendelsohn, S. Baughman, C. C. Benz, L. Dantis, N. T. Sklarin, A. D. Seidman, C. A. Hudis, J. Moore, P. P. Rosen, T. Twaddell, I. C. Henderson, and L. Norton (1996). Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/ neu-overexpressing metastatic breast cancer. J. Clin. Oncol. 14:737-744.
68. P. C. Brooks, R. L. Klemke, S. Schon, J. M. Lewis, M. A. Schwartz, and D. A. Cheresh (1997). Insulin-like growth factor receptor cooperates with integrin αvβ5 to promote tumor cell dissemination in vivo. J. Clin. Invest. 99:1390-1398.
69. M. E. Doerr and J. I. Jones (1996). The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells. J. Biol. Chem. 271:2443-2447.
70. F. Wang, V. M. Weaver, O. W. Petersen, C. A. Larabell, S. Dedhar, P. Briand, R. Lupu, and M. J. Bissell (1998). Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology. Proc. Natl. Acad. Sci. U.S.A. 95:14821-14826.